W-W Ingredients & Drug Interactions
by Pure Herbs
What is this page for?
First and foremost: checking W-W against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
W-W is a dietary supplement by Pure Herbs with 5 active ingredients. Its ingredients are commonly taken for intestinal parasites and worms, digestive complaints, antimicrobial and antifungal support.Based on those ingredients, 787 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Cascara sagrada Bark Extract, Wormwood Aerial Part Extract, Pumpkin extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against W-W by Pure Herbs
Ask about any prescription or over-the-counter medication and we check it for interactions with W-W by Pure Herbs — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of W-W by Pure Herbs
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Low disclosure
W-W contains five active ingredients in liquid form. The product includes cascara sagrada bark extract (a stimulant laxative), wormwood aerial part extract, black walnut husk extract, pumpkin extract, and male fern root extract.
Each plays a different role — cascara sagrada is meant for bowel function, wormwood and black walnut are used traditionally for digestive support, pumpkin seed extract targets prostate and urinary health, and male fern has been used historically for parasites and other conditions.
Does it work?
Not established
The evidence supporting these ingredients is limited. Pumpkin extract is possibly effective for benign prostatic hyperplasia (enlarged prostate), but the others lack strong data.
Black walnut husk, cascara sagrada, wormwood, and male fern all have insufficient reliable evidence or are possibly ineffective for their intended uses based on the data we hold. Cascara sagrada is actually rated possibly ineffective for bowel preparation specifically.
How safe is it?
Well-documented data
This product carries real safety red flags, especially with long-term use. Cascara sagrada can cause abdominal cramps and, over time, may damage kidney function or lead to muscle wasting.
Wormwood contains thujone, a neurotoxin that in higher amounts can cause nausea, vomiting, kidney damage, muscle breakdown, and even seizures — chronic exposure has been linked to hallucinations, tremors, and brain damage. Male fern is potentially toxic with a dangerously narrow margin between an active dose and a poisonous one; it can cause diarrhea, tremors, vision loss, muscle weakness, seizures, and death with severe poisoning.
Black walnut hull extract, which is high in tannins, may cause gastrointestinal upset and skin irritation, and daily use of related species has been linked to tongue cancer risk. All ingredients except pumpkin are not recommended during pregnancy or breastfeeding due to insufficient safety data or potential harm.
Black walnut husk extract should be avoided in pregnancy and while breastfeeding. Cascara sagrada is not recommended during pregnancy or nursing.
Wormwood may stimulate the uterus and is unsafe in pregnancy; avoid while breastfeeding. Male fern is likely unsafe in pregnancy due to toxicity.
Pumpkin as a food is safe during pregnancy and nursing, but concentrated supplements lack safety data — talk to your doctor or pharmacist before using concentrated pumpkin products if you're pregnant or nursing.
Meds to double-check
Moderate interaction found
Before you start W-W, check your medications for interactions with cascara sagrada (warfarin and other blood thinners, corticosteroids, diuretics, stimulant laxatives, digoxin, and CYP3A4 substrates), wormwood (anticonvulsants or seizure medications), and pumpkin extract (lithium). No interactions are documented for black walnut husk extract or male fern root extract in our data, but male fern carries severe toxicity risks regardless.
The bottom line
Scorecard at a glanceFormula with limited ingredient disclosure with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.
This product combines ingredients with limited evidence and serious safety concerns, especially with long-term use. If you take warfarin, anticonvulsants, lithium, diuretics, corticosteroids, digoxin, or any other prescription medication, check your exact drugs with the tool below before starting.
Pregnant or nursing individuals should avoid it and talk to their pharmacist or doctor beforehand.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 5 of 5 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Nov 22, 2022.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about W-W, straight from the product label.
| Brand | Pure Herbs |
|---|---|
| Net contents | 1 Fluid Ounce(s); 30 mL |
| Market status | On market |
| Date entered into DSLD | Nov 22, 2022 |
| DSLD ID | 279982 |
| Product type | Botanical |
| Supplement form | Liquid |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Adult (18 - 50 Years) |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for W-W by Pure Herbs, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Proprietary Blend | 1900 mg | -- |
| Black Walnut Husk Extract | 0 NP | -- |
| Cascara sagrada Bark Extract | 0 NP | -- |
| Wormwood Aerial Part Extract | 0 NP | -- |
| Pumpkin extract | 0 NP | -- |
| Male Fern Root Extract | 0 NP | -- |
Other ingredients: None
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions
Directions: For adults, mix 2 mL (abt. 1/2 tsp) of extract in 2 fl. oz (60 mL) water one time daily preferably with a meal.
Shake well before use
Formulation
Beneficial for digestive health, occasional constipation and maintaining general overall health.
FDA Disclaimer Statement
This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
Precautions
Notice: This product contains Cascara Sagrada. Read and follow directions carefully. Do not use if you have or develop diarrhea, loose stool, or abdominal pain because Cascara Sagrada may worsen these conditions and be harmful to your health. Consult your physician if you have frequent diarrhea or if you are pregnant, nursing, taking medication or have a medical condition.
Consult your physician if you have frequent diarrhea or if you are pregnant, nursing, taking medication or have a medical condition.
Keep out of reach of children
Contains: Walnuts
Brand IP Statement(s)
Pure Herbs, Ltd. Natural Herbal Extracts
FDA Statement of Identity
Dietary Supplement
General Statements
"No expense has been spared to provide the finest nature has to offer."
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
W-W by Pure Herbs label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in W-W by Pure Herbs
These are the 5 active ingredients this product is made of. Select any to open its full monograph.
Serving size2 mL Dosage formLiquid Servings per container15 Amounts shown are per serving.
Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.
Proprietary Blend
Other (inactive) ingredients: None. These complete the product’s ingredient list but are not active constituents.
W-W by Pure Herbs Drug Interactions
HelloPharmacist Interaction Report
W-W by Pure Herbs is a five-ingredient liquid that carries documented interactions with multiple medications.
The most serious concern is cascara sagrada bark extract, which can theoretically increase bleeding risk when taken with warfarin (a blood thinner). This happens because cascara sagrada's laxative effect can cause diarrhea, which boosts warfarin's strength and raises bleeding risk.
Read the full breakdown — every affected drug type, severity by severity
Cascara sagrada also poses Moderate-severity risks with corticosteroids, diuretics (water pills), stimulant laxatives, and digoxin (a heart medication) — all tied to a potential drop in potassium levels (a mineral your heart and muscles need to work properly). Wormwood aerial part extract carries a Moderate interaction with anticonvulsants (seizure medications), since one of its compounds may interfere with seizure control.
Pumpkin extract can theoretically reduce how your body clears lithium (used for mood disorders), potentially raising lithium levels.
Black walnut husk extract and male fern root extract show no interactions documented in our data, though male fern carries serious safety concerns on its own. Altogether, these interactions span 777 individual medications.
Use the search tool below to check your exact prescriptions before starting this product.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against W-W?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in W-W interact with 787 drugs. Click any drug to see the details.
3 of the 5 ingredients in W-W interact with drugs. Each result below shows which ingredient is responsible. Cascara sagrada Bark Extract Wormwood Aerial Part Extract Pumpkin extract
Danthron , DocusateCo-Danthrusate (UK)
How Danthron , Docusate interacts with W-W — through 1 ingredient. Tap an ingredient for the detail:
Cascara Sagrada Bark ExtractStimulant Laxatives Moderate
Interaction Summary
Theoretically, cascara sagrada might have additive adverse effects when taken with stimulant laxatives.
Read the full Cascara Sagrada Bark Extract + Danthron , Docusate interactionDehydrocholic AcidDecholin
How Dehydrocholic Acid interacts with W-W — through 1 ingredient. Tap an ingredient for the detail:
Cascara Sagrada Bark ExtractStimulant Laxatives Moderate
Interaction Summary
Theoretically, cascara sagrada might have additive adverse effects when taken with stimulant laxatives.
Read the full Cascara Sagrada Bark Extract + Dehydrocholic Acid interactionDehydrocholic Acid , DocusateBilax
How Dehydrocholic Acid , Docusate interacts with W-W — through 1 ingredient. Tap an ingredient for the detail:
Cascara Sagrada Bark ExtractStimulant Laxatives Moderate
Interaction Summary
Theoretically, cascara sagrada might have additive adverse effects when taken with stimulant laxatives.
Read the full Cascara Sagrada Bark Extract + Dehydrocholic Acid , Docusate interactionDeserpidine, HydrochlorothiazideOreticyl, Oreticyl Forte
How Deserpidine, Hydrochlorothiazide interacts with W-W — through 1 ingredient. Tap an ingredient for the detail:
Cascara Sagrada Bark ExtractDiuretic Drugs Moderate
Interaction Summary
Theoretically, cascara sagrada might increase the risk of hypokalemia when taken with diuretic drugs.
Read the full Cascara Sagrada Bark Extract + Deserpidine, Hydrochlorothiazide interactionDeserpidine, MethyclothiazideEnduronyl, Enduronyl Forte
How Deserpidine, Methyclothiazide interacts with W-W — through 1 ingredient. Tap an ingredient for the detail:
Cascara Sagrada Bark ExtractDiuretic Drugs Moderate
Interaction Summary
Theoretically, cascara sagrada might increase the risk of hypokalemia when taken with diuretic drugs.
Read the full Cascara Sagrada Bark Extract + Deserpidine, Methyclothiazide interactionDexamethasoneDecadron, Dexone, Dextenza, Dexycu, Hemady, Hexadrol +1 more
How Dexamethasone interacts with W-W — through 1 ingredient. Tap an ingredient for the detail:
Cascara Sagrada Bark ExtractCytochrome P450 3a4 (cyp3a4) Substrates, Corticosteroids Moderate
Interaction Summary
Theoretically, cascara sagrada might decrease the effects of CYP3A4 substrates.
Read the full Cascara Sagrada Bark Extract + Dexamethasone interactionDiazepamDiastat AcuDial, Valium, Valium injection, Valtoco
How Diazepam interacts with W-W — through 2 ingredients. Tap an ingredient for the detail:
Wormwood Aerial Part ExtractAnticonvulsants Moderate
Interaction Summary
Theoretically, taking wormwood might interfere with the effects of anticonvulsant drugs.
Read the full Wormwood Aerial Part Extract + Diazepam interactionCascara Sagrada Bark ExtractCytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
Theoretically, cascara sagrada might decrease the effects of CYP3A4 substrates.
Read the full Cascara Sagrada Bark Extract + Diazepam interactionDigoxinDigitek, Lanoxicaps, Lanoxin
How Digoxin interacts with W-W — through 1 ingredient. Tap an ingredient for the detail:
Cascara Sagrada Bark ExtractDigoxin (lanoxin) Moderate
Interaction Summary
Theoretically, cascara sagrada might cause hypokalemia, potentially increasing the risk of digoxin toxicity.
Read the full Cascara Sagrada Bark Extract + Digoxin interactionDivalproex SodiumDepakote
How Divalproex Sodium interacts with W-W — through 1 ingredient. Tap an ingredient for the detail:
Wormwood Aerial Part ExtractAnticonvulsants Moderate
Interaction Summary
Theoretically, taking wormwood might interfere with the effects of anticonvulsant drugs.
Read the full Wormwood Aerial Part Extract + Divalproex Sodium interactionDocusate Calcium, PhenolphthaleinDoxidan (Canadian)
How Docusate Calcium, Phenolphthalein interacts with W-W — through 1 ingredient. Tap an ingredient for the detail:
Cascara Sagrada Bark ExtractStimulant Laxatives Moderate
Interaction Summary
Theoretically, cascara sagrada might have additive adverse effects when taken with stimulant laxatives.
Read the full Cascara Sagrada Bark Extract + Docusate Calcium, Phenolphthalein interactionDocusate Sodium, PhenolphthaleinCorrectol, Modane Plus
How Docusate Sodium, Phenolphthalein interacts with W-W — through 1 ingredient. Tap an ingredient for the detail:
Cascara Sagrada Bark ExtractStimulant Laxatives Moderate
Interaction Summary
Theoretically, cascara sagrada might have additive adverse effects when taken with stimulant laxatives.
Read the full Cascara Sagrada Bark Extract + Docusate Sodium, Phenolphthalein interactionDocusate Sodium, Sennosides (otc Drug)Senokot-S
How Docusate Sodium, Sennosides (otc Drug) interacts with W-W — through 1 ingredient. Tap an ingredient for the detail:
Cascara Sagrada Bark ExtractStimulant Laxatives Moderate
Interaction Summary
Theoretically, cascara sagrada might have additive adverse effects when taken with stimulant laxatives.
Read the full Cascara Sagrada Bark Extract + Docusate Sodium, Sennosides (otc Drug) interactionEnalapril Maleate, HydrochlorothiazideVaseretic
How Enalapril Maleate, Hydrochlorothiazide interacts with W-W — through 1 ingredient. Tap an ingredient for the detail:
Cascara Sagrada Bark ExtractDiuretic Drugs Moderate
Interaction Summary
Theoretically, cascara sagrada might increase the risk of hypokalemia when taken with diuretic drugs.
Read the full Cascara Sagrada Bark Extract + Enalapril Maleate, Hydrochlorothiazide interactionEphedrine, Phenobarbital, TheophyllineTedral
How Ephedrine, Phenobarbital, Theophylline interacts with W-W — through 1 ingredient. Tap an ingredient for the detail:
Wormwood Aerial Part ExtractAnticonvulsants Moderate
Interaction Summary
Theoretically, taking wormwood might interfere with the effects of anticonvulsant drugs.
Read the full Wormwood Aerial Part Extract + Ephedrine, Phenobarbital, Theophylline interactionEthacrynic AcidEdecrin
How Ethacrynic Acid interacts with W-W — through 1 ingredient. Tap an ingredient for the detail:
Cascara Sagrada Bark ExtractDiuretic Drugs Moderate
Interaction Summary
Theoretically, cascara sagrada might increase the risk of hypokalemia when taken with diuretic drugs.
Read the full Cascara Sagrada Bark Extract + Ethacrynic Acid interactionEthosuximideZarontin
How Ethosuximide interacts with W-W — through 2 ingredients. Tap an ingredient for the detail:
Wormwood Aerial Part ExtractAnticonvulsants Moderate
Interaction Summary
Theoretically, taking wormwood might interfere with the effects of anticonvulsant drugs.
Read the full Wormwood Aerial Part Extract + Ethosuximide interactionCascara Sagrada Bark ExtractCytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
Theoretically, cascara sagrada might decrease the effects of CYP3A4 substrates.
Read the full Cascara Sagrada Bark Extract + Ethosuximide interactionEthotoinPaganone
How Ethotoin interacts with W-W — through 1 ingredient. Tap an ingredient for the detail:
Wormwood Aerial Part ExtractAnticonvulsants Moderate
Interaction Summary
Theoretically, taking wormwood might interfere with the effects of anticonvulsant drugs.
Read the full Wormwood Aerial Part Extract + Ethotoin interactionFelbamateFelbatol
How Felbamate interacts with W-W — through 1 ingredient. Tap an ingredient for the detail:
Wormwood Aerial Part ExtractAnticonvulsants Moderate
Interaction Summary
Theoretically, taking wormwood might interfere with the effects of anticonvulsant drugs.
Read the full Wormwood Aerial Part Extract + Felbamate interactionFludrocortisoneFlorinef Acetate
How Fludrocortisone interacts with W-W — through 1 ingredient. Tap an ingredient for the detail:
Cascara Sagrada Bark ExtractCorticosteroids Moderate
Interaction Summary
Theoretically, cascara sagrada might increase the risk of hypokalemia when taken with corticosteroids.
Read the full Cascara Sagrada Bark Extract + Fludrocortisone interactionFluticasoneFlixotide, Flonase, Flovent, Seretide, Veramyst
How Fluticasone interacts with W-W — through 1 ingredient. Tap an ingredient for the detail:
Cascara Sagrada Bark ExtractCorticosteroids, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cascara sagrada might increase the risk of hypokalemia when taken with corticosteroids.
Read the full Cascara Sagrada Bark Extract + Fluticasone interactionFluticasone Furoate, Umeclidinium, VilanterolTrelegy Ellipta
How Fluticasone Furoate, Umeclidinium, Vilanterol interacts with W-W — through 1 ingredient. Tap an ingredient for the detail:
Cascara Sagrada Bark ExtractCytochrome P450 3a4 (cyp3a4) Substrates, Corticosteroids Moderate
Interaction Summary
Theoretically, cascara sagrada might decrease the effects of CYP3A4 substrates.
Read the full Cascara Sagrada Bark Extract + Fluticasone Furoate, Umeclidinium, Vilanterol interactionFluticasone Furoate, Vilanterol TrifenatateBreo Ellipta
How Fluticasone Furoate, Vilanterol Trifenatate interacts with W-W — through 1 ingredient. Tap an ingredient for the detail:
Cascara Sagrada Bark ExtractCorticosteroids, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cascara sagrada might increase the risk of hypokalemia when taken with corticosteroids.
Read the full Cascara Sagrada Bark Extract + Fluticasone Furoate, Vilanterol Trifenatate interactionFosinopril, HydrochlorothiazideMonopril HCT
How Fosinopril, Hydrochlorothiazide interacts with W-W — through 1 ingredient. Tap an ingredient for the detail:
Cascara Sagrada Bark ExtractDiuretic Drugs Moderate
Interaction Summary
Theoretically, cascara sagrada might increase the risk of hypokalemia when taken with diuretic drugs.
Read the full Cascara Sagrada Bark Extract + Fosinopril, Hydrochlorothiazide interactionFosphenytoinCerebyx
How Fosphenytoin interacts with W-W — through 1 ingredient. Tap an ingredient for the detail:
Wormwood Aerial Part ExtractAnticonvulsants Moderate
Interaction Summary
Theoretically, taking wormwood might interfere with the effects of anticonvulsant drugs.
Read the full Wormwood Aerial Part Extract + Fosphenytoin interactionFosphenytoin SodiumSesquient
How Fosphenytoin Sodium interacts with W-W — through 1 ingredient. Tap an ingredient for the detail:
Wormwood Aerial Part ExtractAnticonvulsants Moderate
Interaction Summary
Theoretically, taking wormwood might interfere with the effects of anticonvulsant drugs.
Read the full Wormwood Aerial Part Extract + Fosphenytoin Sodium interactionFurosemideLasix
How Furosemide interacts with W-W — through 1 ingredient. Tap an ingredient for the detail:
Cascara Sagrada Bark ExtractDiuretic Drugs Moderate
Interaction Summary
Theoretically, cascara sagrada might increase the risk of hypokalemia when taken with diuretic drugs.
Read the full Cascara Sagrada Bark Extract + Furosemide interactionFurosemide, PotassiumDiumide-K Continus, Lasikal
How Furosemide, Potassium interacts with W-W — through 1 ingredient. Tap an ingredient for the detail:
Cascara Sagrada Bark ExtractDiuretic Drugs Moderate
Interaction Summary
Theoretically, cascara sagrada might increase the risk of hypokalemia when taken with diuretic drugs.
Read the full Cascara Sagrada Bark Extract + Furosemide, Potassium interactionGabapentinGralise, Neurontin
How Gabapentin interacts with W-W — through 1 ingredient. Tap an ingredient for the detail:
Wormwood Aerial Part ExtractAnticonvulsants Moderate
Interaction Summary
Theoretically, taking wormwood might interfere with the effects of anticonvulsant drugs.
Read the full Wormwood Aerial Part Extract + Gabapentin interactionGabapentin EnacarbilHorizant
How Gabapentin Enacarbil interacts with W-W — through 1 ingredient. Tap an ingredient for the detail:
Wormwood Aerial Part ExtractAnticonvulsants Moderate
Interaction Summary
Theoretically, taking wormwood might interfere with the effects of anticonvulsant drugs.
Read the full Wormwood Aerial Part Extract + Gabapentin Enacarbil interactionGuanethidine, HydrochlorothiazideEsimil
How Guanethidine, Hydrochlorothiazide interacts with W-W — through 1 ingredient. Tap an ingredient for the detail:
Cascara Sagrada Bark ExtractDiuretic Drugs Moderate
Interaction Summary
Theoretically, cascara sagrada might increase the risk of hypokalemia when taken with diuretic drugs.
Read the full Cascara Sagrada Bark Extract + Guanethidine, Hydrochlorothiazide interactionEach ingredient & the kinds of drugs it affects
For each ingredient in W-W with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.
Cascara sagrada Bark Extract
Corticosteroids
Theoretically, cascara sagrada might increase the risk of hypokalemia when taken with corticosteroids.
Cascara sagrada has stimulant laxative effects, and long-term use has been associated with hypokalemia.
Digoxin (Lanoxin)
Theoretically, cascara sagrada might cause hypokalemia, potentially increasing the risk of digoxin toxicity.
Cascara sagrada has stimulant laxative effects, and long-term use has been associated with hypokalemia.
Diuretic Drugs
Theoretically, cascara sagrada might increase the risk of hypokalemia when taken with diuretic drugs.
Cascara sagrada has stimulant laxative effects, and long-term use has been associated with hypokalemia.
Stimulant Laxatives
Theoretically, cascara sagrada might have additive adverse effects when taken with stimulant laxatives.
Cascara sagrada has stimulant laxative effects and might compound fluid and electrolyte losses when taken with stimulant laxatives.
Warfarin (Coumadin)
Theoretically, cascara sagrada might increase the risk of bleeding when taken with warfarin.
Cascara sagrada has stimulant laxative effects. In some people, cascara sagrada can cause diarrhea. Diarrhea can increase the effects of warfarin, increase international normalized ratio (INR), and increase the risk of bleeding.
Cytochrome P450 3A4 (Cyp3A4) Substrates
Theoretically, cascara sagrada might decrease the effects of CYP3A4 substrates.
In vitro research suggests that cascara sagrada can induce CYP3A4 enzymes, albeit to a much lower degree than rifampin, a known CYP3A4 inducer.
Wormwood Aerial Part Extract
Anticonvulsants
Theoretically, taking wormwood might interfere with the effects of anticonvulsant drugs.
Thujone, a constituent of wormwood, has convulsant effects.
Pumpkin extract
Lithium
Pumpkin might reduce excretion and increase levels of lithium.
Pumpkin is thought to have diuretic properties. Theoretically, this might reduce excretion and increase levels of lithium. The dose of lithium might need to be decreased.
Brand information
Manufacturer and brand details for W-W, from the product label.
Pure Herbs
See all Pure Herbs products- Name
- Pure Herbs, Ltd.
- City
- Sterling Heights
- State
- MI
- Phone Number
- (800) 860-4372
- Web Address
- www.pureherbs.com
W-W by Pure Herbs: Common Questions
Does W-W by Pure Herbs interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Can I take W-W if I'm pregnant or breastfeeding?
What are the most common side effects?
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What is this product supposed to do?
Can I take W-W with my blood thinner?
What makes male fern root extract risky?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if W-W is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind W-W’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Black Walnut
Black walnut is a tree whose green hulls are traditionally used as a natural antiparasitic and digestive remedy, but solid human evidence for these uses is lacking. It contains a compound ca...
Read the full Black Walnut monograph → Herb & supplement monographCascara Sagrada
Interacts with 745 drugsCascara sagrada is a stimulant laxative made from the aged bark of a Pacific Northwest tree, used mainly for short-term relief of constipation. Because it can cause cramping, dehydration, an...
Read the full Cascara Sagrada monograph → Herb & supplement monographWormwood
Interacts with 50 drugsWormwood is a very bitter herb traditionally used to stimulate appetite and ease digestion, and it has early research interest in Crohn's disease. It contains thujone, which can be toxic in...
Read the full Wormwood monograph → Herb & supplement monographPumpkin
Interacts with 1 drugPumpkin is a nutritious squash, and its seeds and seed oil are the parts most often used as supplements, mainly for urinary and prostate symptoms. The evidence for these uses is limited and...
Read the full Pumpkin monograph → Herb & supplement monographMale Fern
Male fern is an old herbal remedy that was once used as a powerful treatment to expel tapeworms. It is now considered outdated and potentially dangerous because of its narrow safety margin a...
Read the full Male Fern monograph →Sources & How We Checked
W-W's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 30 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Black Walnut 3 references
- Blumenthal M, ed. The Complete German Commission E Monographs: Therapeutic Guide to Herbal Medicines. Trans. S. Klein. Boston, MA: American Botanical Council, 1998.
- McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
- Food and Drug Administration. Food Allergen Labeling and Consumer Protection Act of 2004 (FALCPA); Public Law 108-282, Title II. Accessed on May 19, 2021. Available at: https://www.fda.gov/food/food-allergensgluten-free-guidance-documents-regulatory-infor
Cascara Sagrada 9 references
- Blumenthal M, ed. The Complete German Commission E Monographs: Therapeutic Guide to Herbal Medicines. Trans. S. Klein. Boston, MA: American Botanical Council, 1998.
- Newall CA, Anderson LA, Philpson JD. Herbal Medicine: A Guide for Healthcare Professionals. London, UK: The Pharmaceutical Press, 1996.
- Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.
- Covington TR, et al. Handbook of Nonprescription Drugs. 11th ed. Washington, DC: American Pharmaceutical Association, 1996.
- Nusko G, Schneider B, Schneider I, et al. Anthranoid laxative use is not a risk factor for colorectal neoplasia: results of a prospective case control study. Gut 2000;46:651-5. PubMed
- Nadir A, Reddy D, Van Thiel DH. Cascara-sagrada induced intrahepatic cholestasis causing portal hypertension: case report and review of herbal hepatotoxicity. Am J Gastroenterol 2000;95:3634-7. PubMed
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