Butea Superba + Aprocitentan
Aprocitentan brand name: Tryvio.
We found no known interaction between Butea Superba and Aprocitentan in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.
Butea Superba and Aprocitentan
We checked these two against our interaction database. Here is what we found.
No Known Interaction Found
We did not find a documented interaction between Aprocitentan and Butea Superba in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.
If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.
Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.
Butea Superba safety at a glance
Safety guidance is general; always confirm with your pharmacist or doctor for your situation.
Why No Interaction Is Listed for Aprocitentan
Interactions in our licensed database are recorded against drug classes, not just single drug names. Aprocitentan is filed under 7 classifications — including cytochrome p450 2c19 (cyp2c19) inhibitors, cytochrome p450 2c9 (cyp2c9) inhibitors, cytochrome p450 3a4 (cyp3a4) inducers. Butea Superba has documented interactions with 1 drug class — the most serious being phosphodiesterase-5 inhibitors (moderate) — and none of Aprocitentan’s classifications are among them.
Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.
Butea Superba Does Interact With Other Medications
Butea Superba has 7 moderate known drug interactions in our database — Aprocitentan isn’t one of them. If you take anything else, check it against the full list below.
Check Another of Your Medications Against Butea Superba
We haven’t checked that one against Butea Superba yet — ask our pharmacists directly.
Covers the 2,830 medications we’ve checked against Butea Superba. Pick one to open its full report.
See Every Supplement That Interacts With Aprocitentan
This page covers Butea Superba only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Aprocitentan page lists 189 supplements it has a documented interaction with, worst first, each one explained.
The most serious there right now: Activated Charcoal (major), American Hellebore (major), American Mistletoe (major), Beer (major) and Siberian Cocklebur (major).
By severity: 7 major · 161 moderate · 21 minor.
From our pharmacist’s overview on the Aprocitentan page
“Aprocitentan (Tryvio) is prescribed when blood pressure stays high despite other medicines, so anything that pushes your pressure around cuts straight to why you take it. Most of the 189 ingredients here do exactly that: some add to the drop and can leave you dizzy or faint, while others, tyramine among them, push pressure back up and…”
Reviewed by 2 · Jul 18, 2026
Taking Butea Superba as Part of a Dietary Supplement Product? Check It for Interactions
We hold 23 real supplement products containing Butea Superba, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Butea Superba. Even though Butea Superba itself has no known interaction with Aprocitentan, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:
Where Butea Superba and Aprocitentan Sit Against Everything Else
Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.
#689 of 1,452 supplements looked up here in the last 7 days
#424 of 2,830 medications looked up here in the last 7 days
Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.
Where does our data come from?
- Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
- Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Butea Superba reference on this page ↓
- Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Butea Superba and Aprocitentan records this page draws on were last updated July 3, 2026.
- What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
About Butea Superba
What is Butea Superba?
- Erectile dysfunction
- Low libido
- Male sexual performance
- General vitality and energy
- Traditional tonic
Butea superba is a Thai herb traditionally used to support male sexual health, but the human evidence is very limited and mostly small or low-quality. Its safety has not been well studied, so caution is advised, and you should talk with a pharmacist or doctor before trying it—especially if you have a medical condition or take other medicines.
Butea superba · Fabaceae · Root (tuber) · Capsules, tablets, powder, tinctures, topical gels
An interaction check asks whether these two react with each other — it does not ask whether Butea Superba is a good idea for someone in your situation. Here is what our Butea Superba record says about it on its own.
Butea Superba: dosing
There is no well-established or standardized dose for Butea superba. Studies have used different amounts and preparations, so it is hard to recommend a specific, reliable dose.If you choose to use it, follow the directions on the product label and do not exceed them.
From our Butea Superba monograph — the full record covers uses, side effects and every documented interaction.
About Aprocitentan
What Is Aprocitentan Used For?
Brand name: Tryvio
Tryvio is used to treat high blood pressure (hypertension) in adults. It is specifically for people whose blood pressure is not adequately controlled on other blood pressure medications — it is always used together with at least one other antihypertensive drug, not on its own.
Lowering blood pressure helps reduce the risk of serious cardiovascular events such as stroke and heart attack. Tryvio has not been studied as a standalone treatment and is not intended to replace other blood pressure medicines.
Other Drugs & Butea Superba
Browse every other medication we’ve checked against Butea Superba — both the ones with a known interaction and the ones without. Select any drug for the full detail.
No drugs match “”.
7 interactions
No interaction 2,822 drugs checked — show the list
We also checked Butea Superba against these medications and found no known interaction in our sources. Open any page to confirm.
- Apixaban ›
- Levothyroxine ›
- Amlodipine ›
- Warfarin ›
- Methylphenidate ›
- Sertraline ›
- Testosterone ›
- Ivermectin ›
- Losartan Potassium ›
- Abemaciclib ›
- Aspirin ›
- Acetaminophen ›
- Metoprolol ›
- Rosuvastatin ›
- Rivaroxaban ›
- Escitalopram ›
- Clopidogrel ›
- Atorvastatin ›
- Docusate ›
- Tirzepatide ›
- Methamphetamine ›
- Ibuprofen ›
- Warfarin Sodium ›
- Valacyclovir ›
- Hydroxyurea ›
- Sumatriptan ›
- Semaglutide ›
- Prednisone ›
- Propranolol ›
- Lisdexamfetamine ›
- Amitriptyline ›
- Metformin ›
- Amoxicillin ›
- Lisinopril ›
- Isotretinoin ›
- Amlodipine Besylate ›
- Bendamustine ›
- Methotrexate ›
- Bupropion ›
- Amphetamine ›
- Fluoxetine ›
- Doxycycline ›
- Azithromycin ›
- Acyclovir ›
- Pregabalin ›
- Lamotrigine ›
- Dextroamphetamine ›
- Gabapentin ›
- Acetaminophen, Codeine ›
- Levothyroxine, Liothyronine ›
- Clonazepam ›
- Quetiapine ›
- Naproxen ›
- Omeprazole ›
- Letrozole ›
- Duloxetine ›
- Methylene Blue ›
- Buspirone ›
- Citalopram ›
- Ciprofloxacin ›
Showing the 60 most looked-up of 2,822 medications checked with no known interaction — see the full Butea Superba list.
Butea Superba References
The 2 references that drive our Butea Superba monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.
- Cherdshewasart W, Nimsakul N. Clinical trial of Butea superba, an alternative herbal treatment for erectile dysfunction. Asian J Androl 2003;5:243-6.
- Cortés-González JR, Arratia-Maqueo JA, Gómez-Guerra LS, Holmberg AR. The use of Butea superba (Roxb.) compared to sildenafil for treating erectile dysfunction. BJU Int 2010;105(2):225-8. doi: 10.1111/j.1464-410X.2009.08748.x.
Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
Aprocitentan Is Linked to Lower Levels of One Nutrient
Natural Medicines records Aprocitentan as a medicine that can lower these. This is not an interaction with Butea Superba — it is a separate effect of the medicine, and it is a reason some people are advised to supplement rather than to avoid one:
Read the full Aprocitentan nutrient depletion report ›
Depletion records come from the licensed Natural Medicines database. Do not start a supplement on the strength of this page — ask your pharmacist or doctor whether it applies to you.
Taking Butea Superba and Aprocitentan Together: Common Questions
Is it safe to take Butea Superba with Aprocitentan?
How was the Butea Superba and Aprocitentan combination checked?
Does Butea Superba interact with any other medications?
Does Aprocitentan interact with any supplements?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.