Procainamide

59 interactions 5 explained in plain English
Also sold as: Procan® Procanbid® Procapan® Pronestyl®
About Procainamide

Procainamide is used to treat abnormal heart rhythms. It works by making your heart more resistant to abnormal activity. Read the full Procainamide drug information page →

Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jun 30, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Amitriptyline Granisetron Transdermal Patch Histrelin Implant Alfuzosin Lenvatinib Moxifloxacin
58 Major 1 Moderate
All (59) Major (58) Moderate (1)

Major

Procainamide Levofloxacin Levaquin Increased risk of QT interval prolongation Details Procainamide Levofloxacin Injection Levaquin Increased risk of QT interval prolongation Details Procainamide Loperamide Diamode An increased risk of QT interval prolongation, which may increase risk of cardiotoxicity (torsade de pointes, cardiac arrest) Details Procainamide Mefloquine Lariam® An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Procainamide Metronidazole Flagyl An increased risk of QT interval prolongation Details Procainamide Metronidazole Injection Flagyl An increased risk of QT interval prolongation Details Procainamide Metronidazole Topical MetroCream® An increased risk of QT interval prolongation Details Procainamide Metronidazole Vaginal MetroGel® Vaginal An increased risk of QT interval prolongation Details Procainamide Moxifloxacin Avelox Increased risk of QT interval prolongation Details Procainamide Moxifloxacin Injection Avelox Increased risk of QT interval prolongation Details Procainamide Moxifloxacin Ophthalmic Moxeza® Increased risk of QT interval prolongation Details Procainamide Octreotide Bynfezia An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Procainamide Octreotide Injection Bynfezia An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Procainamide Ofloxacin Floxin® An increased risk of QT interval prolongation Details Procainamide Ofloxacin Ophthalmic Ocuflox An increased risk of QT interval prolongation Details Procainamide Ofloxacin Otic Floxin® Otic An increased risk of QT interval prolongation Details Procainamide Olodaterol Oral Inhalation Striverdi An increased risk of QT interval prolongation and an increased risk of ventricular arrhythmias Details Procainamide Oxaliplatin Injection Eloxatin® Increased risk of QT-interval prolongation Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.