Drug & supplement interaction

Capers + Paliperidone

Paliperidone brand name: Invega.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Capers and Paliperidone in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Capers and Paliperidone

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Paliperidone and Capers in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Capers safety at a glance

Capers overall Use caution Generally safe as a food, but concentrated supplements are not well studied.
Pregnancy Use caution Food amounts are likely fine, but avoid medicinal or concentrated doses due to lack of safety data.
Breastfeeding Use caution Food amounts are likely fine, but concentrated supplements lack safety data, so caution is advised.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Paliperidone and Capers? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Paliperidone

Interactions in our licensed database are recorded against drug classes, not just single drug names. Paliperidone is filed under 5 classifications — including antipsychotic drugs, qt interval-prolonging drugs, photosensitizing drugs. Capers has documented interactions with 1 drug class — the most serious being antidiabetes drugs (moderate) — and none of Paliperidone’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Capers Does Interact With Other Medications

Capers has 86 moderate known drug interactions in our database — Paliperidone isn’t one of them. If you take anything else, check it against the full list below.

Moderate 86 No known interaction 2,744 (incl. Paliperidone)
Taking anything else?

Check Another of Your Medications Against Capers

Covers the 2,830 medications we’ve checked against Capers. Pick one to open its full report.

What to actually watch for

What Capers Itself Has Been Linked To

This is not an interaction — nothing below involves Paliperidone. It is the side-effect record for Capers on its own, from the licensed Natural Medicines monograph. If something new turns up after you add Capers, this list is the first place to look.

  • A skin rash Additional detail

    “Orally, capers seem to be well tolerated. No adverse effects have been reported in clinical research; however, a high-quality assessment of safety has not been conducted. Topically, capers can cause contact dermatitis.”

    Capers · Natural Medicines adverse-effect record, reported in dermatitis.

    2 sources cited
    1. 96124. Huseini HF, Hasani-Rnjbar S, Nayebi N, et al. Capparis spinosa L. (Caper) fruit extract in treatment of type 2 diabetic patients: a randomized double-blind placebo-controlled clinical trial. Complement Ther Med. 2013;21(5):447-52. PubMed
    2. 12742. Angelini G, Vena GA, Filotico R, et al. Allergic contact dermatitis from Capparis spinosa L. applied as wet compresses. Contact Dermatitis 1991;24:382-3.

    “Topically, capers can cause contact dermatitis.”

    Capers · Natural Medicines adverse-effect record, reported in dermatitis.

    1 source cited
    1. 12742. Angelini G, Vena GA, Filotico R, et al. Allergic contact dermatitis from Capparis spinosa L. applied as wet compresses. Contact Dermatitis 1991;24:382-3.

Everything above comes from the Natural Medicines adverse-effect record for Capers — expand a row for the licensed statement it rests on. We read the ADVERSE REACTIONS section of Paliperidone’s FDA label too, and the two lists don’t meaningfully overlap — which is why no Paliperidone column appears here.

From our Q&A

Questions About Capers or Paliperidone

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Capers or Paliperidone, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Paliperidone

This page covers Capers only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Paliperidone page lists 64 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), American Hellebore (major), Arsenic (major), Cesium (major) and Ephedra (major).

By severity: 9 major · 44 moderate · 11 minor.

From our pharmacist’s overview on the Paliperidone page

“Paliperidone (Invega) is an antipsychotic for schizophrenia and related conditions that can stretch the heart's QT interval on its own, so this list warrants real vigilance. Nine of the 64 ingredients on file carry a major rating, and most either prolong that QT interval further (grapefruit in large amounts is one of them) or intensify…”

Reviewed by 2 · Jul 18, 2026

Open the Paliperidone interaction page

One more smart check

Taking Capers as Part of a Dietary Supplement Product? Check It for Interactions

We hold 53 real supplement products containing Capers, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Capers. Even though Capers itself has no known interaction with Paliperidone, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Capers and Paliperidone Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Capers
Top half

#597 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Paliperidone
Steady interest

#2,239 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Capers reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Capers and Paliperidone records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Capers

What is Capers?

  • Digestive support
  • Antioxidant source
  • Blood sugar support
  • Anti-inflammatory
  • Skin and traditional tonic uses

Capers are the edible pickled flower buds of the Capparis spinosa shrub, used widely as food and in traditional medicine. They contain antioxidant plant compounds, but high-quality human studies on health benefits are limited, so the supplement claims remain largely unproven. As a food, capers are generally safe, but talk to your pharmacist or doctor before using concentrated extracts.

Capparis spinosa · Capparaceae · Flower buds, fruit, root bark, and leaves · Pickled or brined buds (food), capsules, extracts, dried powder

An interaction check asks whether these two react with each other — it does not ask whether Capers is a good idea for someone in your situation. Here is what our Capers record says about it on its own.

Capers: dosing

There is no established standard dose for capers as a supplement. As a food, people simply use them as a flavoring in small amounts.For capsules or extracts, follow the directions on the product label, since strengths vary widely between brands.

From our Capers monograph — the full record covers uses, side effects and every documented interaction.

Read the full Capers monograph & all interactions
Medication

About Paliperidone

What Is Paliperidone Used For?

Brand name: Invega

Paliperidone treats schizophrenia and schizoaffective disorder. The extended-release tablets (Invega and generic paliperidone) are approved for schizophrenia in adults and adolescents ages 12–17, and for schizoaffective disorder in adults.

Several injectable formulations are also available, each with specific roles. Invega Sustenna and Erzofri extended-release are once-monthly injections approved for schizophrenia and schizoaffective disorder in adults. Invega Trinza is a once-every-3-month injection for schizophrenia in adults who have already been stabilized on a once-monthly paliperidone palmitate injection for at least four months. Invega Hafyera is a once-every-6-month injection for schizophrenia in adults already stabilized on a once-monthly or every-3-month paliperidone palmitate injection.

Most-Reported Side Effects for Paliperidone

From FAERS, the FDA’s public side-effect reporting system (52,996 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Injury 4,361 reports
Gynaecomastia 4,232 reports
Weight increased 2,843 reports
Hospitalisation 2,188 reports
Abnormal weight gain 1,828 reports
See full Paliperidone drug information
Keep checking

Other Drugs & Capers

Browse every other medication we’ve checked against Capers — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
86Moderate
0Minor
2,743No known interaction
86 Moderate 2,743 No interaction
Moderate

86 interactions

Showing 60 of 86 moderate interactions — see all 86 on the Capers page.

No interaction 2,743 drugs checked — show the list

We also checked Capers against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,743 medications checked with no known interaction — see the full Capers list.

See the full Capers interactions page
See every supplement checked against Paliperidone, ranked by severity
Evidence & sources

Capers References

The 3 references that drive our Capers monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Angelini G, Vena GA, Filotico R, et al. Allergic contact dermatitis from Capparis spinosa L. applied as wet compresses. Contact Dermatitis 1991;24:382-3.
  2. Huseini HF, Hasani-Rnjbar S, Nayebi N, et al. Capparis spinosa L. (Caper) fruit extract in treatment of type 2 diabetic patients: a randomized double-blind placebo-controlled clinical trial. Complement Ther Med. 2013;21(5):447-52. PubMed
  3. Vahid H, Bonakdaran S, Khorasani ZM, et al. Effect of Capparis spinosa extract on metabolic parameters in patients with type-2 diabetes: A randomized controlled trial. Endocr Metab Immune Disord Drug Targets. 2019;19(1):100-107. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Capers and Paliperidone Together: Common Questions

Is it safe to take Capers with Paliperidone?
We do not list a known interaction between Capers and Paliperidone. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
How was the Capers and Paliperidone combination checked?
Interactions in our licensed database are recorded against drug classes. Paliperidone is filed under 5 classifications, and Capers has documented interactions with 1 drug class — none of Paliperidone's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Capers interact with any other medications?
Yes. Capers has 86 documented drug interactions in our database — Paliperidone is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Paliperidone interact with any supplements?
Yes. Paliperidone has documented interactions with 64 supplements in our database — Capers is not one of them. The Paliperidone interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Capers monograph Uses, safety profile, and every drug interaction in one place Paliperidone drug information The full plain-English guide to this medication Paliperidone supplement interactions Every supplement checked against Paliperidone, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 3 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Paliperidone and Capers?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.