Promethazine
96 interactions 6 explained in plain English
Also sold as:
Phenadoz
Phenergan
Promethegan
Medically reviewed by
Dr. Brian Staiger, PharmD, BCPS
· Updated Jul 4, 2026
· Editorial policy
· Data sources
Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →
Most serious with:
Butorphanol Nasal Spray
Amitriptyline
Alfuzosin
Felbamate
Butorphanol Injection
Diphenhydramine Topical
Major
Promethazine Acetaminophen And Codeine Capital® & Codeine Explained Increased risk of paralytic ileus and an increased risk of respiratory and CNS depression Details Promethazine Amitriptyline Elavil Explained An increased risk of QT interval prolongation and an increased risk of paralytic ileus Details Promethazine Sertraline Explained An increased risk of QT interval prolongation Details Promethazine Buprenorphine Belbuca Explained An increased risk of QT interval prolongation, an increased risk of CNS and respiratory depression and an increased risk of paraly... Details Promethazine Relugolix Orgovyx Explained Increased risk of QT interval prolongation Details Promethazine Trospium / Xanomeline Cobenfy Explained Increased risk of urinary retention and/or severe constipation leading to paralytic ileus Details Promethazine Amisulpride Injection Barhemsys Increased risk of serious ventricular arrhythmias such as torsades de pointes Details Promethazine Arsenic Trioxide Trisenox An increased risk of QT interval prolongation Details Promethazine Aripiprazole Injection Abilify Increased risk of respiratory, profound sedation, hypotension, coma, death and an increased risk of QT prolongation Details Promethazine Arsenic Trioxide Injection Trisenox An increased risk of QT interval prolongation Details Promethazine Asenapine Transdermal Patch Secuado An increased risk of QT interval prolongation and an increased risk of CNS depression Details Promethazine Azithromycin AzaSite An increased risk of QT interval prolongation Details Promethazine Cabergoline Dostinex® Reduced efficacy of cabergoline and reduced efficacy of dopamine-2 receptors Details Promethazine Aclidinium Oral Inhalation Tudorza Increased risk of urinary retention and/or severe constipation leading to paralytic ileus Details Promethazine Alfuzosin UroXatral An increased risk of QT interval prolongation Details Promethazine Anagrelide Agrylin Increased risk of QT interval prolongation Details Promethazine Atropine Ophthalmic Atropine Care 1% Increased risk of urinary retention and/or severe constipation leading to paralytic ileus Details Promethazine Bedaquiline Sirturo An increased risk of QT interval prolongation Details Promethazine Butorphanol Injection Butorphic Increased risk of respiratory and CNS depression Details Promethazine Butorphanol Nasal Spray Stadol® NS Increased risk of respiratory and CNS depression Details Promethazine Cetirizine Injection Aller-Tec Increased risk of CNS depression Details Promethazine Cetirizine Ophthalmic Zerviate Increased risk of CNS depression Details Promethazine Cyclopentolate Ophthalmic Akpentolate® Increased risk of urinary retention and/or severe constipation leading to paralytic ileus Details Promethazine Dasatinib Phyrago An increased risk of QT interval prolongation Details Promethazine Degarelix Injection Firmagon Increased risk of QT interval prolongation Details Promethazine Deutetrabenazine Austedo An increased risk of QT interval prolongation Details Promethazine Diazepam Nasal Spray Valtoco Increased risk of CNS depression Details Promethazine Diazepam Rectal Diastat Increased risk of CNS depression Details Promethazine Diphenhydramine Injection Banophen Increased risk of paralytic ileus and an increased risk of respiratory, profound sedation, hypotension, coma and death Details Promethazine Diphenhydramine Topical Afterbite with Antihistamine Increased risk of paralytic ileus and an increased risk of respiratory, profound sedation, hypotension, coma and death Details Promethazine Disopyramide Norpace An increased risk of QT interval prolongation Details Promethazine Dofetilide Tikosyn An increased risk of QT interval prolongation Details Promethazine Dolasetron Anzemet An increased risk of QT interval prolongation Details Promethazine Dolasetron Injection Anzemet An increased risk of QT interval prolongation Details Promethazine Encorafenib Braftovi Increased risk of QT interval prolongation Details Promethazine Entrectinib Rozlytrek An increased risk of QT interval prolongation Details Promethazine Eribulin Injection Halaven An increased risk of QT interval prolongation Details Promethazine Esketamine Nasal Spray Spravato Increased risk of sedation Details Promethazine Famotidine Calmicid An increased risk of QT interval prolongation Details Promethazine Famotidine Injection Calmicid An increased risk of QT interval prolongation DetailsNo interactions on this page match that filter — try the next page or clear the filter.
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