Khella - Lanoxin (Digoxin) Interaction
Herbal: Khella
Also Known As: Ammi visnaga, Ammi daucoides, Daucus visnaga, Ammi, Ammi Visnage, Bischofskrautfruchte, Bishop's Weed, Biznaga, Khellin, Khelline, Noukha, Toothpick Ammi, Toothpick Plant, Visnaga, Visnaga Fruit, Visnagin
Drug: Digoxin
Brand names:
Lanoxicaps, Lanoxin, Digitek
Medical Content Editor Dr. Brian Staiger, PharmD
Last updated
Jul 22, 2023
Interaction Details
Digoxin is classified as belonging to the following category: Digoxin (Lanoxin)
Theoretically, khella might decrease the effectiveness of cardiac glycosides like digoxin. The khella constituent visnadin has negative inotropic effects that might counter the effects of cardiac glycosides.
Interaction Rating
Likelihood of Occurrence
PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
References
- Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.
- Duarte J, Torres AI, Zarzuelo A. Cardiovascular effects of visnagin on rats. Planta Med 2000;66:35-9.
Khella Overview
Khella (Ammi visnaga) is a plant native to the Meditearran region and has traditionally been used as an herbal supplement. Khella contains several constituents, including 'khellin', which is found in the seeds of the plant. Khellin dietary supplements have been used to treat a variety of ailments, particularly respiratory problems such as asthma and bronchitis, and cardiovascular issues such as angina pectoris. It is believed to work by relaxing the smooth muscles of the airways, making it easier to breathe. It also is thought to dilate the blood vessels, which can help to lower blood pressure and improve blood flow to the heart. Khella has also been used for dermatological conditions, such as psoriasis and vitiligo.
Digoxin Overview
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Digoxin is used to treat heart failure and abnormal heart rhythms (arrhythmias). It helps the heart work better and it helps control your heart rate.
Khella - More Interactions
Khella interacts with 590 drugs
Interaction Rating Key
These severity listings are for informational use only. Never start, stop or otherwise change your therapy before speaking with your provider.
| Major | The combined use of these agents is strongly discouraged as serious side effects or other negative outcomes could occur. |
| Moderate | Use cautiously under the care of a healthcare professional or avoid this combination. A significant interaction or negative outcome could occur. |
| Minor | Be aware that there is a chance of an interaction. Watch for warning signs of a potential interaction. |
| Unknown | No interactions have been reported or no interaction data is currently available. |
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Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC
Drug descriptions are provided by MedlinePlus.
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In addition to being a clinical pharmacist specializing in pharmacotherapy, Dr. Brian Staiger is a registered herbalist through the American Herbalist Guild. He has combined his passion for pharmacy practice with the study of medical ethnobotany to improve patient care. Feel free to reach out about any of your herbal or medication questions!
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