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Dietary supplement

Trim Cafe Ingredients & Drug Interactions

by TLS

Trim Cafe label
See full label image
Powder Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Trim Cafe against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Trim Cafe is a dietary supplement by TLS with 1 active ingredient. Its ingredients are commonly taken for weight loss, appetite control, cholesterol support.Based on those ingredients, 94 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are WellTrim iG (IGOB131) African Mango (Irvingia gabonensis) seed extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Trim Cafe by TLS

Ask about any prescription or over-the-counter medication and we check it for interactions with Trim Cafe by TLS — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Trim Cafe by TLS

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

Trim Cafe is a single-ingredient powder: WellTrim iG, which is an African mango seed extract (the ingredient name is IGOB131). The product also contains Colombian Arabica coffee powder as an inactive ingredient.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see Irvingia Gabonensis's own graded uses on its monograph.

Why this rating?
  • The label markets this product for: thermogenic slimming supplement for appetite and metabolism.
  • We looked for evidence on: Obesity, Metabolic syndrome, Weight management, Satiety.
  • The closest evidence on file: Irvingia Gabonensis is rated "Insufficient Reliable Evidence To Rate" for Obesity (Natural Medicines).
  • Also on file: Irvingia Gabonensis is rated "Insufficient Reliable Evidence To Rate" for Metabolic syndrome.

The evidence for African mango seed extract isn't established for the claims often made about it. We hold insufficient reliable evidence to rate it for blood sugar control, cholesterol, weight loss, or metabolic syndrome.

That doesn't mean it doesn't work — it means the studies we have aren't strong enough to say either way.

The evidence, ingredient by ingredient Irvingia Gabonensis

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

African mango seed extract is generally well tolerated short-term in studies, though long-term safety and product quality aren't well established. The most common side effects reported are flatulence, headache, insomnia, and nausea.

One rare case of liver inflammation has been reported after supplementation, though it's unclear whether the extract was the direct cause. The safety data advises against use during pregnancy and breastfeeding.

Side effects, ingredient by ingredient Irvingia Gabonensis

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Irvingia Gabonensis.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: diabetes medications.
  • For scale: 94 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check with your pharmacist before taking this product if you're on antidiabetes drugs (blood sugar medications) — the extract can lower blood sugar further and you may need a dose adjustment. Also double-check if you're using testosterone products, as the extract may increase testosterone levels.

Use the search tool on this page to verify your exact medications.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

Trim Cafe is for people interested in African mango extract, but the evidence for its effects on weight or metabolic health isn't solid. If you take diabetes medication or testosterone therapy, talk to your pharmacist before starting — this product can interact with both.

Pregnancy and breastfeeding are reasons to skip it until you've talked with your doctor.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Apr 23, 2020.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Trim Cafe, straight from the product label.

Brand TLS
Net contents 1.75 Oz(s); 50 Gram(s)
Market status On market
Date entered into DSLD Apr 23, 2020
DSLD ID 218168
Product type Botanical
Supplement form Powder
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Women (not pregnant or lactating), Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Trim Cafe by TLS, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
3.3 Gram(s)
Maximum serving Sizes:
3.3 Gram(s)
Servings per container
15
IngredientAmount% DV
WellTrim iG (IGOB131) African Mango (Irvingia gabonensis) seed extract300 mg--

Other ingredients: Colombian Arabica Coffee Powder

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

Gluten free

A thermogenic slimming supplement

What does trim cafe do? You can enjoy TLS trim cafe in an instant. This delicious, thermogenic slimming supplement is formulated to help manage and control appetite, promote satiety and support metabolic balance. Mix up some trim cafe today and support lasting weight loss efforts.

FDA Statement of Identity

Dietary Supplement

General Statements

15- 0.1164 oz (3.3 g) stickpacks

Formula

Contains ingredient WellTrim iG, a clinically studied Irvingia seed extract for weight loss and metabolic wellness.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Precautions

Warning: If you are currently taking any prescription medication or have an ongoing medical condition, you should consult your healthcare practitioner before using this product. Women who are pregnant or breastfeeding should not use this product.

Keep out of the reach of children.

Resale on third-party websites is strictly prohibited unless specifically authorized by Market America or its corporate affiliates. If barcodes are altered or you purchase this product from an unauthorized third-party website, the product is not guaranteed by Market America or it's corporate affiliates.

Brand IP Statement(s)

WellTrim iG is a trademark of Icon Group, LLC. IGOB131 is a trademark of Gateway Health Alliances, Inc. and is protected under U.S. Patent 7,537,790.

Suggested/Recommended/Usage/Directions

Directions for use Mix one stickpack (3.3 g) with 7 fluid ounces of hot water. May use more or less water, based on personal taste preference. As a dietary supplement, it is recommended that you take once daily, or as directed by your healthcare practitioner. Most effective if taken 30-60 minutes before a meal, but not required.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Trim Cafe by TLS label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Trim Cafe label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Trim Cafe by TLS

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size3.3 Gram(s) Dosage formPowder Servings per container15 Amounts shown are per serving.

WellTrim iG (IGOB131) African Mango (Irvingia gabonensis) seed extract

Interacts with
94 drugs
300 mg per serving

Irvingia gabonensis (African mango) is a seed extract marketed mainly for weight loss and metabolic health. A few small studies suggest possible benef...

WellTrim iG (IGOB131) African Mango (Irvingia gabonensis) seed extract monograph & interactions

Other (inactive) ingredients: Colombian Arabica Coffee Powder. These complete the product’s ingredient list but are not active constituents.

Interaction report

Trim Cafe by TLS Drug Interactions

Want to check YOUR meds against Trim Cafe?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
94Drugs
94 Moderate

Ingredients driving the most interactions

WellTrim iG (IGOB131) African Mango (Irvingia gabonensis) seed extract 94

Individual Drug Interactions

The ingredients in Trim Cafe interact with 94 drugs. Click any drug to see the details.

1 of the 1 ingredient in Trim Cafe interact with drugs. Each result below shows which ingredient is responsible. WellTrim iG (IGOB131) African Mango (Irvingia gabonensis) seed extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Trim Cafe with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

WellTrim iG (IGOB131) African Mango (Irvingia gabonensis) seed extract2 drug types · 94 drugs

Antidiabetes Drugs

Theoretically, taking Irvingia gabonensis with antidiabetes drugs might increase the risk of hypoglycemia in some patients.
Human research shows that Irvingia gabonensis decreases blood sugar in diabetic patients being treated with antidiabetes agents. Monitor blood glucose levels closely. Dose adjustments might be necessary.

Likelihood Possible Evidence B
Testosterone

Theoretically, taking Irvingia gabonensis with testosterone products drugs might cause additive effects in some patients.
Animal research suggests that Irvingia gabonensis increases testosterone levels. The mechanism of action is unclear. Until more is known, advise patients taking testosterone to avoid using or use Irvingia gabonensis cautiously.

Likelihood Possible Evidence D
WellTrim iG (IGOB131) African Mango (Irvingia gabonensis) seed extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Trim Cafe, from the product label.

TLS

See all TLS products
Name
Market America, Inc.
Pharmacist Counseling Corner

Trim Cafe by TLS: Common Questions

Does Trim Cafe by TLS interact with any medications?
Yes. Based on its ingredients, Trim Cafe has a known interaction with 94 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Trim Cafe contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take Trim Cafe with my diabetes medication?
Not without checking with your pharmacist first. African mango seed extract can lower blood sugar on its own, so combined with diabetes medication you could get too-low blood sugar (hypoglycemia). Your doctor may need to adjust your dose. Definitely run this by your pharmacist before starting.
Is it safe to take while pregnant or breastfeeding?
No. The safety data advises against use during pregnancy and breastfeeding because there isn't enough information to know it's safe. Talk with your doctor or pharmacist for personalized advice if you're considering it.
What side effects might I notice?
The most common ones are flatulence, headache, insomnia, and nausea. These show up in short-term studies, but we don't have good long-term safety data yet. One very rare case of liver inflammation was reported, though it's unclear if the extract caused it.
Does African mango extract actually help with weight loss?
We don't have enough reliable evidence to say. The studies we hold aren't strong enough to rate it for weight loss, cholesterol, or blood sugar control — that doesn't mean it doesn't work, just that the evidence isn't solid yet.
Can I take this with testosterone therapy?
You should be cautious and check with your pharmacist first. Animal research suggests African mango extract may increase testosterone levels, so taking it with testosterone products might cause the effect to add up. Use only with caution and your doctor's okay.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Trim Cafe label
Go deeper

The Full Monographs Behind Trim Cafe’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Irvingia Gabonensis

Interacts with 94 drugs

Irvingia gabonensis (African mango) is a seed extract marketed mainly for weight loss and metabolic health. A few small studies suggest possible benefits, but the research is limited and low...

Read the full Irvingia Gabonensis monograph →
Sources

Sources & How We Checked

Trim Cafe's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 7 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Irvingia Gabonensis 7 references
  1. Oben JE, Ngondi JL, Momo CN, et al. The use of Cissus quadrangularis/Irvingia gabonensis combination in the management of weight loss: a double-blind placebo-controlled study. Lipids Health Dis 2008;7:12.
  2. Ngondi JL, Etoundi BC, Nyangono CB, et al. IGOB131, a novel seed extract of the West African plant Irvingia gabonensis, significantly reduces body weight and improves metabolic parameters in overweight humans in a randomized double-blind placebo controll
  3. Adamson, I., Okafor, C., and Abu-Bakare, A. A supplement of Dikanut (Irvingia gabonesis) improves treatment of type II diabetics. West Afr.J.Med. 1990;9(2):108-115.
  4. Adamson, I., Okafor, C., and Abu-Bakare, A. Erythrocyte membrane ATPases in diabetes: effect of dikanut (Irvingia gabonensis). Enzyme 1986;36(3):212-215. PubMed
  5. Wolfe OA, Ijeoma UF. Effects of aqueous extracts of Irvingia gabonensis seeds on the hormonal parameters of male guinea pigs. Asian Pacific Journal of Tropical Medicine. 2010;3(3):200-204. DOI
  6. Kilinçalp S, Basar O, Coban S, Yüksel I. Irvingia gabonensis (African mango): innocent magic formula? Acta Gastroenterol Belg 2014;77(1):75-6.
  7. Nonsa-Ard R, Aneknan P, Tong-Un T, Honsawek S, Leelayuwat N. Effects of Irvingia gabonensis Extract on Metabolism, Antioxidants, Adipocytokines, Telomere Length, and Aerobic Capacity in Overweight/Obese Individuals. Nutrients 2022;14(21):4646. PubMed

See these in context on the Irvingia Gabonensis monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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