Aldesleukin

Name: Aldesleukin Drug Interactions
Creator: Dr. Brian Staiger, PharmD, BCPS

33 interactions 261 cited references

Also sold as: Proleukin Proleukin®

About Aldesleukin

Aldesleukin is used to treat advanced renal cell carcinoma (RCC, a type of cancer that begins in the kidney) that has spread to other parts of your body. Aldesleukin is also used to treat melanoma (a type of skin cancer) that has spread to other parts of your body. Aldesleukin is in a class of drugs known as cytokines.… Read the full Aldesleukin drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 11, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Smallpox Monkeypox Vaccine Bacillus Of Calmette And Guerin Vaccine, Live Rubella Virus Vaccine, Live Mumps Virus Vaccine, Live Measles Virus Vaccine, Live Dengue Tetravalent Vaccine, Live

9 Contraindicated 19 Major 5 Moderate

All (33) Contraindicated (9) Major (19) Moderate (5)

Moderate

Aldesleukin Cisplatin An increased risk for hypersensitivity reactions (erythema, pruritus, hypotension) Details Aldesleukin Dacarbazine DTIC-Dome® In increased risk for hypersensitivity reactions (erythema, pruritus, hypotension) Details Aldesleukin Interferon Alfa An increased risk for hypersensitivity reactions (erythema, pruritus, hypotension) Details Aldesleukin Tamoxifen Nolvadex® An increased risk for hypersensitivity reactions (erythema, pruritus, hypotension) Details Aldesleukin Cisplatin Injection Platinol-AQ® An increased risk for hypersensitivity reactions (erythema, pruritus, hypotension) Details

Check another drug

Still have questions about this combination?

Every question gets a real answer from a licensed pharmacist — free, and usually within a day.

Ask the pharmacist

Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.