Pregnenolone + drospirenone, ethinyl estradiol, levomefolate
drospirenone, ethinyl estradiol, levomefolate brand name: Beyaz.
drospirenone, ethinyl estradiol, levomefolate falls into 3 drug categories that Pregnenolone can interact with; the most serious is rated moderate. Theoretically, taking pregnenolone might enhance the effects of estrogens.
Read the full interaction reportPregnenolone and drospirenone, ethinyl estradiol, levomefolate
These two interact in 3 distinct ways. Each one is explained separately below.
Why Are There 3 Interactions?
Pregnenolone interacts with whole categories of medication. drospirenone, ethinyl estradiol, levomefolate falls into 3 of those categories, so it can interact with Pregnenolone in 3 different ways. We’ve listed each one below — your overall risk is driven by the most serious of them (Moderate).
ESTROGENS
1 of 3Why this applies to drospirenone, ethinyl estradiol, levomefolate
drospirenone, ethinyl estradiol, levomefolate falls under ESTROGENS — the group Pregnenolone interacts with.
Pregnenolone is a precursor for several steroid hormones, including estrogens.
Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
Beyaz combines an estrogen (ethinyl estradiol) with a progestin (drospirenone) plus a folate. Here's the idea behind this one: pregnenolone is a hormone your body uses as a starting block to make other hormones, including estrogens. So in theory, adding it on top of your birth control pill could nudge your total estrogen activity a little higher.
I want to be honest that this is a theoretical concern based on how these hormones work, not something proven in studies. If estrogen effects did climb, you might notice things like nausea, breast tenderness, bloating, or mood changes. Since both estrogen and drospirenone can affect clotting and potassium, it's worth a quick chat with your pharmacist or doctor before combining them. Please don't change anything on your own.
- Devlin TM, ed. Textbook of Biochemistry With Clinical Correlations. third ed. New York: Wiley-Liss Inc., 1992.
PROGESTIN
2 of 3drospirenone, ethinyl estradiol, levomefolate also falls under PROGESTIN.
Pregnenolone is a precursor for several steroid hormones, including progestin.
Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
Here's the simple version: Beyaz combines a progestin (drospirenone), an estrogen, and an active form of folate. Pregnenolone is a hormone your body can convert into other steroid hormones, including progestin-like compounds. So in theory, adding it on top of your birth control could nudge your overall hormone levels a little higher and make the progestin-type effects feel stronger.
I want to be honest that this is a theoretical concern based on how these hormones are built, not something proven in studies. If anything did show up, it might look like more of the usual progestin-related effects, things like breast tenderness, bloating, mood shifts, or breakthrough spotting. It shouldn't make your pill less effective. Since pregnenolone is itself a hormone, please run it by your pharmacist or doctor before combining the two.
- Devlin TM, ed. Textbook of Biochemistry With Clinical Correlations. third ed. New York: Wiley-Liss Inc., 1992.
PROGESTERONE
3 of 3drospirenone, ethinyl estradiol, levomefolate also falls under PROGESTERONE.
In humans, some research shows that oral administration of pregnenolone can increase levels of progesterone. However, other research shows no effect on progesterone levels. It is possible the impact of pregnenolone on progesterone levels may be dose dependent.
Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
Here's the gist with Beyaz, which is a birth control pill that combines drospirenone (a progestin), ethinyl estradiol (an estrogen), and a folate. Pregnenolone is a hormone your body can turn into other hormones, including progesterone. The thinking is that adding it on top of your pill might nudge progesterone-like activity a little higher. I want to be honest though: this is only a theoretical concern based on how these hormones work, and the human studies are mixed (some show a small rise in progesterone, others show nothing).
If anything did shift, you might notice more typical progestin-type effects like breast tenderness, bloating, mood changes, or spotting. None of this is a reason to stop your pill or skip the supplement on your own. Since pregnenolone is a hormone itself, please run it by your pharmacist or doctor first.
- Ritsner MS, Gibel A, Shleifer T, et al. Pregnenolone and dehydroepiandrosterone as an adjunctive treatment in schizophrenia and schizoaffective disorder: an 8-week, double-blind, randomized, controlled, 2-center, parallel-group trial. J Clin Psychiatry 20 PubMed
- Marx CE, Keefe RS, Buchanan RW, et al. Proof-of-concept trial with the neurosteroid pregnenolone targeting cognitive and negative symptoms in schizophrenia. Neuropsychopharmacology 2009;34(8):1885-903. PubMed
What These Ratings Mean
Every interaction above is graded three ways — here’s the key to each label.
Clinically significant. Avoid the combination, or use only under close professional supervision.
Usually worth avoiding or managing — may need monitoring, a dose change, or timing apart.
Generally not serious. Be aware of it and mention it to your pharmacist.
- LikelyWell-controlled human studies have demonstrated the likely existence of this interaction.
- ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
- PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
- UnlikelyInteraction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
- AHigh-quality meta-analysis (quantitative systematic review).
- BCase-control study.
- CConsensus.
- DAnecdotal evidence.
These ratings are for information only. Never start, stop, or otherwise change your therapy before speaking with your provider.
Pregnenolone Also Interacts With Other Medications
Pregnenolone has 81 moderate known drug interactions in our database — the drospirenone, ethinyl estradiol, levomefolate one above is among them. If you take anything else, check it against the full list below.
Check Another of Your Medications Against Pregnenolone
We haven’t checked that one against Pregnenolone yet — ask our pharmacists directly.
Covers the 2,830 medications we’ve checked against Pregnenolone. Pick one to open its full report.
See Every Supplement That Interacts With drospirenone, ethinyl estradiol, levomefolate
This page covers Pregnenolone only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the drospirenone, ethinyl estradiol, levomefolate page lists 245 supplements it has a documented interaction with, worst first, each one explained.
The most serious there right now: Activated Charcoal (major), Beer (major), Grapefruit (major), Siberian Cocklebur (major) and St. John's Wort (major).
By severity: 6 major · 200 moderate · 39 minor.
Open the drospirenone, ethinyl estradiol, levomefolate interaction page
Taking Pregnenolone as Part of a Dietary Supplement Product? Check It for Interactions
We hold 303 real supplement products containing Pregnenolone, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Pregnenolone. Your product may carry other ingredients that interact with drospirenone, ethinyl estradiol, levomefolate too, on top of Pregnenolone — and those would not show on this page. Find your product and we’ll check every ingredient on its label:
Where Pregnenolone and drospirenone, ethinyl estradiol, levomefolate Sit Against Everything Else
Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.
#410 of 1,452 supplements looked up here in the last 7 days
#261 of 2,830 medications looked up here in the last 7 days
Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.
About Pregnenolone
What is Pregnenolone?
- Memory and cognitive support
- Anxiety and stress
- Anti-aging
- Fatigue and low energy
- Mood support
Pregnenolone is a hormone your body makes naturally and a building block for other hormones like cortisol, DHEA, estrogen, and testosterone. It is sold as a supplement for memory, mood, and anti-aging, but solid human evidence for these uses is very limited. Because it is a hormone, talk with your pharmacist or doctor before using it.
Other Drugs & Pregnenolone
Browse every other medication we’ve checked against Pregnenolone — both the ones with a known interaction and the ones without. Select any drug for the full detail.
No drugs match “”.
81 interactions
- Estradiol ›
- Norethindrone ›
- Testosterone ›
- Flurazepam ›
- Methyltestosterone ›
- Triazolam ›
- Temazepam ›
- Nitrazepam ›
- Conjugated Estrogens ›
- Diazepam ›
- Medroxyprogesterone ›
- Medroxyprogesterone Acetate ›
- Testosterone Undecanoate ›
- Clobazam ›
- Clonazepam ›
- Clorazepate ›
- Midazolam ›
- Progesterone (prescription Drug) ›
- Alprazolam ›
- Esterified Estrogens ›
- Estropipate ›
- Hydroxyprogesterone ›
- Megestrol Acetate ›
- Methyltestosterone Buccal ›
- Bromazepam ›
- Chlordiazepoxide ›
- Desogestrel ›
- Drospirenone ›
- Estazolam ›
- Estrogen ›
- Estrone ›
- Ethinyl Estradiol ›
- Halazepam ›
- Ketazolam ›
- Lorazepam ›
- Oestrogen ›
- Oxazepam ›
- Prasterone (prescription Drug) ›
- Prazepam ›
- Progesterone ›
- Quazepam ›
- Remimazolam Besylate ›
- Testosterone Enanthate ›
- Tibolone ›
- Ethinyl Estradiol, Norethindrone ›
- Ethinyl Estradiol, Levonorgestrel ›
- Ethinyl Estradiol, Norgestimate ›
- Ethinyl Estradiol, Desogestrel ›
- Ethinyl Estradiol, Norethindrone, Ferrous Fumarate ›
- Desogestrel, Ethinyl Estradiol ›
- Mestranol, Norethindrone ›
- Ethinyl Estradiol, Ethynodiol Diacetate ›
- Levonorgestrel, Ethinyl Estradiol ›
- Ethinyl Estradiol, Norgestrel ›
- Drospirenone, Ethinyl Estradiol ›
- Conjugated Estrogens, Medroxyprogesterone Acetate ›
- Conjugated Estrogens, Meprobamate ›
- Cyproterone Acetate, Ethinyl Estradiol ›
- Ethiny Estradiol, Levonorgestrel ›
- Norelgestromin, Ethinyl Estradiol ›
Showing 60 of 81 moderate interactions — see all 81 on the Pregnenolone page.
No interaction 2,748 drugs checked — show the list
We also checked Pregnenolone against these medications and found no known interaction in our sources. Open any page to confirm.
- Apixaban ›
- Amlodipine ›
- Levothyroxine ›
- Methylphenidate ›
- Warfarin ›
- Abemaciclib ›
- Ivermectin ›
- Sertraline ›
- Acetaminophen ›
- Losartan Potassium ›
- Aspirin ›
- Rosuvastatin ›
- Metoprolol ›
- Escitalopram ›
- Clopidogrel ›
- Rivaroxaban ›
- Atorvastatin ›
- Methamphetamine ›
- Tirzepatide ›
- Docusate ›
- Ibuprofen ›
- Warfarin Sodium ›
- Sumatriptan ›
- Isotretinoin ›
- Valacyclovir ›
- Tadalafil ›
- Hydroxyurea ›
- Amlodipine Besylate ›
- Prednisone ›
- Semaglutide ›
- Metformin ›
- Lisdexamfetamine ›
- Propranolol ›
- Amitriptyline ›
- Amphetamine ›
- Methotrexate ›
- Lisinopril ›
- Amoxicillin ›
- Bupropion ›
- Fluoxetine ›
- Levothyroxine, Liothyronine ›
- Doxycycline ›
- Bendamustine ›
- Pregabalin ›
- Azithromycin ›
- Acyclovir ›
- Lamotrigine ›
- Gabapentin ›
- Dextroamphetamine ›
- Naproxen ›
- Quetiapine ›
- Buspirone ›
- Omeprazole ›
- Duloxetine ›
- Acetaminophen, Codeine ›
- Letrozole ›
- Citalopram ›
- Methylene Blue ›
- Ciprofloxacin ›
- Acetaminophen, Aspirin, Caffeine ›
Showing the 60 most looked-up of 2,748 medications checked with no known interaction — see the full Pregnenolone list.
Sources & How We Checked
Interaction details are evidence-graded and sourced from the Natural Medicines database. The medication overview comes from MedlinePlus.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference for vitamins, herbs and supplements — the basis for our interaction data.
- MedlinePlus, U.S. National Library of Medicine — NIH consumer drug information, used for the medication overviews.
- NIH Dietary Supplement Label Database (DSLD) — Official supplement product labels.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC
drospirenone, ethinyl estradiol, levomefolate Is Linked to Lower Levels of 7 Nutrients
Natural Medicines records drospirenone, ethinyl estradiol, levomefolate as a medicine that can lower these. This is not an interaction with Pregnenolone — it is a separate effect of the medicine, and it is a reason some people are advised to supplement rather than to avoid one:
Read the full drospirenone, ethinyl estradiol, levomefolate nutrient depletion report ›
Depletion records come from the licensed Natural Medicines database. Do not start a supplement on the strength of this page — ask your pharmacist or doctor whether it applies to you.
Taking Pregnenolone and drospirenone, ethinyl estradiol, levomefolate Together: Common Questions
Can you take Pregnenolone with drospirenone, ethinyl estradiol, levomefolate?
Why are there 3 interactions listed for Pregnenolone and drospirenone, ethinyl estradiol, levomefolate?
How serious is the Pregnenolone and drospirenone, ethinyl estradiol, levomefolate interaction?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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