Medication interaction hub

What Supplements Interact with drospirenone, ethinyl estradiol, levomefolate?

drospirenone, ethinyl estradiol, levomefolate brand name: Beyaz. Every interaction below applies to the brands too.

245 Interactions 6 Major 200 Moderate 39 Minor
Curated & coded by · Clinical Pharmacist · Updated September 22, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with drospirenone, ethinyl estradiol, levomefolate? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check drospirenone, ethinyl estradiol, levomefolate against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line

245 supplements and herbal ingredients have interactions with drospirenone, ethinyl estradiol, levomefolate on file in the HelloPharmacist interaction database — 6 rated major, 200 moderate, and 39 minor. The most serious involve Grapefruit, Siberian Cocklebur, Activated Charcoal, Beer and St. John's Wort.

Our assessment: with 6 major-rated interactions on the list, this one deserves real attention — know the major entries before combining anything with drospirenone, ethinyl estradiol, levomefolate.

Major 6 Moderate 200 Minor 39 No known interaction 1,207

Ranked by severity below. Every entry links to the full pharmacist-reviewed report for that exact combination — what can happen, how likely it is, and what to do about it.

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Most Viewed Ingredient Interactions

drospirenone, ethinyl estradiol, levomefolate: Top Interactions at a Glance

The drospirenone, ethinyl estradiol, levomefolate supplement & herbal interactions people checked most in the last 24 hours, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 245 interacting ingredients — plus 1,207 more checked with no known interaction. See the complete ranked list.

Start here

The Most-Checked drospirenone, ethinyl estradiol, levomefolate Combinations Today

The drospirenone, ethinyl estradiol, levomefolate + supplement pages people viewed most in the last 24 hours (resets at midnight). Open any card for the full report.

Minor Likelihood Possible Copper + drospirenone, ethinyl estradiol, levomefolatei

Theoretically, taking copper with contraceptive drugs might increase the levels and toxic effects of copper.

Read the full interaction Minor Likelihood Possible Selenium + drospirenone, ethinyl estradiol, levomefolatei

Contraceptive drugs might increase levels of selenium, although the clinical significance of this effect is unclear.

Read the full interaction Moderate Likelihood Possible Dhea + drospirenone, ethinyl estradiol, levomefolatei

Theoretically, DHEA might increase the levels of drugs metabolized by CYP3A4.

Read the full interaction Moderate Likelihood Likely Potassium + drospirenone, ethinyl estradiol, levomefolatei

Concomitant use increases the risk of hyperkalemia.

Read the full interaction Moderate Likelihood Possible Hemp + drospirenone, ethinyl estradiol, levomefolatei

Theoretically, hemp might interfere with hormone therapy due to its estrogenic effects.

Read the full interaction Minor Likelihood Unlikely Deer Velvet + drospirenone, ethinyl estradiol, levomefolatei

Theoretically, deer velvet might increase the effects and side effects of estrogens.

Read the full interaction
The complete list

Every Supplement Checked Against drospirenone, ethinyl estradiol, levomefolate

All 1,452 ingredients in our database, ranked by severity — 245 with a drospirenone, ethinyl estradiol, levomefolate interaction on file and 1,207 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With drospirenone, ethinyl estradiol, levomefolate?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Copper with drospirenone, ethinyl estradiol, levomefolate?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, taking copper with contraceptive drugs might increase the levels and toxic effects of copper.

Full Copper + drospirenone, ethinyl estradiol, levomefolate answer

Can you take Selenium with drospirenone, ethinyl estradiol, levomefolate?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Contraceptive drugs might increase levels of selenium, although the clinical significance of this effect is unclear.

Full Selenium + drospirenone, ethinyl estradiol, levomefolate answer

Can you take Dhea with drospirenone, ethinyl estradiol, levomefolate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, DHEA might increase the levels of drugs metabolized by CYP3A4.

Full Dhea + drospirenone, ethinyl estradiol, levomefolate answer

Can you take Potassium with drospirenone, ethinyl estradiol, levomefolate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Concomitant use increases the risk of hyperkalemia.

Full Potassium + drospirenone, ethinyl estradiol, levomefolate answer

Can you take Hemp with drospirenone, ethinyl estradiol, levomefolate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, hemp might interfere with hormone therapy due to its estrogenic effects.

Full Hemp + drospirenone, ethinyl estradiol, levomefolate answer

Can you take Gum Arabic with drospirenone, ethinyl estradiol, levomefolate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, gum arabic can alter the absorption of oral drugs due to its fiber content.

Full Gum Arabic + drospirenone, ethinyl estradiol, levomefolate answer

Can you take Gymnema with drospirenone, ethinyl estradiol, levomefolate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, gymnema might increase levels of drugs metabolized by CYP1A2.

Full Gymnema + drospirenone, ethinyl estradiol, levomefolate answer

Can you take Hemp Agrimony with drospirenone, ethinyl estradiol, levomefolate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Hemp agrimony contains hepatotoxic pyrrolizidine alkaloids (PA).

Full Hemp Agrimony + drospirenone, ethinyl estradiol, levomefolate answer

Can you take Hesperidin with drospirenone, ethinyl estradiol, levomefolate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, hesperidin might inhibit P-glycoprotein-mediated drug efflux and potentially increase levels of drugs that are substrates of...

Full Hesperidin + drospirenone, ethinyl estradiol, levomefolate answer

Can you take Higenamine with drospirenone, ethinyl estradiol, levomefolate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, higenamine might increase the levels and clinical effects drugs metabolized by CYP3A4.

Full Higenamine + drospirenone, ethinyl estradiol, levomefolate answer

Can you take Hops with drospirenone, ethinyl estradiol, levomefolate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of large amounts of hops might interfere with hormone replacement therapy due to competition for estrogen rec...

Full Hops + drospirenone, ethinyl estradiol, levomefolate answer

Can you take Horny Goat Weed with drospirenone, ethinyl estradiol, levomefolate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, horny goat weed might increase the effects and side effects of CYP1A2 substrates.

Full Horny Goat Weed + drospirenone, ethinyl estradiol, levomefolate answer

Can you take Hu Zhang with drospirenone, ethinyl estradiol, levomefolate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, hu zhang might increase levels of drugs metabolized by CYP1A2.

Full Hu Zhang + drospirenone, ethinyl estradiol, levomefolate answer

Can you take Indian Long Pepper with drospirenone, ethinyl estradiol, levomefolate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, Indian long pepper might increase the effects and adverse effects of CYP3A4 substrates.

Full Indian Long Pepper + drospirenone, ethinyl estradiol, levomefolate answer

Can you take Indole-3-carbinol with drospirenone, ethinyl estradiol, levomefolate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, indole-3-carbinol might increase the metabolism of CYP1A2 substrates and lower serum concentrations.

Full Indole-3-carbinol + drospirenone, ethinyl estradiol, levomefolate answer

Can you take Ipriflavone with drospirenone, ethinyl estradiol, levomefolate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Ipriflavone is thought to competitively inhibit cytochrome P450 1A2 (CYP1A2).

Full Ipriflavone + drospirenone, ethinyl estradiol, levomefolate answer

Can you take Kava with drospirenone, ethinyl estradiol, levomefolate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, using kava with hepatotoxic drugs might increase the risk of liver damage.

Full Kava + drospirenone, ethinyl estradiol, levomefolate answer

Can you take Khella with drospirenone, ethinyl estradiol, levomefolate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, khella might have additive adverse effects on the liver when used with hepatotoxic drugs.

Full Khella + drospirenone, ethinyl estradiol, levomefolate answer

Can you take Kratom with drospirenone, ethinyl estradiol, levomefolate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, kratom might increase the levels and clinical effects of drugs metabolized by CYP1A2.

Full Kratom + drospirenone, ethinyl estradiol, levomefolate answer

Can you take Kudzu with drospirenone, ethinyl estradiol, levomefolate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use might have additive hepatotoxic effects.

Full Kudzu + drospirenone, ethinyl estradiol, levomefolate answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) drospirenone, ethinyl estradiol, levomefolate is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by drospirenone, ethinyl estradiol, levomefolate, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

drospirenone, ethinyl estradiol, levomefolate sits in 14 interaction categories. Open any one to see what the group means:

Cytochrome P450 3A4 (Cyp3A4) Substrates 121 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

121 of the supplement ingredients on this page reach drospirenone, ethinyl estradiol, levomefolate through this category.

Cytochrome P450 1A2 (Cyp1A2) Substrates 79 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

79 of the supplement ingredients on this page reach drospirenone, ethinyl estradiol, levomefolate through this category.

Estrogens 60 ingredients

Hormone-related medications. Supplements with hormone-like activity can add to or interfere with them.

60 of the supplement ingredients on this page reach drospirenone, ethinyl estradiol, levomefolate through this category.

Hepatotoxic Drugs 38 ingredients

Medications with known liver considerations. Supplements that can stress the liver add to the load.

38 of the supplement ingredients on this page reach drospirenone, ethinyl estradiol, levomefolate through this category.

P-Glycoprotein Substrates 37 ingredients

A drug-transport group: these medications are moved in and out of cells by the P-glycoprotein pump. Supplements that affect the pump can change how much of the drug is absorbed or kept in the body.

37 of the supplement ingredients on this page reach drospirenone, ethinyl estradiol, levomefolate through this category.

Contraceptive Drugs 30 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

30 of the supplement ingredients on this page reach drospirenone, ethinyl estradiol, levomefolate through this category.

Oral Drugs 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach drospirenone, ethinyl estradiol, levomefolate through this category.

Cytochrome P450 3A4 (Cyp3A4) Inhibitors 13 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

13 of the supplement ingredients on this page reach drospirenone, ethinyl estradiol, levomefolate through this category.

Cytochrome P450 1A2 (Cyp1A2) Inhibitors 10 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

10 of the supplement ingredients on this page reach drospirenone, ethinyl estradiol, levomefolate through this category.

Potassium-Sparing Diuretics 8 ingredients

Medications that increase fluid loss. Supplements affecting fluid or electrolytes (like potassium) can interact with them.

8 of the supplement ingredients on this page reach drospirenone, ethinyl estradiol, levomefolate through this category.

Ethinyl Estradiol 3 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

3 of the supplement ingredients on this page reach drospirenone, ethinyl estradiol, levomefolate through this category.

Progesterone 2 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

2 of the supplement ingredients on this page reach drospirenone, ethinyl estradiol, levomefolate through this category.

Cytochrome P450 1A2 (Cyp1A2) Substrates 1 ingredient

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

1 of the supplement ingredient on this page reaches drospirenone, ethinyl estradiol, levomefolate through this category.

Progestin 1 ingredient

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

1 of the supplement ingredient on this page reaches drospirenone, ethinyl estradiol, levomefolate through this category.

Related: does drospirenone, ethinyl estradiol, levomefolate deplete any nutrients?

drospirenone, ethinyl estradiol, levomefolate has 7 reported nutrient associations in the research literature — see the drospirenone, ethinyl estradiol, levomefolate nutrient depletion report.

Check a real product

Take a Supplement Product? Check the Whole Bottle Against drospirenone, ethinyl estradiol, levomefolate

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against drospirenone, ethinyl estradiol, levomefolate.

Search a supplement product

Type a product name, brand, or UPC — smart search across our full catalog.

Grounded search over our product catalog — every verdict comes from our interaction database, never AI guesswork. How we use AI

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Photograph any Supplement Facts panel — we read the ingredients and check each one against your medications. Free, in seconds.

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Prefer typing? The interaction checker looks up products by name too.

Pharmacist Counseling Corner

drospirenone, ethinyl estradiol, levomefolate & Supplements: Common Questions

What supplements interact with drospirenone, ethinyl estradiol, levomefolate?
In our interaction database, 245 supplement and herbal ingredients have an interaction with drospirenone, ethinyl estradiol, levomefolate on file — 6 rated major, 200 moderate, and 39 minor. That number sounds scarier than it is: severity matters far more than the count, which is why the list on this page is ranked instead of alphabetical. Start at the top. The highest-ranked right now: Grapefruit, Siberian Cocklebur, Activated Charcoal.
Which drospirenone, ethinyl estradiol, levomefolate supplement interactions are the most serious?
The 6 major-rated combinations — led by Grapefruit, Siberian Cocklebur, Activated Charcoal, Beer and St. John's Wort — deserve real caution: these are the ones generally best avoided, or used only with your prescriber watching. If you take any of them today, don't panic and don't stop anything abruptly — call your pharmacist first. Jump to the ranked list.
Can I take vitamins or supplements while on drospirenone, ethinyl estradiol, levomefolate?
That depends entirely on which supplement. The honest answer for drospirenone, ethinyl estradiol, levomefolate is in the ranked list above — and if what you take is a combination product with a dozen ingredients, don't check them one by one: photograph the label with our scanner and we'll check the whole thing at once. Try the label scanner or the interaction checker.
Do brands like Beyaz have the same supplement interactions as drospirenone, ethinyl estradiol, levomefolate?
Yes — Beyaz all contain drospirenone, ethinyl estradiol, levomefolate, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
Does drospirenone, ethinyl estradiol, levomefolate deplete any vitamins or nutrients?
It might — drospirenone, ethinyl estradiol, levomefolate has 7 reported nutrient-depletion associations in the research literature, which is a different question from interactions: instead of a supplement changing the drug, the drug may lower a nutrient over time. See the drospirenone, ethinyl estradiol, levomefolate nutrient depletion report for the specifics and what to discuss with your pharmacist.
What about drospirenone, ethinyl estradiol, levomefolate and my other medications?
This page covers drospirenone, ethinyl estradiol, levomefolate against supplements and herbal ingredients. Checking drospirenone, ethinyl estradiol, levomefolate against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 22, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.