Drug & supplement interaction

Coffee Charcoal + Glasdegib

Glasdegib brand name: Daurismo.

Moderate Interaction
Medically reviewed by · Updated September 2026
The bottom line Moderate

Coffee Charcoal has a moderate interaction with Glasdegib. Coffee charcoal can reduce the absorption of orally administered drugs and should be separated from oral drug administration by at least two hours.

Read the full interaction report
SeverityModerate
LikelihoodProbable
EvidenceD
What do Severity, Likelihood & Evidence mean?
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Interaction report

Coffee Charcoal and Glasdegib

Here is the interaction we found between these two, with the evidence behind it.

Moderate

ORAL DRUGS

Why this applies to Glasdegib

Glasdegib falls under ORAL DRUGS — the group Coffee Charcoal interacts with.

Coffee charcoal can reduce the absorption of orally administered drugs and should be separated from oral drug administration by at least two hours.
Severity Moderate Likelihood Probable Evidence D

Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports..

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

Here's the key thing to know: coffee charcoal acts like a sponge in your gut. Because it has that porous, charcoal-like surface, it can grab onto medicines you swallow and keep them from being fully absorbed. Glasdegib (Daurismo) is a pill you take by mouth, so taking it too close to coffee charcoal could mean less of the drug actually gets into your body.

That matters because glasdegib is a cancer treatment, and getting a lower dose than intended could make it work less well against your leukemia. This concern is based on how charcoal behaves in general, not on a study of these two together, so it's more theoretical than proven. To stay safe, separate them by at least a couple of hours, and please check with your oncology team or pharmacist before combining them.

Contact Dr. Brian directly if you have additional questions on this interaction
References
  1. Blumenthal M, ed. The Complete German Commission E Monographs: Therapeutic Guide to Herbal Medicines. Trans. S. Klein. Boston, MA: American Botanical Council, 1998.

What These Ratings Mean

Every interaction above is graded three ways — here’s the key to each label.

Severity how clinically significant the interaction is
Major

Clinically significant. Avoid the combination, or use only under close professional supervision.

Moderate

Usually worth avoiding or managing — may need monitoring, a dose change, or timing apart.

Minor

Generally not serious. Be aware of it and mention it to your pharmacist.

Likelihood how strong the evidence is that the interaction actually happens in people
  • LikelyWell-controlled human studies have demonstrated the likely existence of this interaction.
  • ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
  • UnlikelyInteraction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
Evidence the quality of the studies behind the rating (graded A–D)
  • AHigh-quality meta-analysis (quantitative systematic review).
  • BCase-control study.
  • CConsensus.
  • DAnecdotal evidence.

These ratings are for information only. Never start, stop, or otherwise change your therapy before speaking with your provider.

Keep it in perspective

Coffee Charcoal Also Interacts With Other Medications

Coffee Charcoal has 2,021 moderate known drug interactions in our database — the Glasdegib one above is one of them. If you take anything else, check it against the full list below.

Moderate 2,021 No known interaction 809 (incl. Glasdegib)
Taking anything else?

Check Another of Your Medications Against Coffee Charcoal

Covers the 2,830 medications we’ve checked against Coffee Charcoal. Pick one to open its full report.

Everything else you take

See Every Supplement That Interacts With Glasdegib

This page covers Coffee Charcoal only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Glasdegib page lists 146 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), American Hellebore (major), Arsenic (major), Cesium (major) and Ephedra (major).

By severity: 8 major · 98 moderate · 40 minor.

From our pharmacist’s overview on the Glasdegib page

“Grapefruit is the first thing I would take off the table for anyone on glasdegib (Daurismo), a targeted pill for acute myeloid leukemia. It can push glasdegib levels up because the drug is cleared by the CYP3A4 enzyme, and 121 of the 146 ingredients touch that pathway, some raising its level and others, like St.”

Reviewed by 2 · Jul 18, 2026

Open the Glasdegib interaction page

How much people look this up

Where Coffee Charcoal and Glasdegib Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Coffee Charcoal
Top half

#366 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Glasdegib
Steady interest

#2,086 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Supplement

About Coffee Charcoal

What is Coffee Charcoal?

  • Diarrhea
  • Inflammatory bowel conditions
  • Irritable bowel syndrome (IBS)
  • Mild digestive upset
  • Wound and skin care (topical, traditional)

Coffee charcoal is made by roasting green coffee beans until they turn black, creating a charcoal-like material used traditionally for diarrhea and digestive complaints. Scientific evidence supporting its benefits is very limited, and it should not replace proven treatments. Talk with your pharmacist or doctor before using it, especially if you have a chronic gut condition.

Read the full Coffee Charcoal monograph & all interactions
Medication

About Glasdegib

What Is Glasdegib Used For?

Brand name: Daurismo

Daurismo (glasdegib) is approved to treat newly-diagnosed acute myeloid leukemia (AML) — a fast-growing cancer of the blood and bone marrow. It is used specifically in adults who are 75 years of age or older, or in adults of any age whose other health conditions make intensive induction chemotherapy too risky.

Daurismo is not used alone. It is always given together with low-dose cytarabine, a separate chemotherapy medicine, as part of a 28-day treatment cycle.

See full Glasdegib drug information
Keep checking

Other Drugs & Coffee Charcoal

Browse every other medication we’ve checked against Coffee Charcoal — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
2,021Moderate
0Minor
808No known interaction
2,021 Moderate 808 No interaction
Moderate

2,021 interactions

Showing 60 of 2,021 moderate interactions — see all 2,021 on the Coffee Charcoal page.

No interaction 808 drugs checked — show the list

We also checked Coffee Charcoal against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 808 medications checked with no known interaction — see the full Coffee Charcoal list.

See the full Coffee Charcoal interactions page
See every supplement checked against Glasdegib, ranked by severity
Sources

Sources & How We Checked

Interaction details are evidence-graded and sourced from the Natural Medicines database. The medication overview comes from MedlinePlus.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Coffee Charcoal monograph › Uses, safety, and every drug interaction in one place Glasdegib supplement interactions › Every supplement checked against Glasdegib, ranked by severity Glasdegib drug information › The full plain-English guide to this medication Supplement interaction checker › Check any supplement or product against your medications Browse medications A–Z › Every drug we've checked against herbs & supplements Ask a pharmacist › Free, personal answer from our licensed team
Pharmacist Counseling Corner

Taking Coffee Charcoal and Glasdegib Together: Common Questions

Can you take Coffee Charcoal with Glasdegib?
There is a moderate interaction, so it may be acceptable with monitoring or timing changes — but check with your pharmacist first. Read the full details on this page and confirm with your pharmacist before combining them.
How serious is the Coffee Charcoal and Glasdegib interaction?
We rate it Moderate. This combination may require monitoring, a dose adjustment, or separating the times you take each one. Consult your pharmacist before using them together.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Still Have a Question About Glasdegib and Coffee Charcoal?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.