Medication interaction hub

What Supplements Interact with Ephedrine Sulfate, Hydroxyzine, Theophylline?

Ephedrine Sulfate, Hydroxyzine, Theophylline brand name: Hydroxy Compound. Every interaction below applies to the brands too.

199 Interactions 7 Major 153 Moderate 39 Minor
Curated & coded by · Clinical Pharmacist · Updated September 18, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Ephedrine Sulfate, Hydroxyzine, Theophylline? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Ephedrine Sulfate, Hydroxyzine, Theophylline against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

Someone taking Hydroxy Compound (ephedrine sulfate, hydroxyzine, and theophylline) for breathing problems is juggling three drugs at once, and the supplement list shows it: 199 interacting ingredients, seven of them rated major, and this page deserves genuine seriousness. The sharpest risks come from stimulant botanicals, ephedra above all, that stack onto ephedrine's push on heart rate and blood pressure, and from anticholinergic herbs that deepen hydroxyzine's drying, sedating effects. Even ordinary caffeine adds to the stimulant load.

Theophylline brings a quieter issue. The largest group, 79 ingredients, is handled by the same liver enzyme (CYP1A2) that clears it, so they can change how much theophylline stays in the blood. Most of the 153 moderate and 39 minor entries echo these caffeine and enzyme themes. Activated charcoal is different, rated major because it soaks up oral medication in the gut, so keep any charcoal product well spaced from doses.

— , Clinical Pharmacist · July 18, 2026

Major 7 Moderate 153 Minor 39 No known interaction 1,253

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Most Viewed Ingredient Interactions

Ephedrine Sulfate, Hydroxyzine, Theophylline: Top Interactions at a Glance

The Ephedrine Sulfate, Hydroxyzine, Theophylline supplement & herbal interactions people checked most in the last 24 hours, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 199 interacting ingredients — plus 1,253 more checked with no known interaction. See the complete ranked list.

Start here

The Most-Checked Ephedrine Sulfate, Hydroxyzine, Theophylline Combinations Today

The Ephedrine Sulfate, Hydroxyzine, Theophylline + supplement pages people viewed most in the last 24 hours (resets at midnight). Open any card for the full report.

Moderate Likelihood Probable Coffee + Ephedrine Sulfate, Hydroxyzine, Theophyllinei

Theoretically, concomitant use might increase stimulant adverse effects.

Read the full interaction Minor Likelihood Possible German Chamomile + Ephedrine Sulfate, Hydroxyzine, Theophyllinei

Theoretically, German chamomile might inhibit CYP1A2 and increase levels of drugs metabolized by these enzymes.

Read the full interaction Moderate Likelihood Possible Feverfew + Ephedrine Sulfate, Hydroxyzine, Theophyllinei

Theoretically, feverfew might increase levels of drugs metabolized by CYP1A2.

Read the full interaction Moderate Likelihood Possible Calamus + Ephedrine Sulfate, Hydroxyzine, Theophyllinei

Theoretically, concurrent use of anticholinergic drugs and calamus might decrease the effectiveness of the anticholinergic drug.

Read the full interaction Moderate Likelihood Possible Eucalyptus + Ephedrine Sulfate, Hydroxyzine, Theophyllinei

Theoretically, eucalyptus might increase the levels of CYP1A2 substrates.

Read the full interaction Major Likelihood Probable Activated Charcoal + Ephedrine Sulfate, Hydroxyzine, Theophyllinei

Activated charcoal reduces systemic exposure to many drugs, including those that undergo enterohepatic recirculation, regardless of the route of administration.

Read the full interaction
The complete list

Every Supplement Checked Against Ephedrine Sulfate, Hydroxyzine, Theophylline

All 1,452 ingredients in our database, ranked by severity — 199 with a Ephedrine Sulfate, Hydroxyzine, Theophylline interaction on file and 1,253 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Ephedrine Sulfate, Hydroxyzine, Theophylline?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Coffee with Ephedrine Sulfate, Hydroxyzine, Theophylline?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use might increase stimulant adverse effects.

Full Coffee + Ephedrine Sulfate, Hydroxyzine, Theophylline answer

Can you take German Chamomile with Ephedrine Sulfate, Hydroxyzine, Theophylline?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, German chamomile might inhibit CYP1A2 and increase levels of drugs metabolized by these enzymes.

Full German Chamomile + Ephedrine Sulfate, Hydroxyzine, Theophylline answer

Can you take Feverfew with Ephedrine Sulfate, Hydroxyzine, Theophylline?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, feverfew might increase levels of drugs metabolized by CYP1A2.

Full Feverfew + Ephedrine Sulfate, Hydroxyzine, Theophylline answer

Can you take Calamus with Ephedrine Sulfate, Hydroxyzine, Theophylline?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concurrent use of anticholinergic drugs and calamus might decrease the effectiveness of the anticholinergic drug.

Full Calamus + Ephedrine Sulfate, Hydroxyzine, Theophylline answer

Can you take Eucalyptus with Ephedrine Sulfate, Hydroxyzine, Theophylline?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, eucalyptus might increase the levels of CYP1A2 substrates.

Full Eucalyptus + Ephedrine Sulfate, Hydroxyzine, Theophylline answer

Can you take European Mandrake with Ephedrine Sulfate, Hydroxyzine, Theophylline?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concurrent use might increase absorption of some drugs because of inhibited gastrointestinal (GI) motility caused by European...

Full European Mandrake + Ephedrine Sulfate, Hydroxyzine, Theophylline answer

Can you take Evodia with Ephedrine Sulfate, Hydroxyzine, Theophylline?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Evodia might reduce the levels and clinical effects of CYP1A2 substrates through induction of CYP1A2.

Full Evodia + Ephedrine Sulfate, Hydroxyzine, Theophylline answer

Can you take Fever Bark with Ephedrine Sulfate, Hydroxyzine, Theophylline?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, fever bark might increase or decrease the effects of stimulant drugs.

Full Fever Bark + Ephedrine Sulfate, Hydroxyzine, Theophylline answer

Can you take Glucomannan with Ephedrine Sulfate, Hydroxyzine, Theophylline?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, glucomannan may decrease absorption of drugs taken orally.

Full Glucomannan + Ephedrine Sulfate, Hydroxyzine, Theophylline answer

Can you take Grapefruit with Ephedrine Sulfate, Hydroxyzine, Theophylline?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Grapefruit juice can decrease blood levels of theophylline, potentially decreasing the effectiveness of theophylline.

Full Grapefruit + Ephedrine Sulfate, Hydroxyzine, Theophylline answer

Can you take Green Coffee with Ephedrine Sulfate, Hydroxyzine, Theophylline?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use might increase stimulant adverse effects.

Full Green Coffee + Ephedrine Sulfate, Hydroxyzine, Theophylline answer

Can you take Green Tea with Ephedrine Sulfate, Hydroxyzine, Theophylline?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use might increase stimulant adverse effects.

Full Green Tea + Ephedrine Sulfate, Hydroxyzine, Theophylline answer

Can you take Guarana with Ephedrine Sulfate, Hydroxyzine, Theophylline?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, guarana might increase the levels and adverse effects of theophylline.

Full Guarana + Ephedrine Sulfate, Hydroxyzine, Theophylline answer

Can you take Ilex Guayusa with Ephedrine Sulfate, Hydroxyzine, Theophylline?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use might increase stimulant adverse effects.

Full Ilex Guayusa + Ephedrine Sulfate, Hydroxyzine, Theophylline answer

Can you take Ipriflavone with Ephedrine Sulfate, Hydroxyzine, Theophylline?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Concomitant use of theophylline and ipriflavone can increase serum theophylline levels.

Full Ipriflavone + Ephedrine Sulfate, Hydroxyzine, Theophylline answer

Can you take Lithium with Ephedrine Sulfate, Hydroxyzine, Theophylline?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking lithium supplements with methylxanthines might decrease lithium levels.

Full Lithium + Ephedrine Sulfate, Hydroxyzine, Theophylline answer

Can you take Masterwort with Ephedrine Sulfate, Hydroxyzine, Theophylline?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. The use of masterwort in conjunction with photosensitizing drugs is contraindicated due to the potential for additive photosensitizing effec...

Full Masterwort + Ephedrine Sulfate, Hydroxyzine, Theophylline answer

Can you take Melatonin with Ephedrine Sulfate, Hydroxyzine, Theophylline?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, melatonin might increase levels of drugs metabolized by CYP1A2.

Full Melatonin + Ephedrine Sulfate, Hydroxyzine, Theophylline answer

Can you take Oolong Tea with Ephedrine Sulfate, Hydroxyzine, Theophylline?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use might increase stimulant adverse effects.

Full Oolong Tea + Ephedrine Sulfate, Hydroxyzine, Theophylline answer

Can you take Psilocybin with Ephedrine Sulfate, Hydroxyzine, Theophylline?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of psilocybin with stimulant drugs might increase stimulant adverse effects.

Full Psilocybin + Ephedrine Sulfate, Hydroxyzine, Theophylline answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Ephedrine Sulfate, Hydroxyzine, Theophylline is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Ephedrine Sulfate, Hydroxyzine, Theophylline, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Ephedrine Sulfate, Hydroxyzine, Theophylline sits in 10 interaction categories. Open any one to see what the group means:

Cytochrome P450 1A2 (Cyp1A2) Substrates 79 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

79 of the supplement ingredients on this page reach Ephedrine Sulfate, Hydroxyzine, Theophylline through this category.

Stimulant Drugs 44 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

44 of the supplement ingredients on this page reach Ephedrine Sulfate, Hydroxyzine, Theophylline through this category.

Anticholinergic Drugs 30 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

30 of the supplement ingredients on this page reach Ephedrine Sulfate, Hydroxyzine, Theophylline through this category.

Theophylline 27 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

27 of the supplement ingredients on this page reach Ephedrine Sulfate, Hydroxyzine, Theophylline through this category.

Photosensitizing Drugs 20 ingredients

Medications that make skin more sun-sensitive. Supplements with the same property can compound it.

20 of the supplement ingredients on this page reach Ephedrine Sulfate, Hydroxyzine, Theophylline through this category.

Oral Drugs 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Ephedrine Sulfate, Hydroxyzine, Theophylline through this category.

Seizure Threshold Lowering Drugs 6 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

6 of the supplement ingredients on this page reach Ephedrine Sulfate, Hydroxyzine, Theophylline through this category.

Methylxanthines 5 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

5 of the supplement ingredients on this page reach Ephedrine Sulfate, Hydroxyzine, Theophylline through this category.

Alpha-Adrenergic Agonists 1 ingredient

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

1 of the supplement ingredient on this page reaches Ephedrine Sulfate, Hydroxyzine, Theophylline through this category.

Cytochrome P450 1A2 (Cyp1A2) Substrates 1 ingredient

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

1 of the supplement ingredient on this page reaches Ephedrine Sulfate, Hydroxyzine, Theophylline through this category.

Related: does Ephedrine Sulfate, Hydroxyzine, Theophylline deplete any nutrients?

Ephedrine Sulfate, Hydroxyzine, Theophylline has 1 reported nutrient association in the research literature — see the Ephedrine Sulfate, Hydroxyzine, Theophylline nutrient depletion report.

Check a real product

Take a Supplement Product? Check the Whole Bottle Against Ephedrine Sulfate, Hydroxyzine, Theophylline

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Ephedrine Sulfate, Hydroxyzine, Theophylline.

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Pharmacist Counseling Corner

Ephedrine Sulfate, Hydroxyzine, Theophylline & Supplements: Common Questions

What supplements interact with Ephedrine Sulfate, Hydroxyzine, Theophylline?
Our database currently documents 199 ingredients with a known Ephedrine Sulfate, Hydroxyzine, Theophylline interaction (7 major, 153 moderate, 39 minor). The practical move: scan the major group first, then look up the exact supplements you take rather than reading all 199. The highest-ranked right now: Activated Charcoal, Ephedra, Henbane.
Which Ephedrine Sulfate, Hydroxyzine, Theophylline supplement interactions are the most serious?
Focus on the major group: Activated Charcoal, Ephedra, Henbane, Peyote and Rauvolfia Vomitoria, among others. A major rating means the combination can be clinically significant, not that harm is guaranteed — but it's exactly the kind of thing to run past your pharmacist before your next dose, not after. Jump to the ranked list.
Can I take vitamins or supplements while on Ephedrine Sulfate, Hydroxyzine, Theophylline?
Plenty of supplements coexist fine with Ephedrine Sulfate, Hydroxyzine, Theophylline; a shorter list does not. Rather than memorizing it, check the specific ingredients on your labels — the ranked list above covers every one we've checked, and multi-ingredient products can be checked label-by-label with our scanner. Try the label scanner or the interaction checker.
Do brands like Hydroxy Compound have the same supplement interactions as Ephedrine Sulfate, Hydroxyzine, Theophylline?
Yes — Hydroxy Compound all contain Ephedrine Sulfate, Hydroxyzine, Theophylline, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
Does Ephedrine Sulfate, Hydroxyzine, Theophylline deplete any vitamins or nutrients?
It might — Ephedrine Sulfate, Hydroxyzine, Theophylline has 1 reported nutrient-depletion association in the research literature, which is a different question from interactions: instead of a supplement changing the drug, the drug may lower a nutrient over time. See the Ephedrine Sulfate, Hydroxyzine, Theophylline nutrient depletion report for the specifics and what to discuss with your pharmacist.
What about Ephedrine Sulfate, Hydroxyzine, Theophylline and my other medications?
This page covers Ephedrine Sulfate, Hydroxyzine, Theophylline against supplements and herbal ingredients. Checking Ephedrine Sulfate, Hydroxyzine, Theophylline against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 18, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.