Interactions on record — worth a quick check against your medications. Check your meds →
Dietary supplement

Y Formula Ingredients & Drug Interactions

by Integrative Therapeutics

Y Formula label
See full label image
Softgel Capsule Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Y Formula against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Y Formula is a dietary supplement by Integrative Therapeutics with 4 active ingredients. Its ingredients are commonly taken for digestive upset, respiratory and cold symptoms, antimicrobial support.Based on those ingredients, 1,361 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Goldenseal Extract, Peppermint Oil Aerial Part Extract, Thyme Oil Leaf Extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Y Formula by Integrative Therapeutics

Ask about any prescription or over-the-counter medication and we check it for interactions with Y Formula by Integrative Therapeutics — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Y Formula by Integrative Therapeutics

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 4 of its 4 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

Y Formula contains 4 active ingredients: oregano oil leaf extract, goldenseal extract, peppermint oil aerial part extract, and thyme oil leaf extract. These are delivered in softgel capsules, alongside inactive ingredients including gelatin, glycerin, beeswax, and several other excipients used as binders and carriers.

Does it work?

Strong evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed

This product doesn't appear to be marketed for a specific use, so we graded its ingredients' overall clinical evidence instead.

Strong

Strong clinical evidence supports its ingredients for:

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.
  • Since the label doesn't commit to one use, we graded the ingredients' overall clinical evidence instead.
  • On file: Irritable bowel syndrome (IBS) — rated "Likely Effective" (Peppermint) (Natural Medicines).
  • On file: Barium enema-related colonic spasm — rated "Possibly Effective" (Peppermint) (Natural Medicines).
  • On file: Chemotherapy-induced nausea and vomiting (CINV) — rated "Possibly Effective" (Peppermint) (Natural Medicines).
  • On file: Dyspepsia — rated "Possibly Effective" (Peppermint) (Natural Medicines).
  • On file: Endoscopy-associated adverse effects — rated "Possibly Effective" (Peppermint) (Natural Medicines).

Evidence for these ingredients' effectiveness is largely limited. Peppermint oil shows the strongest data—it's likely effective for irritable bowel syndrome and possibly effective for indigestion, nausea from chemotherapy, and some endoscopy-related discomfort.

For oregano, goldenseal, and thyme, the evidence available to us is insufficient to rate their effectiveness for the conditions they're marketed toward, including acne, bronchitis, asthma, hay fever, and upper respiratory infections.

The evidence, ingredient by ingredient Oregano Goldenseal Peppermint Thyme

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 4 of the 4 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 4 of 4.
  • General safety write-ups exist for 4 of 4.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Oregano oil is well tolerated in food amounts but less studied in concentrated supplement doses. The most common side effect is stomach upset; rarely, allergic reactions including anaphylaxis have been reported in sensitive individuals.

Avoid oregano supplements during pregnancy, though food amounts are likely fine—safety while breastfeeding is not established. Goldenseal has limited human safety data and should generally be used short-term only.

Safety data during pregnancy and breastfeeding are not available, and the safety notes advise against use in both. Common side effects from its berberine content include stomach pain, diarrhea or constipation, nausea, and bitter taste.

Peppermint oil is generally well tolerated and likely safe in pregnancy and lactation at normal doses; side effects may include stomach pain, heartburn, nausea, or dry mouth. Thyme is likely safe in pregnancy and lactation at food amounts; concentrated doses lack safety data.

Possible side effects include headache, dizziness, nausea, or skin irritation when applied topically.

Side effects, ingredient by ingredient Oregano Goldenseal Peppermint Thyme

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 4 of the 4 matched ingredients can interact with medications — Oregano, Peppermint, Thyme, Goldenseal.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; immunosuppressants / transplant drugs; diabetes medications; heart-rhythm medications.
  • For scale: 1,362 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking Y Formula, double-check with your pharmacist if you use blood thinners or antiplatelet drugs (oregano, goldenseal, and thyme all theoretically increase bleeding risk), diabetes medications (oregano and goldenseal may lower blood sugar too much), antihypertensive drugs (goldenseal may lower blood pressure further), CNS depressants like benzodiazepines (goldenseal may increase drowsiness), cyclosporine or other immunosuppressants (peppermint may raise levels, goldenseal may interfere with liver metabolism), estrogen replacement therapy (thyme may reduce its effects), or any medications metabolized by CYP2D6, CYP2C9, CYP3A4, or CYP2C19 enzymes in the liver (goldenseal and peppermint may increase their levels).

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with strong clinical evidence behind its ingredients' uses. Moderate medication interactions have been identified, and safety information is well characterized.

Y Formula combines four botanical extracts with effects that haven't been fully proven but do carry risks with many medications—especially blood thinners, diabetes drugs, blood pressure medications, and drugs metabolized through specific liver pathways. If you take any prescription medication, check your exact drugs against the tool on this page before you start.

Talk to your pharmacist or doctor about whether this product fits your situation.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 4 of 4 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Feb 22, 2024.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Y Formula, straight from the product label.

Brand Integrative Therapeutics
Barcode (UPC) 871791002654
Net contents 90 Softgel(s)
Market status On market
Date entered into DSLD Feb 22, 2024
DSLD ID 302491
Product type Botanical
Supplement form Softgel Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Women (not pregnant or lactating), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Y Formula by Integrative Therapeutics, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Softgel(s)
Maximum serving Sizes:
2 Softgel(s)
Servings per container
45
UPC/BARCODE
871791002654
IngredientAmount% DV
Oregano Oil leaf extract200 mg--
Goldenseal Extract100 mg--
Peppermint Oil Aerial Part Extract100 mg--
Thyme Oil Leaf Extract100 mg--

Other ingredients: Gelatin, Glycerin, Yellow Beeswax, Calcium Carbonate, Water, Purified, Soy Lecithin, Ethylcellulose, Sodium Alginate, Turmeric rhizome color, Medium Chain Triglycerides, Oleic Acid, Soybean Oil, Rosemary Leaf Extract, Stearic Acid

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Precautions

Warning: Do not use if you are pregnant or nursing. If you have diabetes, or are taking any medications, consult a healthcare professional before use.

Keep out of reach of children.

Safety sealed with inner seal. Do not use if seal is broken or missing.

Contains soy.

General Statements

For more information, please visit integrativepro.com.

Storage

Keep tightly closed. Store at room temperature. Avoid excessive heat and direct sunlight.

Formulation

Contains no wheat, gluten, or dairy.

Herbal Blend

Brand IP Statement(s)

Copyright 2022 Distributed by Integrative Therapeutics, LLC

Seals/Symbols

Quality Global Sourcing Bottled & Tested in the USA

FDA Disclaimer Statement

This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

Recommendation: Adults swallow 2 softgels between meals twice daily, or as recommended by a healthcare professional. Do not chew.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Y Formula by Integrative Therapeutics label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Y Formula label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Y Formula by Integrative Therapeutics

These are the 4 active ingredients this product is made of. Select any to open its full monograph.

Serving size2 Softgel(s) Dosage formSoftgel Capsule Servings per container45 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Oregano Oil leaf extract

Interacts with
208 drugs
200 mg per serving

Oregano is a common Mediterranean cooking herb that is also sold as a concentrated oil or supplement, often standardized for a compound called carvacr...

Oregano Oil leaf extract monograph & interactions

Goldenseal Extract

Interacts with
1,237 drugs
100 mg per serving Form: Alkaloids, Hydrastis canadensis Rhizome Extract, Hydrastis canadensis Root Extract

Goldenseal is a popular North American herb that contains berberine, a compound studied for antimicrobial effects. However, strong human evidence for...

Goldenseal Extract monograph & interactions

Peppermint Oil Aerial Part Extract

Interacts with
796 drugs
100 mg per serving Form: Mentha x piperita Oil Aerial Part Extract

Peppermint is a popular herb with the best evidence supporting enteric-coated peppermint oil for easing IBS symptoms. It is generally well tolerated f...

Peppermint Oil Aerial Part Extract monograph & interactions

Thyme Oil Leaf Extract

Interacts with
379 drugs
100 mg per serving Form: Thymus vulgaris Oil Leaf Extract

Thyme is a common kitchen herb that has long been used for coughs, sore throats, and digestive complaints. It is generally safe in the amounts found i...

Thyme Oil Leaf Extract monograph & interactions

Other (inactive) ingredients: Gelatin, Glycerin, Yellow Beeswax, Calcium Carbonate, Water, Purified, Soy Lecithin, Ethylcellulose, Sodium Alginate, Turmeric rhizome color, Medium Chain Triglycerides, Oleic Acid, Soybean Oil, Rosemary Leaf Extract, Stearic Acid. These complete the product’s ingredient list but are not active constituents.

Interaction report

Y Formula by Integrative Therapeutics Drug Interactions

Want to check YOUR meds against Y Formula?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
1,361Drugs
1,346 Moderate 15 Minor

Ingredients driving the most interactions

Goldenseal Extract 1,237
Peppermint Oil Aerial Part Extract 796
Thyme Oil Leaf Extract 379
Oregano Oil leaf extract 208

Individual Drug Interactions

The ingredients in Y Formula interact with 1,361 drugs. Click any drug to see the details.

4 of the 4 ingredients in Y Formula interact with drugs. Each result below shows which ingredient is responsible. Goldenseal Extract Peppermint Oil Aerial Part Extract Thyme Oil Leaf Extract Oregano Oil leaf extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Y Formula with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Goldenseal Extract16 drug types · 1,237 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, goldenseal might increase the risk of bleeding when used with anticoagulant or antiplatelet drugs.
Goldenseal contains berberine. In vitro and animal research shows that berberine can inhibit platelet aggregation. However, this effect has not been reported in humans.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, goldenseal might increase the risk of hypoglycemia when used with antidiabetes drugs.
Goldenseal contains berberine. Clinical research shows that berberine can lower blood glucose levels. However, this effect has not been reported with goldenseal.

Likelihood Possible Evidence D
Antihypertensive Drugs

Theoretically, goldenseal might increase the risk of hypotension when taken with antihypertensive drugs.
Goldenseal contains berberine. Animal research shows that berberine can have hypotensive effects. Also, an analysis of clinical research shows that taking berberine in combination with amlodipine can lower systolic and diastolic blood pressure when compared with amlodipine alone. However, this effect has not been reported with goldenseal.

Likelihood Possible Evidence D
Cns Depressants

Theoretically, goldenseal might increase the sedative effects of CNS depressants.
Goldenseal contains berberine. Animal research shows that berberine can have sedative effects. However, this effect has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2C9 (Cyp2C9) Substrates

Theoretically, goldenseal might increase serum levels of drugs metabolized by CYP2C9.
In vitro research shows that goldenseal root extract can modestly inhibit CYP2C9. This effect may be due to its alkaloid constituents, hydrastine and berberine. However, this effect has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2D6 (Cyp2D6) Substrates

Goldenseal might increase serum levels of drugs metabolized by CYP2D6.
Clinical and in vitro research shows that goldenseal can significantly inhibit CYP2D6 enzymes, potentially increasing levels of drugs metabolized by CYP2D6.

Likelihood Probable Evidence B
Cytochrome P450 2E1 (Cyp2E1) Substrates

Theoretically, goldenseal might increase serum levels of drugs metabolized by CYP2E1.
In vitro research shows that goldenseal root extract can inhibit the activity of CYP2E1. However, this effect has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Goldenseal might increase serum levels of drugs metabolized by CYP3A4.
Most clinical and in vitro research shows that goldenseal inhibits CYP3A4 enzyme activity and increases serum levels of CYP3A4 substrates, such as midazolam. However, in one small clinical study, goldenseal did not affect the levels of indinavir, a CYP3A4 substrate, in healthy volunteers. This is likely due to the fact that indinavir has a high oral bioavailability, making it an inadequate probe for CYP3A4 interactions and/or that it is primarily metabolized by hepatic CYP3A, while goldenseal has more potential to inhibit intestinal CYP3A enzyme activity. Both goldenseal extract and its isolated constituents berberine and hydrastine inhibit CYP3A, with hydrastine possibly having more inhibitory potential than berberine.

Likelihood Possible Evidence B
Dextromethorphan (Robitussin Dm, Others)

Theoretically, goldenseal might increase serum levels of dextromethorphan.
Goldenseal contains berberine. A small clinical study shows that berberine can inhibit cytochrome P450 2D6 (CYP2D6) activity and reduce the metabolism of dextromethorphan.

Likelihood Possible Evidence D
Digoxin (Lanoxin)

Goldenseal might increase serum levels of digoxin, although this effect is unlikely to be clinically significant.
Clinical research shows that goldenseal modestly increases digoxin peak levels by about 14% in healthy volunteers. However, goldenseal does not seem to affect other pharmacokinetic parameters such as area under the curve (AUC). This suggests that goldenseal does not cause a clinically significant interaction with digoxin. Digoxin is a P-glycoprotein substrate. Some evidence suggests that goldenseal constituents might affect P-glycoprotein; however, it is unclear whether these constituents inhibit or induce P-glycoprotein.

Likelihood Probable Evidence B
Losartan (Cozaar)

Theoretically, goldenseal might decrease the conversion of losartan to its active form.
Goldenseal contains berberine. A small clinical study shows that berberine inhibits cytochrome P450 2C9 (CYP2C9) activity and reduces the metabolism of losartan. However, this effect has not been reported with goldenseal.

Likelihood Possible Evidence D
Metformin (Glucophage)

Theoretically, goldenseal might reduce blood levels of metformin.
In vitro research shows that goldenseal extract decreases the bioavailability of metformin, likely by interfering with transport, intestinal permeability, or other processes involved in metformin absorption. It is unclear which, if any, of metformin's transporters are inhibited by goldenseal. Goldenseal does not appear to alter the clearance or half-life of metformin.

Likelihood Possible Evidence D
P-Glycoprotein Substrates

Theoretically, goldenseal might increase or decrease serum levels of P-glycoprotein (P-gp) substrates.
There is conflicting evidence about the effect of goldenseal on P-gp. In vitro research suggests that berberine, a constituent of goldenseal, modestly inhibits P-gp efflux. Other evidence suggests that berberine induces P-gp. In healthy volunteers, goldenseal modestly increases peak levels of the P-gp substrate digoxin by about 14%. However, it does not seem to affect other pharmacokinetic parameters such as area under the curve (AUC). This suggests that goldenseal is not a potent inhibitor of P-gp-mediated drug efflux. Until more is known, goldenseal should be used cautiously with P-gp substrates.

Likelihood Probable Evidence B
Pentobarbital (Nembutal)

Theoretically, goldenseal might increase the sedative effects of pentobarbital.
Animal research shows that berberine, a constituent of goldenseal, can prolong pentobarbital-induced sleeping time. However, this effect has not been reported with goldenseal.

Likelihood Possible Evidence D
Tacrolimus (Prograf)

Theoretically, goldenseal might increase serum levels of tacrolimus.
Goldenseal contains berberine. In a 16-year-old patient with idiopathic nephrotic syndrome who was being treated with tacrolimus 6.5 mg twice daily, intake of berberine 200 mg three times daily increased the blood concentration of tacrolimus from 8 to 22 ng/mL. Following a reduction of tacrolimus dosing to 3 mg daily, blood levels of tacrolimus decreased to 12 ng/mL.

Likelihood Possible Evidence D
Oseltamivir (Tamiflu)

Theoretically, goldenseal might reduce the therapeutic effects of oseltamivir by decreasing its conversion to its active form.
In vitro evidence suggests that goldenseal reduces the formation of the active compound from the prodrug oseltamivir. The mechanism of action and clinical relevance is unclear.

Likelihood Possible Evidence D
Goldenseal Extract full monograph & interactions

Peppermint Oil Aerial Part Extract5 drug types · 796 drugs

Cyclosporine (Neoral, Sandimmune)

Theoretically, peppermint oil might increase the levels and adverse effects of cyclosporine.
In animal research, peppermint oil inhibits cyclosporine metabolism and increases cyclosporine levels. Inhibition of cytochrome P450 3A4 (CYP3A4) may be partially responsible for this interaction. An interaction between peppermint oil and cyclosporine has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2C19 (Cyp2C19) Substrates

Theoretically, peppermint might increase the levels of CYP2C19 substrates.
In vitro research shows that peppermint oil inhibits CYP2C19. So far, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2C9 (Cyp2C9) Substrates

Theoretically, peppermint might increase the levels of CYP2C9 substrates.
In vitro research shows that peppermint oil inhibits CYP2C9. So far, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, peppermint might increase the levels of CYP3A4 substrates.
Clinical research in healthy volunteers shows that a single dose of peppermint oil 600 mg inhibits CYP3A4 enzymes and increases the AUC of felodipine, a CYP3A4 substrate. However, in vitro research suggests that peppermint oil only inhibits CYP3A4 at very high concentrations.

Likelihood Possible Evidence B
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, peppermint might increase the levels of CYP1A2 substrates.
In vitro and animal research shows that peppermint oil and peppermint leaf inhibit CYP1A2. However, in clinical research, peppermint tea did not significantly affect the metabolism of caffeine, a CYP1A2 substrate. It is possible that the 6-day duration of treatment may have been too short to identify a difference.

Likelihood Possible Evidence B
Peppermint Oil Aerial Part Extract full monograph & interactions

Thyme Oil Leaf Extract4 drug types · 379 drugs

Anticholinergic Drugs

Theoretically, concurrent use of anticholinergic drugs and thyme essential oil might reduce the effects of anticholinergic drugs.
In vitro evidence suggests that thyme essential oil and specific essential oil constituents like thymohydroquinone and carvacrol can inhibit acetylcholinesterase (AChE). However, this effect has not been observed in humans.

Likelihood Possible Evidence D
Anticoagulant/Antiplatelet Drugs

Theoretically, thyme leaf extract might have additive effects with anticoagulant or antiplatelet drugs.
In vitro and animal research suggests that thyme leaf extract has antiplatelet effects. However, this effect has not been observed in humans.

Likelihood Possible Evidence D
Cholinergic Drugs

Theoretically, concurrent use of cholinergic drugs and thyme essential oil might cause additive cholinergic effects.
In vitro evidence suggests that thyme essential oil and specific essential oil constituents like thymohydroquinone and carvacrol can inhibit acetylcholinesterase (AChE). However, this effect has not been observed in humans.

Likelihood Possible Evidence D
Estrogens

Theoretically, thyme might competitively inhibit the effects of estrogen replacement therapy.
In vitro research shows that thyme has estrogen receptor-binding activity and phytoestrogen content. However, this effect has not been observed in humans.

Likelihood Possible Evidence D
Thyme Oil Leaf Extract full monograph & interactions

Oregano Oil leaf extract2 drug types · 208 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, oregano might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.
In vitro research shows that aristolochic acid isolated from oregano leaves has antithrombin activity. It has also been reported that oregano oil inhibits arachidonic acid-induced, and ADP-induced, platelet aggregation.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, oregano might increase the risk for hypoglycemia when taken with antidiabetes drugs.
In vitro and animal research shows that oregano extracts might lower blood glucose levels.

Likelihood Possible Evidence D
Oregano Oil leaf extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Y Formula, from the product label.

Integrative Therapeutics

See all Integrative Therapeutics products
Name
Integrative Therapeutics, LLC
City
Green Bay
State
WI
ZipCode
54311
Phone Number
800-931-1709
Web Address
integrativepro.com
Pharmacist Counseling Corner

Y Formula by Integrative Therapeutics: Common Questions

Does Y Formula by Integrative Therapeutics interact with any medications?
Yes. Based on its ingredients, Y Formula has a known interaction with 1,361 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Y Formula contains 4 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Does peppermint oil in this product actually help with IBS?
Peppermint oil is likely effective for irritable bowel syndrome, so that's the strongest evidence claim we can make for an ingredient in Y Formula. It's also possibly effective for indigestion, nausea from chemotherapy, and some endoscopy-related discomfort. For the other ingredients and other conditions this product might be marketed for, the evidence we hold is insufficient to say.
Is it safe to take this while pregnant?
Oregano and goldenseal supplements should be avoided during pregnancy—the safety data advise against them. Peppermint and thyme are likely safe at normal food amounts during pregnancy, but the product is a concentrated supplement. Talk with your doctor or pharmacist about whether Y Formula is right for you during pregnancy, since your individual situation and dosing matter.
Can I breastfeed while taking Y Formula?
Peppermint and thyme are likely safe while breastfeeding at normal amounts. Oregano and goldenseal have safety data that advise against them while breastfeeding. Because this is a concentrated supplement, check with your pharmacist or doctor before starting, so they can weigh the ingredient amounts against your specific situation.
What's the most common side effect I might notice?
Stomach issues are the most frequently reported side effects across these ingredients—nausea, heartburn, stomach pain, diarrhea, or constipation. Oregano and thyme may also cause headache or dizziness. Rare allergic reactions, including serious ones, have been reported with oregano and peppermint in sensitive people.
Can this product interfere with my blood pressure medication?
Yes—goldenseal theoretically increases the effects of blood pressure medications through enzyme inhibition, and thyme may interfere with estrogen therapy if you take that. Goldenseal's berberine has been shown in animal research to lower blood pressure. Have your pharmacist check your specific blood pressure drug against the interaction tool on this page.
Why does this product interact with so many medications?
All four ingredients—especially goldenseal and peppermint—can inhibit enzymes in your liver (CYP2D6, CYP2C9, CYP3A4, and others) that break down many common medications. When these enzymes are slowed, drug levels can rise in your bloodstream, potentially causing more side effects. That's why checking your specific prescriptions is important before starting.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Y Formula label
Go deeper

The Full Monographs Behind Y Formula’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Oregano

Interacts with 208 drugs

Oregano is a common Mediterranean cooking herb that is also sold as a concentrated oil or supplement, often standardized for a compound called carvacrol. While lab studies suggest it may hav...

Read the full Oregano monograph → Herb & supplement monograph

Goldenseal

Interacts with 1,237 drugs

Goldenseal is a popular North American herb that contains berberine, a compound studied for antimicrobial effects. However, strong human evidence for its many traditional uses is largely lac...

Read the full Goldenseal monograph → Herb & supplement monograph

Peppermint

Interacts with 796 drugs

Peppermint is a popular herb with the best evidence supporting enteric-coated peppermint oil for easing IBS symptoms. It is generally well tolerated for most adults, but it can cause heartbu...

Read the full Peppermint monograph → Herb & supplement monograph

Thyme

Interacts with 379 drugs

Thyme is a common kitchen herb that has long been used for coughs, sore throats, and digestive complaints. It is generally safe in the amounts found in food, and some cough products that com...

Read the full Thyme monograph →
Sources

Sources & How We Checked

Y Formula's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 105 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Oregano 12 references
  1. Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.
  2. Benito M, Jorro G, Morales C, et al. Labiatae allergy: systemic reactions due to ingestion of oregano and thyme. Ann Allergy Asthma Immunol 1996;76:416-8. PubMed
  3. Chevallier A. Encyclopedia of Herbal Medicine. 2nd ed. New York, NY: DK Publ, Inc., 2000.
  4. Ciganda C, and Laborde A. Herbal infusions used for induced abortion. J Toxicol.Clin Toxicol. 2003;41:235-239. PubMed
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Goldenseal 34 references
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Peppermint 41 references
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Thyme 18 references
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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

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