Ambrisentan

Name: Ambrisentan Drug Interactions
Creator: Dr. Brian Staiger, PharmD, BCPS

11 interactions 37 cited references

Also sold as: Letairis Letairis®

About Ambrisentan

Ambrisentan is used alone or in combination with tadalafil (Adcirca, Cialis) to treat pulmonary arterial hypertension (PAH, high blood pressure in the vessels that carry blood to the lungs). Ambrisentan may improve the ability to exercise and slow the worsening of symptoms in people with PAH. Ambrisentan is in a class… Read the full Ambrisentan drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 12, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Sparsentan Azathioprine Cyclosporine Levoketoconazole Mercaptopurine Methotrexate

1 Contraindicated 9 Major 1 Moderate

All (11) Contraindicated (1) Major (9) Moderate (1)

Contraindicated

Ambrisentan Sparsentan Filspari An increased risk of hypotension, syncope, hyperkalemia, and changes in renal function (including acute renal failure) Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.