Interactions on record — worth a quick check against your medications. Check your meds →
Dietary supplement

Water-Away Ingredients & Drug Interactions

by Highland Laboratories

Water-Away label
See full label image
Tablet Or Pill Category: Botanical With Nutrients
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 23, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Water-Away against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Water-Away is a dietary supplement by Highland Laboratories with 7 active ingredients. Its ingredients are commonly taken for preventing or treating low potassium (hypokalemia), supporting healthy blood pressure, muscle cramps.Based on those ingredients, 1,222 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Uva ursi leaf 4:1 extract, Buchu leaf 4:1 extract, Parsley. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Water-Away by Highland Laboratories

Ask about any prescription or over-the-counter medication and we check it for interactions with Water-Away by Highland Laboratories — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Water-Away by Highland Laboratories

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 24, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 7 of its 7 active ingredients.
  • “Potassium” is listed as a grouped ingredient — the label gives one combined amount (33 mg) without saying how much of each component you get.

Water-Away contains seven active ingredients. Potassium is listed as a blend whose component ingredients are listed individually below.

The product also includes Buchu leaf 4:1 extract, Black Radish, Parsley, Potassium Chloride, Uva ursi leaf 4:1 extract, Juniper berry 20:1 extract, and Asparagus root 5:1 extract — these are herbal extracts and minerals traditionally used as diuretics (water-removing agents) and for urinary tract support. The inactive ingredients are cellulose, maltodextrin, acacia, organic rice extract, and organic rice concentrate.

Does it work?

Leans against
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Leans against

The strongest graded evidence we hold for the stated purpose leans against a benefit.

Why this rating?
  • The label markets this product for: urinary tract and fluid retention support.
  • We looked for evidence on: Urinary tract infections (UTIs), Kidney stones (nephrolithiasis), urinary discomfort, bladder support, water retention.
  • The closest evidence on file: Uva Ursi is rated "Possibly Ineffective" for Urinary tract infections (UTIs) (Natural Medicines).
  • Also on file: Asparagus is rated "Insufficient Reliable Evidence To Rate" for Kidney stones (nephrolithiasis), Urinary tract infections (UTIs).
  • Also on file: Juniper is rated "Insufficient Reliable Evidence To Rate" for Kidney stones (nephrolithiasis), Urinary tract infections (UTIs).

The evidence for most of Water-Away's ingredients is not well established in the data we hold. Uva ursi has been rated Possibly Ineffective for urinary tract infections, and the other ingredients carry ratings of Insufficient Reliable Evidence for their claimed uses — including Black Radish for diabetes and biliary disorders, Parsley for urinary tract infections and other conditions, Juniper berry for urinary tract infections and kidney stones, and Asparagus root for acne, cancer, constipation, and other conditions.

If you're considering this product for a specific health concern, discuss its likelihood of helping with your doctor or pharmacist.

The evidence, ingredient by ingredient Potassium Buchu Radish Parsley Uva Ursi Juniper Asparagus

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 6 of the 7 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 7 of 7.
  • General safety write-ups exist for 7 of 7.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Parsley and Uva ursi are likely unsafe during pregnancy and should be avoided; Juniper berry is rated unsafe in pregnancy. Potassium Chloride is rated likely safe in pregnancy when used at dietary amounts, but supplements should be used only under medical guidance.

Buchu leaf is traditionally thought to affect the uterus and should be avoided in pregnancy; it is possibly safe while breastfeeding but lacks strong safety data. Black Radish, Parsley, Uva ursi, and Juniper berry are not recommended during breastfeeding due to insufficient safety information.

Asparagus root has mixed pregnancy data (some sources rate it likely safe, others possibly unsafe); dietary amounts are generally fine, but medicinal extracts are less studied. The most common side effects across ingredients are mild digestive upset — nausea, diarrhea, vomiting, abdominal pain, and gas.

Parsley and Uva ursi can cause serious effects at very high doses, and allergic reactions to Parsley and Asparagus have been reported in sensitive individuals.

Side effects, ingredient by ingredient Potassium Buchu Radish Parsley Uva Ursi Juniper Asparagus

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 7 of the 7 matched ingredients can interact with medications — Buchu, Asparagus, Uva Ursi, Radish, Juniper, among others.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; diabetes medications; lithium.
  • For scale: 1,223 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking Water-Away, check with your doctor or pharmacist if you take blood thinners or antiplatelet drugs (aspirin, warfarin, clopidogrel), diabetes medications, water pills or diuretics, lithium, ACE inhibitors or ARBs for blood pressure, potassium-sparing diuretics, liver-metabolized drugs, or pentobarbital and other sedatives. Do not combine with this product without medical clearance.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with graded evidence leaning against its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Water-Away is a multi-ingredient herbal diuretic with interactions affecting over 1,200 medications, most notably blood thinners, diabetes drugs, water pills, and lithium. If you take any prescription medications — especially for heart, blood pressure, diabetes, or mental health — check your specific drugs before starting this product.

Do not use during pregnancy or breastfeeding without talking to your doctor or pharmacist, as several ingredients carry safety concerns in these periods.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 7 of 7 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Oct 21, 2017.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Water-Away, straight from the product label.

Brand Highland Laboratories
Barcode (UPC) 768305117693
Net contents 90 Vegetarian Tablet(s)
Market status On market
Date entered into DSLD Oct 21, 2017
DSLD ID 79929
Product type Botanical With Nutrients
Supplement form Tablet Or Pill
Dietary claims / uses Nutrient, All Other
Intended target group(s) Adult (18 - 50 Years), Gluten Free, Dairy Free, Sugar Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Water-Away by Highland Laboratories, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Vegetarian Tablet(s)
Maximum serving Sizes:
3 Vegetarian Tablet(s)
UPC/BARCODE
768305117693
IngredientAmount% DV
Potassium33 mg1%
Buchu leaf 4:1 extract30 mg--
Black Radish30 mg--
Parsley30 mg--
Potassium Chloride63 mg--
Uva ursi leaf 4:1 extract120 mg--
Juniper berry 20:1 extract60 mg--
Asparagus root 5:1 extract20 mg--

Other ingredients: Cellulose, Maltodextrin, Acacia, organic Rice extract, organic Rice concentrate

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula

Herbs plus Potassium

FDA Statement of Identity

Dietary Supplement

Seals/Symbols

GMP Quality Assured Earth Friendly

General Statements

% Daily Value

Formulation

No soy, salt, yeast, gluten, milk & egg products, sugar, starch, or preservatives.

Suggested/Recommended/Usage/Directions

One to three tablets with a glass of water before a meal, as a dietary supplement.

Precautions

Warning: Not recommended while pregnant or lactating unless directed by health care practitioner.

General

PR 1176

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Water-Away by Highland Laboratories label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Water-Away label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Water-Away by Highland Laboratories

These are the 7 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Vegetarian Tablet(s) Dosage formTablet Or Pill Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Potassium

Interacts with
62 drugs
33 mg per serving

Potassium is an essential mineral your body needs for nerve signals, muscle function, and a steady heartbeat, and most people get enough from a balanc...

Potassium monograph & interactions

Buchu leaf 4:1 extract

Interacts with
481 drugs
30 mg per serving

Buchu is a fragrant South African shrub whose leaves are traditionally used for urinary and bladder complaints and as a diuretic. Solid human studies...

Buchu leaf 4:1 extract monograph & interactions

Black Radish

Interacts with
86 drugs
30 mg per serving

Radish is a common edible root vegetable that is nutritious and generally safe to eat as food. Some people use radish (especially black radish) and it...

Black Radish monograph & interactions

Parsley

Interacts with
443 drugs
30 mg per serving

Parsley is a popular culinary herb that is safe to eat in normal food amounts and is a good source of vitamins K and C. It is traditionally used as a...

Parsley monograph & interactions

Uva ursi leaf 4:1 extract

Interacts with
803 drugs
120 mg per serving

Uva ursi is a traditional herb used mainly for urinary tract infections, and its leaves contain a compound called arbutin that may have antimicrobial...

Uva ursi leaf 4:1 extract monograph & interactions

Juniper berry 20:1 extract

Interacts with
162 drugs
60 mg per serving

Juniper berry is a traditional herb best known for flavoring gin and for its folk use as a diuretic and digestive aid. Solid human evidence for its he...

Juniper berry 20:1 extract monograph & interactions

Asparagus root 5:1 extract

Interacts with
76 drugs
20 mg per serving

Asparagus is a nutritious vegetable that is safe and healthy to eat as part of a normal diet. Most of its claimed medicinal benefits, such as use as a...

Asparagus root 5:1 extract monograph & interactions

Other (inactive) ingredients: Cellulose, Maltodextrin, Acacia, Organic Rice extract, Organic Rice concentrate. These complete the product’s ingredient list but are not active constituents.

Interaction report

Water-Away by Highland Laboratories Drug Interactions

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Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
1,222Drugs
1,183 Moderate 39 Minor

Ingredients driving the most interactions

Uva ursi leaf 4:1 extract 803
Buchu leaf 4:1 extract 481
Parsley 443
Juniper berry 20:1 extract 162
Black Radish 86

Individual Drug Interactions

The ingredients in Water-Away interact with 1,222 drugs. Click any drug to see the details.

7 of the 7 ingredients in Water-Away interact with drugs. Each result below shows which ingredient is responsible. Uva ursi leaf 4:1 extract Buchu leaf 4:1 extract Parsley Juniper berry 20:1 extract Black Radish Asparagus root 5:1 extract Potassium

Each ingredient & the kinds of drugs it affects

For each ingredient in Water-Away with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Uva ursi leaf 4:1 extract6 drug types · 803 drugs

Cytochrome P450 2C19 (Cyp2C19) Substrates

Theoretically, uva ursi may decrease the metabolism of CYP2C19 substrates.
In vitro, uva ursi appears to inhibit cytochrome CYP2C19. This effect has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, uva ursi may decrease the metabolism of CYP3A4 substrates.
In vitro, uva ursi appears to inhibit CYP3A4. This effect has not been reported in humans.

Likelihood Possible Evidence D
Glucuronidated Drugs

Theoretically, uva ursi may increase levels of drugs metabolized by glucuronidation.
In vitro, uva ursi extract appears to strongly inhibit UDP-glucuronosyltransferase (UGT) 1A1 (UGT1A1). However, uva ursi extract does not appear to inhibit UGT1A1 in animal models. This effect has not been reported in humans.

Likelihood Possible Evidence D
Lithium

Theoretically, uva ursi may increase lithium levels, necessitating a decrease in dose.
Uva ursi may have diuretic properties. Diuretics may increase lithium reabsorption with sodium in the proximal tubule of the kidney. Theoretically, uva ursi might reduce excretion and increase levels of lithium.

Likelihood Probable Evidence D
Urinary Acidifying Agents

Effects of uva ursi in the urinary tract may be reduced by urinary acidifying agents.
Uva ursi seems to work best in alkaline urine. Theoretically, taking uva ursi with medications known to acidify the urine may decrease any effects of uva ursi on the urinary tract.

Likelihood Possible Evidence D
P-Glycoprotein Substrates

Theoretically, uva ursi may alter the levels of drugs transported by P-glycoprotein.
In vitro, uva ursi appears to inhibit the multi-drug transporter protein, P-glycoprotein. This effect has not been reported in humans.

Likelihood Possible Evidence D
Uva ursi leaf 4:1 extract full monograph & interactions

Buchu leaf 4:1 extract3 drug types · 481 drugs

Anticoagulant/Antiplatelet Drugs

Buchu may have antiplatelet effects. Theoretically, buchu may enhance the effects of anticoagulant or antiplatelet drugs and increase the risk of bleeding in some patients. Some anticoagulant or antiplatelet drugs include aspirin, clopidogrel (Plavix), dalteparin (Fragmin), enoxaparin (Lovenox), heparin, ticlopidine (Ticlid), warfarin (Coumadin), and others.

Likelihood Possible Evidence D
Hepatotoxic Drugs

Buchu contains pulegone, a known hepatotoxin. There is some concern that buchu may adversely affect the liver, especially when the leaf is used in large doses or the oil is ingested. Theoretically, concomitant use with hepatotoxic drugs might increase the risk of liver damage. Some of these drugs include acarbose (Precose, Prandase), amiodarone (Cordarone), atorvastatin (Lipitor), azathioprine (Imuran), carbamazepine (Tegretol), cerivastatin (Baycol), diclofenac (Voltaren), felbamate (Felbatol), fenofibrate (Tricor), fluvastatin (Lescol), gemfibrozil (Lopid), isoniazid, itraconazole, (Sporanox), ketoconazole (Nizoral), leflunomide (Arava), lovastatin (Mevacor), methotrexate (Rheumatrex), nevirapine (Viramune), niacin, nitrofurantoin (Macrodantin), pioglitazone (Actos), pravastatin (Pravachol), pyrazinamide, rifampin (Rifadin), ritonavir (Norvir), rosiglitazone (Avandia), simvastatin (Zocor), tacrine (Cognex), tamoxifen, terbinafine (Lamisil), valproic acid, and zileuton (Zyflo)

Likelihood Possible Evidence D
Lithium

Buchu is thought to have diuretic properties. Theoretically, buchu might reduce excretion and increase levels of lithium. The dose of lithium might need to be decreased.

Likelihood Probable Evidence D
Buchu leaf 4:1 extract full monograph & interactions

Parsley8 drug types · 443 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, parsley might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.
Animal research suggests that parsley has antiplatelet effects.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, parsley might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Animal research suggests that parsley might decrease blood glucose. Monitor blood glucose levels closely. Dose adjustments might be necessary.

Likelihood Possible Evidence D
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, parsley might increase serum levels of CYP1A2 substrates.
Laboratory research suggests that parsley can inhibit CYP1A2.

Likelihood Possible Evidence D
Diuretic Drugs

Theoretically, parsley might enhance or interfere with the effects of diuretic drugs.
Animal research suggests that parsley seed extract increases urine elimination. Parsley leaf and root might also interfere with diuretic therapy due their purported aquaretic effects.

Likelihood Possible Evidence D
Pentobarbital (Nembutal)

Theoretically, parsley might increase the duration of pentobarbital effects.
Animal research suggests that parsley juice prolongs the action of pentobarbital, perhaps by decreasing cytochrome P450 levels. It is not known if this occurs in humans or if this applies to other barbiturates or sedatives.

Likelihood Possible Evidence D
Sirolimus (Rapamune)

Theoretically, large quantities of parsley might increase sirolimus levels.
In one case report, an adult female with a history of kidney transplant presented with elevated blood sirolimus levels, approximately 4-7 times greater than previous measures, after daily consumption of a juice containing approximately 30 grams of parsley for 7 days. Sirolimus levels returned to normal a week after the parsley juice was discontinued.

Likelihood Possible Evidence D
Warfarin (Coumadin)

Theoretically, large amounts of parsley leaf and root might decrease the effects of warfarin.
Parlsey contains vitamin K.

Likelihood Possible Evidence D
Aspirin

Theoretically, aspirin might increase the severity of allergic reactions to parsley.
In one case, severe urticaria and swelling were reported after taking aspirin with parsley in an individual with a known mild parsley allergy.

Likelihood Unlikely Evidence D
Parsley full monograph & interactions

Juniper berry 20:1 extract3 drug types · 162 drugs

Antidiabetes Drugs

Theoretically, taking juniper berry with antidiabetes medications might cause additive hypoglycemia.
Animal research shows that juniper berry can lower blood glucose.

Likelihood Possible Evidence D
Diuretic Drugs

Theoretically, juniper berry might increase the risk of adverse effects from diuretic drugs.
Juniper berry is thought to have mild diuretic effects.

Likelihood Possible Evidence D
Lithium

Theoretically, juniper berry might reduce lithium excretion and increase serum levels of lithium.
Juniper berry is thought to have mild diuretic effects.

Likelihood Possible Evidence D
Juniper berry 20:1 extract full monograph & interactions

Black Radish1 drug type · 86 drugs

Antidiabetes Drugs

Theoretically, radish might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Animal research shows that radish extract, juice, and sprouts can reduce glucose levels. Animal research also shows that radish root juice 300 mg/kg reduces fasting and postprandial blood glucose in a rat model of diabetes, with effects similar to glibenclamide.

Likelihood Possible Evidence D
Black Radish full monograph & interactions

Asparagus root 5:1 extract2 drug types · 76 drugs

Diuretic Drugs

Theoretically, asparagus root might increase diuresis and electrolyte loss when used with diuretic drugs.
Animal studies show that asparagus root extracts have diuretic effects. This effect has not been reported in humans.

Likelihood Possible Evidence D
Lithium

Theoretically, asparagus root might cause diuresis, reducing lithium clearance.
Animal studies show that asparagus root extracts have diuretic effects. Theoretically, this might reduce excretion and increase levels of lithium. The dose of lithium might need to be decreased.

Likelihood Probable Evidence D
Asparagus root 5:1 extract full monograph & interactions

Potassium3 drug types · 62 drugs

Ace Inhibitors (Aceis)

Using ACEIs with high doses of potassium increases the risk of hyperkalemia.
ACEIs block the actions of the renin-angiotensin-aldosterone system and reduce potassium excretion. Concomitant use of these drugs with potassium supplements increases the risk of hyperkalemia. However, concomitant use of these drugs with moderate dietary potassium intake (about 3775-5200 mg daily) does not increase serum potassium levels.

Likelihood Likely Evidence C
Angiotensin Receptor Blockers (Arbs)

Using ARBs with high doses of potassium increases the risk of hyperkalemia.
ARBs block the actions of the renin-angiotensin-aldosterone system and reduce potassium excretion. Concomitant use of these drugs with potassium supplements increases the risk of hyperkalemia. However, concomitant use of these drugs with moderate dietary potassium intake (about 3775-5200 mg daily) does not increase serum potassium levels.

Likelihood Likely Evidence C
Potassium-Sparing Diuretics

Concomitant use increases the risk of hyperkalemia.
Using potassium-sparing diuretics with potassium supplements increases the risk of hyperkalemia.

Likelihood Likely Evidence C
Potassium full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Water-Away, from the product label.

Highland Laboratories

See all Highland Laboratories products
Name
Highland Laboratories
Pharmacist Counseling Corner

Water-Away by Highland Laboratories: Common Questions

Does Water-Away by Highland Laboratories interact with any medications?
Yes. Based on its ingredients, Water-Away has a known interaction with 1,222 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Water-Away contains 7 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take Water-Away while pregnant or breastfeeding?
No — the safety data advises against it. Parsley and Uva ursi are likely unsafe in pregnancy; Juniper berry is rated unsafe. Several ingredients lack sufficient safety information for breastfeeding. Talk with your doctor or pharmacist before use if you are pregnant or nursing.
What are the herbal extracts in this product supposed to do?
They're traditionally used as diuretics — meaning they're meant to increase urine production and reduce water retention — and to support urinary tract health. However, the evidence for most of them is not well established.
Does this product actually work for urinary tract infections?
The evidence we hold rates Uva ursi as Possibly Ineffective for urinary tract infections, and the other ingredients lack sufficient reliable evidence for that use. If you're treating a urinary tract infection, discuss this product's role with your doctor or pharmacist.
What side effects might I experience?
Digestive upset is most common — nausea, diarrhea, vomiting, abdominal pain, and gas. Allergic reactions, including throat tightness and hives, have been reported with Parsley and Asparagus root in sensitive people. Large doses of Parsley or Uva ursi can cause serious effects, but the doses in this product are unlikely to reach those levels.
Is Potassium Chloride safe in this product?
Potassium from food is safe, but supplements can raise blood potassium to dangerous levels, especially in people with kidney disease or those taking certain blood pressure or water-pill medications. If you have kidney disease or take an ACE inhibitor, ARB, or potassium-sparing diuretic, check with your doctor before using this product.
What is Buchu leaf used for in this product?
Buchu leaf extract is included as a traditional diuretic. It contains a compound called pulegone, which the liver can process, so theoretically it may affect drugs metabolized by the liver or increase the risk of bleeding with blood thinners.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Water-Away label
Go deeper

The Full Monographs Behind Water-Away’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Potassium

Interacts with 62 drugs

Potassium is an essential mineral your body needs for nerve signals, muscle function, and a steady heartbeat, and most people get enough from a balanced diet rich in fruits and vegetables. P...

Read the full Potassium monograph → Herb & supplement monograph

Buchu

Interacts with 481 drugs

Buchu is a fragrant South African shrub whose leaves are traditionally used for urinary and bladder complaints and as a diuretic. Solid human studies are lacking, so its benefits are largely...

Read the full Buchu monograph → Herb & supplement monograph

Radish

Interacts with 86 drugs

Radish is a common edible root vegetable that is nutritious and generally safe to eat as food. Some people use radish (especially black radish) and its extracts for digestion and liver suppo...

Read the full Radish monograph → Herb & supplement monograph

Parsley

Interacts with 443 drugs

Parsley is a popular culinary herb that is safe to eat in normal food amounts and is a good source of vitamins K and C. It is traditionally used as a diuretic and for digestion, but solid hu...

Read the full Parsley monograph → Herb & supplement monograph

Uva Ursi

Interacts with 803 drugs

Uva ursi is a traditional herb used mainly for urinary tract infections, and its leaves contain a compound called arbutin that may have antimicrobial effects in the urine. Evidence in people...

Read the full Uva Ursi monograph → Herb & supplement monograph

Juniper

Interacts with 162 drugs

Juniper berry is a traditional herb best known for flavoring gin and for its folk use as a diuretic and digestive aid. Solid human evidence for its health benefits is limited, and it can irr...

Read the full Juniper monograph → Herb & supplement monograph

Asparagus

Interacts with 76 drugs

Asparagus is a nutritious vegetable that is safe and healthy to eat as part of a normal diet. Most of its claimed medicinal benefits, such as use as a diuretic or for urinary health, come fr...

Read the full Asparagus monograph →
Sources

Sources & How We Checked

Water-Away's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 70 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Potassium 12 references
  1. McEvoy GK, ed. AHFS Drug Information. Bethesda, MD: American Society of Health-System Pharmacists, 1998.
  2. Gennaro A. Remington: The Science and Practice of Pharmacy. 19th ed. Lippincott: Williams & Wilkins, 1996.
  3. Whelton PK, He J, Cutler JA, et al. Effects of oral potassium on blood pressure. Meta-analysis of randomized controlled clinical trials. JAMA 1997;277:1624-32. PubMed
  4. Phillips, C. O., Kashani, A., Ko, D. K., Francis, G., and Krumholz, H. M. Adverse effects of combination angiotensin II receptor blockers plus angiotensin-converting enzyme inhibitors for left ventricular dysfunction: a quantitative review of data from ra DOI
  5. Altieri, P. I., Herrero, C., Suero, R., and Ortiz, A. Bleeding duodenal ulcer in a patient taking slow-releasing potassium tablets. Bol.Asoc.Med P.R. 1977;69(8):276.
  6. Raf, L. E. Enteric-coated potassium chloride tablets and ulcer of the small intestine. Acta Chir Scand Suppl 1967;(374):1-87.
  7. Potassium chloride oral solution [package insert]. Allentown, PA: Lehigh Valley Technologies, Inc.; 2014.
  8. Potassium chloride injection [package insert]. Lake Forest, IL: Hospira Inc.; 2009.
  9. Patel RB, Tannenbaum S, Viana-Tejedor A, et al. Serum potassium levels, cardiac arrhythmias, and mortality following non-ST-elevation myocardial infarction or unstable angina: insights from MERLIN-TIMI 36. Eur Heart J Acute Cardiovasc Care 2017 Feb;6(1):1 PubMed
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See these in context on the Potassium monograph →

Buchu 3 references
  1. Newall CA, Anderson LA, Philpson JD. Herbal Medicine: A Guide for Healthcare Professionals. London, UK: The Pharmaceutical Press, 1996.
  2. Fetrow CW, Avila JR. Professional's Handbook of Complementary & Alternative Medicines. 1st ed. Springhouse, PA: Springhouse Corp., 1999.
  3. Moolla A, Viljoen AM. 'Buchu' - Agathosma betulina and Agathosma crenulata (Retaceae): a review. J Ethnopharmacol 2008;119(3):413-9.

See these in context on the Buchu monograph →

Radish 5 references
  1. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
  2. Damiani E, Aloia AM, Priore MG, Nardulli S, Ferrannini A. Generalized urticaria after ingestion of Raphanus sativus. Ann Allergy Asthma Immunol. 2011 Feb;106(2):168. PubMed
  3. Evans M, Paterson E, Barnes DM. An open label pilot study to evaluate the efficacy of Spanish black radish on the induction of phase I and phase II enzymes in healthy male subjects. BMC Complement Altern Med. 2014 Dec 9;14:475. PubMed
  4. Banihani SA. Radish (Raphanus sativus) and diabetes. Nutrients. 2017;9(9). pii: E1014. PubMed
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See these in context on the Radish monograph →

Parsley 21 references
  1. Newall CA, Anderson LA, Philpson JD. Herbal Medicine: A Guide for Healthcare Professionals. London, UK: The Pharmaceutical Press, 1996.
  2. Leung AY, Foster S. Encyclopedia of Common Natural Ingredients Used in Food, Drugs and Cosmetics. 2nd ed. New York, NY: John Wiley & Sons, 1996.
  3. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
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  7. Eberhard P, Gall HM, Muller I, Moller R. Dramatic augmentation of a food allergy by acetylsalicylic acid. J Allergy Clin Immunol 2000;105:844 PubMed
  8. Tunali T, Yarat A, Yanardag R, et al. Effect of parsley (Petroselinum crispum) on the skin of STZ induced diabetic rats. Phytother Res 1999;13:138-41.. DOI
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  11. Jakovljevic, V., Raskovic, A., Popovic, M., and Sabo, J. The effect of celery and parsley juices on pharmacodynamic activity of drugs involving cytochrome P450 in their metabolism. Eur.J Drug Metab Pharmacokinet. 2002;27(3):153-156. PubMed
  12. Kreydiyyeh, S. I. and Usta, J. Diuretic effect and mechanism of action of parsley. J Ethnopharmacol 2002;79(3):353-357. PubMed
  13. Yanardag, R., Bolkent, S., Tabakoglu-Oguz, A., and Ozsoy-Sacan, O. Effects of Petroselinum crispum extract on pancreatic B cells and blood glucose of streptozotocin-induced diabetic rats. Biol Pharm Bull. 2003;26(8):1206-1210. PubMed
  14. Bolkent, S., Yanardag, R., Ozsoy-Sacan, O., and Karabulut-Bulan, O. Effects of parsley (Petroselinum crispum) on the liver of diabetic rats: a morphological and biochemical study. Phytother.Res 2004;18(12):996-999.
  15. Ozsoy-Sacan, O., Yanardag, R., Orak, H., Ozgey, Y., Yarat, A., and Tunali, T. Effects of parsley (Petroselinum crispum) extract versus glibornuride on the liver of streptozotocin-induced diabetic rats. J Ethnopharmacol 3-8-2006;104(1-2):175-181. PubMed
  16. Peterson, S., Lampe, J. W., Bammler, T. K., Gross-Steinmeyer, K., and Eaton, D. L. Apiaceous vegetable constituents inhibit human cytochrome P-450 1A2 (hCYP1A2) activity and hCYP1A2-mediated mutagenicity of aflatoxin B1. Food Chem.Toxicol. 2006;44(9):147 PubMed
  17. Gadi, D., Bnouham, M., Aziz, M., Ziyyat, A., Legssyer, A., Legrand, C., Lafeve, F. F., and Mekhfi, H. Parsley extract inhibits in vitro and ex vivo platelet aggregation and prolongs bleeding time in rats. J Ethnopharmacol 8-17-2009;125(1):170-174. PubMed
  18. Arslan S, Ucar R, Caliskaner AZ. A Cases of Near-fatal Anaphylaxis: Parsley "Over-use" as an Herbal Remedy. Med Arch. 2014;68(6):426-7.
  19. Foti C, Cassano N, Mistrello G, Amato S, Romita P, Vena GA. Contact urticaria to raw arugula and parsley. Ann Allergy Asthma Immunol. 2011 May;106(5):447-8. PubMed
  20. Farzaei MH, Abbasabadi Z, Ardekani MR, Rahimi R, Farzaei F. Parsley: a review of ethnopharmacology, phytochemistry and biological activities. J Tradit Chin Med. 2013;33(6):815-26. PubMed
  21. Kurtaran M, Koc NS, Aksun MS, Yildirim T, Yilmaz SR, Erdem Y. Petroselinum crispum, a commonly consumed food, affects sirolimus level in a renal transplant recipient: a case report. Ther Adv Drug Saf 2021;12:20420986211009358.

See these in context on the Parsley monograph →

Uva Ursi 8 references
  1. Newall CA, Anderson LA, Philpson JD. Herbal Medicine: A Guide for Healthcare Professionals. London, UK: The Pharmaceutical Press, 1996.
  2. Schulz V, Hansel R, Tyler VE. Rational Phytotherapy: A Physician's Guide to Herbal Medicine. Terry C. Telger, transl. 3rd ed. Berlin, GER: Springer, 1998.
  3. Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.
  4. Wang L, Del Priore LV. Bull's-eye maculopathy secondary to herbal toxicity from uva ursi. Am J Ophthalmol 2004;137:1135-7. PubMed
  5. Beaux, D., Fleurentin, J., and Mortier, F. Effect of extracts of Orthosiphon stamineus Benth, Hieracium pilosella L., Sambucus nigra L. and Arctostaphylos uva-ursi (L.) Spreng. in rats. Phytother.Res 1999;13(3):222-225.
  6. de Arriba SG, Naser B, Nolte KU. Risk assessment of free hydroquinone derived from Arctostaphylos Uva-ursi folium herbal preparations. Int J Toxicol. 2013;32(6):442-453.
  7. Park JB, Kim D, Min JS, et al. Identification and characterization of in vitro inhibitors against UDP-glucuronosyltransferase 1A1 in uva-ursi extracts and evaluation of in vivo uva-ursi-drug interactions. Food Chem Toxicol. 2018;120:651-661. PubMed
  8. Chauhan B, Yu C, Krantis A, et al. In vitro activity of uva-ursi against cytochrome P450 isoenzymes and P-glycoprotein. Can J Physiol Pharmacol. 2007;85(11):1099-107.

See these in context on the Uva Ursi monograph →

Juniper 7 references
  1. Newall CA, Anderson LA, Philpson JD. Herbal Medicine: A Guide for Healthcare Professionals. London, UK: The Pharmaceutical Press, 1996.
  2. The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 1999.
  3. Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.
  4. Robbers JE, Tyler VE. Tyler's Herbs of Choice: The Therapeutic Use of Phytomedicinals. New York, NY: The Haworth Herbal Press, 1999.
  5. Sanchez de Medina F, Gamez MJ, Jimenez I, et al. Hypoglycemic activity of juniper "berries." Planta Med 1994;60:197-200. PubMed
  6. Swanston-Flatt SK, Day C, Bailey CJ, Flatt PR. Traditional plant treatments for diabetes. Studies in normal and streptozotocin diabetic mice. Diabetologia 1990;33:462-4. PubMed
  7. Tammaro A, Adebanjo GAR, Chello C, et al. Bullous dermatitis caused by common juniper. Contact Dermatitis. 2020. PubMed

See these in context on the Juniper monograph →

Asparagus 14 references
  1. The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 1999.
  2. Electronic Code of Federal Regulations. Title 21. Part 182 -- Substances Generally Recognized As Safe. Available at: https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?CFRPart=182
  3. Volz T, Berner D, Weigert C, et al. Fixed food eruption caused by asparagus. J Allergy Clin Immunol 2005;116:1390-2. PubMed
  4. Huang X, Kong L. Steroidal saponins from roots of Asparagus officinalis. Steroids 2006;71:171-6. PubMed
  5. Rodriguez R, Jaramillo S, Rodriguez G, et al. Antioxidant activity of ethanolic extracts from several asparagus cultivars. J Agric Food Chem 2005;53:5212-7. PubMed
  6. Rieker J, Ruzicka T, Neumann NJ, Homey B. Protein contact dermatitis to asparagus. J Allergy Clin Immunol 2004;113:354-5. PubMed
  7. Tabar AI, Alvarez-Puebla MJ, Gomez B, et al. Diversity of asparagus allergy: clinical and immunological features. Clin Exp Allergy 2004;34:131-6. PubMed
  8. Rademaker M, Yung A. Contact dermatitis to Asparagus officinalis. Australas J Dermatol 2000;41:262-3.
  9. Misico, R. I., Nicotra, V. E., Oberti, J. C., Barboza, G., Gil, R. R., and Burton, G. Withanolides and related steroids. Prog.Chem.Org.Nat.Prod. 2011;94:127-229.
  10. Hausen BM, Wolf C. 1,2,3-Trithiane-5-carboxylic acid, a first contact allergen from Asparagus officinalis (Liliaceae). Am J Contact Dermat 1996;7(1):41-46. PubMed
  11. Escribano MM, Munoz-Bellido FJ, Serrano P, et al. Acute urticaria after ingestion of asparagus. Allergy 1998;53(6):622-623. PubMed
  12. Chrubasik S, Droste C, Black A. Asparagus P(R) cannot compete with first-line diuretics in lowering the blood pressure in treatment-requiring antihypertensives. Phytother Res 2009;23:1345-6.
  13. Gaus BM, Scheiba N, Schäkel K. Asparagus-induced fixed food eruptions mimicking cutaneous lupus. Acta Derm Venereol 2014;94:731-2. PubMed
  14. Yanagi T, Shimizu H, Shimizu T. Occupational contact dermatitis caused by asparagus. Contact Dermatitis 2010;63:54. PubMed

See these in context on the Asparagus monograph →

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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

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