Etonogestrel

25 interactions 1 explained in plain English
Also sold as: Nexplanon
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Major

Etonogestrel Isotretinoin Absorica Explained Decreased effectiveness of hormonal contraceptives Details Etonogestrel Bexarotene Targretin Decreased contraceptive effectiveness Details Etonogestrel Bexarotene Topical Targretin Decreased contraceptive effectiveness Details Etonogestrel Dexamethasone Injection Decadron Reduced hormonal contraceptive exposure, reduced efficacy of hormonal contraceptive, increased risk of breakthrough bleeding and/o... Details Etonogestrel Dexamethasone Ophthalmic Dexacidin® (as a combination product containing Dexamethasone, Neomycin, Polymyxin B) Reduced hormonal contraceptive exposure, reduced efficacy of hormonal contraceptive, increased risk of breakthrough bleeding and/o... Details Etonogestrel Enasidenib Idhifa Reduced hormonal contraceptive exposure and reduced efficacy of hormonal contraceptive and an increased risk of breakthrough bleed... Details Etonogestrel Encorafenib Braftovi Reduced hormonal contraceptives exposure and reduced efficacy of hormonal contraceptives Details Etonogestrel Felbamate Felbatol Reduced etonogestrel exposure, reduced efficacy of etonogestrel and an increased risk of breakthrough bleeding/contraceptive failu... Details Etonogestrel Finerenone Kerendia Increased finerenone exposure and an increased risk of finerenone-related adverse effects Details Etonogestrel Ketoconazole Topical Extina® Foam Increased estrogen and/or progestin exposure Details Etonogestrel Lixisenatide Injection Adlyxin® Decreased absorption of oral contraceptives Details Etonogestrel Loperamide Diamode Increased loperamide exposure and an increased risk of loperamide-related adverse effects Details Etonogestrel Meropenem Reduced hormonal contraceptive exposure and an increased risk of contraceptive failure Details Etonogestrel Meropenem Injection Merrem® Reduced hormonal contraceptive exposure and an increased risk of contraceptive failure Details Etonogestrel Methylergonovine Methergine Increased methylergonovine exposure Details Etonogestrel Miconazole Buccal Oravig Increased etonogestrel exposure Details Etonogestrel Miconazole Topical Aloe Vesta Antifungal Increased etonogestrel exposure Details Etonogestrel Miconazole Vaginal Lagicam Increased etonogestrel exposure Details Etonogestrel Miconazole Aloe Vesta Antifungal Increased etonogestrel exposure Details Etonogestrel Mitapivat Aqvesme Reduced hormonal contraceptive exposure Details Etonogestrel Nafcillin Injection Unipen® Injection Reduced hormonal contraceptive exposure and increased risk of breakthrough bleeding and/or contraceptive failure Details Etonogestrel Nevirapine Viramune Reduced hormonal contraceptive exposure, reduced efficacy of hormonal contraceptives and increased risk of breakthrough bleeding a... Details Etonogestrel Nifedipine Adalat® Increased NIFEdipine exposure Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.