Drug & supplement interaction

Black Hoof Mushroom + Guanabenz Acetate

Guanabenz Acetate brand name: Wytensin.

No Known Interaction
Medically reviewed by · Updated June 2026 · Pair last verified Oct 4, 2026
The bottom line No known interaction

We found no known interaction between Black Hoof Mushroom and Guanabenz Acetate in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Black Hoof Mushroom and Guanabenz Acetate

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Guanabenz Acetate and Black Hoof Mushroom in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Black Hoof Mushroom safety at a glance

Black Hoof Mushroo... overall Use caution Generally used in traditional medicine, but human safety data are limited.
Pregnancy Avoid Not enough safety information, so it is best avoided during pregnancy.
Breastfeeding Avoid No reliable safety data, so avoid while breastfeeding.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Guanabenz Acetate and Black Hoof Mushroom? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Guanabenz Acetate

Interactions in our licensed database are recorded against drug classes, not just single drug names. Guanabenz Acetate is filed under 3 classifications — alpha-adrenergic agonists, antihypertensive drugs, oral drugs. Black Hoof Mushroom has documented interactions with 3 drug classes — the most serious being cytochrome p450 1a2 (cyp1a2) substrates (moderate), cytochrome p450 2e1 (cyp2e1) substrates (moderate) and immunosuppressants (moderate) — and none of Guanabenz Acetate’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Black Hoof Mushroom Does Interact With Other Medications

Black Hoof Mushroom has 308 moderate known drug interactions in our database — Guanabenz Acetate isn’t one of them. If you take anything else, check it against the full list below.

Moderate 308 No known interaction 2,522 (incl. Guanabenz Acetate)
Taking anything else?

Check Another of Your Medications Against Black Hoof Mushroom

Covers the 2,830 medications we’ve checked against Black Hoof Mushroom. Pick one to open its full report.

Everything else you take

See Every Supplement That Interacts With Guanabenz Acetate

This page covers Black Hoof Mushroom only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Guanabenz Acetate page lists 137 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), American Hellebore (major), American Mistletoe (major), Tyramine (major) and Adrafinil (moderate).

By severity: 4 major · 112 moderate · 21 minor.

From our pharmacist’s overview on the Guanabenz Acetate page

“Guanabenz acetate (Wytensin) is an older blood pressure medicine, and the 137 supplements on file call for genuine vigilance, beginning with the four rated major. Two are toxic plants that can strain the heart or swing pressure hard, one is tyramine, found in aged cheeses and cured meats, which fights the drug's effect, and one is acti…”

Reviewed by 2 · Jul 18, 2026

Open the Guanabenz Acetate interaction page

How much people look this up

Where Black Hoof Mushroom and Guanabenz Acetate Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Black Hoof Mushroom
Steady interest

#1,223 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Guanabenz Acetate
Steady interest

#1,938 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Black Hoof Mushroom reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified October 4, 2026. The Black Hoof Mushroom and Guanabenz Acetate records this page draws on were last updated June 22, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Black Hoof Mushroom

What is Black Hoof Mushroom?

Black Hoof Mushroom
  • Immune system support
  • Antioxidant support
  • General wellness
  • Traditional cancer-supportive use
  • Inflammation

Black Hoof Mushroom (Phellinus linteus) is a medicinal mushroom long used in East Asian traditional medicine, mainly for immune support. Most of the supporting evidence comes from laboratory and animal studies, and high-quality human research is limited. Talk to your pharmacist or doctor before using it, especially if you have a health condition or take other medicines.

Phellinus linteus · Hymenochaetaceae · Fruiting body (the woody mushroom that grows on tree trunks) · Capsules, tablets, powdered extracts, teas, and tinctures

An interaction check asks whether these two react with each other — it does not ask whether Black Hoof Mushroom is a good idea for someone in your situation. Here is what our Black Hoof Mushroom record says about it on its own.

Black Hoof Mushroom: dosing

There is no well-established standard dose for Black Hoof Mushroom. The amount can vary widely depending on the product, the type of extract, and how it is made.The best approach is to follow the directions on the product label and not take more than recommended. Because formulations differ so much, it is a good idea to review the specific product with your pharmacist or doctor before starting.

From our Black Hoof Mushroom monograph — the full record covers uses, side effects and every documented interaction.

Read the full Black Hoof Mushroom monograph & all interactions
Medication

About Guanabenz

What Is Guanabenz Used For?

Brand name: Wytensin

  • Guanabenz is used to treat high blood pressure. It is in a class of medications called centrally acting alpha2A-adrenergic receptor agonists. Guanabenz works by decreasing your heart rate and relaxing the blood vessels so that blood can flow more easily through the body.

  • High blood pressure is a common condition and when not treated, can cause damage to the brain, heart, blood vessels, kidneys and other parts of the body. Damage to these organs may cause heart disease, a heart attack, heart failure, stroke, kidney failure, loss of vision, and other problems. In addition to taking medication, making lifestyle changes will also help to control your blood pressure. These changes include eating a diet that is low in fat and salt, maintaining a healthy weight, exercising at least 30 minutes most days, not smoking, and using alcohol in moderation.

See full Guanabenz drug information
Keep checking

Other Drugs & Black Hoof Mushroom

Browse every other medication we’ve checked against Black Hoof Mushroom — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
308Moderate
0Minor
2,521No known interaction
308 Moderate 2,521 No interaction
Moderate

308 interactions

Showing 60 of 308 moderate interactions — see all 308 on the Black Hoof Mushroom page.

No interaction 2,521 drugs checked — show the list

We also checked Black Hoof Mushroom against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,521 medications checked with no known interaction — see the full Black Hoof Mushroom list.

See the full Black Hoof Mushroom interactions page
See every supplement checked against Guanabenz Acetate, ranked by severity
Evidence & sources

Black Hoof Mushroom References

The 6 references that drive our Black Hoof Mushroom monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Song, K. S., Cho, S. M., Lee, J. H., Kim, H. M., Han, S. B., Ko, K. S., and Yoo, I. D. B-lymphocyte-stimulating polysaccharide from mushroom Phellinus linteus. Chem Pharm Bull (Tokyo) 1995;43(12):2105-2108. PubMed
  2. Matsuba, S., Matsuno, H., Sakuma, M., and Komatsu, Y. Phellinus linteus Extract Augments the Immune Response in Mitomycin C-Induced Immunodeficient Mice. Evid Based Complement Alternat Med 2008;5(1):85-90.
  3. Kim, G. Y., Roh, S. I., Park, S. K., Ahn, S. C., Oh, Y. H., Lee, J. D., and Park, Y. M. Alleviation of experimental septic shock in mice by acidic polysaccharide isolated from the medicinal mushroom Phellinus linteus. Biol Pharm Bull 2003;26(10):1418-1423 PubMed
  4. Shon, Y. H. and Nam, K. S. Inhibition of cytochrome P450 isozymes in rat liver microsomes by polysaccharides derived from Phellinus linteus. Biotechnol Lett 2003;25(2):167-172. PubMed
  5. Oh, G. S., Lee, M. S., Pae, H. O., Kwon, J., Lee, S. S., Jeong, J. G., Shin, M. K., Kwon, T. O., and Chung, H. T. Effects of oral administration of Phellinus linteus on the production of Th1- and Th2-type cytokines in mice. Immunopharmacol Immunotoxicol 2
  6. Kim, G. Y., Lee, J. Y., Lee, J. O., Ryu, C. H., Choi, B. T., Jeong, Y. K., Lee, K. W., Jeong, S. C., and Choi, Y. H. Partial characterization and immunostimulatory effect of a novel polysaccharide-protein complex extracted from Phellinus linteus. Biosci B

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Black Hoof Mushroom and Guanabenz Acetate Together: Common Questions

Is it safe to take Black Hoof Mushroom with Guanabenz Acetate?
We do not list a known interaction between Black Hoof Mushroom and Guanabenz Acetate. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
How was the Black Hoof Mushroom and Guanabenz Acetate combination checked?
Interactions in our licensed database are recorded against drug classes. Guanabenz Acetate is filed under 3 classifications, and Black Hoof Mushroom has documented interactions with 3 drug classes — none of Guanabenz Acetate's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Black Hoof Mushroom interact with any other medications?
Yes. Black Hoof Mushroom has 308 documented drug interactions in our database — Guanabenz Acetate is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Guanabenz Acetate interact with any supplements?
Yes. Guanabenz Acetate has documented interactions with 137 supplements in our database — Black Hoof Mushroom is not one of them. The Guanabenz Acetate interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Black Hoof Mushroom monograph Uses, safety profile, and every drug interaction in one place Guanabenz drug information The full plain-English guide to this medication Guanabenz Acetate supplement interactions Every supplement checked against Guanabenz Acetate, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 6 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Guanabenz Acetate and Black Hoof Mushroom?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.