Ultimate Aloe Ingredients & Drug Interactions
What is this page for?
First and foremost: checking Ultimate Aloe against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Ultimate Aloe is a dietary supplement by Market America with 1 active ingredient. Its ingredients are commonly taken for minor burns and skin irritation, wound healing, constipation.Based on those ingredients, 461 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are Aloe, Powder, Purified. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Ultimate Aloe by Market America
Ask about any prescription or over-the-counter medication and we check it for interactions with Ultimate Aloe by Market America — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Ultimate Aloe by Market America
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
Ultimate Aloe contains one active ingredient: purified aloe powder. The inactive ingredients are maltodextrin, crystalline fructose, natural flavors, malic acid, natural color, and rebaudioside A — these are fillers and flavor components that help with the powder form.
Does it work?
Moderate evidence
The research we hold shows aloe is possibly effective for acne, obesity, diabetes, psoriasis, burns, and constipation. That means there's some preliminary evidence, but we don't have strong proof yet.
If you're thinking about aloe for one of these, talk with your pharmacist or doctor about whether it makes sense for you and how long you might need to use it.
How safe is it?
Well-documented data
Topical aloe gel is generally well tolerated, but this is an oral powder — and the safety profile shifts when you take aloe by mouth. Oral aloe latex can cause abdominal pain, cramps, and diarrhea, especially at higher doses or with long-term use.
In rare cases, overuse has caused potassium loss (hypokalemia), muscle weakness, and irregular heartbeats. Avoid taking this during pregnancy — aloe latex can stimulate the uterus and act as a strong laxative.
Also avoid it while breastfeeding because safety data is limited and the laxative effects pose a concern.
Meds to double-check
Major interaction found
Before taking this, check your medications against the list — especially digoxin (heart medication), blood thinners like warfarin or clopidogrel, diabetes drugs, diuretics, stimulant laxatives, and any drugs your liver processes (CYP1A2 substrates). The interaction with digoxin is the most serious.
The bottom line
Scorecard at a glanceFully disclosed formula with some supporting evidence behind its ingredients' uses. Major medication interactions have been identified, and safety information is well characterized.
This product is aloe only, so if you take any heart, blood-thinning, diabetes, water, or laxative medications, you need to check it against your specific drugs first. Even if you're on nothing else, don't overuse aloe or take it long-term without talking to your pharmacist.
It's not safe in pregnancy or while nursing.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Jun 20, 2024.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Ultimate Aloe, straight from the product label.
| Brand | Market America |
|---|---|
| Barcode (UPC) | 848570001023 |
| Net contents | 16 Packet(s) |
| Market status | On market |
| Date entered into DSLD | Jun 20, 2024 |
| DSLD ID | 313426 |
| Product type | Botanical |
| Supplement form | Powder |
| Dietary claims / uses | All Other |
| Intended target group(s) | Vegan, Vegetarian, Adult (18 - 50 Years), Gluten Free, Dairy Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Ultimate Aloe by Market America, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Calories | 6 Gram(s) | 2% |
| Total Carbohydrates | 6 Gram(s) | 2% |
| Added Sugars | 3 Gram(s) | 6% |
| Total Sugars | 3 Gram(s) | -- |
| Aloe, Powder, Purified | 300 mg | -- |
Other ingredients: Maltodextrin, Crystalline Fructose, Natural Flavors, Malic Acid, Natural color, Rebaudioside A
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation
Gluten free
Vegan
Formula
ACTIValoe
Brand IP Statement(s)
ACTIValoe is a registered trademark of Aloecorp, Inc.
Precautions
Resale on third-party websites is strictly prohibited unless specifically authorized by Market America or its corporate affiliates. If barcodes are altered or you purchase this product from an unauthorized third-party website, the product is not guaranteed by Market America or its corporate affiliates.
Warning: If you are currently using any prescription drugs, have an ongoing medical condition, or if you are pregnant or breastfeeding, consult your healthcare provider before using this product.
Caution: Discontinue use in the event of an allergic reaction.
Suggested/Recommended/Usage/Directions
Directions for use: Add 1 packet to 4 fluid ounces of water and mix well. Take once daily or as directed by your healthcare provider.
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Ultimate Aloe by Market America label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Ultimate Aloe by Market America
This is the 1 active ingredient this product is made of. Select it to open its full monograph.
Serving size7 Gram(s) Dosage formPowder Servings per container16 Amounts shown are per serving.
Aloe, Powder, Purified
Interacts with461 drugs
Aloe vera gel is widely used on the skin for minor burns and irritation, and some research suggests it may help. Aloe latex (the yellow part) is a str...
Aloe, Powder, Purified monograph & interactionsOther (inactive) ingredients: Maltodextrin, Crystalline Fructose, Natural Flavors, Malic Acid, Natural color, Rebaudioside A. These complete the product’s ingredient list but are not active constituents.
Ultimate Aloe by Market America Drug Interactions
HelloPharmacist Interaction Report
Ultimate Aloe by Market America is a single-ingredient aloe powder that does interact with several medication types.
The most serious concern is digoxin (Lanoxin), a heart medication — overuse of aloe latex can deplete potassium, which increases the risk of digoxin toxicity and serious heart effects.
Read the full breakdown — every affected drug type, severity by severity
Aloe also has moderate interactions with blood thinners (anticoagulants) and antiplatelet drugs like warfarin and aspirin, raising the risk of bleeding. It may lower blood sugar and add to the effect of diabetes medications, so you'll need to monitor your glucose closely if you take them.
Diuretics (water pills) are another concern — aloe can compound the potassium loss these drugs cause. Stimulant laxatives and aloe together can worsen fluid and electrolyte loss, and aloe may reduce how well certain drugs processed by your liver (CYP1A2 substrates) work in your body.
Aloe powder is the only active ingredient here, and our data does show interactions with it. Altogether, these interactions span 460 individual medications.
Before you start, use the checker below to see if any of your prescriptions are on that list.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Ultimate Aloe?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Ultimate Aloe interact with 461 drugs. Click any drug to see the details.
1 of the 1 ingredient in Ultimate Aloe interact with drugs. Each result below shows which ingredient is responsible. Aloe, Powder, Purified
DigoxinDigitek, Lanoxicaps, Lanoxin
How Digoxin interacts with Ultimate Aloe — through 1 ingredient. Tap an ingredient for the detail:
Aloe, Powder, PurifiedDigoxin (lanoxin) Major
Interaction Summary
Theoretically, aloe latex might increase the risk of adverse effects when taken with cardiac glycosides.
Read the full Aloe, Powder, Purified + Digoxin interactionAbciximabReoPro
How Abciximab interacts with Ultimate Aloe — through 1 ingredient. Tap an ingredient for the detail:
Aloe, Powder, PurifiedAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, aloe gel might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.
Read the full Aloe, Powder, Purified + Abciximab interactionAbrocitinibCibinqo
How Abrocitinib interacts with Ultimate Aloe — through 1 ingredient. Tap an ingredient for the detail:
Aloe, Powder, PurifiedAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, aloe gel might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.
Read the full Aloe, Powder, Purified + Abrocitinib interactionAcarboseGlucobay, Prandase, Precose
How Acarbose interacts with Ultimate Aloe — through 1 ingredient. Tap an ingredient for the detail:
Aloe, Powder, PurifiedAntidiabetes Drugs Moderate
Interaction Summary
Aloe might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Read the full Aloe, Powder, Purified + Acarbose interactionAcenocoumarolSintrom
How Acenocoumarol interacts with Ultimate Aloe — through 1 ingredient. Tap an ingredient for the detail:
Aloe, Powder, PurifiedAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, aloe gel might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.
Read the full Aloe, Powder, Purified + Acenocoumarol interactionAcetaminophen, AspirinGemnisyn
How Acetaminophen, Aspirin interacts with Ultimate Aloe — through 1 ingredient. Tap an ingredient for the detail:
Aloe, Powder, PurifiedCytochrome P450 1a2 (cyp1a2) Substrates, Anticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, aloe might decrease the levels and clinical effects of CYP1A2 substrates.
Read the full Aloe, Powder, Purified + Acetaminophen, Aspirin interactionAcetaminophen, Aspirin, CaffeineExcedrin, Excedrin Extra Strength, Excedrin Migraine
How Acetaminophen, Aspirin, Caffeine interacts with Ultimate Aloe — through 1 ingredient. Tap an ingredient for the detail:
Aloe, Powder, PurifiedAnticoagulant/antiplatelet Drugs, Cytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, aloe gel might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.
Read the full Aloe, Powder, Purified + Acetaminophen, Aspirin, Caffeine interactionAcetaminophen, Caffeine, PyrilamineMidol Max Strength Menstrual
How Acetaminophen, Caffeine, Pyrilamine interacts with Ultimate Aloe — through 1 ingredient. Tap an ingredient for the detail:
Aloe, Powder, PurifiedCytochrome P450 1a2 (cyp1a2) Substrates, Diuretic Drugs Moderate
Interaction Summary
Theoretically, aloe might decrease the levels and clinical effects of CYP1A2 substrates.
Read the full Aloe, Powder, Purified + Acetaminophen, Caffeine, Pyrilamine interactionAcetaminophen, IbuprofenCombogesic
How Acetaminophen, Ibuprofen interacts with Ultimate Aloe — through 1 ingredient. Tap an ingredient for the detail:
Aloe, Powder, PurifiedAnticoagulant/antiplatelet Drugs, Cytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, aloe gel might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.
Read the full Aloe, Powder, Purified + Acetaminophen, Ibuprofen interactionAcetaminophen, Pamabrom, PyrilamineMidol Max Strength PMS, Pamprin, Pamprin ES
How Acetaminophen, Pamabrom, Pyrilamine interacts with Ultimate Aloe — through 1 ingredient. Tap an ingredient for the detail:
Aloe, Powder, PurifiedCytochrome P450 1a2 (cyp1a2) Substrates, Diuretic Drugs Moderate
Interaction Summary
Theoretically, aloe might decrease the levels and clinical effects of CYP1A2 substrates.
Read the full Aloe, Powder, Purified + Acetaminophen, Pamabrom, Pyrilamine interactionAcetazolamideAk-Zol, Diamox
How Acetazolamide interacts with Ultimate Aloe — through 1 ingredient. Tap an ingredient for the detail:
Aloe, Powder, PurifiedDiuretic Drugs Moderate
Interaction Summary
Theoretically, aloe latex might increase the risk of hypokalemia when taken with diuretic drugs.
Read the full Aloe, Powder, Purified + Acetazolamide interactionAcetohexamideDymelor
How Acetohexamide interacts with Ultimate Aloe — through 1 ingredient. Tap an ingredient for the detail:
Aloe, Powder, PurifiedAntidiabetes Drugs Moderate
Interaction Summary
Aloe might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Read the full Aloe, Powder, Purified + Acetohexamide interactionAcetylsalicylic AcidEntrophen
How Acetylsalicylic Acid interacts with Ultimate Aloe — through 1 ingredient. Tap an ingredient for the detail:
Aloe, Powder, PurifiedAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, aloe gel might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.
Read the full Aloe, Powder, Purified + Acetylsalicylic Acid interactionAlbiglutideTanzeum
How Albiglutide interacts with Ultimate Aloe — through 1 ingredient. Tap an ingredient for the detail:
Aloe, Powder, PurifiedAntidiabetes Drugs Moderate
Interaction Summary
Aloe might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Read the full Aloe, Powder, Purified + Albiglutide interactionAlogliptinNesina
How Alogliptin interacts with Ultimate Aloe — through 1 ingredient. Tap an ingredient for the detail:
Aloe, Powder, PurifiedAntidiabetes Drugs Moderate
Interaction Summary
Aloe might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Read the full Aloe, Powder, Purified + Alogliptin interactionAlogliptin, MetforminKazano
How Alogliptin, Metformin interacts with Ultimate Aloe — through 1 ingredient. Tap an ingredient for the detail:
Aloe, Powder, PurifiedAntidiabetes Drugs Moderate
Interaction Summary
Aloe might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Read the full Aloe, Powder, Purified + Alogliptin, Metformin interactionAlogliptin, PioglitazoneOseni
How Alogliptin, Pioglitazone interacts with Ultimate Aloe — through 1 ingredient. Tap an ingredient for the detail:
Aloe, Powder, PurifiedAntidiabetes Drugs Moderate
Interaction Summary
Aloe might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Read the full Aloe, Powder, Purified + Alogliptin, Pioglitazone interactionAlteplase, TpaActilyse, Activase
How Alteplase, Tpa interacts with Ultimate Aloe — through 1 ingredient. Tap an ingredient for the detail:
Aloe, Powder, PurifiedAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, aloe gel might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.
Read the full Aloe, Powder, Purified + Alteplase, Tpa interactionAluminum Hydroxide, Aspirin, Codeine Phosphate, Magnesium HydroxideAscriptin Codeine #2
How Aluminum Hydroxide, Aspirin, Codeine Phosphate, Magnesium Hydroxide interacts with Ultimate Aloe — through 1 ingredient. Tap an ingredient for the detail:
Aloe, Powder, PurifiedAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, aloe gel might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.
Read the full Aloe, Powder, Purified + Aluminum Hydroxide, Aspirin, Codeine Phosphate, Magnesium Hydroxide interactionAluminum Hydroxide, Aspirin, Magnesium HydroxideAscriptin
How Aluminum Hydroxide, Aspirin, Magnesium Hydroxide interacts with Ultimate Aloe — through 1 ingredient. Tap an ingredient for the detail:
Aloe, Powder, PurifiedAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, aloe gel might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.
Read the full Aloe, Powder, Purified + Aluminum Hydroxide, Aspirin, Magnesium Hydroxide interactionAmiloride, HydrochlorothiazideAmil-Co, Amilzide, Moduret 25, Moduretic
How Amiloride, Hydrochlorothiazide interacts with Ultimate Aloe — through 1 ingredient. Tap an ingredient for the detail:
Aloe, Powder, PurifiedDiuretic Drugs Moderate
Interaction Summary
Theoretically, aloe latex might increase the risk of hypokalemia when taken with diuretic drugs.
Read the full Aloe, Powder, Purified + Amiloride, Hydrochlorothiazide interactionAmmonium ChlorideAmmonium Chloride
How Ammonium Chloride interacts with Ultimate Aloe — through 1 ingredient. Tap an ingredient for the detail:
Aloe, Powder, PurifiedDiuretic Drugs Moderate
Interaction Summary
Theoretically, aloe latex might increase the risk of hypokalemia when taken with diuretic drugs.
Read the full Aloe, Powder, Purified + Ammonium Chloride interactionAnacaulase-bcdbNexoBrid
How Anacaulase-bcdb interacts with Ultimate Aloe — through 1 ingredient. Tap an ingredient for the detail:
Aloe, Powder, PurifiedAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, aloe gel might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.
Read the full Aloe, Powder, Purified + Anacaulase-bcdb interactionAnagrelideAgrylin
How Anagrelide interacts with Ultimate Aloe — through 1 ingredient. Tap an ingredient for the detail:
Aloe, Powder, PurifiedAnticoagulant/antiplatelet Drugs, Cytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, aloe gel might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.
Read the full Aloe, Powder, Purified + Anagrelide interactionAnisindioneMiradon
How Anisindione interacts with Ultimate Aloe — through 1 ingredient. Tap an ingredient for the detail:
Aloe, Powder, PurifiedAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, aloe gel might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.
Read the full Aloe, Powder, Purified + Anisindione interactionAntidiabetes, Dipeptidyl Peptidase-4 (dpp-iv) InhibitorGlyxambi
How Antidiabetes, Dipeptidyl Peptidase-4 (dpp-iv) Inhibitor interacts with Ultimate Aloe — through 1 ingredient. Tap an ingredient for the detail:
Aloe, Powder, PurifiedAntidiabetes Drugs Moderate
Interaction Summary
Aloe might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Read the full Aloe, Powder, Purified + Antidiabetes, Dipeptidyl Peptidase-4 (dpp-iv) Inhibitor interactionAntithrombin IiiThrombate III
How Antithrombin Iii interacts with Ultimate Aloe — through 1 ingredient. Tap an ingredient for the detail:
Aloe, Powder, PurifiedAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, aloe gel might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.
Read the full Aloe, Powder, Purified + Antithrombin Iii interactionApixabanEliquis
How Apixaban interacts with Ultimate Aloe — through 1 ingredient. Tap an ingredient for the detail:
Aloe, Powder, PurifiedAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, aloe gel might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.
Read the full Aloe, Powder, Purified + Apixaban interactionArgatrobanArgatroban
How Argatroban interacts with Ultimate Aloe — through 1 ingredient. Tap an ingredient for the detail:
Aloe, Powder, PurifiedAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, aloe gel might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.
Read the full Aloe, Powder, Purified + Argatroban interactionArmodafinilNuvigil
How Armodafinil interacts with Ultimate Aloe — through 1 ingredient. Tap an ingredient for the detail:
Aloe, Powder, PurifiedStimulant Laxatives Moderate
Interaction Summary
Theoretically, aloe latex might increase the risk for fluid and electrolyte loss when taken with stimulant laxatives.
Read the full Aloe, Powder, Purified + Armodafinil interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Ultimate Aloe with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.
Aloe, Powder, Purified
Digoxin (Lanoxin)
Theoretically, aloe latex might increase the risk of adverse effects when taken with cardiac glycosides.
Overuse of aloe latex can increase the risk of adverse effects from cardiac glycoside drugs, such as digoxin, due to potassium depletion. Overuse of aloe, along with cardiac glycoside drugs, can increase the risk of toxicity.
Anticoagulant/Antiplatelet Drugs
Theoretically, aloe gel might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.
In vitro research shows that aloe gel can inhibit platelet aggregation. This inhibition was greater than that seen with celecoxib, but less than that seen with aspirin.
Antidiabetes Drugs
Aloe might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Preliminary clinical research suggests aloe gel might lower blood glucose levels and have additive effects when used with antidiabetes drugs. Monitor blood glucose levels closely.
Diuretic Drugs
Theoretically, aloe latex might increase the risk of hypokalemia when taken with diuretic drugs.
Overuse of aloe latex might compound diuretic-induced potassium loss, increasing the risk of hypokalemia.
Stimulant Laxatives
Theoretically, aloe latex might increase the risk for fluid and electrolyte loss when taken with stimulant laxatives.
Due to cathartic laxative effects of aloe latex, concomitant use with other stimulant laxatives might compound fluid and electrolyte loss.
Warfarin (Coumadin)
Theoretically, aloe latex might increase the risk of bleeding when taken with warfarin.
Aloe latex has stimulant laxative effects. In some people aloe latex can cause diarrhea. Diarrhea can increase the effects of warfarin, increase international normalized ratio (INR), and increase the risk of bleeding. Advise patients who take warfarin not to take excessive amounts of aloe vera.
Cytochrome P450 1A2 (Cyp1A2) Substrates
Theoretically, aloe might decrease the levels and clinical effects of CYP1A2 substrates.
In vitro research shows that aloe extract induces CYP1A2 enzymes.
Brand information
Manufacturer and brand details for Ultimate Aloe, from the product label.
Market America
See all Market America products- Name
- Market America, Inc.
- Street Address
- 1302 Pleasant Ridge Road
- City
- Greensboro
- State
- NC
- ZipCode
- 27409
Ultimate Aloe by Market America: Common Questions
Does Ultimate Aloe by Market America interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Is this safe if I take a blood thinner?
Can I take this if I'm pregnant?
Will this help with my constipation?
What's the difference between this powder and aloe gel you'd buy for burns?
Can I take this long-term?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if Ultimate Aloe is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Ultimate Aloe’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Sources & How We Checked
Ultimate Aloe's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 41 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Aloe 41 references
- Newall CA, Anderson LA, Philpson JD. Herbal Medicine: A Guide for Healthcare Professionals. London, UK: The Pharmaceutical Press, 1996.
- Wichtl MW. Herbal Drugs and Phytopharmaceuticals. Ed. N.M. Bisset. Stuttgart: Medpharm GmbH Scientific Publishers, 1994.
- Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.
- Nusko G, Schneider B, Schneider I, et al. Anthranoid laxative use is not a risk factor for colorectal neoplasia: results of a prospective case control study. Gut 2000;46:651-5. PubMed
- Luyckx VA, Ballantine R, Claeys M, et al. Herbal remedy-associated acute renal failure secondary to Cape aloes. Am J Kidney Dis 2002;39:E13. PubMed
- Rajasekaran S, Sivagnanam K, Ravi K, Subramanian S. Hypoglycemic effect of Aloe vera gel on streptozotocin-induced diabetes in experimental rats. J Med Food 2004;7:61-6.
- Williams MS, Burk M, Loprinzi CL, et al. Phase III double-blind evaluation of an aloe vera gel as a prophylactic agent for radiation-induced skin toxicity. Int J Radiat Oncol Biol Phys 1996;36:345-9. PubMed
- Vogler BK, Ernst E. Aloe vera: a systematic review of its clinical effectiveness. Br J Gen Pract 1999;49:823-8.
- Bottenberg MM, Wall GC, Harvey RL, Habib S. Oral aloe vera-induced hepatitis. Ann Pharmacother 2007;41:1740-3. PubMed
- Rabe C, Musch A, Schirmacher P, et al. Acute hepatitis induced by an Aloe vera preparation: a case report. World J Gastroenterol 2005;11:303-4. PubMed
- Kanat O, Ozet A, Ataergin S. Aloe vera-induced acute toxic hepatitis in a healthy young man. Eur J Int Med 2006;17:589. PubMed
- Mueller SO, Stopper H. Characterization of the genotoxicity of anthraquinones in mammalian cells. Biochim Biophys Acta 1999;1428:406-14. PubMed
- Schorkhuber M, Richter M, Dutter A, et al. Effect of anthraquinone laxatives on the proliferation and urokinase secretion of normal, premalignant and malignant colonic epithelial cells. Eur J Cancer 1998;34:1091-8. PubMed
- Yang HN, Kim DJ, Kim YM, et al. Aloe-induced toxic hepatitis. J Korean Med Sci 2010;25:492-5. PubMed
- Choonhakarn C, Busaracome P, Sripanidkulchai B, et al. A prospective, randomized clinical trial comparing topical aloe vera with 0.1% triamcinolone acetonide in mild to moderate plaque psoriasis. J.Eur.Acad.Dermatol.Venereol. 2010;24:168-72. PubMed
- Ishii Y, Tanizawa H, Takino Y. Studies of aloe. IV. Mechanism of cathartic effect. (3). Biol Pharm Bull. 1994;17:495-7. PubMed
- Ishii Y, Tanizawa H, Takino Y. Studies of aloe. V. Mechanism of cathartic effect. (4). Biol Pharm Bull. 1994;17:651-3. PubMed
- Nelemans FA. Clinical and toxicological aspects of anthraquinone laxatives. Pharmacology. 1976;14 Suppl 1:73-7. PubMed
- Paulsen E, Korsholm L, Brandrup F. A double-blind, placebo-controlled study of a commercial Aloe vera gel in the treatment of slight to moderate psoriasis vulgaris. J Eur Acad Dermatol Venereol. 2005;19:326-31.
- Huseini HF, Kianbakht S, Hajiaghaee R, et al. Anti-hyperglycemic and anti-hypercholesterolemic effects of Aloe vera leaf gel in hyperlipidemic type 2 diabetic patients: a randomized double-blind placebo-controlled clinical trial. Planta Med. 2012;78:311-6
- Ferreira, M., Teixeira, M., Silva, E., and Selores, M. Allergic contact dermatitis to Aloe vera. Contact Dermatitis 2007;57(4):278-279.
- Choonhakarn, C., Busaracome, P., Sripanidkulchai, B., and Sarakarn, P. The efficacy of aloe vera gel in the treatment of oral lichen planus: a randomized controlled trial. Br J Dermatol 2008;158(3):573-577. PubMed
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