Drug & supplement interaction

European Mandrake + Setmelanotide

Setmelanotide brand name: Imcivree.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between European Mandrake and Setmelanotide in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

European Mandrake and Setmelanotide

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Setmelanotide and European Mandrake in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

European Mandrake safety at a glance

European Mandrake overall Avoid Mandrake is highly toxic and can be fatal if swallowed.
Pregnancy Likely Unsafe When used orally. European mandrake contains anticholinergic alkaloids that can cross the placenta and adversely effect the fetus; avoid using. Read the full pregnancy detail
Breastfeeding Likely Unsafe When used orally. European mandrake contains anticholinergic alkaloids that can cross the placenta and adversely effect the fetus; avoid using. Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Setmelanotide and European Mandrake? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
Keep it in perspective

European Mandrake Does Interact With Other Medications

European Mandrake has 2,042 moderate known drug interactions in our database — Setmelanotide isn’t one of them. If you take anything else, check it against the full list below.

Moderate 2,042 No known interaction 788 (incl. Setmelanotide)
Taking anything else?

Check Another of Your Medications Against European Mandrake

Covers the 2,830 medications we’ve checked against European Mandrake. Pick one to open its full report.

What to actually watch for

No Interaction Found — But Data Suggests European Mandrake and Setmelanotide May Share Several of the Same Side Effects

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do. 2 of them are worth acting on rather than waiting out — marked below.

  • A severe allergic reaction / An allergic reaction Worth acting on Additional detail

    European Mandrake

    “Orally, European mandrake most commonly causes anticholinergic side effects including confusion, drowsiness, dry mouth, tachycardia, mydriasis, blurred vision, photophobia, decreased urination, decreased sweating and overheating, and flushing (15,17,18). Although some adverse reactions can occur even with low doses, adverse effects are dose related.”

    European Mandrake · Natural Medicines adverse-effect record, reported in cardiac arrest.

    4 sources cited
    1. 15. McEvoy GK, ed. AHFS Drug Information. Bethesda, MD: American Society of Health-System Pharmacists, 1998.
    2. 17. Ellenhorn MJ, et al. Ellenhorn's Medical Toxicology: Diagnoses and Treatment of Human Poisoning. 2nd ed. Baltimore, MD: Williams & Wilkins, 1997.
    3. 18. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
    4. 7022. Helbling A, Brander KA, Pichler WJ. Anaphylactic shock after subcutaneous injection of mandragora D3, a homeopathic drug. J Allergy Clin Immunol 2000;106:989-90. PubMed

    Setmelanotide

    Listed in the ADVERSE REACTIONS section of the FDA label for Setmelanotide. Read the label on DailyMed ›

  • Stomach pain / Nausea Additional detail

    European Mandrake

    Recorded for European Mandrake in the same Natural Medicines adverse-effect record shown under A severe allergic reaction / An allergic reaction above.

    Setmelanotide

    Listed in the ADVERSE REACTIONS section of the FDA label for Setmelanotide. Read the label on DailyMed ›

Reported for European Mandrake but not commonly for Setmelanotide: fainting, hallucinations, blurred vision and anxiety or restlessness.

Effects for Setmelanotide come from the ADVERSE REACTIONS section of its FDA label; effects for European Mandrake come from the Natural Medicines adverse-effect record, quoted above. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

Special populations

European Mandrake in Pregnancy & Breastfeeding

Pregnancy And Lactation Likely Unsafe

When used orally. European mandrake contains anticholinergic alkaloids that can cross the placenta and adversely effect the fetus; avoid using.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

How much people look this up

Where European Mandrake and Setmelanotide Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement European Mandrake
Top 25%

#217 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Setmelanotide
Top 25%

#433 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every European Mandrake reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The European Mandrake and Setmelanotide records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About European Mandrake

What is European Mandrake?

European Mandrake
  • Insomnia (traditional)
  • Pain relief (historical)
  • Anxiety or depression (folk use)
  • Gout and aches (traditional)
  • Sedation or anesthesia (historical)

European mandrake is a highly toxic plant from the nightshade family that was used in ancient and medieval times as a sedative and pain reliever. It contains powerful poisons that can cause serious harm or death, and there is no proof it safely treats any condition. We strongly recommend you do not consume mandrake in any form.

Mandragora officinarum · Solanaceae · Root (and sometimes leaves and fruit) · Historically used as root preparations, extracts, and tinctures; not sold as a safe modern supplement

An interaction check asks whether these two react with each other — it does not ask whether European Mandrake is a good idea for someone in your situation. Here is what our European Mandrake record says about it on its own.

European Mandrake: dosing

There is no safe or established dose of European mandrake. It is not approved or recommended as a dietary supplement, and reputable products are not sold for internal use.Because the plant is highly toxic, we strongly advise against taking it in any amount or form.

From our European Mandrake monograph — the full record covers uses, side effects and every documented interaction.

Read the full European Mandrake monograph & all interactions
Medication

About Setmelanotide Injection

What Is Setmelanotide Injection Used For?

Brand name: Imcivree

Imcivree is used to reduce excess body weight and maintain that weight loss long-term in adults and children with certain rare, specific causes of obesity. It is not intended for general weight loss or common obesity.

Imcivree is approved for: acquired hypothalamic obesity (HO) in patients aged 4 and older; Bardet-Biedl syndrome (BBS) in patients aged 2 and older; and obesity caused by confirmed deficiencies of POMC, PCSK1, or LEPR genes (pathogenic, likely pathogenic, or uncertain-significance variants) in patients aged 2 and older.

See full Setmelanotide Injection drug information
Keep checking

Other Drugs & European Mandrake

Browse every other medication we’ve checked against European Mandrake — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
2,042Moderate
0Minor
787No known interaction
2,042 Moderate 787 No interaction
Moderate

2,042 interactions

Showing 60 of 2,042 moderate interactions — see all 2,042 on the European Mandrake page.

No interaction 787 drugs checked — show the list

We also checked European Mandrake against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 787 medications checked with no known interaction — see the full European Mandrake list.

See the full European Mandrake interactions page
See every supplement checked against Setmelanotide, ranked by severity
Evidence & sources

European Mandrake References

The 4 references that drive our European Mandrake monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. McEvoy GK, ed. AHFS Drug Information. Bethesda, MD: American Society of Health-System Pharmacists, 1998.
  2. Ellenhorn MJ, et al. Ellenhorn's Medical Toxicology: Diagnoses and Treatment of Human Poisoning. 2nd ed. Baltimore, MD: Williams & Wilkins, 1997.
  3. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
  4. Helbling A, Brander KA, Pichler WJ. Anaphylactic shock after subcutaneous injection of mandragora D3, a homeopathic drug. J Allergy Clin Immunol 2000;106:989-90. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking European Mandrake and Setmelanotide Together: Common Questions

Is it safe to take European Mandrake with Setmelanotide?
We do not list a known interaction between European Mandrake and Setmelanotide. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do European Mandrake and Setmelanotide have any of the same side effects?
Yes — our sources link each of them separately to 4 of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
Does European Mandrake interact with any other medications?
Yes. European Mandrake has 2,042 documented drug interactions in our database — Setmelanotide is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

European Mandrake monograph Uses, safety profile, and every drug interaction in one place Setmelanotide Injection drug information The full plain-English guide to this medication Setmelanotide supplement interactions Every supplement checked against Setmelanotide, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 4 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Setmelanotide and European Mandrake?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.