Drug & supplement interaction

Blessed Thistle + Pegloticase

Pegloticase brand name: Krystexxa.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 27, 2026
The bottom line No known interaction

We found no known interaction between Blessed Thistle and Pegloticase in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Blessed Thistle and Pegloticase

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Pegloticase and Blessed Thistle in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Blessed Thistle safety at a glance

Blessed Thistle overall Use caution Often well tolerated in small amounts, but human safety data are limited and large doses can cause nausea or vomiting.
Pregnancy Likely Unsafe When used orally; avoid using. Read the full pregnancy detail
Breastfeeding Use caution Used traditionally to support milk supply, but safety has not been well studied, so check with your doctor first.

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Pegloticase and Blessed Thistle? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Pegloticase

Interactions in our licensed database are recorded against drug classes, not just single drug names. Pegloticase is filed under a single classification — antigout drugs. Blessed Thistle has documented interactions with 3 drug classes — the most serious being antacids (minor), h2-blockers (minor) and proton pump inhibitors (ppis) (minor) — and none of Pegloticase’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Blessed Thistle Does Interact With Other Medications

Blessed Thistle has 36 minor known drug interactions in our database — Pegloticase isn’t one of them. If you take anything else, check it against the full list below.

Minor 36 No known interaction 2,794 (incl. Pegloticase)
Taking anything else?

Check Another of Your Medications Against Blessed Thistle

Covers the 2,830 medications we’ve checked against Blessed Thistle. Pick one to open its full report.

What to actually watch for

No Interaction Found — But Data Suggests Blessed Thistle and Pegloticase May Share a Side Effect

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do.

  • Vomiting Additional detail

    Blessed Thistle

    “Orally, when blessed thistle is used in doses higher than 5 grams per cup of tea, it can cause stomach irritation and vomiting (12).”

    Blessed Thistle · Natural Medicines adverse-effect record, reported in nausea and vomiting.

    1 source cited
    1. 12. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.

    Pegloticase

    Listed in the ADVERSE REACTIONS section of the FDA label for Pegloticase. Read the label on DailyMed ›

Reported for Blessed Thistle but not commonly for Pegloticase: stomach upset, an allergic reaction and a skin rash.

Effects for Pegloticase come from the ADVERSE REACTIONS section of its FDA label; effects for Blessed Thistle come from the Natural Medicines adverse-effect record, quoted above. Where a percentage is shown, it is the share of 3,424 voluntary FDA FAERS reports for Pegloticase that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

Special populations

Blessed Thistle in Pregnancy & Breastfeeding

Pregnancy Likely Unsafe

When used orally; avoid using.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

Everything else you take

See Every Supplement That Interacts With Pegloticase

This page covers Blessed Thistle only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Pegloticase page lists 1 supplement it has a documented interaction with, worst first, each one explained.

The most serious there right now: Inosine (moderate).

By severity: 1 moderate.

From our pharmacist’s overview on the Pegloticase page

“Inosine is the one supplement on record that can work against pegloticase (Krystexxa), the IV enzyme infused for severe gout that has stopped responding to standard treatment. Inosine raises uric acid in the blood and urine, which is precisely what pegloticase exists to lower, so combining the two could blunt the very benefit those inf…”

Reviewed by 2 · Jul 18, 2026

Open the Pegloticase interaction page

One more smart check

Taking Blessed Thistle as Part of a Dietary Supplement Product? Check It for Interactions

We hold 729 real supplement products containing Blessed Thistle, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Blessed Thistle. Even though Blessed Thistle itself has no known interaction with Pegloticase, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Blessed Thistle and Pegloticase Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Blessed Thistle
Top 25%

#278 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Pegloticase
Steady interest

#2,513 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Blessed Thistle reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 27, 2026. The Blessed Thistle and Pegloticase records this page draws on were last updated July 11, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Blessed Thistle

What is Blessed Thistle?

Blessed Thistle
  • Digestive upset and poor appetite
  • Boosting bile flow
  • General bitter tonic
  • Supporting milk supply during breastfeeding (traditional)
  • Wound care (traditional, topical)

Blessed thistle is a bitter herb traditionally used to stimulate appetite and ease mild digestive complaints. High-quality human studies are lacking, so its benefits are not well proven. It is likely fine for short-term use in small, food-like amounts, but it should be avoided in pregnancy and used with caution by people allergic to ragweed and related plants.

Cnicus benedictus · Asteraceae · Aerial parts (leaves, stems, and flowers) · Tea, tincture, liquid extract, capsules, dried herb

An interaction check asks whether these two react with each other — it does not ask whether Blessed Thistle is a good idea for someone in your situation. Here is what our Blessed Thistle record says about it on its own.

Blessed Thistle: dosing

There is no official, standardized dose of blessed thistle. The right amount can vary depending on the product and the form (tea, tincture, or capsules).The best approach is to follow the directions on the product label and not exceed the recommended amount, since large doses are more likely to cause nausea and vomiting.

From our Blessed Thistle monograph — the full record covers uses, side effects and every documented interaction.

Read the full Blessed Thistle monograph & all interactions
Medication

About Pegloticase Injection

What Is Pegloticase Injection Used For?

Brand name: Krystexxa

Krystexxa is used to treat chronic gout in adults whose gout has not responded to conventional treatments — either because standard uric-acid-lowering medications (like xanthine oxidase inhibitors) haven't brought uric acid to a normal level, or because those drugs cannot be used.

Krystexxa is not recommended for people who have high uric acid levels but no gout symptoms (a condition called asymptomatic hyperuricemia).

Most-Reported Side Effects for Pegloticase

From FAERS, the FDA’s public side-effect reporting system (3,686 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Gout 562 reports
Blood uric acid increased 405 reports
Infusion related reaction 365 reports
Therapeutic response decreased 240 reports
Dyspnea 180 reports
See full Pegloticase Injection drug information
Keep checking

Other Drugs & Blessed Thistle

Browse every other medication we’ve checked against Blessed Thistle — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
36Minor
2,793No known interaction
36 Minor 2,793 No interaction
Minor

36 interactions

No interaction 2,793 drugs checked — show the list

We also checked Blessed Thistle against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,793 medications checked with no known interaction — see the full Blessed Thistle list.

See the full Blessed Thistle interactions page
See every supplement checked against Pegloticase, ranked by severity
Evidence & sources

Blessed Thistle References

The 2 references that drive our Blessed Thistle monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
  2. Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Blessed Thistle and Pegloticase Together: Common Questions

Is it safe to take Blessed Thistle with Pegloticase?
We do not list a known interaction between Blessed Thistle and Pegloticase. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Blessed Thistle and Pegloticase have any of the same side effects?
Yes — our sources link each of them separately to one of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
How was the Blessed Thistle and Pegloticase combination checked?
Interactions in our licensed database are recorded against drug classes. Pegloticase is filed under 1 classification, and Blessed Thistle has documented interactions with 3 drug classes — none of Pegloticase's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Blessed Thistle interact with any other medications?
Yes. Blessed Thistle has 36 documented drug interactions in our database — Pegloticase is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Pegloticase interact with any supplements?
Yes. Pegloticase has documented interactions with 1 supplement in our database — Blessed Thistle is not one of them. The Pegloticase interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Blessed Thistle monograph Uses, safety profile, and every drug interaction in one place Pegloticase Injection drug information The full plain-English guide to this medication Pegloticase supplement interactions Every supplement checked against Pegloticase, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 2 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Pegloticase and Blessed Thistle?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.