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Dietary supplement

V-Zyme (Phytochemically Bound Vanadium) Ingredients & Drug Interactions

by Biotics Research Corporation

V-Zyme (Phytochemically Bound Vanadium) label
See full label image
Tablet Or Pill Category: Mineral
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 30, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking V-Zyme (Phytochemically Bound Vanadium) against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

V-Zyme (Phytochemically Bound Vanadium) is a dietary supplement by Biotics Research Corporation with 1 active ingredient. Its ingredients are commonly taken for blood sugar and diabetes support, athletic performance and muscle building, lowering cholesterol.Based on those ingredients, 208 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Vanadium. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against V-Zyme (Phytochemically Bound Vanadium) by Biotics Research Corporation

Ask about any prescription or over-the-counter medication and we check it for interactions with V-Zyme (Phytochemically Bound Vanadium) by Biotics Research Corporation — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of V-Zyme (Phytochemically Bound Vanadium) by Biotics Research Corporation

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 24, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

V-Zyme is a single-ingredient supplement containing vanadium in a phytochemically bound form — meaning the mineral is attached to plant compounds to aid absorption. The tablet also includes cellulose, stearic acid, magnesium stearate, and food glaze as inactive ingredients to hold it together and protect it.

Does it work?

Insufficient evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Insufficient

There isn't enough reliable clinical evidence to rate this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: blood sugar and athletic performance support.
  • We looked for evidence on: Diabetes, Impaired glucose tolerance (prediabetes), Athletic performance, Hyperlipidemia, metabolic health, glucose metabolism.
  • The closest evidence on file: Vanadium is rated "Insufficient Reliable Evidence To Rate" for Athletic performance (Natural Medicines).
  • Also on file: Vanadium is rated "Insufficient Reliable Evidence To Rate" for Diabetes, Hyperlipidemia, Impaired glucose tolerance (prediabetes).

The evidence supports vanadium for treating vanadium deficiency, which is the only condition for which it's rated likely effective. For athletic performance, diabetes, high cholesterol, and cancer, the available evidence is too limited or unreliable to draw firm conclusions — we simply don't have enough solid data to say whether it works for these uses.

The evidence, ingredient by ingredient Vanadium

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Vanadium is generally well tolerated at or below the tolerable upper intake level of 1.8 mg daily. At higher doses, the most common side effects are gastrointestinal — stomach discomfort, diarrhea, gas, and nausea.

Long-term use at high doses is rare but can damage the kidneys. Allergic reactions to vanadium are uncommon but have been reported, typically as skin rashes or itching.

There isn't enough safety data to recommend vanadium supplements during pregnancy or while breastfeeding — talk with your doctor or pharmacist about whether this product is right for you if you're pregnant, planning to become pregnant, or nursing.

Side effects, ingredient by ingredient Vanadium

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Vanadium.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; diabetes medications.
  • For scale: 208 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before you start V-Zyme, double-check with your doctor or pharmacist if you take blood thinners (anticoagulants) or antiplatelet drugs like warfarin or aspirin — vanadium may increase bleeding risk. Also flag any diabetes medications, since vanadium might lower your blood sugar further.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with insufficient evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

V-Zyme may be worth considering if you have a documented vanadium deficiency and want to correct it. If you take blood thinners or diabetes medications, you need to check with your doctor or pharmacist before starting — the interaction risk is real.

The same goes if you're pregnant or breastfeeding. For other uses like athletic performance or diabetes management, the evidence isn't there yet.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Jun 25, 2013.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about V-Zyme (Phytochemically Bound Vanadium), straight from the product label.

Brand Biotics Research Corporation
Net contents 100 Tablet(s)
Market status On market
Date entered into DSLD Jun 25, 2013
DSLD ID 22231
Product type Mineral
Supplement form Tablet Or Pill
Dietary claims / uses All Other
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for V-Zyme (Phytochemically Bound Vanadium) by Biotics Research Corporation, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Tablet(s)
Maximum serving Sizes:
1 Tablet(s)
IngredientAmount% DV
Vanadium20 mcg--

Other ingredients: Cellulose, Stearic Acid, Magnesium Stearate, Food Glaze

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

RECOMMENDATION: One (1) tablet each day as a dietary supplement or as otherwise directed by a healthcare professional.

Precautions

KEEP OUT OF REACH OF CHILDREN

Sealed with an imprinted safety seal for your protection.

Storage

Store in a cool, dry area.

General

Rev. 2/10

FDA Statement of Identity

Dietary Supplement

General Statements

Specially grown, biologically active vegetable culture containing phtochemically bound vanadium and other naturally associated phytochemicals including polyphenoic compounds with SOD and catalase, dehydrated at low temperature to preserve associated enzyme factors.

Brand IP Statement(s)

(C) Copyright 2010

Formula

(Phytochemically Bound Vanadium)

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

V-Zyme (Phytochemically Bound Vanadium) by Biotics Research Corporation label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

V-Zyme (Phytochemically Bound Vanadium) label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in V-Zyme (Phytochemically Bound Vanadium) by Biotics Research Corporation

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Tablet(s) Dosage formTablet Or Pill Amounts shown are per serving.

Vanadium

Interacts with
208 drugs
20 mcg per serving

Vanadium is a trace mineral found in tiny amounts in food, and people get plenty from a normal diet. Supplement claims for diabetes, weight, and athle...

Vanadium monograph & interactions

Other (inactive) ingredients: Cellulose, Stearic Acid, Magnesium Stearate, Food Glaze. These complete the product’s ingredient list but are not active constituents.

Interaction report

V-Zyme (Phytochemically Bound Vanadium) by Biotics Research Corporation Drug Interactions

Want to check YOUR meds against V-Zyme (Phytochemically Bound Vanadium)?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
208Drugs
208 Moderate

Ingredients driving the most interactions

Vanadium 208

Individual Drug Interactions

The ingredients in V-Zyme (Phytochemically Bound Vanadium) interact with 208 drugs. Click any drug to see the details.

1 of the 1 ingredient in V-Zyme (Phytochemically Bound Vanadium) interact with drugs. Each result below shows which ingredient is responsible. Vanadium

Each ingredient & the kinds of drugs it affects

For each ingredient in V-Zyme (Phytochemically Bound Vanadium) with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Vanadium2 drug types · 208 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, vanadium might increase the risk of bleeding when taken with anticoagulant/antiplatelet drugs.
In vitro research shows that the sodium orthovanadate form of vanadium prolongs clotting time, likely through inhibition of thrombin and factor Xa.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, vanadium might increase the risk of hypoglycemia when taken with antidiabetes drugs.
A few very small clinical studies in patients with type 2 diabetes show that the vanadyl sulfate form of vanadium increases insulin sensitivity and might lower blood glucose levels.

Likelihood Probable Evidence B
Vanadium full monograph & interactions
The maker

Brand information

Manufacturer and brand details for V-Zyme (Phytochemically Bound Vanadium), from the product label.

Biotics Research Corporation

See all Biotics Research Corporation products
Name
BIOTICS RESEARCH CORP.
City
Rosenberg
State
Texas
Phone Number
(281) 344-0909
Pharmacist Counseling Corner

V-Zyme (Phytochemically Bound Vanadium) by Biotics Research Corporation: Common Questions

Does V-Zyme (Phytochemically Bound Vanadium) by Biotics Research Corporation interact with any medications?
Yes. Based on its ingredients, V-Zyme (Phytochemically Bound Vanadium) has a known interaction with 208 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
V-Zyme (Phytochemically Bound Vanadium) contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Does vanadium actually work for diabetes?
A few very small studies show that vanadium may improve insulin sensitivity and lower blood glucose in people with type 2 diabetes, but the evidence is too limited to call it proven. If you have diabetes and are interested in trying it, talk it over with your doctor first — especially since combining it with your diabetes medication could lower your blood sugar too much.
What are the side effects if I take too much?
At doses above 1.8 mg daily, vanadium commonly causes stomach problems like nausea, diarrhea, gas, and abdominal discomfort. Taking it at high doses for a long time is rare but can damage your kidneys. Allergic skin reactions have also been reported, though they're uncommon.
Is it safe to take if I'm pregnant or breastfeeding?
There isn't enough safety information on vanadium supplements in pregnancy or while breastfeeding to say it's okay. Talk with your doctor or pharmacist about your individual situation before taking it during these times.
What is vanadium actually used for?
Vanadium is a trace mineral your body needs in small amounts. This supplement is proven effective for treating vanadium deficiency. It's being studied for athletic performance, diabetes, and cholesterol, but the evidence for those uses isn't solid yet.
Can I take this with my blood thinner?
Not without checking first — vanadium may increase your bleeding risk when combined with anticoagulants like warfarin or antiplatelet drugs like aspirin. Talk with your doctor or pharmacist before starting, since they may need to monitor you more closely or adjust your dose.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

V-Zyme (Phytochemically Bound Vanadium) label
Go deeper

The Full Monographs Behind V-Zyme (Phytochemically Bound Vanadium)’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Vanadium

Interacts with 208 drugs

Vanadium is a trace mineral found in tiny amounts in food, and people get plenty from a normal diet. Supplement claims for diabetes, weight, and athletic performance are not well proven, and...

Read the full Vanadium monograph →
Sources

Sources & How We Checked

V-Zyme (Phytochemically Bound Vanadium)'s label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 15 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Vanadium 15 references
  1. Harland BF, Harden-Williams BA. Is vanadium of human nutritional importance yet? J Am Diet Assoc 1994;94:891-4. PubMed
  2. Sitprija V, Tungsanga K, Tosukhowong P, et al. Metabolic problems in northeastern Thailand: possible role of vanadium. Mineral Electrolyte Metab 1998;19:51-6.
  3. Funakoshi T, Shimada H, Kojima S, et al. Anticoagulant action of vanadate. Chem Pharmaceut Bull 1992;40:174-6. PubMed
  4. Halberstam M, Cohen N, Shlimovich P, et al. Oral vanadyl sulfate improves insulin sensitivity in NIDDM but not in obese nondiabetic subjects. Diabetes 1996;45:659-66. PubMed
  5. Cohen N, Halberstam M, Shlimovich P, et al. Oral vanadyl sulfate improves hepatic and peripheral insulin sensitivity in patients with non-insulin-dependent diabetes mellitus. J Clin Invest 1995;95:2501-9. PubMed
  6. Boden G, Chen X, Ruiz J, et al. Effects of vanadyl sulfate on carbohydrate and lipid metabolism in patients with non-insulin-dependent diabetes mellitus. Metabolism 1996;45:1130-5.
  7. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc. Washington, DC: National Academy Press, 2002.
  8. Goldfine AB, Simonson DC, Folli F, et al. Metabolic effects of sodium metavanadate in humans with insulin-dependent and noninsulin-dependent diabetes mellitus in vivo and in vitro studies. J Clin Endocrinol Metab 1995;80:3311-20. PubMed
  9. Cusi K, Cukier S, DeFronzo RA, et al. Vanadyl sulfate improves hepatic and muscle insulin sensitivity in type 2 diabetes. J Clin Endocrinol Metab 2001;86:1410-7.
  10. Peat F, Coomber R, Rana A, Vince A. Vanadium allergy following total knee arthroplasty. BMJ Case Rep 2018;2018. pii: bcr-2017-222092. doi: 10.1136/bcr-2017-222092. PubMed
  11. Jin S, Xia W, Jiang Y, et al. Urinary vanadium concentration in relation to premature rupture of membranes: A birth cohort study. Chemosphere 2018;210:1035-41. doi: 10.1016/j.chemosphere.2018.07.110. PubMed
  12. Garcia-Nunez I, Algaba-Marmol MA, Suarez-Vergara M, et al. Vanadium contact dermatitis: case report and studies performed. Contact Dermatitis 2019;80(2):127-8. PubMed
  13. Zhou Y, Zhu Q, Ma W, et al. Prenatal vanadium exposure, cytokine expression, and fetal growth: a gender-specific analysis in Shanghai MCPC study. Sci Total Environ 2019;685:1152-9. PubMed
  14. Jiang S, Zhou S, Liu H, et al. Concentrations of vanadium in urine with hypertension prevalence and blood pressure levels. Ecotoxicol Environ Saf 2021;213:112028. PubMed
  15. Zhang W, Chen H, Zeng Q, Xu S, Xia W, Li Y. Prenatal and postnatal exposure to vanadium and the immune function of children. J Trace Elem Med Biol 2021;67:126787. PubMed

See these in context on the Vanadium monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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