Procainamide

59 interactions 5 explained in plain English

Also sold as: Procan® Procanbid® Procapan® Pronestyl®

About Procainamide

Procainamide is used to treat abnormal heart rhythms. It works by making your heart more resistant to abnormal activity. Read the full Procainamide drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jun 30, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Amitriptyline Granisetron Transdermal Patch Histrelin Implant Alfuzosin Lenvatinib Moxifloxacin

58 Major 1 Moderate

All (59) Major (58) Moderate (1)

Major

Procainamide Amitriptyline Elavil Explained An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Procainamide Sertraline Explained An increased risk of QT interval prolongation Details Procainamide Buprenorphine Belbuca Explained An increased risk of QT interval prolongation Details Procainamide Relugolix Orgovyx Explained Increased risk of QT interval prolongation Details Procainamide Amisulpride Injection Barhemsys Increased risk of serious ventricular arrhythmias such as torsades de pointes Details Procainamide Arsenic Trioxide Trisenox An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Procainamide Aripiprazole Injection Abilify An increased risk of QT interval prolongation Details Procainamide Arsenic Trioxide Injection Trisenox An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Procainamide Asenapine Transdermal Patch Secuado Increased risk of QT interval prolongation Details Procainamide Azithromycin AzaSite An increased risk of QT interval prolongation and serious cardiac events Details Procainamide Alfuzosin UroXatral An increased risk of QT interval prolongation Details Procainamide Anagrelide Agrylin Increased risk of QT interval prolongation Details Procainamide Chloroquine Aralen® An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Procainamide Dasatinib Phyrago An increased risk of QT interval prolongation Details Procainamide Degarelix Injection Firmagon Increased risk of QT interval prolongation Details Procainamide Deutetrabenazine Austedo An increased risk of QT interval prolongation Details Procainamide Disopyramide Norpace An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Procainamide Dofetilide Tikosyn An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Procainamide Dolasetron Anzemet Cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Procainamide Dolasetron Injection Anzemet Cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Procainamide Encorafenib Braftovi Increased risk of QT interval prolongation Details Procainamide Entrectinib Rozlytrek An increased risk of QT interval prolongation Details Procainamide Flecainide Tambocor® An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Procainamide Foscarnet Injection Foscavir An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Procainamide Fostemsavir Rukobia Increased risk of torsade de pointes Details Procainamide Gatifloxacin Ophthalmic Zymar® An increased risk of QT interval prolongation Details Procainamide Gemifloxacin Factive An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Procainamide Glasdegib Daurismo Increased risk of QT interval prolongation Details Procainamide Goserelin Implant Zoladex Increased risk of QT interval prolongation Details Procainamide Granisetron Transdermal Patch Sancuso An increased risk of QT interval prolongation Details Procainamide Granisetron Injection Granisol An increased risk of QT interval prolongation Details Procainamide Histrelin Implant Supprelin Increased risk of QT interval prolongation Details Procainamide Hydroxychloroquine Plaquenil Increased risk of QT interval prolongation Details Procainamide Inotuzumab Ozogamicin Injection Besponsa Increased risk of QT interval prolongation Details Procainamide Isradipine DynaCirc® An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Procainamide Ivabradine Corlanor Increased risk of QT prolongation Details Procainamide Ketoconazole Topical Extina® Foam Increased risk of QT interval prolongation Details Procainamide Lacosamide Injection Motpoly An increased risk of AV block, bradycardia, and ventricular tachyarrhythmia Details Procainamide Lefamulin Xenleta Increased risk of QT interval prolongation Details Procainamide Lenvatinib Lenvima Increased risk of QT-interval prolongation Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.