Drug & supplement interaction

Bifidobacterium Bifidum + Irbesartan

Irbesartan brand names: Avapro, Aprovel.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Bifidobacterium Bifidum and Irbesartan in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

Know someone taking this? Share
Facebook Post Reddit Email
On this page
Interaction report

Bifidobacterium Bifidum and Irbesartan

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Irbesartan and Bifidobacterium Bifidum in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Bifidobacterium Bifidum safety at a glance

Bifidobacterium Bi... overall Use caution Generally well tolerated in healthy people, but those with weakened immune systems should be cautious.
Pregnancy Possibly Safe When Bifidobacterium bifidum is used orally and appropriately, short-term. A combination of B. bifidum, Lactobacillus acidophilus, and Lacticaseibacillus casei... Read the full pregnancy detail
Breastfeeding Use caution Likely low risk but not well studied, so consult your doctor or pharmacist first.

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Irbesartan and Bifidobacterium Bifidum? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Irbesartan

Interactions in our licensed database are recorded against drug classes, not just single drug names. Irbesartan is filed under 4 classifications — including angiotensin receptor blockers (arbs), cytochrome p450 2c9 (cyp2c9) substrates, antihypertensive drugs. Bifidobacterium Bifidum has documented interactions with 1 drug class — the most serious being antibiotic drugs (moderate) — and none of Irbesartan’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Bifidobacterium Bifidum Does Interact With Other Medications

Bifidobacterium Bifidum has 182 moderate known drug interactions in our database — Irbesartan isn’t one of them. If you take anything else, check it against the full list below.

Moderate 182 No known interaction 2,648 (incl. Irbesartan)
Taking anything else?

Check Another of Your Medications Against Bifidobacterium Bifidum

Covers the 2,830 medications we’ve checked against Bifidobacterium Bifidum. Pick one to open its full report.

What to actually watch for

What Bifidobacterium Bifidum Itself Has Been Linked To

This is not an interaction — nothing below involves Irbesartan. It is the side-effect record for Bifidobacterium Bifidum on its own, from the licensed Natural Medicines monograph. If something new turns up after you add Bifidobacterium Bifidum, this list is the first place to look. One entry is worth acting on rather than waiting out — marked below.

  • A higher chance of infection Worth acting on Additional detail

    “There have been cases of Bifidobacterium sepsis in critically ill patients. However, these cases are rare and none seem to be due to Bifidobacterium bifidum.”

    Bifidobacterium Bifidum · Natural Medicines adverse-effect record, reported in sepsis.

    2 sources cited
    1. 102416. Pruccoli G, Silvestro E, Pace Napoleone C, Aidala E, Garazzino S, Scolfaro C. Are probiotics safe? Bifidobacterium bacteremia in a child with severe heart failure. Infez Med. 2019;27(2):175-178.
    2. 107599. Esaiassen E, Hjerde E, Cavanagh JP, Simonsen GS, Klingenberg C; Norwegian Study Group on Invasive Bifidobacterial Infections. Bifidobacterium bacteremia: Clinical characteristics and a genomic approach to assess pathogenicity. J Clin Microbiol. 2017;55(7) PubMed
  • Bloating or gas / Fever / Vomiting Additional detail

    “Bloating and flatulence have been reported with probiotic use; however, these adverse effects have not been reported from ingestion of Bifidobacterium bifidum in particular. One case of vomiting and fever has been reported in a clinical study for a single child taking B. bifidum and Lactobacillus acidophilus. It is unclear if the probiotics were the causal agent.”

    Bifidobacterium Bifidum · Natural Medicines adverse-effect record, reported in flatulence.

    1 source cited
    1. 90286. Rerksuppaphol S, Rerksuppaphol L. Randomized controlled trial of probiotics to reduce common cold in schoolchildren. Pediatr Int. 2012;54(5):682-7. PubMed

Everything above comes from the Natural Medicines adverse-effect record for Bifidobacterium Bifidum — expand a row for the licensed statement it rests on. We read the ADVERSE REACTIONS section of Irbesartan’s FDA label too, and the two lists don’t meaningfully overlap — which is why no Irbesartan column appears here.

Special populations

Bifidobacterium Bifidum in Pregnancy & Breastfeeding

Pregnancy Possibly Safe

When Bifidobacterium bifidum is used orally and appropriately, short-term. A combination of B. bifidum, Lactobacillus acidophilus, and Lacticaseibacillus casei has been used with apparent safety for 6 weeks starting at 24-28 weeks' gestation.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

Overlapping uses

What Irbesartan Is Prescribed For, and What Bifidobacterium Bifidum Has Been Studied For

These two come up together because they touch the same health topic — not because they do the same job. Irbesartan is a prescription medicine with approved uses on its FDA label. Bifidobacterium Bifidum is a supplement: what follows is what researchers have looked at it for, and how strong that evidence is.

Irbesartan is prescribed for: Irbesartan tablets are used to treat high blood pressure (hypertension). Lowering blood pressure reduces the risk of serious cardiovascular events, including stroke and heart attack. It can be used alone or combined with other blood pressure medicines. Irbesartan tablets are also used to treat diabetic nephropathy — kidney disease caused by diabetes — in adults with type 2 diabetes, high blood pressure, elevated creatinine levels, and significant protein in their urine.

Read the rest of what Irbesartan is prescribed for

In this group, it slows how quickly kidney disease gets worse.

Bifidobacterium Bifidum has been studied for:

  • Diabetic nephropathy studied, not established Bifidobacterium Bifidum has been studied for this. Natural Medicines rates the evidence: Insufficient Reliable Evidence To Rate Read what the research shows

    Bifidobacterium Bifidum for diabetic nephropathy

    Oral Bifidobacterium bifidum has only been evaluated in combination with other ingredients; its effect when used alone is unclear.

Effectiveness ratings and the research summaries above are the verbatim record from the Natural Medicines database, which grades evidence from “Effective” down to “Insufficient Reliable Evidence To Rate”. A rating below the top of that scale means researchers have looked at it — not that it works, and never that it can stand in for a prescribed medicine. Do not stop or replace Irbesartan on your own; if you are taking Bifidobacterium Bifidum for the same health topic, tell your prescriber, especially if the medicine is being adjusted to a target.

From our Q&A

Questions About Bifidobacterium Bifidum or Irbesartan

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Bifidobacterium Bifidum or Irbesartan, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Irbesartan

This page covers Bifidobacterium Bifidum only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Irbesartan page lists 182 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), American Hellebore (major), American Mistletoe (major), Tyramine (major) and Adrafinil (moderate).

By severity: 4 major · 145 moderate · 33 minor.

Open the Irbesartan interaction page

One more smart check

Taking Bifidobacterium Bifidum as Part of a Dietary Supplement Product? Check It for Interactions

We hold 3,041 real supplement products containing Bifidobacterium Bifidum, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Bifidobacterium Bifidum. Even though Bifidobacterium Bifidum itself has no known interaction with Irbesartan, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Bifidobacterium Bifidum and Irbesartan Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Bifidobacterium Bifidum
Top 10%

#113 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Irbesartan
Top 25%

#551 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Bifidobacterium Bifidum reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Bifidobacterium Bifidum and Irbesartan records this page draws on were last updated July 11, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Bifidobacterium Bifidum

What is Bifidobacterium Bifidum?

  • Digestive health and regularity
  • Diarrhea (including antibiotic-related)
  • Irritable bowel syndrome (IBS) symptoms
  • Supporting gut and immune balance
  • Infant gut health

Bifidobacterium bifidum is a 'friendly' bacteria (probiotic) that naturally lives in the human gut and is taken to support digestion and gut balance. Some evidence suggests probiotics may help with certain types of diarrhea and digestive discomfort, but results vary by strain and condition. It is generally well tolerated in healthy people, but anyone who is seriously ill or has a weakened immune system should check with a doctor first.

Bifidobacterium bifidum · Bifidobacteriaceae · Live bacterial cells (probiotic culture) · Capsules, tablets, powders, sachets, chewables, and fermented dairy products; often combined with other probiotic strains

An interaction check asks whether these two react with each other — it does not ask whether Bifidobacterium Bifidum is a good idea for someone in your situation. Here is what our Bifidobacterium Bifidum record says about it on its own.

Bifidobacterium Bifidum: dosing

There is no single standardized dose of B. bifidum. Probiotic amounts are usually measured in colony-forming units (CFU), and products commonly range from millions to many billions of CFU per serving.The best amount depends on the specific product and the reason you are taking it. Take it consistently, and give it a few weeks to judge whether it helps.

From our Bifidobacterium Bifidum monograph — the full record covers uses, side effects and every documented interaction.

Read the full Bifidobacterium Bifidum monograph & all interactions
Medication

About Irbesartan

What Is Irbesartan Used For?

Brand names: Avapro, Aprovel

Irbesartan tablets are used to treat high blood pressure (hypertension). Lowering blood pressure reduces the risk of serious cardiovascular events, including stroke and heart attack. It can be used alone or combined with other blood pressure medicines.

Irbesartan tablets are also used to treat diabetic nephropathy — kidney disease caused by diabetes — in adults with type 2 diabetes, high blood pressure, elevated creatinine levels, and significant protein in their urine. In this group, it slows how quickly kidney disease gets worse.

Most-Reported Side Effects for Irbesartan

From FAERS, the FDA’s public side-effect reporting system (49,395 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Fatigue 2,816 reports
Nausea 2,812 reports
Diarrhea 2,533 reports
Dizziness 2,346 reports
Dyspnea 2,251 reports
See full Irbesartan drug information
Keep checking

Other Drugs & Bifidobacterium Bifidum

Browse every other medication we’ve checked against Bifidobacterium Bifidum — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
182Moderate
0Minor
2,647No known interaction
182 Moderate 2,647 No interaction
Moderate

182 interactions

Showing 60 of 182 moderate interactions — see all 182 on the Bifidobacterium Bifidum page.

No interaction 2,647 drugs checked — show the list

We also checked Bifidobacterium Bifidum against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,647 medications checked with no known interaction — see the full Bifidobacterium Bifidum list.

See the full Bifidobacterium Bifidum interactions page
See every supplement checked against Irbesartan, ranked by severity
Evidence & sources

Bifidobacterium Bifidum References

The 7 references that drive our Bifidobacterium Bifidum monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Pierce A. The American Pharmaceutical Association Practical Guide to Natural Medicines. New York: The Stonesong Press, 1999:19.
  2. Xiao JZ, Takahashi S, Odamaki T, et al. Antibiotic susceptibility of bifidobacterial strains distributed in the Japanese market. Biosci Biotechnol Biochem. 2010;74(2):336-42. PubMed
  3. Rerksuppaphol S, Rerksuppaphol L. Randomized controlled trial of probiotics to reduce common cold in schoolchildren. Pediatr Int. 2012;54(5):682-7. PubMed
  4. Karamali M, Dadkhah F, Sadrkhanlou M, et al. Effects of probiotic supplementation on glycaemic control and lipid profiles in gestational diabetes: a randomized, double-blind, placebo-controlled trial. Diabetes Metab 2016;42(4):234-41. PubMed
  5. Badehnoosh B, Karamali M, Zarrati M, et al. The effects of probiotic supplementation on biomarkers of inflammation, oxidative stress and pregnancy outcomes in gestational diabetes. J Matern Fetal Neonatal Med. 2018 May;31(9):1128-1136.
  6. Pruccoli G, Silvestro E, Pace Napoleone C, Aidala E, Garazzino S, Scolfaro C. Are probiotics safe? Bifidobacterium bacteremia in a child with severe heart failure. Infez Med. 2019;27(2):175-178.
  7. Esaiassen E, Hjerde E, Cavanagh JP, Simonsen GS, Klingenberg C; Norwegian Study Group on Invasive Bifidobacterial Infections. Bifidobacterium bacteremia: Clinical characteristics and a genomic approach to assess pathogenicity. J Clin Microbiol. 2017;55(7) PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Bifidobacterium Bifidum and Irbesartan Together: Common Questions

Is it safe to take Bifidobacterium Bifidum with Irbesartan?
We do not list a known interaction between Bifidobacterium Bifidum and Irbesartan. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Are Bifidobacterium Bifidum and Irbesartan used for the same thing?
They overlap in purpose, which usually means the real question is whether you need both rather than whether they are safe together. This page lists the shared uses and how strong the evidence is for Bifidobacterium Bifidum in each. That is a conversation for your prescriber, especially if Irbesartan is being adjusted to a target.
How was the Bifidobacterium Bifidum and Irbesartan combination checked?
Interactions in our licensed database are recorded against drug classes. Irbesartan is filed under 4 classifications, and Bifidobacterium Bifidum has documented interactions with 1 drug class — none of Irbesartan's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Bifidobacterium Bifidum interact with any other medications?
Yes. Bifidobacterium Bifidum has 182 documented drug interactions in our database — Irbesartan is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Irbesartan interact with any supplements?
Yes. Irbesartan has documented interactions with 182 supplements in our database — Bifidobacterium Bifidum is not one of them. The Irbesartan interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Bifidobacterium Bifidum monograph Uses, safety profile, and every drug interaction in one place Irbesartan drug information The full plain-English guide to this medication Irbesartan supplement interactions Every supplement checked against Irbesartan, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 7 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Irbesartan and Bifidobacterium Bifidum?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.