Drug & supplement interaction

Black Hoof Mushroom + Cevimeline

Cevimeline brand name: Evoxac.

No Known Interaction

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated June 2026 · Pair last verified Sep 13, 2026

The bottom line No known interaction

We found no known interaction between Black Hoof Mushroom and Cevimeline in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Black Hoof Mushroom and Cevimeline

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Cevimeline and Black Hoof Mushroom in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Black Hoof Mushroom safety at a glance

Black Hoof Mushroo... overall Use caution Generally used in traditional medicine, but human safety data are limited.

Pregnancy Avoid Not enough safety information, so it is best avoided during pregnancy.

Breastfeeding Avoid No reliable safety data, so avoid while breastfeeding.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Cevimeline and Black Hoof Mushroom? Ask Dr. Brian Staiger, PharmD, BCPS directly ›

How we checked

Why No Interaction Is Listed for Cevimeline

Interactions in our licensed database are recorded against drug classes, not just single drug names. Cevimeline is filed under 5 classifications — including cholinergic drugs, cytochrome p450 2d6 (cyp2d6) substrates, cytochrome p450 3a4 (cyp3a4) substrates. Black Hoof Mushroom has documented interactions with 3 drug classes — the most serious being cytochrome p450 1a2 (cyp1a2) substrates (moderate), cytochrome p450 2e1 (cyp2e1) substrates (moderate) and immunosuppressants (moderate) — and none of Cevimeline’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Black Hoof Mushroom Does Interact With Other Medications

Black Hoof Mushroom has 308 moderate known drug interactions in our database — Cevimeline isn’t one of them. If you take anything else, check it against the full list below.

Moderate 308 No known interaction 2,522 (incl. Cevimeline)

Taking anything else?

Check Another of Your Medications Against Black Hoof Mushroom

Covers the 2,830 medications we’ve checked against Black Hoof Mushroom. Pick one to open its full report.

What to actually watch for

What Cevimeline’s Own FDA Label Lists

This is not an interaction — none of it involves Black Hoof Mushroom. These are the most notable effects listed in the ADVERSE REACTIONS section of Cevimeline’s own FDA label, for the medication by itself. Knowing the drug’s own list makes it easier to work out the likely cause if something new turns up while you take both. One of them is worth acting on rather than waiting out — marked below.

A higher chance of infection Worth acting on
Passing urine more often
Flushing
A stuffy or runny nose
Sore throat
Sweating
Joint pain mentioned in 4.4% of FDA reports for Cevimeline
Back pain
Cough
Anxiety or restlessness

Showing the 10 most notable of 20 label-listed effects — ranked by how unusual each one is across medicines generally, with serious effects weighted up.

From the ADVERSE REACTIONS section of the FDA label for Cevimeline. Read the label on DailyMed › Where a percentage is shown, it is the share of 2,695 voluntary FDA FAERS reports for Cevimeline that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Black Hoof Mushroom’s licensed record lists no adverse effects our clinical vocabulary could match, so there is no Black Hoof Mushroom side to compare — that is a limit of the record, not a statement that Black Hoof Mushroom has no side effects.

Everything else you take

See Every Supplement That Interacts With Cevimeline

This page covers Black Hoof Mushroom only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Cevimeline page lists 169 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Grapefruit (major), St. John's Wort (major), 1,3-dmaa (moderate) and Acacia Rigidula (moderate).

By severity: 3 major · 125 moderate · 41 minor.

From our pharmacist’s overview on the Cevimeline page

“Cevimeline (Evoxac) stimulates saliva flow for the dry mouth of Sjögren's syndrome, and because the liver clears it through the CYP3A4 and CYP2D6 enzyme pathways, this interaction list warrants real attention. Three of the 169 ingredients rate major, and they come first: grapefruit can raise cevimeline levels, St.”

Reviewed by 2 · Jul 18, 2026

Open the Cevimeline interaction page

How much people look this up

Where Black Hoof Mushroom and Cevimeline Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Black Hoof Mushroom

Steady interest

#925 of 1,452 supplements looked up here in the last 7 days

29 days ago today

Medication Cevimeline

Steady interest

#2,138 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?

Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Black Hoof Mushroom reference on this page ↓
Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Black Hoof Mushroom and Cevimeline records this page draws on were last updated June 22, 2026.
What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.

Data structure & sourcing designed and verified by Dr. Brian Staiger, PharmD, BCPS.

Supplement

About Black Hoof Mushroom

What is Black Hoof Mushroom?

Immune system support
Antioxidant support
General wellness
Traditional cancer-supportive use
Inflammation

Black Hoof Mushroom (Phellinus linteus) is a medicinal mushroom long used in East Asian traditional medicine, mainly for immune support. Most of the supporting evidence comes from laboratory and animal studies, and high-quality human research is limited. Talk to your pharmacist or doctor before using it, especially if you have a health condition or take other medicines.

Phellinus linteus · Hymenochaetaceae · Fruiting body (the woody mushroom that grows on tree trunks) · Capsules, tablets, powdered extracts, teas, and tinctures

An interaction check asks whether these two react with each other — it does not ask whether Black Hoof Mushroom is a good idea for someone in your situation. Here is what our Black Hoof Mushroom record says about it on its own.

Black Hoof Mushroom: dosing

There is no well-established standard dose for Black Hoof Mushroom. The amount can vary widely depending on the product, the type of extract, and how it is made.The best approach is to follow the directions on the product label and not take more than recommended. Because formulations differ so much, it is a good idea to review the specific product with your pharmacist or doctor before starting.

From our Black Hoof Mushroom monograph — the full record covers uses, side effects and every documented interaction.

Read the full Black Hoof Mushroom monograph & all interactions

Medication

About Cevimeline

What Is Cevimeline Used For?

Brand name: Evoxac

Cevimeline — available as cevimeline hydrochloride capsules and as the brand Evoxac — is used to relieve the symptoms of dry mouth in patients with Sjögren's Syndrome, an autoimmune condition that damages the glands that make saliva and tears.

Most-Reported Side Effects for Cevimeline

From FAERS, the FDA’s public side-effect reporting system (2,695 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Headache 176 reports

Nausea 166 reports

Diarrhea 164 reports

Fatigue 155 reports

Dyspnea 138 reports

See full Cevimeline drug information

Keep checking

Other Drugs & Black Hoof Mushroom

Browse every other medication we’ve checked against Black Hoof Mushroom — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major

308Moderate

0Minor

2,521No known interaction

308 Moderate 2,521 No interaction

Moderate

308 interactions

Showing 60 of 308 moderate interactions — see all 308 on the Black Hoof Mushroom page.

No interaction 2,521 drugs checked — show the list

We also checked Black Hoof Mushroom against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,521 medications checked with no known interaction — see the full Black Hoof Mushroom list.

See the full Black Hoof Mushroom interactions page

See every supplement checked against Cevimeline, ranked by severity

Evidence & sources

Black Hoof Mushroom References

The 6 references that drive our Black Hoof Mushroom monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

Song, K. S., Cho, S. M., Lee, J. H., Kim, H. M., Han, S. B., Ko, K. S., and Yoo, I. D. B-lymphocyte-stimulating polysaccharide from mushroom Phellinus linteus. Chem Pharm Bull (Tokyo) 1995;43(12):2105-2108. PubMed
Matsuba, S., Matsuno, H., Sakuma, M., and Komatsu, Y. Phellinus linteus Extract Augments the Immune Response in Mitomycin C-Induced Immunodeficient Mice. Evid Based Complement Alternat Med 2008;5(1):85-90.
Kim, G. Y., Roh, S. I., Park, S. K., Ahn, S. C., Oh, Y. H., Lee, J. D., and Park, Y. M. Alleviation of experimental septic shock in mice by acidic polysaccharide isolated from the medicinal mushroom Phellinus linteus. Biol Pharm Bull 2003;26(10):1418-1423 PubMed
Shon, Y. H. and Nam, K. S. Inhibition of cytochrome P450 isozymes in rat liver microsomes by polysaccharides derived from Phellinus linteus. Biotechnol Lett 2003;25(2):167-172. PubMed
Oh, G. S., Lee, M. S., Pae, H. O., Kwon, J., Lee, S. S., Jeong, J. G., Shin, M. K., Kwon, T. O., and Chung, H. T. Effects of oral administration of Phellinus linteus on the production of Th1- and Th2-type cytokines in mice. Immunopharmacol Immunotoxicol 2
Kim, G. Y., Lee, J. Y., Lee, J. O., Ryu, C. H., Choi, B. T., Jeong, Y. K., Lee, K. W., Jeong, S. C., and Choi, Y. H. Partial characterization and immunostimulatory effect of a novel polysaccharide-protein complex extracted from Phellinus linteus. Biosci B

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Black Hoof Mushroom and Cevimeline Together: Common Questions

Is it safe to take Black Hoof Mushroom with Cevimeline?

We do not list a known interaction between Black Hoof Mushroom and Cevimeline. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.

How was the Black Hoof Mushroom and Cevimeline combination checked?

Interactions in our licensed database are recorded against drug classes. Cevimeline is filed under 5 classifications, and Black Hoof Mushroom has documented interactions with 3 drug classes — none of Cevimeline's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.

Does Black Hoof Mushroom interact with any other medications?

Yes. Black Hoof Mushroom has 308 documented drug interactions in our database — Cevimeline is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.

Does Cevimeline interact with any supplements?

Yes. Cevimeline has documented interactions with 169 supplements in our database — Black Hoof Mushroom is not one of them. The Cevimeline interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Black Hoof Mushroom monograph Uses, safety profile, and every drug interaction in one place Cevimeline drug information The full plain-English guide to this medication Cevimeline supplement interactions Every supplement checked against Cevimeline, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 6 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Cevimeline and Black Hoof Mushroom?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.