Drug & supplement interaction

Black Hoof Mushroom + Evolocumab

Evolocumab brand name: Repatha.

No Known Interaction
Medically reviewed by · Updated June 2026 · Pair last verified Oct 4, 2026
The bottom line No known interaction

We found no known interaction between Black Hoof Mushroom and Evolocumab in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Black Hoof Mushroom and Evolocumab

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Evolocumab and Black Hoof Mushroom in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Black Hoof Mushroom safety at a glance

Black Hoof Mushroo... overall Use caution Generally used in traditional medicine, but human safety data are limited.
Pregnancy Avoid Not enough safety information, so it is best avoided during pregnancy.
Breastfeeding Avoid No reliable safety data, so avoid while breastfeeding.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Evolocumab and Black Hoof Mushroom? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
Keep it in perspective

Black Hoof Mushroom Does Interact With Other Medications

Black Hoof Mushroom has 308 moderate known drug interactions in our database — Evolocumab isn’t one of them. If you take anything else, check it against the full list below.

Moderate 308 No known interaction 2,522 (incl. Evolocumab)
Taking anything else?

Check Another of Your Medications Against Black Hoof Mushroom

Covers the 2,830 medications we’ve checked against Black Hoof Mushroom. Pick one to open its full report.

What to actually watch for

What Evolocumab’s Own FDA Label Lists

This is not an interaction — none of it involves Black Hoof Mushroom. These are the most notable effects listed in the ADVERSE REACTIONS section of Evolocumab’s own FDA label, for the medication by itself. Knowing the drug’s own list makes it easier to work out the likely cause if something new turns up while you take both. 7 of them are worth acting on rather than waiting out — marked below.

  • High blood sugar Worth acting on
  • Raised blood pressure Worth acting on
  • Bleeding or bruising Worth acting on mentioned in 3.0% of FDA reports for Evolocumab
  • A severe allergic reaction Worth acting on
  • Hives Worth acting on
  • A higher chance of infection Worth acting on
  • An allergic reaction Worth acting on
  • Back pain mentioned in 3.5% of FDA reports for Evolocumab
  • Sore throat
  • Muscle pain mentioned in 3.4% of FDA reports for Evolocumab

Showing the 10 most notable of 18 label-listed effects — ranked by how unusual each one is across medicines generally, with serious effects weighted up.

From the ADVERSE REACTIONS section of the FDA label for Evolocumab. Read the label on DailyMed › Where a percentage is shown, it is the share of 161,222 voluntary FDA FAERS reports for Evolocumab that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Black Hoof Mushroom’s licensed record lists no adverse effects our clinical vocabulary could match, so there is no Black Hoof Mushroom side to compare — that is a limit of the record, not a statement that Black Hoof Mushroom has no side effects.

From our Q&A

Questions About Black Hoof Mushroom or Evolocumab

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Black Hoof Mushroom or Evolocumab, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

How much people look this up

Where Black Hoof Mushroom and Evolocumab Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Black Hoof Mushroom
Steady interest

#991 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Evolocumab
Steady interest

#2,468 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Black Hoof Mushroom reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified October 4, 2026. The Black Hoof Mushroom and Evolocumab records this page draws on were last updated June 22, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Black Hoof Mushroom

What is Black Hoof Mushroom?

Black Hoof Mushroom
  • Immune system support
  • Antioxidant support
  • General wellness
  • Traditional cancer-supportive use
  • Inflammation

Black Hoof Mushroom (Phellinus linteus) is a medicinal mushroom long used in East Asian traditional medicine, mainly for immune support. Most of the supporting evidence comes from laboratory and animal studies, and high-quality human research is limited. Talk to your pharmacist or doctor before using it, especially if you have a health condition or take other medicines.

Phellinus linteus · Hymenochaetaceae · Fruiting body (the woody mushroom that grows on tree trunks) · Capsules, tablets, powdered extracts, teas, and tinctures

An interaction check asks whether these two react with each other — it does not ask whether Black Hoof Mushroom is a good idea for someone in your situation. Here is what our Black Hoof Mushroom record says about it on its own.

Black Hoof Mushroom: dosing

There is no well-established standard dose for Black Hoof Mushroom. The amount can vary widely depending on the product, the type of extract, and how it is made.The best approach is to follow the directions on the product label and not take more than recommended. Because formulations differ so much, it is a good idea to review the specific product with your pharmacist or doctor before starting.

From our Black Hoof Mushroom monograph — the full record covers uses, side effects and every documented interaction.

Read the full Black Hoof Mushroom monograph & all interactions
Medication

About Evolocumab Injection

What Is Evolocumab Injection Used For?

Brand name: Repatha

Repatha (evolocumab) injection is used to lower LDL cholesterol — often called 'bad' cholesterol — as an add-on to diet and exercise in adults with hypercholesterolemia (high cholesterol), and in adults and children aged 10 and older with heterozygous familial hypercholesterolemia (HeFH) or homozygous familial hypercholesterolemia (HoFH), which are inherited conditions that cause very high cholesterol levels from birth.

Repatha is also used to reduce the risk of major cardiovascular events — including heart attack, stroke, unstable angina requiring hospitalization, and cardiovascular death — in adults who are at increased risk for these events.

Most-Reported Side Effects for Evolocumab

From FAERS, the FDA’s public side-effect reporting system (161,222 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Device difficult to use 32,925 reports
Drug dose omission by device 24,638 reports
Injection site pain 10,927 reports
Product storage error 6,676 reports
Back pain 5,587 reports
See full Evolocumab Injection drug information Evolocumab NDC codes and packages
Keep checking

Other Drugs & Black Hoof Mushroom

Browse every other medication we’ve checked against Black Hoof Mushroom — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
308Moderate
0Minor
2,521No known interaction
308 Moderate 2,521 No interaction
Moderate

308 interactions

Showing 60 of 308 moderate interactions — see all 308 on the Black Hoof Mushroom page.

No interaction 2,521 drugs checked — show the list

We also checked Black Hoof Mushroom against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,521 medications checked with no known interaction — see the full Black Hoof Mushroom list.

See the full Black Hoof Mushroom interactions page
See every supplement checked against Evolocumab, ranked by severity
Evidence & sources

Black Hoof Mushroom References

The 6 references that drive our Black Hoof Mushroom monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Song, K. S., Cho, S. M., Lee, J. H., Kim, H. M., Han, S. B., Ko, K. S., and Yoo, I. D. B-lymphocyte-stimulating polysaccharide from mushroom Phellinus linteus. Chem Pharm Bull (Tokyo) 1995;43(12):2105-2108. PubMed
  2. Matsuba, S., Matsuno, H., Sakuma, M., and Komatsu, Y. Phellinus linteus Extract Augments the Immune Response in Mitomycin C-Induced Immunodeficient Mice. Evid Based Complement Alternat Med 2008;5(1):85-90.
  3. Kim, G. Y., Roh, S. I., Park, S. K., Ahn, S. C., Oh, Y. H., Lee, J. D., and Park, Y. M. Alleviation of experimental septic shock in mice by acidic polysaccharide isolated from the medicinal mushroom Phellinus linteus. Biol Pharm Bull 2003;26(10):1418-1423 PubMed
  4. Shon, Y. H. and Nam, K. S. Inhibition of cytochrome P450 isozymes in rat liver microsomes by polysaccharides derived from Phellinus linteus. Biotechnol Lett 2003;25(2):167-172. PubMed
  5. Oh, G. S., Lee, M. S., Pae, H. O., Kwon, J., Lee, S. S., Jeong, J. G., Shin, M. K., Kwon, T. O., and Chung, H. T. Effects of oral administration of Phellinus linteus on the production of Th1- and Th2-type cytokines in mice. Immunopharmacol Immunotoxicol 2
  6. Kim, G. Y., Lee, J. Y., Lee, J. O., Ryu, C. H., Choi, B. T., Jeong, Y. K., Lee, K. W., Jeong, S. C., and Choi, Y. H. Partial characterization and immunostimulatory effect of a novel polysaccharide-protein complex extracted from Phellinus linteus. Biosci B

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Black Hoof Mushroom and Evolocumab Together: Common Questions

Is it safe to take Black Hoof Mushroom with Evolocumab?
We do not list a known interaction between Black Hoof Mushroom and Evolocumab. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Does Black Hoof Mushroom interact with any other medications?
Yes. Black Hoof Mushroom has 308 documented drug interactions in our database — Evolocumab is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Black Hoof Mushroom monograph Uses, safety profile, and every drug interaction in one place Evolocumab Injection drug information The full plain-English guide to this medication Evolocumab supplement interactions Every supplement checked against Evolocumab, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 6 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Evolocumab and Black Hoof Mushroom?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.