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Lederle Leucovorin calcium folinate 5 mg Tablet, 24-count — NDC 00069-5886-24 package photo
Label image from the product's FDA listing (DailyMed) — may show a different pack size or an older label revision.

Lederle Leucovorin calcium folinate 5 mg Tablet, 24-count — NDC 0069-5886-24 (Billing 00069-5886-24)

by Pfizer Laboratories Div Pfizer Inc · 24 TABLET in 1 BOTTLE

This is a package of 24 tablets of Lederle Leucovorin calcium folinate 5 mg Tablet from Pfizer Laboratories Div Pfizer Inc, marketed since Dec 2025 and currently FDA-listed, this package's marketing is listed to end Mar 2027. It is the main listing for this product, which comes in 2 package sizes.

NDC 00069-5886-24
🏷️ FDA NDC (as labeled) 0069-5886-24 billing pads the labeler segment with a zero
This package
Contains24-count Pack sizes2 compare ↓
Main listing for product 0069-5886 · Also comes in: 100 tablets 0069-5886-99
Rx only On market Non-controlled ⇄ Compare with another NDC
🗂️ FDA directory synced Oct 1, 2026 · this listing last changed Jul 24, 2026 · sources: openFDA · FDA label (DailyMed) · FDA Orange & Purple Book · First Databank · CMS NADAC, ASP, Medicare & Medicaid · RxNorm
📋 All sources & update times →

This page is curated, coded, and maintained by

Compiled from public FDA, CMS, DailyMed, NADAC, and related drug data sources. Editorial policy

NDC database record

One package, one record: these facts belong to NDC 0069-5886-24 alone.

Record
FDA NDC Directory package listing · Human prescription drug
Code segments
0069 labeler · 5886 product · 24 package
Package marketed since
Dec 18, 2025
Package marketing ended
Mar 31, 2027
Sample package
No — commercial package
Billing quantity
24 EA per package
Barcode (UPC)
0066063817221, 0066063817207
FDA record last changed
Jul 24, 2026

Identity & classification

Regulatory identifiers FDA, NLM and CMS codes for this package

FDA NDC (as labeled) 0069-5886-24
Product NDC 0069-5886
11-digit billing NDC 00069588624
NCPDP billing unit EA — each (per item)
RxCUI 197863
UNII RPR1R4C0P4
UPC 0066063817221, 0066063817207
SPL Set ID 4734ce39-440d-4a8f-8613-2905408b42cd
Established class (EPC) Folate Analog
Chemical class Folic Acid
DEA schedule Non-controlled
Marketing category UNAPPROVED DRUG FOR USE IN DRUG SHORTAGE
Marketing status On market
FDA listing status Listed (active directory)
Marketing start 2025-12-18
Marketing end 2027-03-31
Route ORAL
Dosage form TABLET
Substance LEUCOVORIN CALCIUM

Drug-database identifiers Medi-Span GPI and First Databank GCN / HICL / AHFS classification

GPI-14 21755040100310
GCN Seq No 044539
GCN 87558
HICL code 001063
Ingredient (HICL) Leucovorin Calcium
HIC1 code V
Therapeutic class — broad (HIC1) Neoplasms
HIC2 code V1
Therapeutic class — intermediate (HIC2) Antineoplastic Drugs
HIC3 code V1I
Therapeutic class — specific (HIC3) Chemotherapy Rescue/Antidote Agents
AHFS code 91:04.12.00
AHFS class Chemotherapy Antidotes/Protectants
FDB label name LEDERLE LEUCOVORIN 5 MG TABLET
FDB brand name Leucovorin Calcium
Legend status F — Federal legend — prescription drug or device
Quick answers
  • GSN (GCN sequence number): 044539
  • GCN: 87558
  • GPI-14 (Medi-Span): 21755040100310
  • HICL (First Databank): 001063
  • AHFS class code: 91:04.12.00
  • RxCUI (RxNorm): 197863
Why two NDCs? The FDA registers this code as 0069-5886-24 — a 4-4-2 layout, and that's what's printed on the package and shown on DailyMed. For insurance claims, every NDC is standardized to a uniform 11-digit 5-4-2 format by adding a zero to the labeler segment → 00069-5886-24. Same drug, same package — only the format differs.
Where does this data come from?
Identifiers from the FDA openFDA NDC Directory and Structured Product Labeling; RxCUI from RxNorm (NLM); GPI from Medi-Span; GCN / HIC / AHFS / legend from First Databank.

RxNorm drug class

This medicine belongs to the Folate Analog class.

Pharmacologic class Folate Analog
Drug family (ATC) Detoxifying agents for antineoplastic treatment
Where does this data come from?
Therapeutic classes from RxNorm RxClass (U.S. National Library of Medicine) — Established Pharmacologic Class (FDA), ATC drug family (WHO) and mechanism of action, matched by this product’s RxCUI.

Clinical

Label name LEDERLE LEUCOVORIN 5 MG TABLET Ingredient Leucovorin Calcium
📗 Our plain-language guide HelloPharmacist
  • It depends on which chemotherapy you're getting. If you're on methotrexate, leucovorin acts like a protective antidote — it steps in to restore the folate your cells need, shieldin...
  • Why am I being given leucovorin alongside my chemotherapy?
  • Yes — you can take Leucovorin Calcium tablets with or without food. Food isn't expected to meaningfully affect how your body absorbs it. If you have trouble swallowing the tablet,...
  • Can I take the leucovorin tablet with food?
📖 Read our full Leucovorin guide →

Supplement & herbal interactions

🌿 Drug–supplement interaction checker →
Where does this data come from?
Plain-language summary from MedlinePlus (U.S. National Library of Medicine); supplement & herbal interactions and nutrient depletion data from the Natural Medicines database; our full guide is HelloPharmacist editorial content.

Pricing

A drug doesn't have one price. Each row is a different public payment system, and none is what you'd pay at the counter — that depends on your insurance. The ⓘ on each row explains what it measures.

Price systemPer eachPer package
Retail pharmacies payNADAC · weekly Not in the retail survey — common for institutional, discontinued, or low-volume packs.
Medicaid paysCMS SDUD · 12 mo No recent Medicaid claims on file for this NDC — rare and low-volume NDCs are suppressed in the public data.
Medicare drug plans payPart D · quarterly No Part D plan price is available for this NDC in our data.
ℹ️
No price is published for this exact package yet. CMS surveys NADAC per package size, so a different pack of the same drug often has one.
Try another pack size: 100 tablets
Where does this data come from?
NADAC (National Average Drug Acquisition Cost) is the CMS weekly pharmacy-acquisition-cost survey — what pharmacies pay. ASP (Average Sales Price) is the CMS Medicare Part B drug-payment file, published quarterly. Medicaid pays is computed by us from CMS State Drug Utilization Data (total reimbursed ÷ units, trailing 12 months) — gross of rebates and inclusive of dispensing fees, so it reflects what Medicaid paid, not an acquisition cost. Medicare drug plans pay is the median negotiated point-of-sale unit cost across plans listing this NDC in the CMS quarterly Prescription Drug Plan pricing files, before rebates. The VA pays is the federal contract price (FSS, and the statutory Big 4 ceiling where listed) from the VA National Acquisition Center pharmaceutical price file. All are free public government data; each measures a different payer, so the figures are not directly comparable.

Packaging — all sizes for this product

Package NDCDescription Marketing startMarketing endStatus
00069-5886-24 You're viewing this Main listing 24 TABLET in 1 BOTTLE 2025-12-18 Mar 31, 2027 Active
00069-5886-99 0069-5886-99 100 TABLET in 1 BOTTLE 2025-12-18 Mar 31, 2027 Active

You're viewing the smallest of 2 pack sizes for this product.

Pack size FAQ

What quantity is in this package?
This is a 24-count package — 24 tablet in 1 bottle.
How does this package differ from NDC 00069-5886-99?
Both are Lederle Leucovorin calcium folinate 5 mg Tablet — the drug itself is identical. This page's package is the 24-count one, while NDC 00069-5886-99 is the 100 tablets package.
What NDC number is used to bill for this package of Lederle Leucovorin calcium folinate 5 mg Tablet?
Use the 11-digit billing form listed in the identifiers section of this page. Pharmacy and medical claims use the 11-digit form; the FDA label may print a shorter form of the same code.

Therapeutic equivalents

ProductLabelerPackNADAC/unitTEStatusPrice vs. this
Leucovorin Calcium 5 mg 00054-4496-13 Hikma 30 tablets $0.330 AB Availability likely —
Leucovorin Calcium 5 mg 00054-8496-19 Hikma 50 tablets $0.330 AB Availability likely —
Leucovorin Calcium 5 mg 00555-0484-01 Teva 30 tablets $0.330 AB Availability likely —
Leucovorin Calcium 5 mg 42806-0358-01 Epic 100 tablets $0.330 AB Availability likely —
Leucovorin Calcium 5 mg 50742-0181-01 Ingenus 100 tablets $0.330 AB Availability likely —
Leucovorin Calcium 5 mg 69315-0184-01 Leading 100 tablets $0.330 AB Availability likely —
Lederle Leucovorin 5 mgthis 00069-5886-24 Pfizer 24 tablets — — FDA listed —
Leucovorin Calcium 5 mg 71205-0908-00 Proficient 100 tablets — AB FDA listed —
Lederle Leucovorin 5 mg 73591-5886-01 FARMASIERRA 100 tablets — — FDA listed —
About this product: other versions of the same ingredient, strength and form are listed above, least expensive first, with FDA equivalence ratings where available.
Where does this data come from?
Equivalents are other NDCs of the same ingredient, form and route from the openFDA NDC Directory, ranked least-expensive-first by NADAC. Therapeutic-equivalence (AB) ratings come from the FDA Orange Book; biologics use the FDA Purple Book for biosimilar & interchangeable status.

Availability & generic status

🏛️
2025
On the market since
Dec 2025
📍
2026
Currently FDA-listed
1 year listed
🔒
·
No generic listed yet
brand only
ℹ️No FDA-approved generic found

We did not find an FDA-approved generic match for this exact strength, form and route.

Where does this data come from?
Patents and exclusivity from the FDA Orange Book (small-molecule drugs), refreshed from public FDA data. Generic launch timing is an estimate, not a guarantee.

Inactive Ingredients / Excipients

Inactive ingredients, also called excipients, are components of the drug product other than the active ingredient. They may include fillers, dyes, coatings, preservatives, flavors, or other formulation ingredients.

🧪 Avoiding an ingredient? See Leucovorin inactive ingredients by manufacturer: every current product's list side by side, so you can ask your pharmacy for the version that does not list it.

Loading inactive ingredients from the official FDA label in the background. No external source is being called by this page request.
Where does this data come from?
Source: official FDA Structured Product Labeling (SPL) via DailyMed and the openFDA label index. Structured IACT rows and label-wide narrative are kept separate; availability and product-level specificity depend on the submitted label.

Inactive ingredient FAQ

Are inactive ingredients the same for every manufacturer?
No. Inactive ingredients can differ by manufacturer, dosage form, strength, and package / product version.
Why might an inactive ingredient be missing?
Some SPLs do not provide a complete structured inactive-ingredient list, and older or unusual labels may only include the information in narrative text.
Can inactive ingredients matter?
Yes. They can matter for allergies, intolerances, dyes, gluten / lactose concerns, preservatives, and formulation differences — but confirm with a pharmacist or the manufacturer when it’s clinically important.

Manufacturer & labeler

LabelerPfizer Laboratories Div Pfizer Inc
Labeler code00069
First marketedDec 2025
Product typeHuman Prescription Drug
Portfolio242 products on file

More NDCs from Pfizer Laboratories Div Pfizer Inc labeler code 00069

The labeler markets the product; the application holder owns the FDA approval. They’re often the same company but can differ (e.g. a repackager or an authorized generic). A mailing address / phone appears here when the manufacturer includes it in the product’s FDA label (not all do).
Where does this data come from?
Labeler, application holder and registered establishment from the FDA openFDA NDC Directory and Drugs@FDA; address/contact from the product’s FDA label.

Full prescribing information FDA SPL

The complete FDA label for this product — the official prescribing information, verbatim, section by section. Jump with a chip, search within the label, or expand everything.
📄 Package Label / Principal Display Panel
📄 Package Label / Principal Display Panel 82 words ▾

PACKAGE/LABEL PRINCIPAL DISPLAY PANEL – 24 count bottle label DIN 02170493 Pr LEDERLE LEUCOVORIN ®/MD Calcium folinate tablets USP Comprimés de folinate de calcium, USP 5 mg 24 tablets / comprimés Pfizer PACKAGE/LABEL PRINCIPAL DISPLAY PANEL – 24 count bottle label

PACKAGE/LABEL PRINCIPAL DISPLAY PANEL – 100 count bottle label DIN 02170493 Pr LEDERLE LEUCOVORIN ®/MD Calcium folinate tablets USP Comprimés de folinate de calcium, USP 5 mg 100 tablets / comprimés Pfizer PACKAGE/LABEL PRINCIPAL DISPLAY PANEL – 100 count bottle label

Source: FDA Structured Product Labeling, mirrored from DailyMed / openFDA. Prefer the government’s original formatting? View this label on DailyMed ↗

Reported adverse events (FAERS)

Read carefully: FAERS reports are voluntary and unverified. Counts are not incidence, do not establish causation, are subject to reporting bias, and cannot be used to compare one drug to another. Shown for signal context only. Reports for LEDERLE LEUCOVORIN (this brand).

Top reported reactions

Diarrhoea469
Nausea371
Neutropenia365
Vomiting275
Fatigue248
Pyrexia244
Neuropathy Peripheral224

Age at onset

Neonate8
Infant3
Child4
Adolescent7
Adult371
Elderly238

Reporter sex

4,739 reports
Male · 54%
Female · 44%
Unknown · 2%

Serious outcomes

Hospitalization1,761
Death898
Life-threatening361
Disabling75
Reports over time (by year) — tap or hover for the count & year
2019 2021 2023 2026 851 0
Most recent year is provisional (FAERS lags ~3 months).
Where does this data come from?
Adverse-event reports from the FDA Adverse Event Reporting System (FAERS) via openFDA. FAERS reports are voluntary and unverified — counts are not incidence and don’t establish causation.

About this NDC listing & data coverage

Finished prescription product Marketed without an FDA application

Listed without an FDA application

This product's marketing category indicates it is marketed without an approved FDA application (no NDA, ANDA, or BLA on file). Having an NDC does not by itself establish FDA approval — the NDC Directory is a listing system, not an approval decision. Approval-linked data such as Orange Book therapeutic-equivalence ratings therefore does not apply.

What data is (and isn’t) available for this NDC — tap to expand
NDC identity (package / product / labeler codes) ✓ Available
Labeler ✓ Available
Product & package description ✓ Available
Marketing category & status ✓ Available
Active ingredient / dosage form / route ✓ Available
FDA label (SPL via DailyMed) ✓ Available
Package photos ✓ Available
Inactive ingredients (structured) — Not published for this NDC The labeler did not submit a structured excipient list, or no SPL is available.
NADAC pharmacy acquisition price (CMS) — Not published for this NDC CMS publishes NADAC only for NDCs reported in its retail-pharmacy survey.
Orange Book / therapeutic-equivalence data — Not published for this NDC Applies only to products approved under an NDA/ANDA; many listings are out of scope.
HCPCS J-code billing crosswalk — Not published for this NDC Most self-administered / retail products have no J-code — that is normal.
Medicaid utilization (CMS SDUD) — Not published for this NDC CMS reports utilization only for NDCs with Medicaid claims above its privacy threshold.
“Not published” reflects what the public FDA / CMS / NLM sources provide for this exact package code — it is a property of the data feeds, not a judgment about the product.

Questions about this listing

Is this NDC FDA-approved?
An NDC listing does not by itself establish FDA approval — the NDC Directory records that a product is listed with FDA, not that it was reviewed and approved. This listing's marketing category is "Unapproved Drug For Use In Drug Shortage". Products approved under an application carry an NDA, ANDA, or BLA number.
Why is there no price listed?
The pricing shown on our NDC pages comes from CMS NADAC, a voluntary survey of retail community pharmacy invoices. CMS does not publish a NADAC for every NDC — packages outside the retail survey (institutional and hospital products, bulk packages, discontinued items, and many OTC items) may never receive one. A missing price reflects the survey's scope, not this product's actual cost, and does not mean the product is free or unavailable.
Is the NDC printed on the package the same as the 11-digit billing NDC?
Yes, they identify this exact package in different formats. The form printed on the packaging and shown on DailyMed is the one the FDA registered. Insurance claims use a fixed 11-digit 5-4-2 format, so the short segment is padded with a leading zero and the dashes are dropped. The Identity section at the top of this page lists each form of this code.
Is this package still being marketed?
Yes, per the latest FDA NDC Directory data on this page it is currently marketed — but Pfizer Laboratories Div Pfizer Inc has reported a marketing end date of 2027-03-31, after which this package is expected to stop being marketed. The directory data on this page refreshes weekly.
Does this product come in other package sizes?
Yes — the FDA directory lists 1 other package presentation of this same product, including 100 tablets (00069-5886-99). Each has its own NDC and its own page — see the package list near the top of this page.
Who lists this product with the FDA?
Pfizer Laboratories Div Pfizer Inc is the labeler of record for this NDC — the company under whose FDA-assigned code the package is listed. The labeler may be the manufacturer itself or a distributor marketing the product under its own code.
Do I need a prescription for this product?
This NDC is listed with FDA as a prescription product, so it is dispensed under a prescriber's order. Your pharmacist can tell you whether any over-the-counter forms of the same medication exist.
This page identifies an FDA-listed package (the NDC) and reports public regulatory and pricing data about the listing. It is reference information, not a medical recommendation — talk to your pharmacist or prescriber about your own medication.
Where does this data come from?
Listing facts (marketing category, packager status, marketing dates) from the FDA openFDA NDC Directory; label availability from DailyMed; pricing coverage from CMS NADAC; equivalence scope from the FDA Orange Book.
← 00069-5820-43 · Pfizer 00069-6001-21 · Pfizer →
For educational and professional reference only — not medical advice. Pricing reflects published NADAC and CMS ASP (free public data) and may differ from your acquisition cost; always verify before billing or dispensing.