Drug & supplement interaction

Evodia + Cladribine

Cladribine brand names: Leustatin, Mavenclad.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Evodia and Cladribine in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Evodia and Cladribine

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Cladribine and Evodia in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Evodia safety at a glance

Evodia overall Use caution Limited human safety data exist, so use carefully and under professional guidance.
Pregnancy Possibly Unsafe When used orally. Active constituents in evodia have uterine stimulant activity in animal models. Evodia might also decrease litter size in animal models. Theor... Read the full pregnancy detail
Breastfeeding Avoid There is not enough safety information, so it is best to avoid while breastfeeding.

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Cladribine and Evodia? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Cladribine

Interactions in our licensed database are recorded against drug classes, not just single drug names. Cladribine is filed under 2 classifications — immunosuppressants, oral drugs. Evodia has documented interactions with 11 drug classes — the most serious being anticoagulant/antiplatelet drugs (moderate), caffeine (moderate) and chlorzoxazone (parafon forte, paraflex) (moderate) — and none of Cladribine’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Evodia Does Interact With Other Medications

Evodia has 950 moderate known drug interactions in our database — Cladribine isn’t one of them. If you take anything else, check it against the full list below.

Moderate 950 No known interaction 1,880 (incl. Cladribine)
Taking anything else?

Check Another of Your Medications Against Evodia

Covers the 2,830 medications we’ve checked against Evodia. Pick one to open its full report.

What to actually watch for

What Evodia Itself Has Been Linked To

This is not an interaction — nothing below involves Cladribine. It is the side-effect record for Evodia on its own, from the licensed Natural Medicines monograph. If something new turns up after you add Evodia, this list is the first place to look. One entry is worth acting on rather than waiting out — marked below.

  • An irregular heartbeat Worth acting on Additional detail

    “There is no reliable evidence regarding the safety of evodia from clinical trials. In animal studies, evodia has induced QT prolongation and Torsade de pointes.”

    Evodia · Natural Medicines adverse-effect record, reported in torsades de pointes.

    1 source cited
    1. 97035. Baburin I, Varkvisser R, Schramm A, et al. Dehydroevodiamine and hortiamine, alkaloids from the traditional Chinese herbal drug Evodia rutaecarpa, are IKr blockers with proarrhythmic effects in vitro and in vivo. Pharmacol Res. 2018 May;131:150-163. DOI

    “In animal studies, evodia acts as a proarrhythmic agent with a dose-dependent effect. Evodia infusion has resulted in QT prolongation and Torsade de pointes. It is not clear what dose of evodia, if any, is required to produce a similar effect in humans.”

    Evodia · Natural Medicines adverse-effect record, reported in torsades de pointes.

    1 source cited
    1. 97035. Baburin I, Varkvisser R, Schramm A, et al. Dehydroevodiamine and hortiamine, alkaloids from the traditional Chinese herbal drug Evodia rutaecarpa, are IKr blockers with proarrhythmic effects in vitro and in vivo. Pharmacol Res. 2018 May;131:150-163. DOI

Everything above comes from the Natural Medicines adverse-effect record for Evodia — expand a row for the licensed statement it rests on. We read the ADVERSE REACTIONS section of Cladribine’s FDA label too, and the two lists don’t meaningfully overlap — which is why no Cladribine column appears here.

Special populations

Evodia in Pregnancy & Breastfeeding

Pregnancy Possibly Unsafe

When used orally. Active constituents in evodia have uterine stimulant activity in animal models. Evodia might also decrease litter size in animal models. Theoretically, taking evodia during pregnancy might adversely affect pregnancy outcome.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

Everything else you take

See Every Supplement That Interacts With Cladribine

This page covers Evodia only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Cladribine page lists 70 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Active Hexose Correlated Compound (ahcc) (moderate), Alfalfa (moderate), American Ginseng (moderate) and Andrographis (moderate).

By severity: 1 major · 59 moderate · 10 minor.

From our pharmacist’s overview on the Cladribine page

“Cladribine (Leustatin, Mavenclad) treats hairy cell leukemia and relapsing multiple sclerosis by deliberately knocking down part of the immune system, so this list calls for real vigilance. Of the 70 supplements and herbs on file, 53 are immune stimulators, herbs like astragalus, ashwagandha, and ginseng that could push immunity back u…”

Reviewed by 2 · Jul 18, 2026

Open the Cladribine interaction page

One more smart check

Taking Evodia as Part of a Dietary Supplement Product? Check It for Interactions

We hold 182 real supplement products containing Evodia, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Evodia. Even though Evodia itself has no known interaction with Cladribine, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Evodia and Cladribine Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Evodia
Top 25%

#352 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Cladribine
Steady interest

#2,575 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Evodia reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Evodia and Cladribine records this page draws on were last updated July 11, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Evodia

What is Evodia?

  • Digestive upset and nausea
  • Headaches
  • Menstrual cramps
  • Abdominal pain
  • Diarrhea

Evodia is a fruit used in traditional Chinese medicine, most often for digestive complaints, headaches, and menstrual pain. Human evidence for these uses is very limited, and it is mostly studied in laboratory and animal research. Talk with a pharmacist or doctor before using it, and avoid it during pregnancy and breastfeeding.

Tetradium ruticarpum · Rutaceae · Dried unripe fruit · Dried fruit, powder, capsules, tablets, teas, and traditional herbal formulas

An interaction check asks whether these two react with each other — it does not ask whether Evodia is a good idea for someone in your situation. Here is what our Evodia record says about it on its own.

Evodia: dosing

There is no well-established standard dose for evodia. Traditional use often relies on combination formulas prepared by trained practitioners, and modern supplement products vary widely in strength and ingredients.If you choose to use evodia, follow the directions on the product label and do not exceed the recommended amount.

From our Evodia monograph — the full record covers uses, side effects and every documented interaction.

Read the full Evodia monograph & all interactions
Medication

About Cladribine

What Is Cladribine Used For?

Brand names: Leustatin, Mavenclad

Cladribine tablets (brand name Mavenclad) are used to treat relapsing forms of multiple sclerosis (MS) in adults — specifically relapsing-remitting MS and active secondary progressive MS. Because of its significant safety profile, it is generally reserved for patients who haven't responded well to, or can't tolerate, other MS medicines. It is not recommended for clinically isolated syndrome (CIS), a first episode that may or may not lead to MS.

Cladribine injection (given intravenously) is a separate product used to treat active hairy cell leukemia — a rare blood cancer — in patients who have clinically significant anemia, low white blood cell counts, low platelets, or disease-related symptoms.

Most-Reported Side Effects for Cladribine

From FAERS, the FDA’s public side-effect reporting system (9,555 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Fatigue 814 reports
Headache 681 reports
Lymphocyte count decreased 488 reports
Multiple sclerosis relapse 474 reports
Nausea 423 reports
See full Cladribine drug information
Keep checking

Other Drugs & Evodia

Browse every other medication we’ve checked against Evodia — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
950Moderate
0Minor
1,879No known interaction
950 Moderate 1,879 No interaction
Moderate

950 interactions

Showing 60 of 950 moderate interactions — see all 950 on the Evodia page.

No interaction 1,879 drugs checked — show the list

We also checked Evodia against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 1,879 medications checked with no known interaction — see the full Evodia list.

See the full Evodia interactions page
See every supplement checked against Cladribine, ranked by severity
Evidence & sources

Evodia References

The 13 references that drive our Evodia monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Sheu JR, Kan YC, Hung WC, et al. The antiplatelet activity of rutaecarpine, an alkaloid isolated from Evodia rutaecarpa, is mediated through inhibition of phospholipase C. Thromb Res 1998;92:53-64. PubMed
  2. Sheu JR, Hung WC, Lee YM, Yen MH. Mechanism of inhibition of platelet aggregation by rutaecarpine, an alkaloid isolated from Evodia rutaecarpa. Eur J Pharmacol 1996;318:469-75. PubMed
  3. Ueng YF, Tsai TH, Don MJ, et al. Alteration of the pharmacokinetics of theophylline by rutaecarpine, an alkaloid of the medicinal herb Evodia rutaecarpa, in rats. J Pharm Pharmacol 2005;57:227-32.
  4. King CL, Kong YC, Wong NS, et al. Uterotonic effect of Evodia rutaecarpa alkaloids. J Nat Prod 1980;43:577-82. PubMed
  5. Ueng YF, Jan WC, Lin LC, et al. The alkaloid rutaecarpine is a selective inhibitor of cytochrome P450 1A in mouse and human liver microsomes. Drug Metab Dispos 2002;30:349-53. PubMed
  6. Iwata H, Tezuka Y, Kadota S, et al. Mechanism-based inactivation of human liver microsomal CYP3A4 by rutaecarpine and limonin from Evodia fruit extract. Drug Metab Pharmacokinet 2005;20:34-45. PubMed
  7. Sheu JR, Hung WC, Wu CH, et al. Antithrombotic effect of rutaecarpine, an alkaloid isolated from Evodia rutaecarpa, on platelet plug formation in in vivo experiments. Br J Haematol 2000;110:110-5.
  8. Tsai TH, Chang CH, Lin LC. Effects of Evodia rutaecarpa and rutaecarpine on the pharmacokinetics of caffeine in rats. Planta Med 2005;71:640-5.
  9. Lee SK, Kim NH, Lee J, et al. Induction of cytochrome P450s by rutaecarpine and metabolism of rutaecarpine by cytochrome P450s. Planta Med 2004;70:753-7. PubMed
  10. Baburin I, Varkvisser R, Schramm A, et al. Dehydroevodiamine and hortiamine, alkaloids from the traditional Chinese herbal drug Evodia rutaecarpa, are IKr blockers with proarrhythmic effects in vitro and in vivo. Pharmacol Res. 2018 May;131:150-163. DOI
  11. Zhang W, Guo J, Wang D, et al. Effect of CYP3A inducer/inhibitor on pharmacokinetics of five alkaloids in Evodiae Fructus. Chem Biol Interact 2020;327:109146. PubMed
  12. Huang CJ, Huang WC, Lin WT, et al. Rutaecarpine, an alkaloid from Evodia rutaecarpa, can prevent platelet activation in humans and reduce microvascular thrombosis in mice: crucial role of the PI3K/Akt/GSK3ß signal axis through a cyclic nucleotides/VASP-in
  13. Bista SR, Lee SK, Thapa D, et al. Effects of oral rutaecarpine on the pharmacokinetics of intravenous chlorzoxazone in rats. Toxicol Res 2008;24(3):195-9. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Evodia and Cladribine Together: Common Questions

Is it safe to take Evodia with Cladribine?
We do not list a known interaction between Evodia and Cladribine. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
How was the Evodia and Cladribine combination checked?
Interactions in our licensed database are recorded against drug classes. Cladribine is filed under 2 classifications, and Evodia has documented interactions with 11 drug classes — none of Cladribine's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Evodia interact with any other medications?
Yes. Evodia has 950 documented drug interactions in our database — Cladribine is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Cladribine interact with any supplements?
Yes. Cladribine has documented interactions with 70 supplements in our database — Evodia is not one of them. The Cladribine interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Evodia monograph Uses, safety profile, and every drug interaction in one place Cladribine drug information The full plain-English guide to this medication Cladribine supplement interactions Every supplement checked against Cladribine, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 13 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Cladribine and Evodia?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.