Drug & supplement interaction

Buchu + Plazomicin Sulfate

Plazomicin Sulfate brand name: Zemdri.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Oct 4, 2026
The bottom line No known interaction

We found no known interaction between Buchu and Plazomicin Sulfate in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Buchu and Plazomicin Sulfate

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Plazomicin Sulfate and Buchu in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Buchu safety at a glance

Buchu overall Use caution Generally used in food amounts, but medicinal doses lack strong safety data and the essential oil may be irritating.
Pregnancy Likely Unsafe When used in medicinal amounts; buchu is reported to be an abortifacient. Read the full pregnancy detail
Breastfeeding Possibly Safe When used in food amounts. There is insufficient reliable information available about the safety of using larger amounts; avoid using. Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Plazomicin Sulfate and Buchu? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Plazomicin Sulfate

Interactions in our licensed database are recorded against drug classes, not just single drug names. Plazomicin Sulfate is filed under 3 classifications — aminoglycoside antibiotics, antibiotic drugs, nephrotoxic drugs. Buchu has documented interactions with 3 drug classes — the most serious being anticoagulant/antiplatelet drugs (moderate), hepatotoxic drugs (moderate) and lithium (moderate) — and none of Plazomicin Sulfate’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Buchu Does Interact With Other Medications

Buchu has 483 moderate known drug interactions in our database — Plazomicin Sulfate isn’t one of them. If you take anything else, check it against the full list below.

Moderate 483 No known interaction 2,347 (incl. Plazomicin Sulfate)
Taking anything else?

Check Another of Your Medications Against Buchu

Covers the 2,830 medications we’ve checked against Buchu. Pick one to open its full report.

What to actually watch for

What Plazomicin Sulfate’s Own FDA Label Lists

This is not an interaction — none of it involves Buchu. These are the most notable effects listed in the ADVERSE REACTIONS section of Plazomicin Sulfate’s own FDA label, for the medication by itself. Knowing the drug’s own list makes it easier to work out the likely cause if something new turns up while you take both. 7 of them are worth acting on rather than waiting out — marked below.

  • Hearing loss Worth acting on
  • Low potassium Worth acting on
  • Kidney problems Worth acting on
  • Raised blood pressure Worth acting on
  • Shortness of breath Worth acting on
  • Liver problems Worth acting on
  • An allergic reaction Worth acting on
  • Low blood pressure
  • Stomach upset
  • Constipation

Showing the 10 most notable of 15 label-listed effects — ranked by how unusual each one is across medicines generally, with serious effects weighted up.

From the ADVERSE REACTIONS section of the FDA label for Plazomicin Sulfate. Read the label on DailyMed › Buchu’s licensed record lists no adverse effects our clinical vocabulary could match, so there is no Buchu side to compare — that is a limit of the record, not a statement that Buchu has no side effects.

Special populations

Buchu in Pregnancy & Breastfeeding

Pregnancy Likely Unsafe

When used in medicinal amounts; buchu is reported to be an abortifacient.

Lactation Possibly Safe

When used in food amounts. There is insufficient reliable information available about the safety of using larger amounts; avoid using.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

Everything else you take

See Every Supplement That Interacts With Plazomicin Sulfate

This page covers Buchu only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Plazomicin Sulfate page lists 35 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Asarabacca (major), Siberian Cocklebur (major), Aristolochia (moderate), Bacillus Coagulans (moderate) and Bacillus Subtilis (moderate).

By severity: 2 major · 31 moderate · 2 minor.

From our pharmacist’s overview on the Plazomicin Sulfate page

“Plazomicin (Zemdri) is an IV antibiotic reserved for serious urinary tract infections, and like other aminoglycosides it can strain the kidneys all by itself. That is why the two major-rated entries on this list matter most: Siberian cocklebur and asarabacca can both harm the kidneys, and stacking either onto plazomicin could compound…”

Reviewed by 2 · Jul 18, 2026

Open the Plazomicin Sulfate interaction page

One more smart check

Taking Buchu as Part of a Dietary Supplement Product? Check It for Interactions

We hold 128 real supplement products containing Buchu, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Buchu. Even though Buchu itself has no known interaction with Plazomicin Sulfate, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Buchu and Plazomicin Sulfate Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Buchu
Top 25%

#285 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Plazomicin Sulfate
Steady interest

#1,508 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Buchu reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified October 4, 2026. The Buchu and Plazomicin Sulfate records this page draws on were last updated July 11, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Buchu

What is Buchu?

Buchu
  • Urinary tract complaints
  • Diuretic (increasing urine flow)
  • Bloating and fluid retention
  • Mild digestive upset
  • Antimicrobial/antiseptic use
  • Flavoring and fragrance

Buchu is a fragrant South African shrub whose leaves are traditionally used for urinary and bladder complaints and as a diuretic. Solid human studies are lacking, so its benefits are largely unproven, and it should be avoided in pregnancy and breastfeeding. Talk to a pharmacist or doctor before using it, especially if you have kidney or liver problems.

Agathosma betulina · Rutaceae · Leaves and essential oil · Tea, capsules, tincture, dried leaf, essential oil

An interaction check asks whether these two react with each other — it does not ask whether Buchu is a good idea for someone in your situation. Here is what our Buchu record says about it on its own.

Buchu: dosing

There is no well-established standardized dose for buchu. Traditional preparations include teas made from the dried leaf and tinctures, but reliable human studies have not confirmed a safe and effective amount.If you choose to use a buchu product, follow the directions on the label and do not exceed them. Avoid taking the concentrated essential oil internally.

From our Buchu monograph — the full record covers uses, side effects and every documented interaction.

Read the full Buchu monograph & all interactions
Medication

About Plazomicin Injection

What Is Plazomicin Injection Used For?

Brand name: Zemdri

Zemdri (plazomicin) is used in adults 18 and older to treat complicated urinary tract infections (cUTI), including pyelonephritis (kidney infection). It is for infections caused by certain susceptible bacteria: Escherichia coli, Klebsiella pneumoniae, Proteus mirabilis and Enterobacter cloacae.

Because only limited safety and effectiveness data are available, it is reserved for people with limited or no alternative treatment options. It does not treat viral infections.

See full Plazomicin Injection drug information
Keep checking

Other Drugs & Buchu

Browse every other medication we’ve checked against Buchu — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
483Moderate
0Minor
2,346No known interaction
483 Moderate 2,346 No interaction
Moderate

483 interactions

Showing 60 of 483 moderate interactions — see all 483 on the Buchu page.

No interaction 2,346 drugs checked — show the list

We also checked Buchu against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,346 medications checked with no known interaction — see the full Buchu list.

See the full Buchu interactions page
See every supplement checked against Plazomicin Sulfate, ranked by severity
Evidence & sources

Buchu References

The 3 references that drive our Buchu monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Newall CA, Anderson LA, Philpson JD. Herbal Medicine: A Guide for Healthcare Professionals. London, UK: The Pharmaceutical Press, 1996.
  2. Fetrow CW, Avila JR. Professional's Handbook of Complementary & Alternative Medicines. 1st ed. Springhouse, PA: Springhouse Corp., 1999.
  3. Moolla A, Viljoen AM. 'Buchu' - Agathosma betulina and Agathosma crenulata (Retaceae): a review. J Ethnopharmacol 2008;119(3):413-9.

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Buchu and Plazomicin Sulfate Together: Common Questions

Is it safe to take Buchu with Plazomicin Sulfate?
We do not list a known interaction between Buchu and Plazomicin Sulfate. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
How was the Buchu and Plazomicin Sulfate combination checked?
Interactions in our licensed database are recorded against drug classes. Plazomicin Sulfate is filed under 3 classifications, and Buchu has documented interactions with 3 drug classes — none of Plazomicin Sulfate's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Buchu interact with any other medications?
Yes. Buchu has 483 documented drug interactions in our database — Plazomicin Sulfate is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Plazomicin Sulfate interact with any supplements?
Yes. Plazomicin Sulfate has documented interactions with 35 supplements in our database — Buchu is not one of them. The Plazomicin Sulfate interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Buchu monograph Uses, safety profile, and every drug interaction in one place Plazomicin Injection drug information The full plain-English guide to this medication Plazomicin Sulfate supplement interactions Every supplement checked against Plazomicin Sulfate, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 3 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Plazomicin Sulfate and Buchu?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.