Major interaction on record — check this product against your medications before combining. Based on 1 of 6 ingredients. Check your meds →
Dietary supplement

Xtreme Trim RDS-X Ingredients & Drug Interactions

by Vitamin World

Xtreme Trim RDS-X label
See full label image
Softgel Capsule Category: Botanical With Nutrients
Most serious interaction: Major
Clinical methodology reviewed by · Updated Sep 9, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Xtreme Trim RDS-X against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Major

Xtreme Trim RDS-X is a dietary supplement by Vitamin World with 6 active ingredients. Its ingredients are commonly taken for high cholesterol, vitamin b3 deficiency (pellagra), heart health support.Based on those ingredients, 1,424 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are Niacin. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Xtreme Trim RDS-X by Vitamin World

Ask about any prescription or over-the-counter medication and we check it for interactions with Xtreme Trim RDS-X by Vitamin World — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Xtreme Trim RDS-X by Vitamin World

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Partial disclosure
Ingredient Transparency · database check
Partial

Most active ingredients list an amount, but at least one is hidden in a blend or missing.

Why this rating?
  • The label discloses an exact amount for 6 of its 11 active ingredients.
  • “Xtreme Trim RDS-X Blend” is a proprietary blend — the label gives one combined amount (1,575 mg) without saying how much of each component you get.
  • “Xtreme RDS-X Burn Blend” is a proprietary blend — the label gives one combined amount (426 mg) without saying how much of each component you get.

Xtreme Trim RDS-X contains 11 ingredients, of which six are actives we could review: niacin (a B vitamin), caffeine (a stimulant), cayenne pepper, xanthinol nicotinate, black pepper extract, and green tea extract. These are paired with monounsaturated and polyunsaturated fats, plus five proprietary blends (Xtreme Trim RDS-X Blend, Burn Blend, Amped Blend, Melt Blend, and Activation Blend) whose exact contents are not disclosed—we have no interaction data on the last four.

The product also contains inactive ingredients including gelatin, vegetable glycerin, and a few other minor components.

Does it work?

Strong evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed

This product doesn't appear to be marketed for a specific use, so we graded its ingredients' overall clinical evidence instead.

Strong

Strong clinical evidence supports its ingredients for:

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.
  • Since the label doesn't commit to one use, we graded the ingredients' overall clinical evidence instead.
  • On file: Neonatal apnea — rated "Effective" (Caffeine) (Natural Medicines).
  • On file: Postoperative headache — rated "Effective" (Caffeine) (Natural Medicines).
  • On file: Athletic performance — rated "Likely Effective" (Caffeine) (Natural Medicines).
  • On file: Diabetic neuropathy — rated "Likely Effective" (Capsicum) (Natural Medicines).
  • On file: Mental alertness — rated "Likely Effective" (Caffeine) (Natural Medicines).

Niacin is likely effective for pellagra and possibly effective for HIV/AIDS-related dyslipidemia and metabolic syndrome. Caffeine is effective for neonatal apnea and postoperative headache, and likely effective for mental alertness and athletic performance.

Cayenne pepper is likely effective for two types of nerve pain (postherpetic and diabetic neuropathy) and possibly effective for cluster headache, back pain, and postoperative nausea. Green tea extract is likely effective for human papillomavirus (HPV) and possibly effective for ovarian cancer and high cholesterol.

Black pepper extract has insufficient reliable evidence to rate—we don't yet have solid proof it works for the conditions studied. The effectiveness of xanthinol nicotinate and the proprietary blends is not established in our data.

The evidence, ingredient by ingredient Niacin

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 5 of the 5 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 5 of 5.
  • General safety write-ups exist for 5 of 5.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Niacin is generally well tolerated in food amounts and at prescription doses when monitored by a healthcare provider. Most common side effects are flushing (up to 70% of patients may experience it), gastrointestinal complaints like nausea, heartburn, and diarrhea, and elevated liver enzymes.

Rare serious effects include liver toxicity, myopathy (muscle weakness), blood clotting problems, and vision changes. Caffeine in moderate doses is typically well tolerated, with common effects including anxiety, headache, insomnia, nausea, and tremor; stroke is rare.

Cayenne pepper is generally well tolerated in food amounts or extracts up to 200 mg daily, with common effects being digestive upset and flushing; rare serious effects include heart attack and high blood pressure. Black pepper is well tolerated as a food spice or single medicinal dose, causing burning aftertaste, indigestion, or cough; allergic reactions are rare.

Green tea is generally well tolerated as a beverage or extract for up to 12 months, with common effects including nausea, bloating, and diarrhea; rare serious effects include liver injury, low potassium, and a blood clotting disorder. Niacin is rated likely safe in pregnancy and lactation at normal dietary amounts, though high-dose supplements should be avoided.

Caffeine and black pepper have no pregnancy/lactation data on file. Cayenne pepper and green tea have no pregnancy/lactation ratings in our data.

Side effects, ingredient by ingredient Niacin

Meds to double-check

Major interaction found
Known Interaction Concern · database check
Major identified

At least one ingredient has a documented Major-severity interaction. Check your medications for a personalized result.

Why this rating?
  • 5 of the 5 matched ingredients can interact with medications — Black Pepper, Niacin, Capsicum, Green Tea, Caffeine.
  • The most serious interaction on file is rated Major.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; immunosuppressants / transplant drugs; diabetes medications; lithium.
  • For scale: 1,425 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking Xtreme Trim RDS-X, double-check these medication types with your pharmacist or doctor: blood pressure drugs (especially nadolol), cholesterol-lowering statins (especially atorvastatin), blood thinners and antiplatelet drugs, diabetes medications, stimulants like ephedrine, seizure medications, gout drugs, heart stress-test agents, sedatives and barbiturates, antipsychotics like clozapine, certain antibiotics (quinolones and rifampin), phenytoin, cyclosporine, theophylline, aspirin, ACE inhibitors, and ciprofloxacin. The medication interaction list spans 1,403 individual medications across all ingredients combined, making a pharmacist check essential.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glancePartially disclosed formula with strong clinical evidence behind its ingredients' uses. Major medication interactions have been identified, and safety information is well characterized.

This product combines several stimulating and metabolism-focused ingredients and should be reviewed by your pharmacist or doctor before you start, especially if you take any medications—particularly blood pressure drugs, statins, blood thinners, diabetes medications, seizure drugs, or sedatives. If you take nadolol or atorvastatin, this product poses a documented risk.

The individual ingredients are generally well tolerated, but the combination and the proprietary blends create a complex interaction profile that needs a personalized check.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 5 of 11 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Apr 25, 2013.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Xtreme Trim RDS-X, straight from the product label.

Brand Vitamin World
Barcode (UPC) 766443276166
Net contents 120 Rapid Release Softgel(s)
Market status On market
Date entered into DSLD Apr 25, 2013
DSLD ID 20459
Product type Botanical With Nutrients
Supplement form Softgel Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free, Dairy Free, Sugar Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Xtreme Trim RDS-X by Vitamin World, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Softgel(s)
Maximum serving Sizes:
2 Softgel(s)
Servings per container
60
UPC/BARCODE
766443276166
IngredientAmount% DV
Calories15 {Calories}--
Total Carbohydrates1 g1%
Calories from Fat10 {Calories}--
Niacin14 mg70%
Total Fat1 g1%
Monounsaturated Fat0 g--
Caffeine187 mg--
Cayenne Pepper0 NP--
Xanthinol Nicotinate0 NP--
Black Pepper extract0 NP--
Green Tea extract0 NP--
Polyunsaturatured Fat0.5 g--
Xtreme Trim RDS-X Blend1575 mg--
Xtreme RDS-X Burn Blend426 mg--
Xtreme RDS-X Amped Blend817 mg--
Xtreme RDS-X Melt Blend269 mg--
Xtreme RDS-X Activation Blend64 mg--

Other ingredients: Gelatin, Vegetable Glycerin, Contains <2% of:

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Precautions

If you are taking any medications, planning any medical procedure or have any medical condition, consult your doctor before use.

Avoid this product if you are allergic to aspirin, if you have liver or kidney disease or high blood pressure.

Avoid additional consumption of caffeine, which may intensify adverse effects.

WARNING: Not intended for use by pregnant or nursing women.

Discontinue use and consult your doctor if any adverse reactions occur.

Not intended for use by persons under the age of 18. Keep out of reach of children.

Do not use if seal under cap is broken or missing.

NOTICE: Use of this product may cause skin flushing, burning, itching or rash. Do not take on an empty stomach.

Formula

This product contains caffeine.

FDA Disclaimer Statement

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

General Statements

This product has been developed, manufactured and packaged by Vitamin World. Our world-class facilities allow us to control exactly what goes into each product. It is your assurance that you are getting the highest quality and freshest products. You have our guarantee!

Get healthy.

RDS-X RAPID RELEASE SYSTEM EXTREME BIOCHEMICAL THERMOGENIC COMPOUNDS* ENERGY BOOSTING INGREDIENTS* NEUROMUSCULAR & INTENSITY SUPPORT*

Seals/Symbols

QA QUALITY ASSURED

Formulation

No Artificial Flavor or Sweetener, No Preservatives, No Sugar, No Starch, No Milk, No Lactose, No Gluten, No Wheat, No Yeast, No Fish. Sodium Free.

Storage

Store at room temperature.

Brand IP Statement(s)

(C)2013 Vitamin World, Inc.

General

PROD. #27616 B52567 07C

FDA Statement of Identity

DIETARY SUPPLEMENT

Suggested/Recommended/Usage/Directions

DIRECTIONS: For adults, take two (2) softgels two times daily 30-60 minutes before your workout or with a meal. Limit your use to no more than two (2) softgels in a 4-hour period. Begin with one (1) softgel to assess individual tolerance.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Xtreme Trim RDS-X by Vitamin World label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Xtreme Trim RDS-X label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Xtreme Trim RDS-X by Vitamin World

These are the 6 active ingredients this product is made of. Select any to open its full monograph.

Serving size2 Softgel(s) Dosage formSoftgel Capsule Servings per container60 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Niacin

Interacts with
727 drugs
14 mg per serving

Niacin (vitamin B3) is an essential nutrient your body needs for energy and metabolism, and deficiency is uncommon in most developed countries. Prescr...

Niacin monograph & interactions

Polyunsaturatured Fat

0.5 g per serving

Xtreme Trim RDS-X Blend

1575 mg per serving
  • › Xtreme RDS-X Burn Blend
  • › Xtreme RDS-X Amped Blend
  • › Xtreme RDS-X Melt Blend
  • › Xtreme RDS-X Activation Blend

Other (inactive) ingredients: Gelatin, Vegetable Glycerin, Contains <2% of:. These complete the product’s ingredient list but are not active constituents.

Interaction report

Xtreme Trim RDS-X by Vitamin World Drug Interactions

Want to check YOUR meds against Xtreme Trim RDS-X?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
1,424Drugs
13 Major 1,387 Moderate 24 Minor

Ingredients driving the most interactions

Niacin 727

Individual Drug Interactions

The ingredients in Xtreme Trim RDS-X interact with 1,424 drugs. Click any drug to see the details.

1 of the 6 ingredients in Xtreme Trim RDS-X interact with drugs. Each result below shows which ingredient is responsible. Niacin

Each ingredient & the kinds of drugs it affects

For each ingredient in Xtreme Trim RDS-X with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Niacin15 drug types · 727 drugs

Alcohol (Ethanol)

Concomitant use of alcohol and niacin might increase the risk of flushing and hepatotoxicity.
Alcohol can exacerbate the flushing and pruritus associated with niacin. Large doses of niacin might also exacerbate liver dysfunction associated with chronic alcohol use. A case report describes delirium and lactic acidosis in a patient taking niacin 3 grams daily who ingested 1 liter of wine. Advise patients to avoid large amounts of alcohol while taking niacin.

Likelihood Probable Evidence D
Allopurinol (Zyloprim)

Theoretically, niacin might antagonize the therapeutic effects of uricosurics such as allopurinol.
Large doses of niacin can reduce urinary excretion of uric acid, potentially resulting in hyperuricemia. Doses of uricosurics such as allopurinol might need to be increased to maintain control of gout in patients who start taking niacin. People who have frequent attacks of gout despite uricosuric therapy should avoid niacin.

Likelihood Probable Evidence C
Anticoagulant/Antiplatelet Drugs

Theoretically, niacin may have additive effects when used with anticoagulant or antiplatelet drugs.
Several cases of clotting factor synthesis deficiency and coagulopathy have been reported in patients taking sustained-release niacin. Also, thrombocytopenia has been reported in patients treated with niacin or niacin plus lovastatin.

Likelihood Possible Evidence D
Antidiabetes Drugs

Niacin can increase blood glucose levels and may diminish the effects of antidiabetes drugs.
Niacin impairs glucose tolerance in a dose-dependent manner, probably by causing or aggravating insulin resistance and increasing hepatic production of glucose. In diabetes patients, niacin 4.5 grams daily for 5 weeks can increase plasma glucose by an average of 16% and glycated hemoglobin (HbA1c) by 21%. However, lower doses of 1.5 grams daily or less appear to have minimal effects on blood glucose. In some patients, glucose levels increase when niacin is started, but then return to baseline when a stable dose is reached. Up to 35% of patients with diabetes may need adjustments in hypoglycemic therapy when niacin is added.

Likelihood Probable Evidence B
Antihypertensive Drugs

Theoretically, niacin may increase the risk of hypotension when used with antihypertensive drugs.
The vasodilating effects of niacin can cause hypotension. Furthermore, some clinical evidence suggests that a one-hour infusion of niacin can reduce systolic, diastolic, and mean blood pressure in hypertensive patients. This effect is not observed in normotensive patients.

Likelihood Possible Evidence B
Bile Acid Sequestrants

Bile acid sequestrants can bind niacin and decrease absorption. Separate administration by 4-6 hours to avoid an interaction.
In vitro studies show that colestipol (Colestid) binds about 98% of available niacin and cholestyramine (Questran) binds 10% to 30%.

Likelihood Possible Evidence D
Gemfibrozil (Lopid)

Theoretically, concomitant use of niacin and gemfibrozil might increase the risk of myopathy in some patients.
A case of myopathy from concomitant use of niacin and gemfibrozil has been reported. Niacin alone has also been associated with cases of myopathy. Using gemfibrozil with niacin might further increase the risk of developing myopathy.

Likelihood Possible Evidence D
Hepatotoxic Drugs

Theoretically, concomitant use of niacin and hepatotoxic drugs might increase the risk of hepatotoxicity.
Niacin has been associated with cases of liver toxicity, especially when used in pharmacologic doses. Sustained-release niacin preparations appear to be associated with a higher risk of hepatotoxicity than immediate-release niacin.

Likelihood Possible Evidence D
Hmg-Coa Reductase Inhibitors ("Statins")

Theoretically, concomitant use of niacin and statins might increase the risk of myopathy and rhabdomyolysis in some patients.
Some case reports have raised concerns that niacin might increase the risk of myopathy and rhabdomyolysis when combined with statins. However, a significantly increased risk of myopathy has not been demonstrated in clinical trials, including those using an FDA-approved combination of lovastatin and niacin (Advicor).

Likelihood Possible Evidence D
Probenecid (Benemid)

Theoretically, niacin might antagonize the therapeutic effects of uricosurics such as probenecid.
Large doses of niacin reduce urinary excretion of uric acid, potentially causing hyperuricemia. Doses of uricosurics such as probenecid might need to be increased to maintain control of gout in patients who start taking niacin. People who have frequent attacks of gout despite uricosuric therapy should avoid niacin.

Likelihood Probable Evidence C
Sulfinpyrazone (Anturane)

Theoretically, niacin might antagonize the therapeutic effects of uricosurics such as sulfinpyrazone.
Large doses of niacin reduce urinary excretion of uric acid, potentially causing hyperuricemia. Doses of uricosurics such as sulfinpyrazone might need to be increased to maintain control of gout in patients who start taking niacin. People who have frequent attacks of gout despite uricosuric therapy should avoid niacin.

Likelihood Probable Evidence C
Thyroid Hormone

Theoretically, niacin might antagonize the therapeutic effects of thyroid hormones.
Clinical research and case reports suggests that taking niacin can reduce serum levels of thyroxine-binding globulin by up to 25% and moderately reduce levels of thyroxine (T4). Patients taking thyroid hormone for hypothyroidism might need dose adjustments when using niacin.

Likelihood Probable Evidence D
Transdermal Nicotine (Nicoderm)

Theoretically, concomitant use of niacin and transdermal nicotine might increase the risk of flushing and dizziness.
Niacin and nicotine can both cause flushing and dizziness.

Likelihood Possible Evidence D
Warfarin (Coumadin)

There is limited evidence that niacin may increase the anticoagulant effects of warfarin.
In a case report, a patient on warfarin developed an elevated international normalized ratio (INR) of 3.9 after taking niacin for two weeks. The patient's INR was previously stable, ranging between 2 and 3 in recent months, and no other medication changes were identified. The elevated INR returned to therapeutic range within 4 days following the discontinuation of niacin.

Likelihood Possible Evidence D
Aspirin

Large doses of aspirin might alter the clearance of niacin.
Aspirin is often used with niacin to reduce niacin-induced flushing. Doses of 80-975 mg aspirin have been used, but 325 mg appears to be optimal. Aspirin also seems to reduce the clearance of niacin by competing for glycine conjugation. Taking aspirin 1 gram seems to reduce niacin clearance by 45%. This is probably a dose-related effect and not clinically significant with the more common aspirin dose of 325 mg.

Likelihood Likely Evidence B
Niacin full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Xtreme Trim RDS-X, from the product label.

Vitamin World

See all Vitamin World products
Name
Vitamin World, Inc.
City
Ronkonkoma
State
NY
ZipCode
11779
Pharmacist Counseling Corner

Xtreme Trim RDS-X by Vitamin World: Common Questions

Does Xtreme Trim RDS-X by Vitamin World interact with any medications?
Yes. Based on its ingredients, Xtreme Trim RDS-X has a known interaction with 1,424 medications, including 13 rated major. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Xtreme Trim RDS-X contains 6 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Does this product contain caffeine?
Yes. This product contains caffeine, which is a stimulant. It's likely effective for boosting mental alertness and athletic performance. Caffeine can cause anxiety, insomnia, headache, and tremor in some people, so if you're sensitive to caffeine or take certain medications, check with your pharmacist first.
What is cayenne pepper doing in here?
Cayenne pepper (capsicum) is included for its active compound, capsaicin. It's likely effective for nerve pain—both postherpetic neuropathy (after shingles) and diabetic neuropathy—and possibly effective for cluster headache and back pain. It commonly causes digestive upset and burning sensations, which usually settle down with continued use.
Is niacin safe to take in this product?
Niacin at normal dietary amounts is safe, but high supplemental doses like those sometimes used for cholesterol can cause flushing, stomach issues, and liver problems if monitored closely. This product contains niacin, so if you have liver disease, gout, or take certain medications, talk to your pharmacist before starting.
What is the green tea extract supposed to do?
Green tea extract is likely effective for human papillomavirus (HPV) and possibly effective for reducing cancer risk and lowering cholesterol. However, it can significantly lower blood levels of certain medications like atorvastatin (a statin) and nadolol (a blood pressure drug), so it's critical to check with your pharmacist if you take either of those.
Can I take this if I'm pregnant or breastfeeding?
Niacin at normal dietary amounts is likely safe in pregnancy and lactation, but high-dose niacin should be avoided unless prescribed by your doctor. Caffeine passes into breast milk and should be limited; high amounts in pregnancy have been studied with caution. For cayenne pepper, black pepper extract, and green tea extract, we don't have enough safety data on supplement-strength doses in pregnancy or breastfeeding—talk with your doctor or pharmacist for personalized advice.
What are these 'blends' in the ingredient list?
Four of the ingredients are proprietary blends—Xtreme RDS-X Amped Blend, Melt Blend, and Activation Blend—meaning the exact contents and amounts are not disclosed. We hold no interaction data on them, so we can't tell you what they do or if they interact with your medications. Ask the manufacturer or your pharmacist for the full ingredient breakdown.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Xtreme Trim RDS-X label
Go deeper

The Full Monographs Behind Xtreme Trim RDS-X’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Niacin

Interacts with 727 drugs

Niacin (vitamin B3) is an essential nutrient your body needs for energy and metabolism, and deficiency is uncommon in most developed countries. Prescription-strength niacin has been used to...

Read the full Niacin monograph →
Sources

Sources & How We Checked

Xtreme Trim RDS-X's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 639 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Niacin 66 references
  1. Garg R, Malinow MR, Pettinger M, et al. Niacin treatment increases plasma homocysteine levels. Am Heart J 1999;138:1082-7.
  2. Anon. Inositol hexaniacinate. Altern Med Rev 1998;3:222-3.
  3. Knodel LC, Talbert RL. Adverse effects of hypolipidaemic drugs. Med Toxicol 1987;2:10-32. PubMed
  4. Guyton JR, Blazing MA, Hagar J, et al. Extended-release niacin vs gemfibrozil for the treatment of low levels of high-density lipoprotein cholesterol. Niaspan-Gemfibrozil Study Group. Arch Intern Med 2000;160:1177-84. PubMed
  5. Gibbons LW, Gonzalez V, Gordon N, Grundy S. The prevalence of side effects with regular and sustained-release nicotinic acid. Am J Med 1995;99:378-85. PubMed
  6. Whelan AM, Price SO, Fowler SF, Hainer BL. The effect of aspirin on niacin-induced cutaneous reactions. J Fam Pract 1992;34:165-8.
  7. Jungnickel PW, Maloley PA, Vander Tuin EL, et al. Effect of two aspirin pretreatment regimens on niacin-induced cutaneous reactions. J Gen Intern Med 1997;12:591-6. PubMed
  8. Capuzzi DM, Guyton JR, Morgan JM, et al. Efficacy and safety of an extended-release niacin (Niaspan): a long-term study. Am J Cardiol 1998;82:74-81;disc. 85U-6U. PubMed
  9. Gray DR, Morgan T, Chretien SD, Kashyap ML. Efficacy and safety of controlled-release niacin in dyslipoproteinemic veterans. Ann Intern Med 1994;121:252-8. PubMed
  10. McKenney JM, Proctor JD, Harris S, Chinchili VM. A comparison of the efficacy and toxic effects of sustained- vs immediate-release niacin in hypercholesterolemic patients. JAMA 1994;271:672-7. DOI
  11. Knopp RH, Alagona P, Davidson M, et al. Equivalent efficacy of a time-release form of niacin (Niaspan) given once-a-night versus plain niacin in the management of hyperlipidemia. Metabolism 1998;47:1097-104. PubMed
  12. Knopp RH. Clinical profiles of plain versus sustained-release niacin (Niaspan) and the physiologic rationale for nighttime dosing. Am J Cardiol 1998;82:24U-28U;discussion 39U-41U. PubMed
  13. Garg A, Grundy SM. Nicotinic acid as therapy for dyslipidemia in non-insulin-dependent diabetes mellitus. JAMA 1990;264:723-6. DOI
  14. Leighton RF, Gordon NF, Small GS, et al. Dental and gingival pain as side effects of niacin therapy. Chest 1998;114:1472-4. PubMed
  15. American Society of Health-System Pharmacists. ASHP Therapeutic Position Statement on the safe use of niacin in the management of dyslipidemias. Am J Health Syst Pharm 1997;54:2815-9. DOI
  16. Vega GL, Grundy SM. Lipoprotein responses to treatment with lovastatin, gemfibrozil, and nicotinic acid in normolipidemic patients with hypoalphalipoproteinemia. Arch Intern Med 1994;154:73-82. DOI
  17. Guyton JR, Goldberg AC, Kreisberg RA, et al. Effectiveness of once-nightly dosing of extended-release niacin alone and in combination for hypercholesterolemia. Am J Cardiol 1998;82:737-43.
  18. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline (2000). Washington, DC: National Academy Press, 2000. Available at: http://b
  19. Brown BG, Zhao XQ, Chait A, et al. Simvastatin and niacin, antioxidant vitamins, or the combination for the prevention of coronary disease. N Engl J Med 2001;345:1583-93. DOI
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See these in context on the Niacin monograph →

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See these in context on the Black Pepper monograph →

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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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