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Dietary supplement

Triple Chlorophyll Ingredients & Drug Interactions

by GNC Natural Brand

Triple Chlorophyll label
See full label image
Softgel Capsule Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Triple Chlorophyll against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Triple Chlorophyll is a dietary supplement by GNC Natural Brand with 2 active ingredients. Its ingredients are commonly taken for preventing or treating copper deficiency, supporting red blood cell formation, bone and connective tissue health.Based on those ingredients, 368 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Chlorophyll Complex, Copper. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Triple Chlorophyll by GNC Natural Brand

Ask about any prescription or over-the-counter medication and we check it for interactions with Triple Chlorophyll by GNC Natural Brand — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Triple Chlorophyll by GNC Natural Brand

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 3 of its 3 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains 3 active ingredients. Copper is an essential mineral your body needs in small amounts for healthy nerves and connective tissue — this supplement provides it as a dietary source.

Chlorophyll Complex is the green pigment from plants. Polyunsaturated Fat rounds out the formula.

The softgel capsule also contains soybean oil, gelatin, glycerin, and titanium dioxide as inactive ingredients to hold everything together.

Does it work?

Strong evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed

This product doesn't appear to be marketed for a specific use, so we graded its ingredients' overall clinical evidence instead.

Strong

Strong clinical evidence supports its ingredients for:

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.
  • Since the label doesn't commit to one use, we graded the ingredients' overall clinical evidence instead.
  • On file: Copper deficiency — rated "Likely Effective" (Copper) (Natural Medicines).

The evidence we hold shows copper is likely effective for treating copper deficiency. For chlorophyll complex, the data we have doesn't establish reliable evidence for wound healing, herpes, shingles, skin cancer, pancreatitis, or other conditions — the evidence is rated insufficient.

Copper has been rated possibly ineffective for Alzheimer disease.

The evidence, ingredient by ingredient Copper Chlorophyll

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 2 of the 2 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 2 of 2.
  • General safety write-ups exist for 2 of 2.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Copper is safe in the amounts found in food and standard supplements, but excess copper can be toxic. You'll want to stay within recommended amounts and avoid high-dose copper supplements unless your doctor advises it — including during pregnancy, when copper is needed but high doses should be avoided.

Chlorophyll is generally well tolerated in short-term use, though high-quality long-term safety data are limited. The most common side effect from oral chlorophyll is photosensitization — increased sensitivity to sunlight.

Rarely, it can cause pseudoporphyria, a blistering condition. Topical chlorophyll cream has been reported to cause dermatitis.

Side effects, ingredient by ingredient Copper Chlorophyll

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 2 of the 2 matched ingredients can interact with medications — Chlorophyll, Copper.
  • The most serious interaction on file is rated Moderate.
  • For scale: 368 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Double-check this product if you take penicillamine (Cuprimine, Depen) — copper reduces how your body absorbs it. Also check before using if you're on birth control pills, methotrexate (Trexall), or photosensitizing drugs like certain antibiotics and some acne or psoriasis treatments.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with strong clinical evidence behind its ingredients' uses. Moderate medication interactions have been identified, and safety information is well characterized.

If you take penicillamine, birth control pills, methotrexate, or any photosensitizing drugs, check with your pharmacist before starting this product. Copper is useful for deficiency, but the chlorophyll's effectiveness for any specific condition isn't established in our data.

It's generally well tolerated, but watch for sun sensitivity and skin irritation.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 3 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Nov 25, 2011.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Triple Chlorophyll, straight from the product label.

Brand GNC Natural Brand
Barcode (UPC) 048107045555
Net contents 90 Softgel Capsule(s)
Market status On market
Date entered into DSLD Nov 25, 2011
DSLD ID 2266
Product type Non-nutrient/non-botanical
Supplement form Softgel Capsule
Dietary claims / uses All Other
Intended target group(s) Adult (18 - 50 Years), Gluten Free, Dairy Free, Sugar Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Triple Chlorophyll by GNC Natural Brand, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
UPC/BARCODE
048107045555
IngredientAmount% DV
Copper2 mg100%
Calories10 {Calories}--
Calories from Fat10 {Calories}--
Polyunsaturated Fat0.5 Gram(s)--
Total Fat1 Gram(s)2%
Chlorophyll Complex60 mg--

Other ingredients: Soybean Oil, Gelatin, Glycerin, Titanium Dioxide

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

DIRECTIONS: As a dietary supplement, take one capsule daily. Do not exceed one capsule per day.

Precautions

KEEP OUT OF REACH OF CHILDREN

Storage

Store in a cool, dry place.

General

CODE 023110 FCG

General Statements

Conforms to USP <2091> for weight.

MADE IN THE USA

Meets USP <2040> disintegration.

SIZE

Formulation

No Sugar, No Starch, No Artificial Colors, No Artificial Flavors, No Preservatives, No Wheat, No Gluten, No Corn, No Dairy. Yeast Free

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Triple Chlorophyll by GNC Natural Brand label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Triple Chlorophyll label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Triple Chlorophyll by GNC Natural Brand

These are the 2 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Capsule(s) Dosage formSoftgel Capsule Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Copper

Interacts with
31 drugs
2 mg per serving

Copper is an essential trace mineral your body needs in small amounts for making red blood cells, supporting nerves and bones, and helping enzymes wor...

Copper monograph & interactions

Chlorophyll Complex

Interacts with
337 drugs
60 mg per serving

Chlorophyll is the green pigment found in plants and algae, and supplements often use a stable form called chlorophyllin. It is most studied for reduc...

Chlorophyll Complex monograph & interactions

Other (inactive) ingredients: Soybean Oil, Gelatin, Glycerin, Titanium Dioxide. These complete the product’s ingredient list but are not active constituents.

Interaction report

Triple Chlorophyll by GNC Natural Brand Drug Interactions

Want to check YOUR meds against Triple Chlorophyll?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
368Drugs
338 Moderate 30 Minor

Ingredients driving the most interactions

Chlorophyll Complex 337
Copper 31

Individual Drug Interactions

The ingredients in Triple Chlorophyll interact with 368 drugs. Click any drug to see the details.

2 of the 2 ingredients in Triple Chlorophyll interact with drugs. Each result below shows which ingredient is responsible. Chlorophyll Complex Copper

Each ingredient & the kinds of drugs it affects

For each ingredient in Triple Chlorophyll with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Chlorophyll Complex2 drug types · 337 drugs

Methotrexate (Trexall, Others)

Theoretically, chlorophyll may reduce the clearance of methotrexate.
In one case report, a 54-year-old male developed delayed clearance of intravenous high-dose methotrexate with concomitant use of chlorophyll. When chlorophyll was stopped 2 days prior to methotrexate treatment, methotrexate clearance was unaffected.

Likelihood Possible Evidence B
Photosensitizing Drugs

Theoretically, concomitant use of chlorophyll with photosensitizing drugs may have additive effects.
Chlorophyll has been reported to cause photosensitization. In two case reports, pseudoporphyria developed after oral intake of chlorophyll. Theoretically, concomitant use with other photosensitizing drugs may exacerbate this effect.

Likelihood Probable Evidence B
Chlorophyll Complex full monograph & interactions

Copper2 drug types · 31 drugs

Penicillamine (Cuprimine, Depen)

Theoretically, taking copper with penicillamine might decrease the absorption of penicillamine; separate dosing by at least 2 hours.
Copper chelates penicillamine, which decreases its absorption and may reduce its clinical effects.

Likelihood Probable Evidence D
Contraceptive Drugs

Theoretically, taking copper with contraceptive drugs might increase the levels and toxic effects of copper.
A meta-analysis of clinical studies suggests that chronic use of oral contraceptives increases serum copper levels by a mean of 57 mcg/dL. In most people, this resulted in levels above the normal reference range for copper.

Likelihood Possible Evidence D
Copper full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Triple Chlorophyll, from the product label.

GNC Natural Brand

See all GNC Natural Brand products
Phone Number
1-888-462-2548
Pharmacist Counseling Corner

Triple Chlorophyll by GNC Natural Brand: Common Questions

Does Triple Chlorophyll by GNC Natural Brand interact with any medications?
Yes. Based on its ingredients, Triple Chlorophyll has a known interaction with 368 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Triple Chlorophyll contains 2 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is this safe to take during pregnancy?
Copper is needed in pregnancy and recommended amounts are considered acceptable, but avoid high-dose supplements unless your doctor advises it. Chlorophyll, however, doesn't have enough reliable safety data in pregnancy — the safety data advises against it. Talk with your doctor before using this product if you're pregnant.
What about breastfeeding?
We don't have safety data on file for chlorophyll during breastfeeding, so it's best to avoid it unless your doctor advises otherwise. Talk with your pharmacist before starting.
Does copper in this supplement actually work?
Copper is likely effective if you have a copper deficiency. If you're looking to use it for Alzheimer disease, the evidence rates it as possibly ineffective. For other uses, we don't have enough reliable evidence to say.
Can chlorophyll cause skin problems?
Yes — the most common side effect from taking it by mouth is photosensitization, meaning increased sensitivity to sunlight. Topical chlorophyll cream can cause dermatitis. Rarely, oral chlorophyll has caused pseudoporphyria, a blistering condition on the hands.
Is copper toxic at the dose in this supplement?
Copper is safe in amounts found in standard supplements and food, but excess copper can be toxic. As long as you stay within recommended amounts and don't combine it with other high-dose copper sources, it should be fine.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Triple Chlorophyll label
Go deeper

The Full Monographs Behind Triple Chlorophyll’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Copper

Interacts with 31 drugs

Copper is an essential trace mineral your body needs in small amounts for making red blood cells, supporting nerves and bones, and helping enzymes work. Most people get enough copper from fo...

Read the full Copper monograph → Herb & supplement monograph

Chlorophyll

Interacts with 337 drugs

Chlorophyll is the green pigment found in plants and algae, and supplements often use a stable form called chlorophyllin. It is most studied for reducing body and fecal odor and as a topical...

Read the full Chlorophyll monograph →
Sources

Sources & How We Checked

Triple Chlorophyll's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 16 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Copper 11 references
  1. Murry JJ, Healy MD. Drug-mineral interactions: a new responsibility for the hospital dietician. J Am Diet Assoc 1991;91:66-73.
  2. Campbell IA, Elmes PC. Ethambutol and the eye: zinc and copper (letter). Lancet 1975;2:711. DOI
  3. Segal S, Kaminski S. Drug-nutrient interactions. American Druggist 1996 Jul;42-8.
  4. Kozak SF, Inderlied CB, Hsu HY, et al. The role of copper on ethambutol's antimicrobial action and implications for ethambutol-induced optic neuropathy. Diag Microbiol Infect Dis 1998;30:83-7. PubMed
  5. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc. Washington, DC: National Academy Press, 2002.
  6. Cantilena LR, Klaassen CD. The effect of chelating agents on the excretion of endogenous metals. Toxicol Appl Pharmacol 1982;63:344-50.
  7. Babic Z, Tariba B, Kovacic J, Pizent A, Varnai VM, Macan J. Relevance of serum copper elevation induced by oral contraceptives: a meta-analysis. Contraception. 2013 Jun;87(6):790-800. PubMed
  8. Qui Q, Zhang F, Zhu W, Wu J, Liang M. Copper in diabetes mellitus: a meta-analysis and systematic review of plasma and serum studies. Biol Trace Elem Res 2017;177(1):53-63.
  9. Walker-Smith PK, Keith DJ, Kennedy CT, Sansom JE. Allergic contact dermatitis caused by copper. Contact Dermatitis 2016;75(3):186-7. PubMed
  10. Gallentine A. Third-degree burn on the neuropathic lower extremity in a patient with diabetes while wearing a copper-containing compression sock: a case report. Wound Manag Prev 2021;67(12):26-29. DOI
  11. Chung KJ, Chin YM, Wong MS, Sanmugam A, Singaravel S, Nah SA. Effectiveness of table salt versus copper sulphate in treating umbilical granuloma: A pilot randomized controlled trial. J Pediatr Surg 2022;57(2):261-265. PubMed

See these in context on the Copper monograph →

Chlorophyll 5 references
  1. Mathews-Roth MM. Carotenoids in erythropoietic protoporphyria and other photosensitivity diseases. Ann N Y Acad Sci, 1993; 691:127-38. PubMed
  2. Belen'kii, G. B. and Krikun, B. L. [Treatment of herpes simplex and herpes zoster by chlorophyll preparations]. Sov.Med. 1971;34(1):151-152.
  3. Brooks SL, Sanders J, Seymour JF, Mellor JD. A case of delayed methotrexate clearance following administration of a complementary medication containing chlorophyll. J Oncol Pharm Pract. 2014 Jun;20(3):225-8. PubMed
  4. Rossi E, Borchard K, Cole JM. Pseudoporphyria following self-medication with chlorophyll. Australas J Dermatol. 2015 Feb;56(1):47-8. PubMed
  5. Zhao CY, Frew JW, Muhaidat J, et al. Chlorophyll-induced pseudoporphyria with ongoing photosensitivity after cessation - a case series of four patients. J Eur Acad Dermatol Venereol 2016;30(7):1239-42. PubMed

See these in context on the Chlorophyll monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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