Interactions on record — worth a quick check against your medications. Based on 1 of 2 ingredients. Check your meds →
Dietary supplement

Tru Niagen Unflavored Ingredients & Drug Interactions

by ChromaDex

Tru Niagen Unflavored label
See full label image
Powder Category: Vitamin
Most serious interaction: Minor
Clinical methodology reviewed by · Updated Oct 7, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Tru Niagen Unflavored against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Minor

Tru Niagen Unflavored is a dietary supplement by ChromaDex with 2 active ingredients. Its ingredients are commonly taken for healthy aging, boosting cellular energy, supporting metabolism.Based on those ingredients, 172 medications have a known interaction with it, the most serious rated minor. The ingredients most likely to interact are Niagen. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Tru Niagen Unflavored by ChromaDex

Ask about any prescription or over-the-counter medication and we check it for interactions with Tru Niagen Unflavored by ChromaDex — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Tru Niagen Unflavored by ChromaDex

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Oct 6, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 2 of its 2 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

Tru Niagen Unflavored is a powder with 2 active ingredients: nicotinamide riboside (Niagen) and fiber. Nicotinamide riboside is a form of vitamin B3 that's converted in your body to NAD+, a molecule involved in cell energy and repair.

The inactive ingredients are inulin, which serves as a carrier or filler.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see Nicotinamide Riboside's own graded uses on its monograph.

Why this rating?
  • The label markets this product for: Age better and increase NAD+.
  • We looked for evidence on: Athletic performance, Physical performance, Cellular energy, Metabolic health, Healthy aging.
  • The closest evidence on file: Nicotinamide Riboside is rated "Insufficient Reliable Evidence To Rate" for Athletic performance (Natural Medicines).
  • Also on file: Nicotinamide Riboside is rated "Insufficient Reliable Evidence To Rate" for Physical performance.

The evidence for nicotinamide riboside isn't established yet. The data we hold rates it as having insufficient reliable evidence for age-related cognitive decline, age-related macular degeneration, Alzheimer's disease, athletic performance, nonalcoholic fatty liver disease, and heart failure.

That means the studies so far haven't been robust enough to say whether it works for any of these uses.

The evidence, ingredient by ingredient Nicotinamide Riboside

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Nicotinamide riboside appears generally well tolerated in short-term studies, but long-term safety isn't fully known. The most common side effects reported in trials are bloating, muscle pain, nausea, itching, sweating, and changes in bowel movements.

A few people have reported leg cramps or mild muscle soreness. The safety data advises against use during pregnancy and while breastfeeding — there isn't enough information to know it's safe in those situations.

Side effects, ingredient by ingredient Nicotinamide Riboside

Meds to double-check

Minor interactions only
Known Interaction Concern · database check
Minor only

Only Minor-severity interactions are documented for these ingredients.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Nicotinamide Riboside.
  • The most serious interaction on file is rated Minor.
  • For scale: 172 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check your blood pressure medications (antihypertensive drugs) with your doctor or pharmacist before starting this product — there's a minor risk that nicotinamide riboside may add to their effect and lower your blood pressure too much. We could not check the fiber ingredient against medications.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Only minor medication interactions are documented, and safety information is well characterized.

Tru Niagen Unflavored is a nicotinamide riboside supplement that's generally well tolerated short-term but with limited long-term safety data and no strong evidence yet for the conditions it's marketed for. If you take blood pressure medication, check with your doctor or pharmacist first.

Pregnant or breastfeeding? Talk it over with your healthcare provider — there isn't enough data to know it's safe.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jun 16, 2022.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Tru Niagen Unflavored, straight from the product label.

Brand ChromaDex
Barcode (UPC) 856029008141
Net contents 0.14 Ounce(s); 4 Gram(s)
Market status On market
Date entered into DSLD Jun 16, 2022
DSLD ID 266733
Product type Vitamin
Supplement form Powder
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Kosher, Halal
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Tru Niagen Unflavored by ChromaDex, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
4 Gram(s)
Maximum serving Sizes:
4 Gram(s)
UPC/BARCODE
856029008141
IngredientAmount% DV
Calories15 Calorie(s)--
Total Carbohydrates4 Gram(s)1%
Fiber3 Gram(s)10%
Niagen300 mg--

Other ingredients: Inulin

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Precautions

CAUTION: If you are pregnant, nursing, or taking any medications, please seek the advice of a healthcare professional prior to use.

Not intended for use by children under 18.

Do not use if sealed packet is ripped or torn.

Storage

Storage Information: Store in a cool, dry place.

General Statements

Patents: See NRPatents.com

Formulation

Age better Increases NAD+

Unflavored

Vegetarian

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

Directions: Daily—Add contents of 1 packet to 16 fl oz of cold or room-temperature liquid while stirring, mix thoroughly until dissolved.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Seals/Symbols

NSF Certified Sport Crescent M (Halal)

Formula

Star-K (Kosher)

Crescent M (Halal)

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Tru Niagen Unflavored by ChromaDex label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Tru Niagen Unflavored label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Tru Niagen Unflavored by ChromaDex

These are the 2 active ingredients this product is made of. Select any to open its full monograph.

Serving size4 Gram(s) Dosage formPowder Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Fiber

3 Gram(s) per serving

Niagen

Interacts with
172 drugs
300 mg per serving Form: Nicotinamide Riboside Chloride

Nicotinamide riboside (NR) is a form of vitamin B3 that the body converts into NAD+, a molecule involved in cellular energy and repair. Early human st...

Niagen monograph & interactions

Other (inactive) ingredients: Inulin. These complete the product’s ingredient list but are not active constituents.

Interaction report

Tru Niagen Unflavored by ChromaDex Drug Interactions

Want to check YOUR meds against Tru Niagen Unflavored?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
172Drugs
172 Minor

Ingredients driving the most interactions

Niagen 172

Individual Drug Interactions

The ingredients in Tru Niagen Unflavored interact with 172 drugs. Click any drug to see the details.

1 of the 2 ingredients in Tru Niagen Unflavored interact with drugs. Each result below shows which ingredient is responsible. Niagen

Each ingredient & the kinds of drugs it affects

For each ingredient in Tru Niagen Unflavored with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Niagen1 drug type · 172 drugs

Antihypertensive Drugs

Theoretically, nicotinamide riboside may have additive effects with antihypertensive drugs, potentially increasing the risk for hypotension.
One small clinical study suggests that nicotinamide riboside can modestly reduce blood pressure in hypertensive patients. However, other clinical research did not find a reduction in blood pressure when compared with control.

Likelihood Possible Evidence D
Niagen full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Tru Niagen Unflavored, from the product label.

ChromaDex

See all ChromaDex products
Name
ChromaDex, Inc
Street Address
10900 Wilshire Blvd Suite 600
City
Los Angeles
State
CA
ZipCode
90024
Phone Number
888-642-4361
Web Address
TruNiagen.com
Pharmacist Counseling Corner

Tru Niagen Unflavored by ChromaDex: Common Questions

Does Tru Niagen Unflavored by ChromaDex interact with any medications?
Yes. Based on its ingredients, Tru Niagen Unflavored has a known interaction with 172 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Tru Niagen Unflavored contains 2 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What are the most common side effects?
Bloating, muscle pain, nausea, itching, sweating, and changes in bowel movements have been reported in clinical trials. A small number of people reported leg cramps or mild muscle soreness. Most effects were mild and temporary.
Is it safe to use while pregnant or breastfeeding?
The safety data advises against it during pregnancy and breastfeeding because there isn't enough information to know it's safe. Talk with your doctor or pharmacist about your specific situation.
Does it actually work for brain health or fitness?
The evidence we hold rates nicotinamide riboside as having insufficient reliable evidence for age-related cognitive decline, Alzheimer's disease, athletic performance, and other conditions it's marketed for. That means the studies haven't been strong enough yet to say whether it works.
What is Niagen?
Niagen is the brand name for nicotinamide riboside, a form of vitamin B3. Your body converts it into NAD+, a molecule involved in cell energy and repair.
Is there anything I should know about long-term use?
Nicotinamide riboside appears well tolerated in short-term studies, but long-term safety isn't fully known. If you're planning to take it regularly, check with your doctor or pharmacist.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Tru Niagen Unflavored is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Tru Niagen Unflavored label
Go deeper

The Full Monographs Behind Tru Niagen Unflavored’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Nicotinamide Riboside

Interacts with 172 drugs

Nicotinamide riboside (NR) is a form of vitamin B3 that the body converts into NAD+, a molecule involved in cellular energy and repair. Early human studies show it can reliably raise NAD+ le...

Read the full Nicotinamide Riboside monograph →
Sources

Sources & How We Checked

Tru Niagen Unflavored's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 7 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Nicotinamide Riboside 7 references
  1. Martens CR, Denman BA, Mazzo MR, et al. Chronic nicotinamide riboside supplementation is well-tolerated and elevates NAD+ in healthy middle-aged and older adults. Nat Commun 2018;9(1):1286. PubMed
  2. Dollerup OL, Christensen B, Svart M, et al. A randomized placebo-controlled clinical trial of nicotinamide riboside in obese men: safety, insulin-sensitivity, and lipid-mobilizing effects. Am J Clin Nutr 2018;108(2):343-53. PubMed
  3. Dellinger RW, Santos SR, Morris M, et al. Repeat dose NRPT (nicotinamide riboside and pterostilbene) increases NAD+ levels in humans safety and sustainably: a randomized, double-blind, placebo-controlled study. NPJ J Aging Mech Dis 2017;3:17.
  4. Conze D, Brenner C, Kruger CL. Safety and metabolism of long-term administration of NIAGEN (nicotinamide riboside chloride) in a randomized, double-blind, placebo-controlled clinical trial of healthy overweight adults. Sci Rep 2019;9(1):9772. PubMed
  5. Remie CME, Roumans KHM, Moonen MPB, et al. Nicotinamide riboside supplementation alters body composition and skeletal muscle acetylcarnitine concentrations in healthy obese humans. Am J Clin Nutr. 2020;112(2):413-426. PubMed
  6. Turck D, Castenmiller J, de Henauw S, et al. Safety of nicotinamide riboside chloride as a novel food pursuant to Regulation (EU) 2015/2283 and bioavailability of nicotinamide from this source, in the context of Directive 2002/46/EC. EFSA J. 2019;17(8):e0
  7. EFSA Panel on Nutrition, Novel Foods and Food Allergens (NDA), Turck D, et al. Extension of use of nicotinamide riboside chloride as a novel food pursuant to Regulation (EU) 2015/2283. EFSA J 2021;19(11):e06843.

See these in context on the Nicotinamide Riboside monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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