Interactions on record — worth a quick check against your medications. Check your meds →
Dietary supplement

Trim Cafe Ingredients & Drug Interactions

by TLS

Trim Cafe label
See full label image
Powder Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Oct 7, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Trim Cafe against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Trim Cafe is a dietary supplement by TLS with 1 active ingredient. Its ingredients are commonly taken for weight loss, appetite control, cholesterol support.Based on those ingredients, 94 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are WellTrim iG (IGOB131) African Mango (Irvingia gabonensis) seed extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Trim Cafe by TLS

Ask about any prescription or over-the-counter medication and we check it for interactions with Trim Cafe by TLS — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
Prefer a human? Send your question to our licensed pharmacists — free, answered by email within 24 hours.

HelloPharmacist Scorecard of Trim Cafe by TLS

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 17, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

Trim Cafe is a powder with one active ingredient: WellTrim iG (IGOB131), which is an African Mango seed extract standardized as IGOB131. The powder also contains Colombian Arabic Coffee powder as an inactive ingredient.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see Irvingia Gabonensis's own graded uses on its monograph.

Why this rating?
  • The label markets this product for: appetite control and metabolic balance support.
  • We looked for evidence on: Obesity, Metabolic syndrome, Diabetes, Hypercholesterolemia, weight management, satiety.
  • The closest evidence on file: Irvingia Gabonensis is rated "Insufficient Reliable Evidence To Rate" for Diabetes (Natural Medicines).
  • Also on file: Irvingia Gabonensis is rated "Insufficient Reliable Evidence To Rate" for Hypercholesterolemia, Obesity, Metabolic syndrome.

The evidence for African Mango in Trim Cafe isn't established. We hold insufficient reliable evidence to rate it for obesity, diabetes, high cholesterol, or metabolic syndrome.

That doesn't mean it doesn't work—it means the human research available isn't solid enough to say one way or the other. If you're looking for weight or cholesterol support, talk with your doctor or pharmacist about what the science actually backs.

The evidence, ingredient by ingredient Irvingia Gabonensis

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

African Mango is generally well tolerated in short-term studies, but long-term safety and product quality aren't well established, so be aware of that if you're thinking of using it long-term. The most common side effects reported are flatulence, headache, insomnia, and nausea.

One rare case of acute liver inflammation (hepatitis) was reported in a person taking 350 mg twice daily for ten days, though it's unclear if African Mango was the cause. Safety data is not sufficient during pregnancy or breastfeeding, so it's best avoided if you're pregnant or nursing.

Side effects, ingredient by ingredient Irvingia Gabonensis

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Irvingia Gabonensis.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: diabetes medications.
  • For scale: 94 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check with your doctor or pharmacist before starting Trim Cafe if you take antidiabetes drugs—African Mango may lower your blood sugar further and require dose adjustment. Also use caution or avoid it if you're on testosterone products, since the extract may raise testosterone levels.

These are the two medication types with documented interactions.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

Trim Cafe is worth a conversation with your doctor or pharmacist if you're interested in it—especially if you take diabetes medication or testosterone products, since those interactions need monitoring. The supplement is generally tolerated short-term, but the evidence for what it actually does isn't strong, and long-term safety isn't well studied.

Check your own medications with the tool on this page, and then run the idea past your healthcare provider before you start.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Jun 24, 2019.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Trim Cafe, straight from the product label.

Brand TLS
Net contents 1.75 oz.; 50 Gram(s)
Market status On market
Date entered into DSLD Jun 24, 2019
DSLD ID 204151
Product type Botanical
Supplement form Powder
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Trim Cafe by TLS, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
3.3 Gram(s)
Maximum serving Sizes:
3.3 Gram(s)
Servings per container
15
IngredientAmount% DV
WellTrim iG (IGOB131) African Mango (Irvingia gabonensis) seed extract300 mg--

Other ingredients: Colombian Arabic Coffee powder

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Seals/Symbols

Gluten free

Formulation

Gluten free

General Statements

A thermogenic slimming supplement

15-0.1164oz (3.3 g) stickpads

What does trim cafe do? You can enjoy TLS Trim Cafe in an instant. This delicious, thermogenic slimming supplement is formulated to help manage and control appetite, promote satiety and support metabolic balance. Mix up some Trim Cafe today and support lasting weight loss efforts.

FDA Statement of Identity

Dietary Supplement

Formula

Contains ingredients WellTrim iG, a clinically studied Irvingia seed extract for weight loss and metabolic wellness.

FDA Disclaimer Statement

These statements have not been evaluated by the Food Drug and Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Precautions

Warning: If you are currently taking any prescription medication or have an ongoing medical condition, you should consult your healthcare practitioner before using this product. Women who are pregnant or breastfeeding should not use this product.

Keep out of the reach of children.

Resale on third-party websites is strictly prohibited unless specifically authorized by Market America or its corporate affiliates. If barcodes are altered or you purchase this product from an unauthorized third-party website, the product is not guaranteed by Market America or its corporate affiliates.

Brand IP Statement(s)

WellTrim iG is a trademark of Icon Group, LLC. IGOBI31 is a trademark of Gateway Health Alliances, Inc. and is protected under U.S. Patent 7,573,790.

Suggested/Recommended/Usage/Directions

Directions for use Mix one stickpack (3.3 g) with 7 fluid ounces of hot water. May use more or less water, based on personal taste preference. As a dietary supplement, it is recommended that you take once daily, or as directed by your healthcare practitioner. Most effective if taken 30-60 minutes before a meal, but not required.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Trim Cafe by TLS label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Trim Cafe label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Trim Cafe by TLS

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size3.3 Gram(s) Dosage formPowder Servings per container15 Amounts shown are per serving.

WellTrim iG (IGOB131) African Mango (Irvingia gabonensis) seed extract

Interacts with
94 drugs
300 mg per serving

Irvingia gabonensis (African mango) is a seed extract marketed mainly for weight loss and metabolic health. A few small studies suggest possible benef...

WellTrim iG (IGOB131) African Mango (Irvingia gabonensis) seed extract monograph & interactions

Other (inactive) ingredients: Colombian Arabic Coffee powder. These complete the product’s ingredient list but are not active constituents.

Interaction report

Trim Cafe by TLS Drug Interactions

Want to check YOUR meds against Trim Cafe?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
94Drugs
94 Moderate

Ingredients driving the most interactions

WellTrim iG (IGOB131) African Mango (Irvingia gabonensis) seed extract 94

Individual Drug Interactions

The ingredients in Trim Cafe interact with 94 drugs. Click any drug to see the details.

1 of the 1 ingredient in Trim Cafe interact with drugs. Each result below shows which ingredient is responsible. WellTrim iG (IGOB131) African Mango (Irvingia gabonensis) seed extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Trim Cafe with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

WellTrim iG (IGOB131) African Mango (Irvingia gabonensis) seed extract2 drug types · 94 drugs

Antidiabetes Drugs

Theoretically, taking Irvingia gabonensis with antidiabetes drugs might increase the risk of hypoglycemia in some patients.
Human research shows that Irvingia gabonensis decreases blood sugar in diabetic patients being treated with antidiabetes agents. Monitor blood glucose levels closely. Dose adjustments might be necessary.

Likelihood Possible Evidence B
Testosterone

Theoretically, taking Irvingia gabonensis with testosterone products drugs might cause additive effects in some patients.
Animal research suggests that Irvingia gabonensis increases testosterone levels. The mechanism of action is unclear. Until more is known, advise patients taking testosterone to avoid using or use Irvingia gabonensis cautiously.

Likelihood Possible Evidence D
WellTrim iG (IGOB131) African Mango (Irvingia gabonensis) seed extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Trim Cafe, from the product label.

TLS

See all TLS products
Name
Market America, Inc.
Pharmacist Counseling Corner

Trim Cafe by TLS: Common Questions

Does Trim Cafe by TLS interact with any medications?
Yes. Based on its ingredients, Trim Cafe has a known interaction with 94 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Trim Cafe contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take Trim Cafe if I have diabetes?
Human research shows African Mango can lower blood sugar, so if you're already on diabetes medication, combining them could drop your blood sugar too low. You'd need to monitor your levels closely and may need a dose adjustment to your medication. Talk with your doctor before starting—don't add it on your own.
What are the side effects?
The most common ones reported are flatulence, headache, insomnia, and nausea. These show up in short-term studies; long-term side effects aren't well documented. One rare case of liver inflammation was reported, though it's not clear if African Mango caused it.
Is this safe during pregnancy or breastfeeding?
There isn't enough safety data for either. The evidence advises against using it while pregnant or nursing. Talk with your doctor or pharmacist about what makes sense for your situation.
Can I take this with testosterone products?
African Mango may raise testosterone levels based on animal research, so there's a theoretical risk of additive effects if you're on testosterone. Use it cautiously or avoid it, and check with your doctor first.
Does Trim Cafe actually work for weight loss or cholesterol?
The evidence we hold isn't strong enough to say. We have insufficient reliable evidence to rate African Mango for obesity or high cholesterol. You may see marketing claims, but the science behind them isn't solid yet.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Trim Cafe is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Trim Cafe label
Go deeper

The Full Monographs Behind Trim Cafe’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Irvingia Gabonensis

Interacts with 94 drugs

Irvingia gabonensis (African mango) is a seed extract marketed mainly for weight loss and metabolic health. A few small studies suggest possible benefits, but the research is limited and low...

Read the full Irvingia Gabonensis monograph →
Sources

Sources & How We Checked

Trim Cafe's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 7 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Irvingia Gabonensis 7 references
  1. Oben JE, Ngondi JL, Momo CN, et al. The use of Cissus quadrangularis/Irvingia gabonensis combination in the management of weight loss: a double-blind placebo-controlled study. Lipids Health Dis 2008;7:12.
  2. Ngondi JL, Etoundi BC, Nyangono CB, et al. IGOB131, a novel seed extract of the West African plant Irvingia gabonensis, significantly reduces body weight and improves metabolic parameters in overweight humans in a randomized double-blind placebo controll
  3. Adamson, I., Okafor, C., and Abu-Bakare, A. A supplement of Dikanut (Irvingia gabonesis) improves treatment of type II diabetics. West Afr.J.Med. 1990;9(2):108-115.
  4. Adamson, I., Okafor, C., and Abu-Bakare, A. Erythrocyte membrane ATPases in diabetes: effect of dikanut (Irvingia gabonensis). Enzyme 1986;36(3):212-215. PubMed
  5. Wolfe OA, Ijeoma UF. Effects of aqueous extracts of Irvingia gabonensis seeds on the hormonal parameters of male guinea pigs. Asian Pacific Journal of Tropical Medicine. 2010;3(3):200-204. DOI
  6. Kilinçalp S, Basar O, Coban S, Yüksel I. Irvingia gabonensis (African mango): innocent magic formula? Acta Gastroenterol Belg 2014;77(1):75-6.
  7. Nonsa-Ard R, Aneknan P, Tong-Un T, Honsawek S, Leelayuwat N. Effects of Irvingia gabonensis Extract on Metabolism, Antioxidants, Adipocytokines, Telomere Length, and Aerobic Capacity in Overweight/Obese Individuals. Nutrients 2022;14(21):4646. PubMed

See these in context on the Irvingia Gabonensis monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Supplement interaction checker › Check any supplement or product against your medications Drug–drug interactions › Check two or more of your medications against each other Browse medications A–Z › Every drug we've checked against herbs & supplements NDC & pricing lookup › Find a drug’s NDCs, packaging and costs Ask a pharmacist › Free, personal answer from our licensed team