Drug & supplement interaction

Arsenic + Sevelamer

Sevelamer brand name: Renagel.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Arsenic and Sevelamer in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the label for Sevelamer states a food rule worth keeping to, and the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Arsenic and Sevelamer

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Sevelamer and Arsenic in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Arsenic safety at a glance

Arsenic overall Avoid Inorganic arsenic is a known poison and carcinogen and should not be taken as a supplement.
Pregnancy Likely Safe When organic arsenic is consumed in food amounts. Organic forms of arsenic found in a normal diet have not been linked to toxicity. Read the full pregnancy detail
Breastfeeding Likely Safe When organic arsenic is consumed in food amounts. Organic forms of arsenic found in a normal diet have not been linked to toxicity. Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Sevelamer and Arsenic? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Sevelamer

Interactions in our licensed database are recorded against drug classes, not just single drug names. Sevelamer is filed under 2 classifications — including oral drugs. Arsenic has documented interactions with 1 drug class — the most serious being qt interval-prolonging drugs (major) — and none of Sevelamer’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Arsenic Does Interact With Other Medications

Arsenic has 161 major, known drug interactions in our database — Sevelamer isn’t one of them. If you take anything else, check it against the full list below.

Major 161 No known interaction 2,669 (incl. Sevelamer)
Taking anything else?

Check Another of Your Medications Against Arsenic

Covers the 2,830 medications we’ve checked against Arsenic. Pick one to open its full report.

What to actually watch for

No Interaction Found — But Data Suggests Arsenic and Sevelamer May Share Several of the Same Side Effects

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do. One of them is worth acting on rather than waiting out — marked below.

  • Bleeding or bruising Worth acting on Additional detail

    Arsenic

    “Orally, organic forms of arsenic found in the diet are well tolerated, with no clear links to adverse effects. However, high doses or chronic intake of inorganic arsenic is associated with potentially serious adverse effects.

    Serious Adverse Effects (Rare):

    Orally: With the acute ingestion of inorganic arsenic, anemia, arrhythmias, bruising, gastrointestinal irritation or damage, hepatotoxicity, and peripheral neurop…”

    Arsenic · Natural Medicines adverse-effect record, reported in anemia.

    “Orally, doses of inorganic arsenic 1 mg/kg daily can cause hematopoietic depression including anemia, arrhythmias, and blood vessel damage leading to bruising. Acute ingestion of inorganic arsenic 10 mg/kg daily or more causes vasodilation and myocardial depression leading to myocardial injury, shock, and circulatory failure (17,7135,16313,16316,102892).”

    Arsenic · Natural Medicines adverse-effect record, reported in anemia.

    6 sources cited
    1. 7135. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc. Washington, DC: National Academy Press, 2002.
    2. 16309. Uthus EO, Seaborn CD. Deliberations and evaluations of the approaches, endpoints and paradigms for dietary recommendations of the other trace elements. J Nutr 1996;126:2452s-2459s. PubMed
    3. 16312. US Department of Health and Human Services. Agency for Toxic Substances and Disease Registry. Public Health Statement: Arsenic. August 2007. Available at: www.atsdr.cdc.gov/toxprofiles/tp2-c1-b.pdf (Accessed 14 April 2008).
    4. 17. Ellenhorn MJ, et al. Ellenhorn's Medical Toxicology: Diagnoses and Treatment of Human Poisoning. 2nd ed. Baltimore, MD: Williams & Wilkins, 1997.
    5. 16313. Eckhert CD. Other trace elements. In: Shils ME, Shike M, Ross AC, et al (eds). Modern Nutrition in Health and Disease. 10th ed. Philadelphia, PA: Lippincott Williams & Wilkins, 2006.
    6. 16316. Ratnaike RN. Acute and chronic arsenic toxicity. Postgrad Med J 2003;79:391-6. PubMed

    Sevelamer

    Listed in the ADVERSE REACTIONS section of the FDA label for Sevelamer. Read the label on DailyMed ›

  • Bloating or gas / Stomach upset / Stomach pain Additional detail

    Arsenic

    “Orally, acute ingestion of inorganic arsenic 5 mg, or sometimes less, can cause vomiting, diarrhea, stomach cramps, and flatulence. These effects usually resolve in about 12 hours without treatment. Doses of inorganic arsenic 1 mg/kg daily can cause gastrointestinal irritation.”

    Arsenic · Natural Medicines adverse-effect record, reported in anorexia.

    6 sources cited
    1. 16316. Ratnaike RN. Acute and chronic arsenic toxicity. Postgrad Med J 2003;79:391-6. PubMed
    2. 102893. Dani SU. A curious association of chronic homeopathic arsenic ingestion with nonspecific symptoms in a Swiss teenager. Swiss Med Wkly 2019;149:w20071. PubMed
    3. 7135. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc. Washington, DC: National Academy Press, 2002.
    4. 16309. Uthus EO, Seaborn CD. Deliberations and evaluations of the approaches, endpoints and paradigms for dietary recommendations of the other trace elements. J Nutr 1996;126:2452s-2459s. PubMed
    5. 16312. US Department of Health and Human Services. Agency for Toxic Substances and Disease Registry. Public Health Statement: Arsenic. August 2007. Available at: www.atsdr.cdc.gov/toxprofiles/tp2-c1-b.pdf (Accessed 14 April 2008).
    6. 17. Ellenhorn MJ, et al. Ellenhorn's Medical Toxicology: Diagnoses and Treatment of Human Poisoning. 2nd ed. Baltimore, MD: Williams & Wilkins, 1997.

    Sevelamer

    Listed in the ADVERSE REACTIONS section of the FDA label for Sevelamer. Read the label on DailyMed ›

  • Diarrhea / Vomiting Additional detail

    Arsenic

    “Orally, high doses of inorganic arsenic can cause death. In one case, a 24-year-old female receiving a combination of arsenic trioxide, realgar, and mung bean flour from an illegal medical provider died within days of taking the compounded preparation. Laboratory analysis revealed the amount of arsenic consumed to be around 1.1 grams on day 1 and 0.9 grams on day 4.”

    Arsenic · Natural Medicines adverse-effect record, reported in diarrhea.

    2 sources cited
    1. 102892. Lu P, Ma JQ, Li F, et al. A fatal case of acute arsenic poisoning. J Forensic Sci 2019;64(4):1271-3. PubMed
    2. 106541. Liu R, Tabuchi T, Kitamura T, Miyashiro I, Sobue T. Long-term observational study on 6223 survivors of arsenic poisoning due to contaminated milk powder during infancy. Cancer Sci 2020;111(10):3873-3880. PubMed

    Sevelamer

    Listed in the ADVERSE REACTIONS section of the FDA label for Sevelamer. Read the label on DailyMed ›

Reported for Arsenic but not commonly for Sevelamer: trouble concentrating, numbness or tingling, kidney problems and liver problems.

Effects for Sevelamer come from the ADVERSE REACTIONS section of its FDA label; effects for Arsenic come from the Natural Medicines adverse-effect record, quoted above. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

Special populations

Arsenic in Pregnancy & Breastfeeding

Pregnancy And Lactation Likely Safe

When organic arsenic is consumed in food amounts. Organic forms of arsenic found in a normal diet have not been linked to toxicity.

Pregnancy And Lactation Likely Unsafe

When inorganic arsenic is taken orally, especially when used long-term or in high doses. While exposure to inorganic arsenic in drinking water does not seem to increase the risk of neural tube defects, it has been associated with an increased risk for spontaneous abortion, stillbirth, and neonatal mortality. Exposure to inorganic arsenic in drinking water and other sources while pregnant has also been linked to changes in birth weight, length, and head circumference, with one study showing that higher maternal blood arsenic levels are associated with 44% greater odds of delivering a small for gestational age infant and 103% greater odds of delivering a large for gestational age infant. Avoid arsenic supplements and water contaminated with arsenic during pregnancy or lactation.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

How to take them

Some Sevelamer Products Have a Food Rule — Arsenic Should Not Break It

At least one FDA label for a product containing Sevelamer says to take it with food. If you take Arsenic on an empty stomach out of habit, keep them separate — and take Sevelamer with a meal where the label says to.

This may not be true of your version. Food instructions belong to the product, not the ingredient: two Sevelamer products can carry different directions, and extended-release forms often differ from immediate-release ones. The label we read is quoted below — check the directions on your own box or bottle, or ask your pharmacist, for how to take the exact product you were given.

2 DOSAGE AND ADMINISTRATION Starting dose of Renvela is 0.8 or 1.6 grams administered orally three times per day with meals based on serum phosphorus levels for adult patients and based on body surface area (BSA) category for pediatric patients.

From the Dosage and Administration section of the FDA label we read for Sevelamer — where that label names a specific product, the instruction is that product's. Read the label on DailyMed ›

A food rule is not an interaction — it is about how much of the medicine you absorb. The directions that came with your own product, and your pharmacist, outrank anything on this page.

Everything else you take

See Every Supplement That Interacts With Sevelamer

This page covers Arsenic only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Sevelamer page lists 18 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Coffee Charcoal (moderate), European Mandrake (moderate), Glucomannan (moderate) and Guar Gum (moderate).

By severity: 1 major · 7 moderate · 10 minor.

From our pharmacist’s overview on the Sevelamer page

“Kidney patients who take sevelamer (Renagel) to control phosphorus have a real reason to pause over this page, and activated charcoal is why. It carries the only major rating here because it can trap medicines in the gut and sharply cut the amount the body actually gets.”

Reviewed by 2 · Jul 18, 2026

Open the Sevelamer interaction page

One more smart check

Taking Arsenic as Part of a Dietary Supplement Product? Check It for Interactions

We hold 4 real supplement products containing Arsenic, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Arsenic. Even though Arsenic itself has no known interaction with Sevelamer, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Arsenic and Sevelamer Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Arsenic
Top half

#578 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Sevelamer
Steady interest

#2,407 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Arsenic reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Arsenic and Sevelamer records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Arsenic

What is Arsenic?

Arsenic
  • Homeopathic digestive complaints
  • Traditional remedy for inflammatory conditions
  • Prescription use in certain leukemias (medical, not supplement)
  • Anxiety and restlessness (homeopathic tradition)

Arsenic is a naturally occurring element that is toxic in its inorganic form, and it is not a supplement you should take to improve your health. While arsenic trioxide is a real, doctor-prescribed cancer medicine, and tiny homeopathic doses exist, there is no good reason to take arsenic on your own. Avoid arsenic-containing products and talk to a pharmacist or doctor about any concerns.

Mineral/trace element (not a plant part) · Homeopathic preparations (e.g. Arsenicum album), trace amounts in food and water

An interaction check asks whether these two react with each other — it does not ask whether Arsenic is a good idea for someone in your situation. Here is what our Arsenic record says about it on its own.

Arsenic: dosing

There is no safe or recommended supplement dose of arsenic. It is not a nutrient you need to add to your diet, and no health authority recommends taking arsenic supplements.Homeopathic products that list arsenic are usually extremely dilute, but they still have no proven benefit. The only legitimate dosed use of arsenic is the prescription medicine arsenic trioxide, which is calculated and given by cancer specialists in a hospital setting.If you are considering any product that contains arsenic, do not guess at a dose.

From our Arsenic monograph — the full record covers uses, side effects and every documented interaction.

Read the full Arsenic monograph & all interactions
Medication

About Sevelamer

What Is Sevelamer Used For?

Brand name: Renagel

Sevelamer is used to control serum phosphorus (the level of phosphorus in your blood) in people with chronic kidney disease (CKD) who are on dialysis. High phosphorus is a serious problem for dialysis patients and needs to be managed with medication and diet.

Sevelamer carbonate tablets and Renvela® (sevelamer carbonate) oral suspension are approved for adults and children 6 years of age and older. Sevelamer hydrochloride tablets are indicated for adults with CKD on dialysis; their safety and effectiveness in CKD patients not on dialysis have not been studied.

See full Sevelamer drug information
Keep checking

Other Drugs & Arsenic

Browse every other medication we’ve checked against Arsenic — both the ones with a known interaction and the ones without. Select any drug for the full detail.

161Major
0Moderate
0Minor
2,668No known interaction
161 Major 2,668 No interaction
Major

161 interactions

Showing 60 of 161 major interactions — see all 161 on the Arsenic page.

No interaction 2,668 drugs checked — show the list

We also checked Arsenic against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,668 medications checked with no known interaction — see the full Arsenic list.

See the full Arsenic interactions page
See every supplement checked against Sevelamer, ranked by severity
Evidence & sources

Arsenic References

The 35 references that drive our Arsenic monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. McEvoy GK, ed. AHFS Drug Information. Bethesda, MD: American Society of Health-System Pharmacists, 1998.
  2. Ellenhorn MJ, et al. Ellenhorn's Medical Toxicology: Diagnoses and Treatment of Human Poisoning. 2nd ed. Baltimore, MD: Williams & Wilkins, 1997.
  3. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc. Washington, DC: National Academy Press, 2002.
  4. Uthus EO, Seaborn CD. Deliberations and evaluations of the approaches, endpoints and paradigms for dietary recommendations of the other trace elements. J Nutr 1996;126:2452s-2459s. PubMed
  5. Nielsen FH. Nutritional requirements for boron, silicon, vanadium, nickel, and arsenic: current knowledge and speculation. FASEB J 1991;5:2661-7. DOI
  6. US Department of Health and Human Services. Agency for Toxic Substances and Disease Registry. Public Health Statement: Arsenic. August 2007. Available at: www.atsdr.cdc.gov/toxprofiles/tp2-c1-b.pdf (Accessed 14 April 2008).
  7. Eckhert CD. Other trace elements. In: Shils ME, Shike M, Ross AC, et al (eds). Modern Nutrition in Health and Disease. 10th ed. Philadelphia, PA: Lippincott Williams & Wilkins, 2006.
  8. Ratnaike RN. Acute and chronic arsenic toxicity. Postgrad Med J 2003;79:391-6. PubMed
  9. Wasserman GA, Liu X, Parvez F, et al. Water arsenic exposure and children's intellectual function in Araihazar, Bangladesh. Environ Health Perspect 2004;112:1329-33. PubMed
  10. Lamm SH, Ferdosi H, Dissen EK, Li J, Ahn J. A systematic review and meta-regression analysis of lung cancer risk and inorganic arsenic in drinking water. Int J Environ Res Public Health 2015;12(12):15498-515. PubMed
  11. Hsueh YM, Chen WJ, Lee CY, et al. Association of arsenic methylation capacity with developmental delays and health status in children: a prospective case-control trial. Sci Rep 2016;6:37287. PubMed
  12. Moon KA, Oberoi S, Barchowsky A, et al. A dose-response meta-analysis of chronic arsenic exposure and incident cardiovascular disease. Int J Epidemiol 2017;46(6):1924-39. PubMed
  13. Dong J, Su SY. The association between arsenic and children's intelligence: a meta-analysis. Biol Trace Elem Res 2009;129(1-3):88-93. PubMed
  14. Nong Q, Zhang Y, Guallar E, Zhong Q. Arsenic exposure and predicted 10-year atherosclerotic cardiovascular risk using the pooled cohort equations in U.S. hypertensive adults. Int J Environ Res Public Health 2016;13(11). pii: E1093. PubMed
  15. Sung TC, Huang JW, Guo HR. Association between arsenic exposure and diabetes: a meta-analysis. Biomed Res Int 2015;2015:368087. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Arsenic and Sevelamer Together: Common Questions

Is it safe to take Arsenic with Sevelamer?
We do not list a known interaction between Arsenic and Sevelamer. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Arsenic and Sevelamer have any of the same side effects?
Yes — our sources link each of them separately to 6 of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
Should I take Arsenic and Sevelamer at the same time of day?
At least one FDA label for a product containing Sevelamer says to take it with food. If you take Arsenic on an empty stomach out of habit, keep them separate and take Sevelamer with a meal where the label says to. Food instructions belong to the product rather than the ingredient — two Sevelamer products can differ — so check the directions on your own box. This is about absorption, not an interaction.
How was the Arsenic and Sevelamer combination checked?
Interactions in our licensed database are recorded against drug classes. Sevelamer is filed under 2 classifications, and Arsenic has documented interactions with 1 drug class — none of Sevelamer's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Arsenic interact with any other medications?
Yes. Arsenic has 161 documented drug interactions in our database — Sevelamer is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Sevelamer interact with any supplements?
Yes. Sevelamer has documented interactions with 18 supplements in our database — Arsenic is not one of them. The Sevelamer interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Arsenic monograph Uses, safety profile, and every drug interaction in one place Sevelamer drug information The full plain-English guide to this medication Sevelamer supplement interactions Every supplement checked against Sevelamer, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 35 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Sevelamer and Arsenic?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.