Chicory - Avandamet (Metformin, Rosiglitazone) Interaction
Herbal: Chicory
Also Known As: Cichorium intybus, Achicoria, Barbe de Capucin, Blue Sailors, Cheveux de Paysans, Chicorée, Cichorii Herba, Cichorii Radix, Common Chicory Root, Écoubette, Hendibeh, Herbe à Café, Hinduba, Kasani, Kasni, Racine de Chicorée Commune, Succory
Drug: Metformin, Rosiglitazone
Brand names:
Avandamet
Medical Content Editor Dr. Brian Staiger, PharmD
Last updated
May 04, 2025
Interaction Details
Metformin, Rosiglitazone is classified as belonging to the following category: Antidiabetes Drugs
Theoretically, chicory might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Animal and in vitro research shows that chicory extracts have antidiabetic effects.
Interaction Rating
Likelihood of Occurrence
PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
References
- Street RA, Sidana J, Prinsloo G. Cichorium intybus: traditional uses, phytochemistry, pharmacology, and toxicology. Evid Based Complement Alternat Med 2013;2013:579319.
- Devi Kt R, Sivalingam N. Cichorium intybus attenuates Streptozotocin-induced pancreatic ß-cell damage by inhibiting NF-?B activation and oxidative stress. J Appl Biomed 2020;18(2-3):70-9.
Chicory Overview
Chicory root is the root of the chicory plant, which is native to Europe and Asia. It is a perennial plant that belongs to the daisy family and has blue, purple, or pink flowers that bloom in the summer. Chicory root is often used as a coffee substitute and in traditional medicine.
Chicory root is purported to have diuretic, laxative, and digestive properties and has been traditionally used to treat constipation, indigestion, and liver and gallbladder disorders. Chicory root is also thought to have antioxidant and anti-inflammatory effects and has been used to improve skin health and treat skin conditions such as acne and eczema.
Chicory root is a source of inulin (not to be confused with insulin), a type of soluble fiber that is used as a sweetener and to improve digestive health.
Chicory - More Interactions
Chicory interacts with 84 drugs
Interaction Rating Key
These severity listings are for informational use only. Never start, stop or otherwise change your therapy before speaking with your provider.
| Major | The combined use of these agents is strongly discouraged as serious side effects or other negative outcomes could occur. |
| Moderate | Use cautiously under the care of a healthcare professional or avoid this combination. A significant interaction or negative outcome could occur. |
| Minor | Be aware that there is a chance of an interaction. Watch for warning signs of a potential interaction. |
| Unknown | No interactions have been reported or no interaction data is currently available. |
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Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC
Drug descriptions are provided by MedlinePlus.
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In addition to being a clinical pharmacist specializing in pharmacotherapy, Dr. Brian Staiger is a registered herbalist through the American Herbalist Guild. He has combined his passion for pharmacy practice with the study of medical ethnobotany to improve patient care. Feel free to reach out about any of your herbal or medication questions!
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