Aldesleukin

33 interactions 261 cited references
Also sold as: Proleukin Proleukin®
About Aldesleukin

Aldesleukin is used to treat advanced renal cell carcinoma (RCC, a type of cancer that begins in the kidney) that has spread to other parts of your body. Aldesleukin is also used to treat melanoma (a type of skin cancer) that has spread to other parts of your body. Aldesleukin is in a class of drugs known as cytokines.… Read the full Aldesleukin drug information page →

Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 11, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Smallpox Monkeypox Vaccine Bacillus Of Calmette And Guerin Vaccine, Live Rubella Virus Vaccine, Live Mumps Virus Vaccine, Live Measles Virus Vaccine, Live Dengue Tetravalent Vaccine, Live
9 Contraindicated 19 Major 5 Moderate
All (33) Contraindicated (9) Major (19) Moderate (5)

Contraindicated

Aldesleukin Bacillus Of Calmette And Guerin Vaccine, Live An increased risk of infection by the live vaccine Details Aldesleukin Dengue Tetravalent Vaccine, Live An increased risk of infection by the live vaccine Details Aldesleukin Measles Virus Vaccine, Live An increased risk of infection by the live vaccine Details Aldesleukin Mumps Virus Vaccine, Live An increased risk of infection by the live vaccine Details Aldesleukin Rubella Virus Vaccine, Live An increased risk of infection by the live vaccine Details Aldesleukin Smallpox Monkeypox Vaccine An increased risk of infection by the live vaccine Details Aldesleukin Typhoid Vaccine Typhim VI® An increased risk of infection by the live vaccine Details Aldesleukin Varicella Virus Vaccine, Live An increased risk of infection by the live vaccine Details Aldesleukin Yellow Fever Vaccine Stamaril An increased risk of infection by the live vaccine Details

Major

Aldesleukin Adenovirus Vaccine Type 4, Live An increased risk of infection by the live vaccine Details Aldesleukin Adenovirus Vaccine Type 7, Live An increased risk of infection by the live vaccine Details Aldesleukin Betamethasone Betavet Reduced antitumor effectiveness Details Aldesleukin Cholera Vaccine Ipol An increased risk of infection by the live vaccine Details Aldesleukin Cortisone Reduced antitumor effectiveness Details Aldesleukin Deflazacort Emflaza Reduced antitumor effectiveness Details Aldesleukin Dexamethasone Reduced antitumor effectiveness Details Aldesleukin Ebola Zaire Vaccine, Live An increased risk of infection by the live vaccine Details Aldesleukin Hydrocortisone Ala-Cort Reduced antitumor effectiveness Details Aldesleukin Influenza Virus Vaccine, Live An increased risk of infection by the live vaccine Details Aldesleukin Methylprednisolone Depo-Medrol Reduced antitumor effectiveness Details Aldesleukin Paramethasone Reduced antitumor effectiveness Details Aldesleukin Prednisolone Flo-Pred® Reduced antitumor effectiveness Details Aldesleukin Prednisone Deltasone Reduced antitumor effectiveness Details Aldesleukin Rotavirus Vaccine, Live An increased risk of infection by the live vaccine Details Aldesleukin Triamcinolone Aller-Cort Reduced antitumor effectiveness Details Aldesleukin Dexamethasone Injection Decadron Reduced antitumor effectiveness Details Aldesleukin Dexamethasone Ophthalmic Dexacidin® (as a combination product containing Dexamethasone, Neomycin, Polymyxin B) Reduced antitumor effectiveness Details Aldesleukin Hydrocortisone Injection A-Hydrocort® Reduced antitumor effectiveness Details

Moderate

Aldesleukin Cisplatin An increased risk for hypersensitivity reactions (erythema, pruritus, hypotension) Details Aldesleukin Dacarbazine DTIC-Dome® In increased risk for hypersensitivity reactions (erythema, pruritus, hypotension) Details Aldesleukin Interferon Alfa An increased risk for hypersensitivity reactions (erythema, pruritus, hypotension) Details Aldesleukin Tamoxifen Nolvadex® An increased risk for hypersensitivity reactions (erythema, pruritus, hypotension) Details Aldesleukin Cisplatin Injection Platinol-AQ® An increased risk for hypersensitivity reactions (erythema, pruritus, hypotension) Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.