Naratriptan

21 interactions 4 explained in plain English
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Methylergonovine Dihydroergotamine Nasal Spray Dihydroergotamine Injection Acetaminophen And Codeine Palonosetron Injection Nalbuphine Injection
3 Contraindicated 18 Major
All (21) Contraindicated (3) Major (18)

Contraindicated

Naratriptan Dihydroergotamine Injection DHE-45® Injection Prolonged vasospastic reactions Details Naratriptan Dihydroergotamine Nasal Spray Migranal Prolonged vasospastic reactions Details Naratriptan Methylergonovine Methergine Prolonged vasospastic reactions Details

Major

Naratriptan Acetaminophen And Codeine Capital® & Codeine Explained Increased risk of serotonin syndrome Details Naratriptan Amitriptyline Elavil Explained Increased risk of serotonin syndrome (hypertension, hyperthermia, myoclonus, mental status changes) Details Naratriptan Sertraline Explained An increased risk of serotonin syndrome Details Naratriptan Buprenorphine Belbuca Explained An increased risk of serotonin syndrome Details Naratriptan Butorphanol Injection Butorphic Increased risk of serotonin syndrome Details Naratriptan Butorphanol Nasal Spray Stadol® NS Increased risk of serotonin syndrome Details Naratriptan Dolasetron Anzemet Increased risk of serotonin syndrome Details Naratriptan Dolasetron Injection Anzemet Increased risk of serotonin syndrome Details Naratriptan Fentanyl Transdermal Patch Duragesic® Increased risk of serotonin syndrome Details Naratriptan Granisetron Transdermal Patch Sancuso Increased risk of serotonin syndrome Details Naratriptan Granisetron Injection Granisol Increased risk of serotonin syndrome Details Naratriptan Hydromorphone Injection Dilaudid Increased risk of serotonin syndrome Details Naratriptan Hydromorphone Rectal available generically Increased risk of serotonin syndrome Details Naratriptan Linezolid Injection Zyvox An increased risk of serotonin syndrome Details Naratriptan Lithium Carbonate Lithobid Increased risk of serotonin syndrome Details Naratriptan Morphine Injection Astramorph® PF Increased risk of serotonin syndrome Details Naratriptan Nalbuphine Injection Nubain® Increased risk of serotonin syndrome Details Naratriptan Palonosetron Injection Aloxi® An increased risk of serotonin syndrome Details

Check another drug

Still have questions about this combination?

Every question gets a real answer from a licensed pharmacist — free, and usually within a day.

Ask the pharmacist
Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.