Drug & supplement interaction

Beet + Ephedrine Sulfate, Hydroxyzine, Theophylline

Ephedrine Sulfate, Hydroxyzine, Theophylline brand name: Hydroxy Compound.

Minor Interaction
Medically reviewed by · Updated September 2026
The bottom line Minor

Beet has a minor interaction with Ephedrine Sulfate, Hydroxyzine, Theophylline. Theoretically, beet might decrease the levels and clinical effects of CYP1A2 substrates.

Read the full interaction report
SeverityMinor
LikelihoodPossible
EvidenceD
What do Severity, Likelihood & Evidence mean?
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Interaction report

Beet and Ephedrine Sulfate, Hydroxyzine, Theophylline

Here is the interaction we found between these two, with the evidence behind it.

Minor

CYTOCHROME P450 1A2 (CYP1A2) SUBSTRATES

Why this applies to Ephedrine Sulfate, Hydroxyzine, Theophylline

Ephedrine Sulfate, Hydroxyzine, Theophylline falls under CYTOCHROME P450 1A2 (CYP1A2) SUBSTRATES — the group Beet interacts with.

Theoretically, beet might decrease the levels and clinical effects of CYP1A2 substrates.
In vitro research suggests that beet induces CYP1A2 enzymes.
Severity Minor Likelihood Possible Evidence D

Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

Here's the gist with this combo product, focusing on the theophylline part, since that's the ingredient your body clears using an enzyme called CYP1A2. Beet, in lab studies, seems to speed up (induce) that enzyme. In theory, that could lower your theophylline levels a bit, which might make it work less well for your breathing or asthma. The same enzyme idea applies loosely to the ephedrine and hydroxyzine pieces too.

Now, the honest part: this is only based on test-tube research, not real patients, so it's rated minor and theoretical. Eating a normal serving of beets almost certainly won't move the needle. Concentrated beetroot supplements are the bigger unknown. Since theophylline is a touchy drug with a narrow safe range, just check with your pharmacist or doctor before adding beet supplements.

Contact Dr. Brian directly if you have additional questions on this interaction
References
  1. Haron MH, Dale O, Martin K, et al. Evaluation of the Herb-Drug Interaction Potential of Commonly Used Botanicals on the US Market with Regard to PXR- and AhR-Mediated Influences on CYP3A4 and CYP1A2. J Diet Suppl 2022. PubMed

What These Ratings Mean

Every interaction above is graded three ways — here’s the key to each label.

Severity how clinically significant the interaction is
Major

Clinically significant. Avoid the combination, or use only under close professional supervision.

Moderate

Usually worth avoiding or managing — may need monitoring, a dose change, or timing apart.

Minor

Generally not serious. Be aware of it and mention it to your pharmacist.

Likelihood how strong the evidence is that the interaction actually happens in people
  • LikelyWell-controlled human studies have demonstrated the likely existence of this interaction.
  • ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
  • UnlikelyInteraction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
Evidence the quality of the studies behind the rating (graded A–D)
  • AHigh-quality meta-analysis (quantitative systematic review).
  • BCase-control study.
  • CConsensus.
  • DAnecdotal evidence.

These ratings are for information only. Never start, stop, or otherwise change your therapy before speaking with your provider.

Keep it in perspective

Beet Also Interacts With Other Medications

Beet has 643 moderate, 217 minor known drug interactions in our database — the Ephedrine Sulfate, Hydroxyzine, Theophylline one above is one of them. If you take anything else, check it against the full list below.

Moderate 643 Minor 217 No known interaction 1,970 (incl. Ephedrine Sulfate, Hydroxyzine, Theophylline)
Taking anything else?

Check Another of Your Medications Against Beet

Covers the 2,830 medications we’ve checked against Beet. Pick one to open its full report.

Everything else you take

See Every Supplement That Interacts With Ephedrine Sulfate, Hydroxyzine, Theophylline

This page covers Beet only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Ephedrine Sulfate, Hydroxyzine, Theophylline page lists 199 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Ephedra (major), Henbane (major), Peyote (major) and Rauvolfia Vomitoria (major).

By severity: 7 major · 153 moderate · 39 minor.

From our pharmacist’s overview on the Ephedrine Sulfate, Hydroxyzine, Theophylline page

“Someone taking Hydroxy Compound (ephedrine sulfate, hydroxyzine, and theophylline) for breathing problems is juggling three drugs at once, and the supplement list shows it: 199 interacting ingredients, seven of them rated major, and this page deserves genuine seriousness. The sharpest risks come from stimulant botanicals, ephedra above…”

Reviewed by 2 · Jul 18, 2026

Open the Ephedrine Sulfate, Hydroxyzine, Theophylline interaction page

One more smart check

Taking Beet as Part of a Dietary Supplement Product? Check It for Interactions

We hold 4,785 real supplement products containing Beet, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Beet. Your product may carry other ingredients that interact with Ephedrine Sulfate, Hydroxyzine, Theophylline too, on top of Beet — and those would not show on this page. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Beet and Ephedrine Sulfate, Hydroxyzine, Theophylline Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Beet
Top 5%

#38 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Ephedrine Sulfate, Hydroxyzine, Theophylline
Top 25%

#355 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Supplement

About Beet

What is Beet?

Beet
  • High blood pressure
  • Exercise and athletic performance
  • Heart and circulation support
  • General antioxidant/anti-inflammatory support
  • Liver and digestive support

Beet, especially beetroot juice, is a nitrate-rich food that may modestly lower blood pressure and slightly improve exercise performance in some people. It is generally safe as a food, but supplement effects are modest and not a substitute for prescribed treatment, so talk with your pharmacist or doctor before relying on it.

Read the full Beet monograph & all interactions
Keep checking

Other Drugs & Beet

Browse every other medication we’ve checked against Beet — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
643Moderate
217Minor
1,969No known interaction
643 Moderate 217 Minor 1,969 No interaction
Moderate

643 interactions

Showing 60 of 643 moderate interactions — see all 643 on the Beet page.

Minor

217 interactions

Showing 60 of 217 minor interactions — see all 217 on the Beet page.

No interaction 1,969 drugs checked — show the list

We also checked Beet against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 1,969 medications checked with no known interaction — see the full Beet list.

See the full Beet interactions page
See every supplement checked against Ephedrine Sulfate, Hydroxyzine, Theophylline, ranked by severity
Sources

Sources & How We Checked

Interaction details are evidence-graded and sourced from the Natural Medicines database. The medication overview comes from MedlinePlus.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Beet monograph › Uses, safety, and every drug interaction in one place Ephedrine Sulfate, Hydroxyzine, Theophylline supplement interactions › Every supplement checked against Ephedrine Sulfate, Hydroxyzine, Theophylline, ranked by severity Supplement interaction checker › Check any supplement or product against your medications Browse medications A–Z › Every drug we've checked against herbs & supplements Ask a pharmacist › Free, personal answer from our licensed team
Pharmacist Counseling Corner

Taking Beet and Ephedrine Sulfate, Hydroxyzine, Theophylline Together: Common Questions

Can you take Beet with Ephedrine Sulfate, Hydroxyzine, Theophylline?
There is only a minor interaction, which is usually not serious. Read the full details on this page and confirm with your pharmacist before combining them.
How serious is the Beet and Ephedrine Sulfate, Hydroxyzine, Theophylline interaction?
We rate it Minor. This interaction is generally not clinically significant, but it remains worth noting and discussing with your pharmacist.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Still Have a Question About Ephedrine Sulfate, Hydroxyzine, Theophylline and Beet?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.