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Dietary supplement

Willow Extract Ingredients & Drug Interactions

by Oregon's Wild Harvest

Willow Extract label
See full label image
Liquid Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Oct 7, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Willow Extract against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Willow Extract is a dietary supplement by Oregon's Wild Harvest with 1 active ingredient. Its ingredients are commonly taken for low back pain, osteoarthritis joint pain, headache.Based on those ingredients, 127 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Willow, Fresh. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Willow Extract by Oregon's Wild Harvest

Ask about any prescription or over-the-counter medication and we check it for interactions with Willow Extract by Oregon's Wild Harvest — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Willow Extract by Oregon's Wild Harvest

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Oct 6, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: willow, made from fresh plant material and standardized to willow bark. Willow bark has been used traditionally to help with pain and inflammation.

The product also includes alcohol as an inactive ingredient.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: pain and inflammation relief.
  • We looked for evidence on: Back pain, Headache, Joint pain, Osteoarthritis, Dysmenorrhea, Myalgia — and 4 related terms.
  • The strongest evidence on file: Willow Bark is rated "Possibly Effective" for Back pain (Natural Medicines).
  • Also on file: Willow Bark is rated "Insufficient Reliable Evidence To Rate" for Headache, Myalgia, Osteoarthritis, Joint pain, and more.

Willow bark is possibly effective for back pain based on current evidence. For headache, common cold, and influenza, there isn't enough reliable evidence in our data to rate whether it works.

If you're considering this product for one of those other uses, talk with your doctor or pharmacist about what the research actually supports.

The evidence, ingredient by ingredient Willow Bark

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Willow bark is generally well tolerated in the short term by healthy adults, but it acts like aspirin and isn't safe for everyone. The most common side effects are digestive — diarrhea, heartburn, indigestion, and vomiting.

Some people may develop itching, rash, or swollen eyes if they're sensitive to it. Rarely, it can cause gastrointestinal bleeding or kidney problems.

Because it has aspirin-like effects, you should avoid it during pregnancy, especially later in pregnancy, and there isn't enough safety information to use it while breastfeeding.

Side effects, ingredient by ingredient Willow Bark

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Willow Bark.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs.
  • For scale: 127 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, check with your doctor or pharmacist if you take any blood thinners or antiplatelet drugs (like warfarin or clopidogrel) — willow bark may increase bleeding risk. You should also clear it if you take aspirin, other salicylate pain relievers (choline magnesium trisalicylate, salsalate), or acetazolamide, as the combination could raise side effects.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Willow Extract may help with back pain, but because it works like aspirin and interacts with blood thinners and other pain relievers, it's not for everyone. If you take any blood thinner, aspirin, or other prescription medication, check with your doctor or pharmacist before starting.

If you're pregnant, breastfeeding, or allergic to aspirin, talk with your healthcare provider first.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated May 23, 2024.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Willow Extract, straight from the product label.

Brand Oregon's Wild Harvest
Barcode (UPC) 706195001623
Net contents 1 Fluid Ounce(s); 30 mL
Market status On market
Date entered into DSLD May 23, 2024
DSLD ID 307374
Product type Botanical
Supplement form Liquid
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Women (not pregnant or lactating), Organic, Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Willow Extract by Oregon's Wild Harvest, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 mL
Maximum serving Sizes:
1 mL
Servings per container
30
UPC/BARCODE
706195001623
IngredientAmount% DV
Willow, Fresh667 mg--

Other ingredients: Alcohol

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

Organic to our roots As certified organic farmers since 1994, our regenerative practices heal the land and water and sequester carbon from the atmosphere, while ensuring that pure, potent herbal medicine is available today and for future generations. Peace.

Formulation

Free from: Gluten, dairy and soy allergens.

Organic

Non GMO GF (Gluten free)

Certified organic by Oregon Tilth

Precautions

Caution: Keep out of reach of children.

Do not take if pregnant or nursing. If taking medication consult with a healthcare professional before use.

Discontinue use if unusual symptoms occur.

Do not exceed recommended dose.

Brand IP Statement(s)

Oregon's Wild Harvest Herbal Supplement since 1994

FDA Statement of Identity

Herbal Supplement

Seals/Symbols

USDA Organic

Oregon Tilth Certified Organic (OTCO)

Suggested/Recommended/Usage/Directions

Suggested use: Take 1 mL three times daily in warm water or juice or as directed by your healthcare professional. 1 mL = approx. 40 drops.

Shake well.

Formula

Alcohol Content: Not more than 50%

Storage

Store upright in a cool, dry place.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Willow Extract by Oregon's Wild Harvest label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Willow Extract label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Willow Extract by Oregon's Wild Harvest

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 mL Dosage formLiquid Servings per container30 Amounts shown are per serving.

Willow, Fresh

Interacts with
127 drugs
667 mg per serving

Willow bark is a traditional plant remedy that contains salicin, a compound related to aspirin, and is most often used for pain and inflammation. Some...

Willow, Fresh monograph & interactions

Other (inactive) ingredients: Alcohol. These complete the product’s ingredient list but are not active constituents.

Interaction report

Willow Extract by Oregon's Wild Harvest Drug Interactions

Want to check YOUR meds against Willow Extract?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
127Drugs
127 Moderate

Ingredients driving the most interactions

Willow, Fresh 127

Individual Drug Interactions

The ingredients in Willow Extract interact with 127 drugs. Click any drug to see the details.

1 of the 1 ingredient in Willow Extract interact with drugs. Each result below shows which ingredient is responsible. Willow, Fresh

Each ingredient & the kinds of drugs it affects

For each ingredient in Willow Extract with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Willow, Fresh5 drug types · 127 drugs

Acetazolamide

Theoretically, willow bark might result in additive adverse effects associated with acetazolamide.
Willow bark contains salicin, a plant salicylate. Human case reports suggests that a combination of acetazolamide and salicylate increases unbound plasma levels of acetazolamide, as well as adverse effects related to acetazolamide.

Likelihood Possible Evidence D
Anticoagulant/Antiplatelet Drugs

Theoretically, willow bark might increase the risk of bleeding when taken with anticoagulant/antiplatelet drugs.
Willow bark has antiplatelet effects, but less so than aspirin.

Likelihood Probable Evidence D
Aspirin

Theoretically, willow bark might increase the effects and adverse effects of aspirin.
Willow bark contains salicin, a plant salicylate. It might have an additive effect when taken with other salicylate-containing drugs such as aspirin.

Likelihood Probable Evidence D
Choline Magnesium Trisalicylate (Trilisate)

Theoretically, willow bark might increase the effects and adverse effects of choline magnesium trisalicylate.
Willow bark contains salicin, a plant salicylate. It might have an additive effect when taken with other salicylate-containing drugs such as choline magnesium trisalicylate.

Likelihood Probable Evidence D
Salsalate (Disalcid)

Theoretically, willow bark might increase the effects and adverse effects of salsalate.
Willow bark contains salicin, a plant salicylate. It might have an additive effect when taken with other salicylate-containing drugs such as salsalate.

Likelihood Probable Evidence D
Willow, Fresh full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Willow Extract, from the product label.

Oregon's Wild Harvest

See all Oregon's Wild Harvest products
Name
Oregon's Wild Harvest
City
Redmond
State
OR
ZipCode
97756
Phone Number
800-316-6869
Web Address
oregonswildharvest.com
Pharmacist Counseling Corner

Willow Extract by Oregon's Wild Harvest: Common Questions

Does Willow Extract by Oregon's Wild Harvest interact with any medications?
Yes. Based on its ingredients, Willow Extract has a known interaction with 127 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Willow Extract contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take willow extract if I take aspirin?
No, you shouldn't combine them without checking with your doctor first. Willow bark contains a compound similar to aspirin, so taking both together could increase both the effects and side effects of aspirin. Your doctor or pharmacist can advise what's safe for your situation.
Is willow extract safe if I'm pregnant?
No. Because willow bark has aspirin-like effects, the safety data advises against it during pregnancy, especially in the later stages. Talk with your doctor or pharmacist about safe options for pain or inflammation during pregnancy.
Can I take willow extract while breastfeeding?
There isn't enough safety information available to know whether it's safe while breastfeeding. To be cautious, avoid it during lactation and discuss safer alternatives with your doctor or pharmacist.
What side effects does willow extract usually cause?
Most people tolerate it well, but the most common side effects are digestive: diarrhea, heartburn, indigestion, and vomiting. Some people may get itching or rash, and rarely it can cause gastrointestinal bleeding.
Does willow extract really work for back pain?
Willow bark is possibly effective for back pain based on the evidence we have. Results vary from person to person, so talk with your doctor about whether it's right for your situation.
Can I take this if I'm allergic to aspirin?
No. Because willow bark acts like aspirin, people allergic to aspirin may have serious allergic reactions to willow, including anaphylaxis. Avoid this product if you have an aspirin allergy.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Willow Extract label
Go deeper

The Full Monographs Behind Willow Extract’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Willow Bark

Interacts with 127 drugs

Willow bark is a traditional plant remedy that contains salicin, a compound related to aspirin, and is most often used for pain and inflammation. Some evidence suggests it may modestly help...

Read the full Willow Bark monograph →
Sources

Sources & How We Checked

Willow Extract's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 12 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Willow Bark 12 references
  1. Chrubasik S, Eisenberg E, Balan E, et al. Treatment of low back pain exacerbations with willow bark extract: a randomized double-blind study. Am J Med 2000;109:9-14. PubMed
  2. Schmid B, Ludtke R, Selbmann HK, et al. Efficacy and tolerability of a standardized willow bark extract in patients with osteoarthritis: randomized placebo-controlled, double blind clinical trial. Phytother Res 2001;15:344-50. PubMed
  3. Biegert C, Wagner I, Ludtke R, et al. Efficacy and safety of willow bark extract in the treatment of osteoarthritis and rheumatoid arthritis: results of 2 randomized double-blind controlled trials. J Rheumatol 2004;31:2121-30.
  4. Unsworth J, d'Assis-Fonseca A, Beswick DT, Blake DR. Serum salicylate levels in a breast fed infant. Ann Rheum Dis 1987;46:638-9. PubMed
  5. Clark JH, Wilson WG. A 16-day-old breast-fed infant with metabolic acidosis caused by salicylate. Clin Pediatr (Phila) 1981;20:53-4. PubMed
  6. Chrubasik S, Kunzel O, Model A, et al. Treatment of low back pain with a herbal or synthetic anti-rheumatic: a randomized controlled study. Willow bark extract for low back pain. Rheumatology (Oxford) 2001;40:1388-93. PubMed
  7. Schmid B, Kotter I, Heide L. Pharmacokinetics of salicin after oral administration of a standardised willow bark extract. Eur J Clin Pharmacol. 2001;57:387-91. PubMed
  8. Krivoy N, Pavlotzky E, Chrubasik S, et al. Effect of salicis cortex extract on human platelet aggregation. Planta Med 2001;67:209-12. PubMed
  9. Mills SY, Jacoby RK, Chacksfield M, Willoughby M. Effect of a proprietary herbal medicine on the relief of chronic arthritic pain: a double-blind study. Br J Rheumatol 1996;35:874-8. PubMed
  10. Chrubasik, S., Kunzel, O., Black, A., Conradt, C., and Kerschbaumer, F. Potential economic impact of using a proprietary willow bark extract in outpatient treatment of low back pain: an open non-randomized study. Phytomedicine 2001;8(4):241-251. PubMed
  11. <p>Moro PA, Flacco V, Cassetti F, Clementi V, Colombo ML, Chiesa GM, Menniti-Ippolito F, Raschetti R, Santuccio C. Hypovolemic shock due to severe gastrointestinal bleeding in a child taking an herbal syrup. Ann Ist Super Sanita. 2011;47(3):278-83.</p>
  12. Sweeney, K. R., Chapron, D. J., Brandt, J. L., Gomolin, I. H., Feig, P. U., and Kramer, P. A. Toxic interaction between acetazolamide and salicylate: case reports and a pharmacokinetic explanation. Clin Pharmacol Ther 1986;40(5):518-524.

See these in context on the Willow Bark monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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