Drug & supplement interaction

Khella + Prednisone

Prednisone brand names: Deltasone, Cortan, Orasone, Prednisone, Prednicen-M, and others.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Oct 4, 2026
The bottom line No known interaction

We found no known interaction between Khella and Prednisone in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the label for Prednisone states a food rule worth keeping to, and the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Khella and Prednisone

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Prednisone and Khella in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Khella safety at a glance

Khella overall Use caution May cause side effects like nausea and sun sensitivity, and quality of evidence is limited.
Pregnancy Likely Unsafe When used orally. The active constituent, khellin, has uterine stimulant activity; contraindicated. Read the full pregnancy detail
Breastfeeding Avoid Not enough safety data; avoid use while breastfeeding.

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Prednisone and Khella? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Prednisone

Interactions in our licensed database are recorded against drug classes, not just single drug names. Prednisone is filed under 7 classifications — including corticosteroids, cytochrome p450 2c19 (cyp2c19) inducers, immunosuppressants. Khella has documented interactions with 3 drug classes — the most serious being digoxin (lanoxin) (moderate), hepatotoxic drugs (moderate) and photosensitizing drugs (moderate) — and none of Prednisone’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Khella Does Interact With Other Medications

Khella has 620 moderate known drug interactions in our database — Prednisone isn’t one of them. If you take anything else, check it against the full list below.

Moderate 620 No known interaction 2,210 (incl. Prednisone)
Taking anything else?

Check Another of Your Medications Against Khella

Covers the 2,830 medications we’ve checked against Khella. Pick one to open its full report.

What to actually watch for

No Interaction Found — But Data Suggests Khella and Prednisone May Share Several of the Same Side Effects

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do.

  • Reduced appetite / Constipation / Nausea Additional detail

    Khella

    “Orally, prolonged use or use of high doses of khella can cause nausea, dizziness, constipation, lack of appetite, headache, itching, and insomnia. In some patients, khella can cause elevated liver transaminase and gamma-glutamyltransferase (GGT) levels (2). There is also some concern that khella might cause photosensitivity (2,7162).”

    Khella · Natural Medicines adverse-effect record, reported in cluster headache.

    2 sources cited
    1. 2. Blumenthal M, ed. The Complete German Commission E Monographs: Therapeutic Guide to Herbal Medicines. Trans. S. Klein. Boston, MA: American Botanical Council, 1998.
    2. 7162. Dr. Duke's Phytochemical and Ethnobotanical Databases. Available at: http://www.ars-grin.gov/duke/.

    “Orally, prolonged use or use of high doses of khella can cause nausea, constipation, and lack of appetite (2).”

    Khella · Natural Medicines adverse-effect record, reported in constipation.

    1 source cited
    1. 2. Blumenthal M, ed. The Complete German Commission E Monographs: Therapeutic Guide to Herbal Medicines. Trans. S. Klein. Boston, MA: American Botanical Council, 1998.

    Prednisone

    Listed in the ADVERSE REACTIONS section of the FDA label for Prednisone. Read the label on DailyMed ›

  • Trouble sleeping / Dizziness / Headache Additional detail

    Khella

    “Orally, prolonged use or use of high doses of khella can cause dizziness, headache, and insomnia (2).”

    Khella · Natural Medicines adverse-effect record, reported in cluster headache.

    1 source cited
    1. 2. Blumenthal M, ed. The Complete German Commission E Monographs: Therapeutic Guide to Herbal Medicines. Trans. S. Klein. Boston, MA: American Botanical Council, 1998.

    Prednisone

    Listed in the ADVERSE REACTIONS section of the FDA label for Prednisone. Read the label on DailyMed ›

Reported for Khella but not commonly for Prednisone: sun sensitivity and itching.

Effects for Prednisone come from the ADVERSE REACTIONS section of its FDA label; effects for Khella come from the Natural Medicines adverse-effect record, quoted above. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

Special populations

Khella in Pregnancy & Breastfeeding

Pregnancy Likely Unsafe

When used orally. The active constituent, khellin, has uterine stimulant activity; contraindicated.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

How to take them

Some Prednisone Products Have a Food Rule — Khella Should Not Break It

At least one FDA label for a product containing Prednisone says to take it with food. If you take Khella on an empty stomach out of habit, keep them separate — and take Prednisone with a meal where the label says to.

This may not be true of your version. Food instructions belong to the product, not the ingredient: two Prednisone products can carry different directions, and extended-release forms often differ from immediate-release ones. The label we read is quoted below — check the directions on your own box or bottle, or ask your pharmacist, for how to take the exact product you were given.

DOSAGE AND ADMINISTRATION Gastric irritation may be reduced if taken before, during, or immediately after meals or with food or milk.

From the Dosage and Administration section of the FDA label we read for Prednisone — where that label names a specific product, the instruction is that product's. Read the label on DailyMed ›

A food rule is not an interaction — it is about how much of the medicine you absorb. The directions that came with your own product, and your pharmacist, outrank anything on this page.

Overlapping uses

What Prednisone Is Prescribed For, and What Khella Has Been Studied For

These two come up together because they touch the same health topic — not because they do the same job. Prednisone is a prescription medicine with approved uses on its FDA label. Khella is a supplement: what follows is what researchers have looked at it for, and how strong that evidence is.

Prednisone is prescribed for: Prednisone is used as an anti-inflammatory or immunosuppressive medicine (one that lowers immune activity). It treats many conditions across several body systems. Main groups include: Allergic conditions, such as severe allergic rhinitis, atopic dermatitis and drug reactions Joint and autoimmune conditions, such as rheumatoid arthritis and lupus Skin, gut, blood, eye, lung and kidney conditions Hormone (endocrine) conditions, such as adrenal insufficiency Palliative care for certain leukemias and lymphomas Prednisone delayed-release tablets (including Rayos) are also labeled for organ transplant rejection, asthma, COPD flares, and idiopathic pulmonary fibrosis. The standard tablet and solution labels list other uses, such as bursitis, tenosynovitis and severe psoriasis.

Khella has been studied for:

  • Psoriasis studied, not established Khella has been studied for this. Natural Medicines rates the evidence: Insufficient Reliable Evidence To Rate Read what the research shows

    Khella for psoriasis

    Preliminary clinical research suggests that taking the khella constituent khellin by mouth, in combination with sunlight exposure, helps clear psoriatic lesions.

    1 source cited
    1. 1908. Abdel-Fattah A, Aboul-Enein MN, Wassel G, El-Menshawi B. Preliminary report on the therapeutic effect of khellin in psoriasis. Dermatologica 1983;167:109-10. PubMed

Effectiveness ratings and the research summaries above are the verbatim record from the Natural Medicines database, which grades evidence from “Effective” down to “Insufficient Reliable Evidence To Rate”. A rating below the top of that scale means researchers have looked at it — not that it works, and never that it can stand in for a prescribed medicine. Do not stop or replace Prednisone on your own; if you are taking Khella for the same health topic, tell your prescriber, especially if the medicine is being adjusted to a target.

From our Q&A

Questions About Khella or Prednisone

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Khella or Prednisone, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Prednisone

This page covers Khella only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Prednisone page lists 208 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Grapefruit (major), Lily-of-the-valley (major), St. John's Wort (major) and Acacia Rigidula (moderate).

By severity: 4 major · 168 moderate · 36 minor.

From our pharmacist’s overview on the Prednisone page

“Prednisone (Deltasone) suppresses the immune system to control inflammation, and that mechanism shapes most of what can go wrong on this 208-ingredient list, which I read as one to approach carefully rather than casually. Four entries rate major.”

Reviewed by 2 · Jul 18, 2026

Open the Prednisone interaction page

One more smart check

Taking Khella as Part of a Dietary Supplement Product? Check It for Interactions

We hold 43 real supplement products containing Khella, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Khella. Even though Khella itself has no known interaction with Prednisone, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Khella and Prednisone Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Khella
Steady interest

#776 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Prednisone
Top 5%

#30 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Khella reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified October 4, 2026. The Khella and Prednisone records this page draws on were last updated July 11, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Khella

What is Khella?

Khella
  • Asthma and bronchitis
  • Angina and heart-related chest pain
  • Kidney stones
  • Vitiligo and psoriasis
  • Mild high blood pressure

Khella is a Mediterranean herb whose seeds contain compounds like khellin that may relax smooth muscle in the airways and blood vessels. While it has a long history of traditional use for breathing and heart problems, modern evidence in supplement form is limited, and it can cause side effects and sun sensitivity, so talk with your pharmacist or doctor before using it.

Ammi visnaga · Apiaceae · Dried ripe fruit (seeds) · Capsules, tinctures, teas, standardized extracts

An interaction check asks whether these two react with each other — it does not ask whether Khella is a good idea for someone in your situation. Here is what our Khella record says about it on its own.

Khella: dosing

There is no well-established, standardized dose for khella supplements. The right amount depends on the product, how it is prepared, and the amount of active compounds it contains.Because strength varies widely between products, follow the directions on the label and do not exceed them. Avoid long-term use unless guided by a healthcare professional.

From our Khella monograph — the full record covers uses, side effects and every documented interaction.

Read the full Khella monograph & all interactions
Medication

About Prednisone

What Is Prednisone Used For?

Brand names: Deltasone, Cortan, Orasone, Prednisone, Prednicen-M, Meticorten, Sterapred, Rayos

Prednisone is used as an anti-inflammatory or immunosuppressive medicine (one that lowers immune activity). It treats many conditions across several body systems.

Main groups include:

  • Allergic conditions, such as severe allergic rhinitis, atopic dermatitis and drug reactions
  • Joint and autoimmune conditions, such as rheumatoid arthritis and lupus
  • Skin, gut, blood, eye, lung and kidney conditions
  • Hormone (endocrine) conditions, such as adrenal insufficiency
  • Palliative care for certain leukemias and lymphomas

Prednisone delayed-release tablets (including Rayos) are also labeled for organ transplant rejection, asthma, COPD flares, and idiopathic pulmonary fibrosis. The standard tablet and solution labels list other uses, such as bursitis, tenosynovitis and severe psoriasis.

See full Prednisone drug information
Keep checking

Other Drugs & Khella

Browse every other medication we’ve checked against Khella — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
620Moderate
0Minor
2,209No known interaction
620 Moderate 2,209 No interaction
Moderate

620 interactions

Showing 60 of 620 moderate interactions — see all 620 on the Khella page.

No interaction 2,209 drugs checked — show the list

We also checked Khella against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,209 medications checked with no known interaction — see the full Khella list.

See the full Khella interactions page
See every supplement checked against Prednisone, ranked by severity
Evidence & sources

Khella References

The 10 references that drive our Khella monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Blumenthal M, ed. The Complete German Commission E Monographs: Therapeutic Guide to Herbal Medicines. Trans. S. Klein. Boston, MA: American Botanical Council, 1998.
  2. Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.
  3. Abdel-Fattah A, Aboul-Enein MN, Wassel GM, El-Menshawi BS. An approach to the treatment of vitiligo by khellin. Dermatologica 1982;165:136-40. PubMed
  4. Duarte J, Torres AI, Zarzuelo A. Cardiovascular effects of visnagin on rats. Planta Med 2000;66:35-9. PubMed
  5. Abdel-Fattah A, Aboul-Enein MN, Wassel G, El-Menshawi B. Preliminary report on the therapeutic effect of khellin in psoriasis. Dermatologica 1983;167:109-10. PubMed
  6. Ossenkoppele PM, van der Sluis WG, van Vloten WA. [Phototoxic dermatitis following the use of Ammi majus fruit for vitiligo]. Ned Tijdschr Geneeskd 1991;135:478-80.
  7. Harvengt C, Desager JP. HDL-cholesterol increase in normolipaemic subjects on khellin: a pilot study. Int J Clin Pharmacol Res 1983;3:363-6.
  8. Dr. Duke's Phytochemical and Ethnobotanical Databases. Available at: http://www.ars-grin.gov/duke/.
  9. de Leeuw J, van der BN, Maierhofer G, et al. A case study to evaluate the treatment of vitiligo with khellin encapsulated in L-phenylalanin stabilized phosphatidylcholine liposomes in combination with ultraviolet light therapy. Eur J Dermatol 2003;13(5):
  10. Orecchia G, Perfetti L. Photochemotherapy with topical khellin and sunlight in vitiligo. Dermatology 1992;184(2):120-123. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Khella and Prednisone Together: Common Questions

Is it safe to take Khella with Prednisone?
We do not list a known interaction between Khella and Prednisone. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Khella and Prednisone have any of the same side effects?
Yes — our sources link each of them separately to 6 of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
Should I take Khella and Prednisone at the same time of day?
At least one FDA label for a product containing Prednisone says to take it with food. If you take Khella on an empty stomach out of habit, keep them separate and take Prednisone with a meal where the label says to. Food instructions belong to the product rather than the ingredient — two Prednisone products can differ — so check the directions on your own box. This is about absorption, not an interaction.
Are Khella and Prednisone used for the same thing?
They overlap in purpose, which usually means the real question is whether you need both rather than whether they are safe together. This page lists the shared uses and how strong the evidence is for Khella in each. That is a conversation for your prescriber, especially if Prednisone is being adjusted to a target.
How was the Khella and Prednisone combination checked?
Interactions in our licensed database are recorded against drug classes. Prednisone is filed under 7 classifications, and Khella has documented interactions with 3 drug classes — none of Prednisone's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Khella interact with any other medications?
Yes. Khella has 620 documented drug interactions in our database — Prednisone is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Prednisone interact with any supplements?
Yes. Prednisone has documented interactions with 208 supplements in our database — Khella is not one of them. The Prednisone interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Khella monograph Uses, safety profile, and every drug interaction in one place Prednisone drug information The full plain-English guide to this medication Prednisone supplement interactions Every supplement checked against Prednisone, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 10 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Prednisone and Khella?

Our pharmacists answer your medication & supplement questions — free.

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.