Interactions on record — worth a quick check against your medications. Based on 3 of 4 ingredients. Check your meds →
Dietary supplement

Triple Strength Liquid L-Carnitine Fruit Punch Ingredients & Drug Interactions

by GNC Total Lean

Triple Strength Liquid L-Carnitine Fruit Punch label
See full label image
Liquid Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 9, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Triple Strength Liquid L-Carnitine Fruit Punch against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Triple Strength Liquid L-Carnitine Fruit Punch is a dietary supplement by GNC Total Lean with 4 active ingredients. Its ingredients are commonly taken for morning sickness in pregnancy, premenstrual syndrome (pms), preventing or treating b6 deficiency.Based on those ingredients, 229 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Vitamin B6, L-Carnitine. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Triple Strength Liquid L-Carnitine Fruit Punch by GNC Total Lean

Ask about any prescription or over-the-counter medication and we check it for interactions with Triple Strength Liquid L-Carnitine Fruit Punch by GNC Total Lean — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Triple Strength Liquid L-Carnitine Fruit Punch by GNC Total Lean

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 3 of its 3 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains three active ingredients: Vitamin B6, Pantothenic Acid, and L-Carnitine. Vitamin B6 supports nerve and brain function and helps your body use amino acids; Pantothenic Acid (a B vitamin) aids in breaking down fats and carbohydrates for energy; and L-Carnitine is an amino acid that helps move fatty acids into your cells' power plants (mitochondria) so they can be burned for fuel.

The liquid also contains several inactive ingredients — purified water, vegetable glycerin, citric acid, natural and artificial flavors, potassium sorbate, sodium hexametaphosphate, calcium propionate, sucralose, acesulfame potassium, and FD&C Red #40 — which serve as a base, preservatives, and sweeteners.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: supports conversion of fatty acids into energy.
  • We looked for evidence on: Athletic performance, Exercise-induced muscle damage, Exercise-induced muscle soreness, Cachexia, Cancer-related fatigue, Chemotherapy-related fatigue — and 4 related terms.
  • The strongest evidence on file: L-carnitine is rated "Possibly Effective" for Congestive heart failure (CHF) (Natural Medicines).
  • Also on file: Pantothenic Acid is rated "Insufficient Reliable Evidence To Rate" for Athletic performance, Chronic fatigue syndrome (CFS), Heart failure.
  • Also on file: L-carnitine is rated "Insufficient Reliable Evidence To Rate" for Athletic performance, Cachexia, Cancer-related fatigue.

L-Carnitine is effective for L-carnitine deficiency and possibly effective for high cholesterol (hyperlipidemia), heart failure, and angina according to the research we've reviewed. Vitamin B6 is effective for sideroblastic anemia and B6 deficiency itself, and likely effective for elevated homocysteine levels; it's also possibly effective for pregnancy-related nausea and vomiting.

Pantothenic acid is effective for pantothenic acid deficiency. For other uses — like hay fever, alopecia, or alcoholism — the evidence we hold isn't established enough to rate.

The evidence, ingredient by ingredient Vitamin B6 Pantothenic Acid L-carnitine

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 3 of the 3 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 3 of 3.
  • General safety write-ups exist for 3 of 3.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

At typical supplement doses, all three ingredients are generally well tolerated. Vitamin B6 is safe at normal amounts from food and standard supplements, though high doses taken over time can damage nerves — doses exceeding 1,000 mg daily or total cumulative doses of 1,000 grams or more carry the highest risk, though neuropathy can occur at lower amounts too.

L-Carnitine at normal doses is generally well tolerated; common side effects may include stomach upset, diarrhea, nausea, and a fishy body odor. Pantothenic acid is considered safe for most people at typical supplement doses.

Pregnant women should consult their doctor before taking high-dose B6 or L-Carnitine supplements, though the amounts in prenatal vitamins are fine. Safety data for L-Carnitine while breastfeeding is limited, so caution is advised.

Side effects, ingredient by ingredient Vitamin B6 Pantothenic Acid L-carnitine

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 2 of the 3 matched ingredients can interact with medications — Vitamin B6, L-carnitine.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; Parkinson's medications.
  • For scale: 229 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before you take this product, double-check if you're on blood thinners (warfarin or acenocoumarol) — L-Carnitine may strengthen their anticoagulant effect. Also check thyroid hormone replacement (L-Carnitine may reduce its effectiveness), blood pressure drugs (Vitamin B6 may lower pressure further), and the heart drugs amiodarone, phenobarbital, and phenytoin (B6 interactions).

If you take levodopa alone for Parkinson's disease (not the combination Sinemet), B6 may weaken it.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

This product may help with energy and carnitine deficiency, but its Moderate interactions with blood thinners, thyroid medication, and certain seizure or heart drugs make it important to check first. If you take warfarin, acenocoumarol, thyroid hormone, blood pressure medication, amiodarone, phenobarbital, phenytoin, or levodopa alone, talk to your pharmacist before starting.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 3 of 3 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated May 24, 2017.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Triple Strength Liquid L-Carnitine Fruit Punch, straight from the product label.

Brand GNC Total Lean
Barcode (UPC) 048107129620
Net contents 16 fl. Oz.; 473 mL
Market status On market
Date entered into DSLD May 24, 2017
DSLD ID 74456
Product type Non-nutrient/non-botanical
Supplement form Liquid
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Sugar Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Triple Strength Liquid L-Carnitine Fruit Punch by GNC Total Lean, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Tbsp
Maximum serving Sizes:
1 Tbsp
Servings per container
30
UPC/BARCODE
048107129620
IngredientAmount% DV
Calories20 Calorie(s)--
Sugar0 Gram(s)--
Vitamin B62 mg100%
Carbohydrates0 Gram(s)--
Pantothenic Acid25 mg250%
L-Carnitine3000 mg--

Other ingredients: purified Water, Vegetable Glycerin, Citric Acid, Natural and Artificial flavors, Potassium Sorbate, Sodium Hexametaphosphate, Calcium Propionate, Sucralose, Acesulfame Potassium, FD&C Red #40

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

Satisfaction Guarantee Try this product at our risk. If you are not completely satisfied, bring back the unused portion with your receipt to place of purchase for a full refund.

Supports the conversion of fatty acids into energy Fuels exercise and muscle recovery

Ultra concentrated Natural & artificial flavors Scientifically formulated Amazing taste

Are you up for the challenge? Visit GNC.com/TLC to join and for more information. For Additional Healthy Weight Management Support, Try These Scientifically Formulated GNC Total Lean Products: Live Lean & Fit Pak Lean Shake 25 CLA Lean Bars

Precautions

Keep out of reach of children.

Warning: Consult your physician prior to using this product if you are pregnant, nursing, taking medication, or have a medical condition.

Discontinue use two weeks prior to surgery.

Storage

Refrigerate after opening.

Refrigerate after opening.

FDA Statement of Identity

Dietary Supplement

Formulation

Sugar free

Formula

With 3000 mg of L-carnitine

General

CODE 732218 CQG

Suggested/Recommended/Usage/Directions

Directions: As a dietary supplement, take one tablespoon daily. May be taken directly, or added to water or your favorite beverage. For best results, take 30-60 minutes prior to exercise. Shake well before each use.

Brand IP Statement(s)

GNC Total Lean challenge

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Triple Strength Liquid L-Carnitine Fruit Punch by GNC Total Lean label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Triple Strength Liquid L-Carnitine Fruit Punch label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Triple Strength Liquid L-Carnitine Fruit Punch by GNC Total Lean

These are the 4 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Tbsp Dosage formLiquid Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Vitamin B6

Interacts with
210 drugs
2 mg per serving Form: Pyridoxine Hydrochloride

Vitamin B6 (pyridoxine) is an essential water-soluble vitamin that your body needs for metabolism, brain function, and making red blood cells. It is b...

Vitamin B6 monograph & interactions

Carbohydrates

0 Gram(s) per serving
  • › Sugar

Pantothenic Acid

No known
interactions
25 mg per serving Form: D-Calcium Pantothenate

Pantothenic acid is vitamin B5, an essential nutrient your body uses to turn food into energy. True deficiency is very rare because it is found in nea...

Pantothenic Acid monograph & interactions

L-Carnitine

Interacts with
19 drugs
3000 mg per serving Form: L-Carnitine, L-Carnitine HCl

L-carnitine is a compound your body makes naturally and also gets from foods like meat. It helps cells turn fat into energy, and supplements are most...

L-Carnitine monograph & interactions

Other (inactive) ingredients: Purified Water, Vegetable Glycerin, Citric Acid, Natural and Artificial flavors, Potassium Sorbate, Sodium Hexametaphosphate, Calcium Propionate, Sucralose, Acesulfame Potassium, FD&C Red #40. These complete the product’s ingredient list but are not active constituents.

Interaction report

Triple Strength Liquid L-Carnitine Fruit Punch by GNC Total Lean Drug Interactions

Want to check YOUR meds against Triple Strength Liquid L-Carnitine Fruit Punch?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
229Drugs
224 Moderate 5 Minor

Ingredients driving the most interactions

Vitamin B6 210
L-Carnitine 19

Individual Drug Interactions

The ingredients in Triple Strength Liquid L-Carnitine Fruit Punch interact with 229 drugs. Click any drug to see the details.

2 of the 4 ingredients in Triple Strength Liquid L-Carnitine Fruit Punch interact with drugs. Each result below shows which ingredient is responsible. Vitamin B6 L-Carnitine

Each ingredient & the kinds of drugs it affects

For each ingredient in Triple Strength Liquid L-Carnitine Fruit Punch with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Vitamin B65 drug types · 210 drugs

Amiodarone (Cordarone)

Theoretically, vitamin B6 might increase the photosensitivity caused by amiodarone.
Despite initial case reports suggesting that pyridoxine may have a protective effect against amiodarone-induced photosensitivity, preliminary clinical research suggests that pyridoxine may actually exacerbate this adverse effect.

Likelihood Possible Evidence B
Antihypertensive Drugs

Theoretically, vitamin B6 may have additive effects when used with antihypertensive drugs.
Research in hypertensive rats shows that vitamin B6 can decrease systolic blood pressure. Similarly, clinical research in patients with hypertension shows that taking high doses of vitamin B6 may reduce systolic and diastolic blood pressure, possibly by reducing plasma levels of epinephrine and norepinephrine.

Likelihood Possible Evidence B
Phenobarbital (Luminal)

High doses of vitamin B6 may reduce the levels and clinical effects of phenobarbital.
Preliminary clinical evidence suggests that vitamin B6 200 mg daily can reduce plasma levels of phenobarbital, possibly by increasing metabolism. It is not known whether lower doses have any effect. Advise people taking phenobarbital to avoid high doses of vitamin B6.

Likelihood Possible Evidence D
Phenytoin (Dilantin)

High doses of vitamin B6 may reduce the levels and clinical effects of phenytoin.
Preliminary clinical evidence suggests that vitamin B6 200 mg daily can reduce plasma levels of phenytoin, possibly by increasing metabolism. It is not known whether lower doses have any effect. Advise people taking phenytoin to avoid high doses of vitamin B6.

Likelihood Possible Evidence D
Levodopa

Vitamin B6 may increase the metabolism of levodopa when taken alone, but not when taken in conjunction with carbidopa.
Vitamin B6 (pyridoxine) enhances the metabolism of levodopa, reducing its clinical effects. However, this interaction does not occur when carbidopa is used concurrently with levodopa (Sinemet). Therefore, it is not likely to be a problem in most people.

Likelihood Unlikely Evidence D
Vitamin B6 full monograph & interactions

L-Carnitine3 drug types · 19 drugs

Acenocoumarol (Sintrom)

Theoretically, L-carnitine might increase the anticoagulant effects of acenocoumarol.
L-carnitine might enhance the anticoagulant effects of acenocoumarol, an oral anticoagulant similar to warfarin, but shorter-acting. There are at least two case reports of INR elevation with concomitant use. In one case, a 33-year-old male with a previously stable INR had an elevated INR of 4.65 after L-carnitine was started and continued for 10 weeks. INR normalized after discontinuation of the L-carnitine-containing product.

Likelihood Possible Evidence D
Thyroid Hormone

Theoretically, L-carnitine might decrease the effectiveness of thyroid hormone replacement.
L-carnitine appears to act as a peripheral thyroid hormone antagonist by inhibiting entry of thyroid hormone into the nucleus of cells. Taking L-carnitine also seems to diminish some of the symptoms of hyperthyroidism.

Likelihood Probable Evidence B
Warfarin (Coumadin)

Theoretically, L-carnitine might increase the anticoagulant effects of warfarin.
L-carnitine might increase the anticoagulant effects of acenocoumarol, a shorter-acting oral anticoagulant similar to warfarin. There is not enough information to know whether this interaction occurs with L-carnitine and warfarin.

Likelihood Possible Evidence D
L-Carnitine full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Triple Strength Liquid L-Carnitine Fruit Punch, from the product label.

GNC Total Lean

See all GNC Total Lean products
Name
General Nutrition Corporation
City
Pittsburgh
State
PA
ZipCode
15222
Phone Number
1-888-462-2548
Web Address
gnc.com
Pharmacist Counseling Corner

Triple Strength Liquid L-Carnitine Fruit Punch by GNC Total Lean: Common Questions

Does Triple Strength Liquid L-Carnitine Fruit Punch by GNC Total Lean interact with any medications?
Yes. Based on its ingredients, Triple Strength Liquid L-Carnitine Fruit Punch has a known interaction with 229 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Triple Strength Liquid L-Carnitine Fruit Punch contains 4 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Will this help me lose weight or burn fat?
L-Carnitine is effective for L-carnitine deficiency and is possibly effective for cholesterol and heart conditions — it helps move fatty acids into cells where they're burned for energy. The product isn't marketed as a weight-loss supplement in the data we have, so check with your pharmacist about realistic expectations for your situation.
Is it safe to take this while I'm pregnant?
The amounts of Vitamin B6 in prenatal vitamins are considered fine, but high-dose supplements need your doctor's OK — B6 can harm nerves at very high doses. There isn't enough reliable safety data for L-Carnitine in pregnancy, so talk with your doctor or pharmacist for personalized advice. Pantothenic acid safety data during pregnancy isn't on file here.
What side effects might I notice?
At typical doses, all three ingredients are generally well tolerated. L-Carnitine may cause stomach cramps, diarrhea, nausea, or a fishy body odor. Vitamin B6 can cause headache, nausea, heartburn, or loss of appetite. Pantothenic acid may cause diarrhea. High doses of B6 over time can damage nerves.
Can I take this if I'm breastfeeding?
The data we hold doesn't cover B6 or Pantothenic Acid safety while breastfeeding. L-Carnitine safety while breastfeeding isn't well studied, so caution is advised. Talk with your doctor or pharmacist before starting.
Does this interact with supplements or other vitamins?
The interaction data we hold covers medications only. If you take other supplements or vitamins, ask your pharmacist to check them alongside your medications.
What does each ingredient actually do?
L-Carnitine helps move fats into your cells to be burned for energy. Vitamin B6 supports nerve and brain function and helps your body use amino acids. Pantothenic Acid (a B vitamin) helps break down fats and carbs for energy.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Triple Strength Liquid L-Carnitine Fruit Punch label
Go deeper

The Full Monographs Behind Triple Strength Liquid L-Carnitine Fruit Punch’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Vitamin B6

Interacts with 210 drugs

Vitamin B6 (pyridoxine) is an essential water-soluble vitamin that your body needs for metabolism, brain function, and making red blood cells. It is best known for helping with pregnancy-rel...

Read the full Vitamin B6 monograph → Herb & supplement monograph

Pantothenic Acid

Pantothenic acid is vitamin B5, an essential nutrient your body uses to turn food into energy. True deficiency is very rare because it is found in nearly all foods, and most people meet thei...

Read the full Pantothenic Acid monograph → Herb & supplement monograph

L-carnitine

Interacts with 19 drugs

L-carnitine is a compound your body makes naturally and also gets from foods like meat. It helps cells turn fat into energy, and supplements are most clearly useful for people with a true ca...

Read the full L-carnitine monograph →
Sources

Sources & How We Checked

Triple Strength Liquid L-Carnitine Fruit Punch's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 84 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Vitamin B6 32 references
  1. Hansten PD, Horn JR. Drug Interactions Analysis and Management. Vancouver, WA: Applied Therapeutics Inc., 1997 and updates.
  2. Yates AA, Schlicker SA, Suitor CW. Dietary reference intakes: The new basis for recommendations for calcium and related nutrients, B vitamins, and choline. J Am Diet Assoc 1998;98:699-706. PubMed
  3. Geerling BJ, Dagnelie PC, Badart-Smook A, et al. Diet as a risk factor for the development of ulcerative colitis. Am J Gastroenterol 2000;95:1008-13. PubMed
  4. South M. Neonatal seizures after pyridoxine use -- reply. Lancet 1999;354:2083. PubMed
  5. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline (2000). Washington, DC: National Academy Press, 2000. Available at: http://b
  6. Baxter P, Aicardi J. Neonatal seizures after pyridoxine use. Lancet 1999;354:2082-3. PubMed
  7. Bendich A, Cohen M. Vitamin B6 safety issues. Ann N Y Acad Sci 1990;585:321-30.
  8. Schaumburg H, Kaplan J, Windebank A. Sensory neuropathy from pyridoxine abuse. A new megavitamin syndrome. N Engl J Med 1983;309:445-8. PubMed
  9. Gordon N. Pyridoxine dependency: an update. Dev Med Child Neurol 1997;39:63-5. PubMed
  10. Lewis PJ. Pain in the hand and wrist. Pyridoxine supplements may help patients with carpal tunnel syndrome. BMJ 1995;310:1534. PubMed
  11. Kaufman G. Pyridoxine against amiodarone-induced photosensitivity (letter). Lancet 1984;1:51-2. PubMed
  12. Mulrow JP, Mulrow CD, McKenna WJ. Pyridoxine and amiodarone-induced photosensitivity. Ann Intern Med 1985;103:68-9. PubMed
  13. Kawada A, Kashima A, Shiraishi H, et al. Pyridoxine-induced photosensitivity and hypophosphatasia. Dermatology 2000;201:356-60.. PubMed
  14. Vasile A, Goldberg R, Kornberg B. Pyridoxine toxicity: report of a case. J Am Osteopath Assoc 1984;83:790-1. DOI
  15. Hansson O, Sillanpaa M. Pyridoxine and serum concentration of phenytoin and phenobarbitone. Lancet 1976;1:256. DOI
  16. Jansen T, Romiti R, Kreuter A, Altmeyer P. Rosacea fulminans triggered by high-dose vitamins B6 and B12. J Eur Acad Dermatol Venereol 2001;15:484-5..
  17. Chittumma P, Kaewkiattikun K, Wiriyasiriwach B. Comparison of the effectiveness of ginger and vitamin B6 for treatment of nausea and vomiting in early pregnancy: a randomized double-blind controlled trial. J Med Assoc Thai 2007;90:15-20.
  18. Hatzitolios, A., Iliadis, F., Katsiki, N., and Baltatzi, M. Is the anti-hypertensive effect of dietary supplements via aldehydes reduction evidence based? A systematic review. Clin Exp.Hypertens. 2008;30(7):628-639. PubMed
  19. Vasdev, S., Ford, C. A., Parai, S., Longerich, L., and Gadag, V. Dietary vitamin B6 supplementation attenuates hypertension in spontaneously hypertensive rats. Mol.Cell Biochem. 1999;200(1-2):155-162.
  20. de, Vogel S., Dindore, V., van, Engeland M., Goldbohm, R. A., van den Brandt, P. A., and Weijenberg, M. P. Dietary folate, methionine, riboflavin, and vitamin B-6 and risk of sporadic colorectal cancer. J Nutr 2008;138(12):2372-2378. PubMed
  21. Hagen, I., Nesheim, B. I., and Tuntland, T. No effect of vitamin B-6 against premenstrual tension. A controlled clinical study. Acta Obstet.Gynecol.Scand. 1985;64(8):667-670. PubMed
  22. Aybak, M., Sermet, A., Ayyildiz, M. O., and Karakilcik, A. Z. Effect of oral pyridoxine hydrochloride supplementation on arterial blood pressure in patients with essential hypertension. Arzneimittelforschung. 1995;45(12):1271-1273.
  23. Lal, K. J., Dakshinamurti, K., and Thliveris, J. The effect of vitamin B6 on the systolic blood pressure of rats in various animal models of hypertension. J Hypertens. 1996;14(3):355-363. PubMed
  24. Lauritzen CH, Reuter HD, Repges R, Bohnert K, and Schmidt U. Treatment of premenstrual tension syndrome with Vitex agnus castus. Controlled, double-blind study versus pyridoxine. Phytomed 1997;4(3):183-189. PubMed
  25. Fonseca VA, Lavery LA, Thethi TK, et al. Metanx in type 2 diabetes with peripheral neuropathy: A randomized trial. Am J Med 2013;126(2):141-9. PubMed
  26. Hankey GJ, Eikelboom JW, Yi Q, et al. Treatment with B vitamins and incidence of cancer in patients with previous stroke or transient ischemic attack: Results of a randomized placebo-controlled trial. Stroke 2012;43(6):1572-7. PubMed
  27. Hoyer-Kuhn H, Kohbrok S, Volland R, Franklin J, Hero B, Beck BB, Hoppe B. Vitamin B6 in primary hyperoxaluria I: first prospective trial after 40 years of practice. Clin J Am Soc Nephrol. 2014 Mar;9(3):468-77. PubMed
  28. Mahmoud A, Tabassum S, Al Enazi S, et al. Amelioration of levetiracetam-induced behavioral side effects by pyridoxine. A randomized double blind controlled study. Pediatr Neurol 2021;119:15-21. PubMed
  29. Gupta M, Gallante B, Bamberger JN, et al. Prospective randomized evaluation of idiopathic hyperoxaluria treatments. J Endourol 2021;35(12):1844-1851. PubMed
  30. Li H, Chen M, Liang S, et al. Excessive vitamin B6 during treatment is related to poor prognosis of patients with nasopharyngeal carcinoma: A U-shaped distribution suggests low dose supplement. Clin Nutr 2021;40(4):2293-2300. PubMed
  31. Tanigawa J, Nabatame S, Tominaga K, et al. High-dose pyridoxine treatment for inherited glycosylphosphatidylinositol deficiency. Brain Dev 2021;43(6):680-687. PubMed
  32. Committee on Practice Bulletins-Obstetrics. ACOG Practice Bulletin No. 189: Nausea And Vomiting Of Pregnancy. Obstet Gynecol. 2018;131(1):e15-e30. PubMed

See these in context on the Vitamin B6 monograph →

Pantothenic Acid 11 references
  1. McEvoy GK, ed. AHFS Drug Information. Bethesda, MD: American Society of Health-System Pharmacists, 1998.
  2. Yates AA, Schlicker SA, Suitor CW. Dietary reference intakes: The new basis for recommendations for calcium and related nutrients, B vitamins, and choline. J Am Diet Assoc 1998;98:699-706. PubMed
  3. Debourdeau PM, Djezzar S, Estival JL, et al. Life-threatening eosinophilic pleuropericardial effusion related to vitamins B5 and H. Ann Pharmacother 2001;35:424-6. DOI
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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

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