Interactions on record — worth a quick check against your medications. Based on 1 of 6 ingredients. Check your meds →
Dietary supplement

Ultimate EFA Plus Ingredients & Drug Interactions

by Youngevity

Ultimate EFA Plus label
See full label image
Softgel Capsule Category: Fat/fatty Acid
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 23, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Ultimate EFA Plus against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Ultimate EFA Plus is a dietary supplement by Youngevity with 6 active ingredients. Its ingredients are commonly taken for heart health, healthy cooking fat, skin moisturizing.Based on those ingredients, 86 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Oleic Acid. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Ultimate EFA Plus by Youngevity

Ask about any prescription or over-the-counter medication and we check it for interactions with Ultimate EFA Plus by Youngevity — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Ultimate EFA Plus by Youngevity

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 8 of its 8 active ingredients.
  • “Total Omega” is listed as a grouped ingredient — the label gives one combined amount (827 mg) without saying how much of each component you get.

Ultimate EFA Plus contains 8 active ingredients — a blend of omega and essential fatty acids including eicosapentaenoic acid and docosahexaenoic acid (both omega-3s from fish oil), gamma-linolenic acid (an omega-6), alpha-linolenic acid (another omega-3), linoleic acid, oleic acid, and monounsaturated and polyunsaturated fats. The product also contains several inactive ingredients: fish oil, organic flax seed oil, borage seed oil, sunflower oil, gelatin, glycerin, mixed tocopherols, and purified water.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: essential fatty acids support cardiovascular health.
  • We looked for evidence on: Coronary heart disease (CHD), Hypercholesterolemia, Hypertension, Stroke, Atherosclerosis, Dyslipidemia.
  • The strongest evidence on file: Oleic Acid is rated "Possibly Effective" for Coronary heart disease (CHD) (Natural Medicines).
  • Also on file: Oleic Acid is rated "Possibly Effective" for Hypercholesterolemia.
  • Also on file: Oleic Acid is rated "Insufficient Reliable Evidence To Rate" for Hypertension, Stroke.

Oleic acid — one of the ingredients in this product — is rated possibly effective for high cholesterol (hypercholesterolemia) and coronary heart disease. For the other active ingredients in Ultimate EFA Plus, we hold no effectiveness ratings in our data.

That doesn't mean they don't work; it means the evidence we have on file isn't established or sufficient to rate them.

The evidence, ingredient by ingredient Oleic Acid

How safe is it?

Some data gaps
Safety Information · database check
Some gaps

Safety data exists for these ingredients, but with some important gaps.

Why this rating?
  • We hold adverse-effect (side-effect) data for 0 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Oleic acid from foods like olive oil is considered generally well tolerated when eaten in normal amounts. However, concentrated supplement doses of oleic acid haven't been well studied — the safety data from food amounts don't automatically carry over to supplement levels.

During pregnancy and breastfeeding, food amounts are considered safe, but we don't have good safety data on concentrated supplements, so talk with your doctor or pharmacist about whether this product is right for you at those times.

Side effects, ingredient by ingredient Oleic Acid

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Oleic Acid.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: diabetes medications.
  • For scale: 86 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

If you take antidiabetes drugs (like metformin, sulfonylureas, or insulin), talk to your pharmacist before starting Ultimate EFA Plus. Oleic acid may increase their effects on your blood sugar.

For the five other active ingredients we couldn't check, no interaction data is available in our files, but that's not a guarantee none exist — your pharmacist can help you search for any concerns with your specific medications.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and some safety-information gaps remain.

This supplement may appeal to someone looking for essential fatty acids and omega fats. If you take a blood sugar–lowering medication, check with your pharmacist first — oleic acid in this product may increase how those drugs work.

For anyone else, the main caution is that concentrated doses haven't been as well studied as the same fats from food sources.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 8 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Nov 21, 2020.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Ultimate EFA Plus, straight from the product label.

Brand Youngevity
Barcode (UPC) 20989
Net contents 90 Softgel(s)
Market status On market
Date entered into DSLD Nov 21, 2020
DSLD ID 240047
Product type Fat/fatty Acid
Supplement form Softgel Capsule
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Children 4 or More Years of Age, Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Ultimate EFA Plus by Youngevity, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Softgel(s)
Maximum serving Sizes:
1 Softgel(s)
Servings per container
90
UPC/BARCODE
20989
IngredientAmount% DV
Calories12 Calorie(s)--
Calories from Fat11 Calorie(s)--
Total Fat1 Gram(s)2%
Eicosapentaenoic Acid171 mg--
Docosahexaenoic Acid114 mg--
Cholesterol3 mg1%
Gamma-Linolenic Acid19 mg--
Monounsaturated Fat1 Gram(s)--
Saturated Fat1 Gram(s)1%
Linoleic Acid103 mg--
Oleic Acid120 mg--
Alpha-Linolenic Acid300 mg--
Polyunsaturated Fat1 Gram(s)--
Total Omega827 mg--

Other ingredients: Fish Oil, organic Flax seed Oil, Gelatin, Glycerin, Borage seed Oil, purified Water, Sunflower Oil, Mixed Tocopherols

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula

Ultimate EFA Plus is a proprietary blend of essential fatty acids from Borage, Flax and fish oils. Used as part of a healthy diet, essential fatty acids may support the body in many ways, especially cardiovascular health.

Precautions

Warning: If you are pregnant, nursing or taking medications, consult your healthcare professional before using this product.

This product contains ingredients derived from anchovy and/or sardine and/or pollock.

Keep out of reach of children.

Suggested/Recommended/Usage/Directions

Directions: Take 1 soft gel, three times a day or as directed by your healthcare professional.

FDA Disclaimer Statement

This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Formulation

Manufactured in the U.S.A.

FDA Statement of Identity

Dietary Supplement

Seals/Symbols

IFOS

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Ultimate EFA Plus by Youngevity label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Ultimate EFA Plus label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Ultimate EFA Plus by Youngevity

These are the 6 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Softgel(s) Dosage formSoftgel Capsule Servings per container90 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Total Omega

827 mg per serving
  • › Eicosapentaenoic Acid
  • › Docosahexaenoic Acid
  • › Gamma-Linolenic Acid
  • › Linoleic Acid
  • › Oleic Acid
  • › Alpha-Linolenic Acid

Other (inactive) ingredients: Fish Oil, Organic Flax seed Oil, Gelatin, Glycerin, Borage seed Oil, Purified Water, Sunflower Oil, Mixed Tocopherols. These complete the product’s ingredient list but are not active constituents.

Interaction report

Ultimate EFA Plus by Youngevity Drug Interactions

Want to check YOUR meds against Ultimate EFA Plus?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
86Drugs
86 Moderate

Ingredients driving the most interactions

Oleic Acid 86

Individual Drug Interactions

The ingredients in Ultimate EFA Plus interact with 86 drugs. Click any drug to see the details.

1 of the 6 ingredients in Ultimate EFA Plus interact with drugs. Each result below shows which ingredient is responsible. Oleic Acid

Each ingredient & the kinds of drugs it affects

For each ingredient in Ultimate EFA Plus with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Oleic Acid1 drug type · 86 drugs

Antidiabetes Drugs

Theoretically, oleic acid might increase the effects of antidiabetes drugs. Preliminary clinical research in patients with type 2 diabetes taking oral hypoglycemic drugs shows that eating a diet rich in oleic acid from olive oil decreases fasting blood glucose levels when compared to eating a diet rich in linoleic acid from sunflower oil. It is unknown if taking oleic acid supplements would have this effect or if this change is clinically significant. Until more is known, use caution. Dose adjustment may be necessary. Some antidiabetes drugs include glimepiride (Amaryl), glyburide (DiaBeta, Glynase PresTab, Micronase), insulin, metformin (Glucophage), pioglitazone (Actos), rosiglitazone (Avandia), and others.

Likelihood Possible Evidence B
Oleic Acid full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Ultimate EFA Plus, from the product label.

Youngevity

See all Youngevity products
Name
Youngevity
Street Address
2400 Boswell Road
City
Chula Vista
State
CA
ZipCode
91914
Phone Number
1.800.982.3189
Web Address
www.youngevity.com
Pharmacist Counseling Corner

Ultimate EFA Plus by Youngevity: Common Questions

Does Ultimate EFA Plus by Youngevity interact with any medications?
Yes. Based on its ingredients, Ultimate EFA Plus has a known interaction with 86 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Ultimate EFA Plus contains 6 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Will this help with high cholesterol?
The oleic acid in this product is rated possibly effective for high cholesterol. That means there's some evidence it may help, but it's not a sure thing. Talk with your doctor about whether adding this to your routine makes sense for your cholesterol goals.
Is it safe to take during pregnancy?
Food amounts of oleic acid are considered safe in pregnancy, but this product is a concentrated supplement, and we don't have good safety data on supplement-level doses during pregnancy or breastfeeding. Talk with your doctor or pharmacist before taking it.
What's the difference between all these omega fats and oils?
This product blends several types of essential fats: omega-3s like eicosapentaenoic acid and docosahexaenoic acid (from fish oil), omega-6s like gamma-linolenic acid (from borage), and monounsaturated and polyunsaturated fats like oleic and linoleic acids. Your body needs all of them, but in the right balance.
Should I take this if I'm on blood sugar medication?
Check with your pharmacist first. Oleic acid in this product may boost how well your blood sugar medication works, which could lower your blood sugar more than expected. Your pharmacist can tell you whether your specific drug is affected and whether you need to monitor your blood sugar more carefully.
Can you tell me about side effects?
We don't have adverse effect data on file for the ingredients in this product. If you have questions about side effects, ask your pharmacist or doctor.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Ultimate EFA Plus label
Go deeper

The Full Monographs Behind Ultimate EFA Plus’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Oleic Acid

Interacts with 86 drugs

Oleic acid is a heart-healthy monounsaturated fat found mainly in olive oil, canola oil, avocados, and nuts. As part of a Mediterranean-style diet, it is widely viewed as a healthier replace...

Read the full Oleic Acid monograph →
Sources

Sources & How We Checked

Ultimate EFA Plus's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 19 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Oleic Acid 19 references
  1. Madigan C, Ryan M, Owens D, et al. Dietary unsaturated fatty acids in type 2 diabetes: higher levels of postprandial lipoprotein on a linoleic acid-rich sunflower oil diet compared with an oleic acid-rich olive oil diet. Diabetes Care 2000;23:1472-7. PubMed
  2. Gillingham, L. G., Gustafson, J. A., Han, S. Y., Jassal, D. S., and Jones, P. J. High-oleic rapeseed (canola) and flaxseed oils modulate serum lipids and inflammatory biomarkers in hypercholesterolaemic subjects. Br J Nutr 2011;105(3):417-427. PubMed
  3. Jones PJ, Senanayake VK, Pu S, Jenkins DJ, Connelly PW, Lamarche B, Couture P, Charest A, Baril-Gravel L, West SG, Liu X, Fleming JA, McCrea CE, Kris-Etherton PM. DHA-enriched high-oleic acid canola oil improves lipid profile and lowers predicted cardiova
  4. Cater, N. B., Heller, H. J., and Denke, M. A. Comparison of the effects of medium-chain triacylglycerols, palm oil, and high oleic acid sunflower oil on plasma triacylglycerol fatty acids and lipid and lipoprotein concentrations in humans. Am.J Clin.Nutr PubMed
  5. Mozaffarian D, Clarke R. Quantitative effects on cardiovascular risk factors and coronary heart disease risk of replacing partially hydrogenated vegetable oils with other fats and oils. Eur J Clin Nutr. 2009;63(Suppl 2):S22-33. PubMed
  6. Cao Y, Hou L, Wang W. Dietary total fat and fatty acids intake, serum fatty acids and risk of breast cancer: A meta-analysis of prospective cohort studies. Int J Cancer. 2016;138(8):1894-904. doi: 10.1002/ijc.29938. PubMed
  7. FDA completes review of qualified health claim petition for oleic acid and the risk of coronary heart disease. November 2018. Available at: www.fda.gov/Food/NewsEvents/ConstituentUpdates/ucm624758.htm. Accessed January 25, 2019.
  8. Liu X, Kris-Etherton PM, West SG, et al. Effects of canola and high-oleic-acid canola oils on abdominal fat mass in individuals with central obesity. Obesity. 2016;24(11):2261-2268. PubMed
  9. Bowen KJ, Kris-Etherton PM, West SG, et al. Diets enriched with conventional or high-oleic acid canola oils lower atherogenic lipids and lipoproteins compared to a diet with a western fatty acid profile in adults with central adiposity. J Nutr. 2019;149(3 PubMed
  10. Steffen BT, Duprez D, Szklo M, Guan W, Tsai MY. Circulating oleic acid levels are related to greater risks of cardiovascular events and all-cause mortality: The Multi-Ethnic Study of Atherosclerosis. J Clin Lipidol. 2018;12(6):1404-1412. PubMed
  11. Banim PJ, Luben R, Khaw KT, Hart AR. Dietary oleic acid is inversely associated with pancreatic cancer - Data from food diaries in a cohort study. Pancreatology. 2018;18(6):655-660. PubMed
  12. Morin SJ, Gaziano JM, Djoussé L. Relation between plasma phospholipid oleic acid and risk of heart failure. Eur J Nutr. 2018;57(8):2937-2942. PubMed
  13. Samieri C, Féart C, Proust-Lima C, et al. Olive oil consumption, plasma oleic acid, and stroke incidence: the Three-City Study. Neurology. 2011;77(5):418-25. PubMed
  14. Compher CW, Kinosian BP, Rubesin SE, Ratcliffe SJ, Metz DC. Energy absorption is reduced with oleic acid supplements in human short bowel syndrome. JPEN J Parenter Enteral Nutr. 2009;33(1):102-8. PubMed
  15. Ben Fradj MK, Ouanes Y, Hadj-Taieb S, et al. Decreased oleic acid and marine n?-?3 polyunsaturated fatty acids in Tunisian patients with urothelial bladder cancer. Nutr Cancer. 2018;70(7):1043-1050.
  16. de Silva PS, Luben R, Shrestha SS, Khaw KT, Hart AR. Dietary arachidonic and oleic acid intake in ulcerative colitis etiology: a prospective cohort study using 7-day food diaries. Eur J Gastroenterol Hepatol. 2014;26(1):11-8. PubMed
  17. Higashi K, Shige H, Ito T, et al. Effect of a low-fat diet enriched with oleic acid on postprandial lipemia in patients with type 2 diabetes mellitus. Lipids. 2001;36(1):1-6. PubMed
  18. Lin HC, van Citters GW, Heimer F, Bonorris G. Slowing of gastrointestinal transit by oleic acid: a preliminary report of a novel, nutrient-based treatment in humans. Dig Dis Sci. 2001;46(2):223-9. PubMed
  19. Li D, Tong Y, Li Y. Associations between dietary oleic acid and linoleic acid and depressive symptoms in perimenopausal women: The Study of Women's Health Across the Nation. Nutrition. 2020 Mar;71:110602. PubMed

See these in context on the Oleic Acid monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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