Interactions on record — worth a quick check against your medications. Based on 2 of 5 ingredients. Check your meds →
Dietary supplement

Total Pregnenolone Ingredients & Drug Interactions

by Nutri-West

Total Pregnenolone label
See full label image
Tablet Or Pill Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Total Pregnenolone against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Total Pregnenolone is a dietary supplement by Nutri-West with 5 active ingredients. Its ingredients are commonly taken for memory and cognitive support, anxiety and stress, anti-aging.Based on those ingredients, 82 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Pregnenolone. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Total Pregnenolone by Nutri-West

Ask about any prescription or over-the-counter medication and we check it for interactions with Total Pregnenolone by Nutri-West — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Total Pregnenolone by Nutri-West

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 17, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 1 of its 5 active ingredients.
  • “In a base of” is listed as a grouped ingredient — the label doesn't break down how much of each component you get.

Total Pregnenolone contains 5 active ingredients. The star player is pregnenolone, a naturally occurring steroid hormone precursor your body normally makes and converts into estrogen, testosterone, progesterone, and other hormones.

The other ingredients are xylitol (a sugar alcohol), fructose, maltodextrin, and spearmint flavoring. There are no inactive fillers or binders listed.

Does it work?

Strong evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed

This product doesn't appear to be marketed for a specific use, so we graded its ingredients' overall clinical evidence instead.

Strong

Strong clinical evidence supports its ingredients for:

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.
  • Since the label doesn't commit to one use, we graded the ingredients' overall clinical evidence instead.
  • On file: Dental caries — rated "Likely Effective" (Xylitol) (Natural Medicines).
  • On file: Otitis media — rated "Possibly Effective" (Xylitol) (Natural Medicines).

The evidence for pregnenolone isn't established in our data — we have no effectiveness ratings for conditions like Alzheimer disease, autism spectrum disorder, back pain, or bipolar disorder. Xylitol, one of the inactive ingredients here, is likely effective for preventing tooth decay and possibly effective for ear infections, but that's not the purpose of this product.

If you're taking it for a specific health concern, talk with your doctor about whether the research supports its use for that condition.

The evidence, ingredient by ingredient Pregnenolone Xylitol

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 2 of the 2 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 2 of 2.
  • General safety write-ups exist for 2 of 2.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Pregnenolone is a hormone with limited human safety data, so you should use it only under guidance from your healthcare professional. The most common side effects reported in trials are acne, agitation, diarrhea, drowsiness, excitement, hair loss, and sweating.

Some people have also reported skin rashes, possibly related to sun sensitivity, which cleared on their own. Xylitol at high doses (30–40 grams) can cause diarrhea and gas, though food amounts are generally well tolerated.

Xylitol is toxic to dogs, so keep this product away from pets.

Side effects, ingredient by ingredient Pregnenolone Xylitol

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 2 matched ingredients can interact with medications — Pregnenolone.
  • The most serious interaction on file is rated Moderate.
  • For scale: 82 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, check with your doctor or pharmacist if you take estrogens, progestins, progesterone, testosterone, or any benzodiazepines (like diazepam). Pregnenolone may boost the effects of the first four and reduce the calming effects of the last.

All of these are Moderate-severity interactions. Use the search tool on this page to look up your exact medications.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with strong clinical evidence behind its ingredients' uses. Moderate medication interactions have been identified, and safety information is well characterized.

Total Pregnenolone is a hormone supplement best used only under the guidance of a healthcare professional — the evidence for its effectiveness isn't established in our data, and it carries real risks of side effects and interactions with hormone-based and sedative medications. If you take any estrogens, progestins, testosterone, progesterone, benzodiazepines, or any other prescriptions, check them with your doctor or pharmacist before starting this product.

Pregnant or breastfeeding? This one isn't for you.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 5 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Dec 24, 2013.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Total Pregnenolone, straight from the product label.

Brand Nutri-West
Net contents 90 Chewable Tablet(s)
Market status On market
Date entered into DSLD Dec 24, 2013
DSLD ID 28637
Product type Non-nutrient/non-botanical
Supplement form Tablet Or Pill
Dietary claims / uses All Other
Intended target group(s) Adult (18 - 50 Years), Gluten Free, Dairy Free, Sugar Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Total Pregnenolone by Nutri-West, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Tablet(s)
Maximum serving Sizes:
1 Tablet(s)
IngredientAmount% DV
Xylitol0 NP--
Fructose0 NP--
Maltodextrin0 NP--
Pregnenolone2.4 mg--
In a base of0 NP--
natural Spearmint flavoring0 NP--

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

Manufactured under strict GMP & USP guidelines.

"When You Want The Best"

0784 MFG 06/2010

FOR DISTRIBUTION BY HEALTH CARE PROFESSIONALS ONLY.

Suggested/Recommended/Usage/Directions

Directions for use: Chew one tablet daily or as directed.

Formulation

Contains no gluten, starch, salt, sugar, wheat, corn, yeast, soy, milk, or preservatives.

Storage

Store in cool, dry place.

Precautions

KEEP OUT OF REACH OF CHILDREN.

TAMPER RESISTANT OUTER SEAL DO NOT USE IF BROKEN.

FDA Statement of Identity

Dietary Supplement

General

Product # 2741

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Total Pregnenolone by Nutri-West label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Total Pregnenolone label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Total Pregnenolone by Nutri-West

These are the 5 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Tablet(s) Dosage formTablet Or Pill Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Pregnenolone

Interacts with
82 drugs
2.4 mg per serving

Pregnenolone is a hormone your body makes naturally and a building block for other hormones like cortisol, DHEA, estrogen, and testosterone. It is sol...

Pregnenolone monograph & interactions

In a base of

0 NP per serving
  • › Xylitol
  • › Fructose
  • › Maltodextrin
  • › Natural Spearmint flavoring
Interaction report

Total Pregnenolone by Nutri-West Drug Interactions

Want to check YOUR meds against Total Pregnenolone?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
82Drugs
82 Moderate

Ingredients driving the most interactions

Pregnenolone 82

Individual Drug Interactions

The ingredients in Total Pregnenolone interact with 82 drugs. Click any drug to see the details.

1 of the 5 ingredients in Total Pregnenolone interact with drugs. Each result below shows which ingredient is responsible. Pregnenolone

Each ingredient & the kinds of drugs it affects

For each ingredient in Total Pregnenolone with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Pregnenolone5 drug types · 82 drugs

Benzodiazepines

Concomitant use of pregnenolone may reduce the effects of benzodiazepines.
Very preliminary clinical research shows that chronic use of pregnenolone reduces sedative effects of diazepam when compared with chronic use of placebo. This effect may be related to the activity of pregnenolone at GABAA receptors.

Likelihood Probable Evidence B
Estrogens

Theoretically, taking pregnenolone might enhance the effects of estrogens.
Pregnenolone is a precursor for several steroid hormones, including estrogens.

Likelihood Possible Evidence D
Progesterone

Theoretically, taking pregnenolone might enhance the effects of progesterone.
In humans, some research shows that oral administration of pregnenolone can increase levels of progesterone. However, other research shows no effect on progesterone levels. It is possible the impact of pregnenolone on progesterone levels may be dose dependent.

Likelihood Possible Evidence D
Progestin

Theoretically, taking pregnenolone might enhance the effects of progestin.
Pregnenolone is a precursor for several steroid hormones, including progestin.

Likelihood Possible Evidence D
Testosterone

Theoretically, taking pregnenolone might enhance the effects of testosterone.
Pregnenolone is a precursor for several steroid hormones, including testosterone. However, preliminary clinical research shows that taking pregnenolone 30-500 mg orally daily for up to 8 weeks does not affect testosterone levels.

Likelihood Possible Evidence D
Pregnenolone full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Total Pregnenolone, from the product label.

Nutri-West

See all Nutri-West products
Name
Nutri-West
City
Douglas
State
Wy
ZipCode
82633
Pharmacist Counseling Corner

Total Pregnenolone by Nutri-West: Common Questions

Does Total Pregnenolone by Nutri-West interact with any medications?
Yes. Based on its ingredients, Total Pregnenolone has a known interaction with 82 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Total Pregnenolone contains 5 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What is pregnenolone and why is it in this product?
Pregnenolone is a steroid hormone your body naturally produces and uses to make other hormones like estrogen, testosterone, and progesterone. It's included in this supplement because some people believe it may support certain health concerns, though the evidence for most of those uses isn't established in our data.
Will this help with memory or brain health?
We don't have reliable evidence that pregnenolone works for Alzheimer disease or other cognitive concerns. If you're interested in it for that reason, talk with your doctor about what the research actually shows and whether it's right for you.
Is it safe to take if I'm on birth control?
That depends on the specific medication and your situation — pregnenolone may enhance the effects of estrogens and progestins found in many birth control pills. You need to check with your doctor or pharmacist before adding this product, since changes in how your birth control works could matter.
Can I take this if I take an anti-anxiety medication like Valium?
Pregnenolone may reduce the sedative effects of benzodiazepines like diazepam (Valium), so this is a real concern. Don't start this product without talking to your doctor or pharmacist first — they can help you decide if it's safe with your specific medication.
What side effects should I watch for?
The most commonly reported side effects are acne, agitation, diarrhea, drowsiness, excitement, hair loss, and sweating. Some people have also reported skin rashes. If you notice any of these or anything unusual, talk with your healthcare provider.
Is xylitol in this product safe?
Xylitol is generally well tolerated in food amounts, but high doses can cause diarrhea and gas. Keep this product away from pets — xylitol is toxic to dogs.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Total Pregnenolone label
Go deeper

The Full Monographs Behind Total Pregnenolone’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Pregnenolone

Interacts with 82 drugs

Pregnenolone is a hormone your body makes naturally and a building block for other hormones like cortisol, DHEA, estrogen, and testosterone. It is sold as a supplement for memory, mood, and...

Read the full Pregnenolone monograph → Herb & supplement monograph

Xylitol

Xylitol is a sugar alcohol used as a low-calorie sweetener that has the best-supported benefit for reducing cavities, especially in chewing gum or lozenges. It is generally safe for people i...

Read the full Xylitol monograph →
Sources

Sources & How We Checked

Total Pregnenolone's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 13 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Xylitol 7 references
  1. Martindale W. Martindale the Extra Pharmacopoeia. Pharmaceutical Press, 1999.
  2. Weissman JD, Fernandez F, Hwang PH. Xylitol nasal irrigation in the management of chronic rhinosinusitis: a pilot study. Laryngoscope 2011;121:2468-72. PubMed
  3. Okamoto K, Kagami M, Kawai M, et al. Anaphylaxis to xylitol diagnosed by skin prick test and basophil activation test. Allergol Int. 2019;68(1):130-131. PubMed
  4. Rabago D, Kille T, Mundt M, Obasi C. Results of a RCT assessing saline and xylitol nasal irrigation for CRS and fatigue in Gulf War illness. Laryngoscope Investig Otolaryngol 2020;5(4):613-620.
  5. Wołyniec W, Szwarc A, Kasprowicz K, et al. Impact of hydration with beverages containing free sugars or xylitol on metabolic and acute kidney injury markers after physical exercise. Front Physiol 2022;13:841056. PubMed
  6. Bordier V, Teysseire F, Drewe J, et al. Effects of a 5-week intake of erythritol and xylitol on vascular function, abdominal fat and glucose tolerance in humans with obesity: a pilot trial. BMJ Nutr Prev Health 2023;6(2):264-272. PubMed
  7. Margulis I, Cohen-Kerem R, Stein N, et al. Xylitol nasal spray for prevention of recurrent acute otitis media in children: A prospective two-center cohort study. Int J Pediatr Otorhinolaryngol 2024;176:111818. PubMed

See these in context on the Xylitol monograph →

Pregnenolone 6 references
  1. Devlin TM, ed. Textbook of Biochemistry With Clinical Correlations. third ed. New York: Wiley-Liss Inc., 1992.
  2. Fung LK, Libove RA, Phillips J, Haddad F, Hardan AY.Brief report: an open-label study of the neurosteroid pregnenolone in adults with autism spectrum disorder. J Autism Dev Disord 2014;44(11):2971-7. PubMed
  3. Brown ES, Park J, Marx CE, et al. A randomized, double-blind, placebo-controlled trial of pregnenolone for bipolar depression. Neuropsychopharmacology 2014;39(12):2867-73. PubMed
  4. Ritsner MS, Gibel A, Shleifer T, et al. Pregnenolone and dehydroepiandrosterone as an adjunctive treatment in schizophrenia and schizoaffective disorder: an 8-week, double-blind, randomized, controlled, 2-center, parallel-group trial. J Clin Psychiatry 20 PubMed
  5. Meieran SE, Reus VI, Webster R, Shafton R, Wolkowitz OM. Chronic pregnenolone effects in normal humans: attenuation of benzodiazepine-induced sedation. Psychoneuroendocrinology 2004;29(4):486-500. PubMed
  6. Marx CE, Keefe RS, Buchanan RW, et al. Proof-of-concept trial with the neurosteroid pregnenolone targeting cognitive and negative symptoms in schizophrenia. Neuropsychopharmacology 2009;34(8):1885-903. PubMed

See these in context on the Pregnenolone monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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