Medication interaction hub

What Supplements Interact with Theophylline?

Theophylline brand names: T-Phyl, Duraphyl, Aerolate JR, Aerolate SR, Theo-Dur, and others. Every interaction below applies to the brands too.

126 Interactions 3 Major 89 Moderate 34 Minor
Curated & coded by · Clinical Pharmacist · Updated September 22, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Theophylline? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Theophylline against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

Stop ephedra before anything else if you take theophylline (Theo-Dur, Slo-Bid, and others) for asthma or COPD. Both are stimulants, and together they raise the risk of serious heart and nervous system effects; Sida cordifolia, an herb that contains ephedrine, carries the same major rating. Theophylline is a narrow-therapeutic-index drug, meaning small shifts in its blood level matter, so the 126 interacting ingredients on this page deserve real vigilance.

Most of the rest works by nudging that blood level. Caffeine in coffee, tea, guarana, and cocoa slows theophylline's clearance and can push it toward toxicity, and dozens of other herbs act on the same liver enzyme, which is where many of the 89 moderate entries fall. Another 34 are minor. Activated charcoal, the third major-rated item, does the opposite, soaking up the dose before it absorbs, so keep it well separated from your theophylline.

— , Clinical Pharmacist · July 18, 2026

Major 3 Moderate 89 Minor 34 No known interaction 1,326

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Most Viewed Ingredient Interactions

Theophylline: Top Interactions at a Glance

The Theophylline supplement & herbal interactions people checked most in the last 24 hours, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 126 interacting ingredients — plus 1,326 more checked with no known interaction. See the complete ranked list.

Start here

The Most-Checked Theophylline Combinations Today

The Theophylline + supplement pages people viewed most in the last 24 hours (resets at midnight). Open any card for the full report.

Moderate Likelihood Possible St. John's Wort + Theophyllinei

St.

Read the full interaction Moderate Likelihood Possible Slippery Elm + Theophyllinei

Theoretically, slippery elm may slow the absorption and reduce serum levels of oral drugs.

Read the full interaction Minor Likelihood Unlikely Kava + Theophyllinei

It is unclear if kava inhibits CYP1A2; research is conflicting.

Read the full interaction Minor Likelihood Possible Turmeric + Theophyllinei

Theoretically, turmeric might increase levels of drugs metabolized by CYP1A2.

Read the full interaction Minor Likelihood Unlikely Turpentine Oil + Theophyllinei

There is some concern that turpentine oil can inhibit CYP1A2 enzyme activity by up to 90% via induction of inflammation and subsequent downregulation of CYP act...

Read the full interaction Minor Likelihood Unlikely Diindolylmethane + Theophyllinei

Theoretically, diindolylmethane might lower serum levels of CYP1A2 substrates.

Read the full interaction
The complete list

Every Supplement Checked Against Theophylline

All 1,452 ingredients in our database, ranked by severity — 126 with a Theophylline interaction on file and 1,326 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Theophylline?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take St. John's Wort with Theophylline?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. St.

Full St. John's Wort + Theophylline answer

Can you take Slippery Elm with Theophylline?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, slippery elm may slow the absorption and reduce serum levels of oral drugs.

Full Slippery Elm + Theophylline answer

Can you take Kava with Theophylline?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. It is unclear if kava inhibits CYP1A2; research is conflicting.

Full Kava + Theophylline answer

Can you take Turmeric with Theophylline?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, turmeric might increase levels of drugs metabolized by CYP1A2.

Full Turmeric + Theophylline answer

Can you take Turpentine Oil with Theophylline?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. There is some concern that turpentine oil can inhibit CYP1A2 enzyme activity by up to 90% via induction of inflammation and subsequent downr...

Full Turpentine Oil + Theophylline answer

Can you take White Pepper with Theophylline?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, white pepper might increase levels of theophylline.

Full White Pepper + Theophylline answer

Can you take Zizyphus with Theophylline?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, zizyphus might decrease the levels and clinical effects of drugs metabolized by CYP1A2.

Full Zizyphus + Theophylline answer

Can you take Thyroid Extract with Theophylline?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Food and medications can interfere with thyroid hormone absorption.

Full Thyroid Extract + Theophylline answer

Can you take Adenosine with Theophylline?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Methylxanthines are competitive antagonists of adenosine and can block its pharmacologic effects.

Full Adenosine + Theophylline answer

Can you take Agar with Theophylline?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Agar forms a thick gel, which may disrupt the absorption of nutrients and medications.

Full Agar + Theophylline answer

Can you take Algin with Theophylline?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, algin can alter the absorption of oral drugs.

Full Algin + Theophylline answer

Can you take Aloe with Theophylline?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, aloe might decrease the levels and clinical effects of CYP1A2 substrates.

Full Aloe + Theophylline answer

Can you take Ashwagandha with Theophylline?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, ashwagandha might decrease the levels and clinical effects of CYP1A2 substrates.

Full Ashwagandha + Theophylline answer

Can you take Atractylodes with Theophylline?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, atractylodes might decrease the levels of CYP1A2 substrates.

Full Atractylodes + Theophylline answer

Can you take Bael with Theophylline?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Bael extract and its constituent marmesinin inhibited cytochrome P450 1A2 (CYP1A2) activity in vitro.

Full Bael + Theophylline answer

Can you take Beet with Theophylline?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, beet might decrease the levels and clinical effects of CYP1A2 substrates.

Full Beet + Theophylline answer

Can you take Black Psyllium with Theophylline?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.

Full Black Psyllium + Theophylline answer

Can you take Blond Psyllium with Theophylline?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.

Full Blond Psyllium + Theophylline answer

Can you take Broccoli Sprout with Theophylline?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, broccoli sprout might reduce levels and effects of drugs metabolized by CYP1A2.

Full Broccoli Sprout + Theophylline answer

Can you take Carob with Theophylline?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, carob might also impair the absorption of oral drugs.

Full Carob + Theophylline answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Theophylline is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Theophylline, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Theophylline sits in 6 interaction categories. Open any one to see what the group means:

Cytochrome P450 1A2 (Cyp1A2) Substrates 79 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

79 of the supplement ingredients on this page reach Theophylline through this category.

Theophylline 27 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

27 of the supplement ingredients on this page reach Theophylline through this category.

Oral Drugs 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Theophylline through this category.

Seizure Threshold Lowering Drugs 6 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

6 of the supplement ingredients on this page reach Theophylline through this category.

Methylxanthines 5 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

5 of the supplement ingredients on this page reach Theophylline through this category.

Cytochrome P450 1A2 (Cyp1A2) Substrates 1 ingredient

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

1 of the supplement ingredient on this page reaches Theophylline through this category.

About Theophylline

Theophylline is a bronchodilator medication used to prevent and treat wheezing, shortness of breath, and chest tightness caused by lung diseases like asthma and chronic bronchitis.

Generic name: Theophylline  ·  Brand names: T-Phyl, Duraphyl, Aerolate JR, Aerolate SR, Theo-Dur, Slo-Bid, Theo-24, Uniphyl, Slo-phyllin Gyrocaps, Theolair, Theolair SR, Quibron-T/SR, Quibron-T, Aerolate III, Theo-X, Bronkodyl, Theoclear LA-130, Constant-T, Theoclear LA-260, Elixophyllin, Theovent, Theobid Jr Duracap, Respbid, Theobid Duracap.

See the full Theophylline drug information

Related: does Theophylline deplete any nutrients?

Theophylline has 48 reported nutrient associations in the research literature — see the Theophylline nutrient depletion report.

Check a real product

Take a Supplement Product? Check the Whole Bottle Against Theophylline

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Theophylline.

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Pharmacist Counseling Corner

Theophylline & Supplements: Common Questions

What supplements interact with Theophylline?
In our interaction database, 126 supplement and herbal ingredients have an interaction with Theophylline on file — 3 rated major, 89 moderate, and 34 minor. That number sounds scarier than it is: severity matters far more than the count, which is why the list on this page is ranked instead of alphabetical. Start at the top. The highest-ranked right now: Activated Charcoal, Ephedra, Sida Cordifolia.
Which Theophylline supplement interactions are the most serious?
The 3 major-rated combinations — led by Activated Charcoal, Ephedra and Sida Cordifolia — deserve real caution: these are the ones generally best avoided, or used only with your prescriber watching. If you take any of them today, don't panic and don't stop anything abruptly — call your pharmacist first. Jump to the ranked list.
Can I take vitamins or supplements while on Theophylline?
That depends entirely on which supplement. The honest answer for Theophylline is in the ranked list above — and if what you take is a combination product with a dozen ingredients, don't check them one by one: photograph the label with our scanner and we'll check the whole thing at once. Try the label scanner or the interaction checker.
Do brands like T-Phyl have the same supplement interactions as Theophylline?
Yes — T-Phyl, Duraphyl, Aerolate JR, Aerolate SR, Theo-Dur and other brands all contain Theophylline, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
Does Theophylline deplete any vitamins or nutrients?
It might — Theophylline has 48 reported nutrient-depletion associations in the research literature, which is a different question from interactions: instead of a supplement changing the drug, the drug may lower a nutrient over time. See the Theophylline nutrient depletion report for the specifics and what to discuss with your pharmacist.
What about Theophylline and my other medications?
This page covers Theophylline against supplements and herbal ingredients. Checking Theophylline against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker, or read the full Theophylline drug information.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 22, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.