Drug & supplement interaction

Fenugreek + Latanoprostene Bunod

Latanoprostene Bunod brand name: Vyzulta.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Fenugreek and Latanoprostene Bunod in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

Know someone taking this? Share
Facebook Post Reddit Email
On this page
Interaction report

Fenugreek and Latanoprostene Bunod

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Latanoprostene Bunod and Fenugreek in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Fenugreek safety at a glance

Fenugreek overall Use caution Generally well tolerated in food amounts, but supplement doses may cause side effects and aren't right for everyone.
Pregnancy Likely Unsafe When used orally in amounts greater than those found in food. Fenugreek has potential oxytoxic and uterine stimulant activity. There are case reports of congeni... Read the full pregnancy detail
Breastfeeding Possibly Safe When used orally to stimulate lactation, short-term. Although most available clinical studies lack safety testing in the lactating parent or infant, some eviden... Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Pharmacist analysis

Fenugreek is generally considered relatively safe in regard to potential drug interactions.

Nevertheless, interactions are possible between fenugreek and:

  • 'Blood-thinning' drugs
  • Drugs that lower blood pressure
  • Drugs that low blood sugar

Fenugreek contains some components that can prevent blood from clotting. However, there is not enough research to confirm whether the amount of these components present in common fenugreek products can have a clinically significant effect.

Fenugreek may also have an additive effect with blood sugar-lowering medication and blood pressure-lowering medication.

All of these potential interactions are documented individually on our specific drug-herbal interaction pages.

—

Still wondering about combining Latanoprostene Bunod and Fenugreek? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
Keep it in perspective

Fenugreek Does Interact With Other Medications

Fenugreek has 224 moderate, 165 minor known drug interactions in our database — Latanoprostene Bunod isn’t one of them. If you take anything else, check it against the full list below.

Moderate 224 Minor 165 No known interaction 2,441 (incl. Latanoprostene Bunod)
Taking anything else?

Check Another of Your Medications Against Fenugreek

Covers the 2,830 medications we’ve checked against Fenugreek. Pick one to open its full report.

What to actually watch for

No Interaction Found — But Data Suggests Fenugreek and Latanoprostene Bunod May Share a Side Effect

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do.

  • Swelling Additional detail

    Fenugreek

    “Fenugreek can cause allergic reactions when used orally and topically, and when the powder is inhaled. Orally, fenugreek has caused bronchospasm, diarrhea, and itching, and skin reactions severe enough to require intravenous human immunoglobulin. Topically, fenugreek paste has resulted in facial swelling, wheezing, and numbness around the head.”

    Fenugreek · Natural Medicines adverse-effect record, reported in asthma.

    2 sources cited
    1. 719. Patil SP, Niphadkar PV, Bapat MM. Allergy to fenugreek (Trigonella foenum graecum). Ann Allergy Asthma Immunol 1997;78:297-300. PubMed
    2. 96068. Ouzir M, El Bairi K, Amzazi S. Toxicological properties of fenugreek (Trigonella foenum graecum). Food Chem Toxicol. 2016 Oct;96:145-54. PubMed

    Latanoprostene Bunod

    Listed in the ADVERSE REACTIONS section of the FDA label for Latanoprostene Bunod. Read the label on DailyMed ›

Reported for Fenugreek but not commonly for Latanoprostene Bunod: fainting, an allergic reaction, stomach pain and wheezing.

Effects for Latanoprostene Bunod come from the ADVERSE REACTIONS section of its FDA label; effects for Fenugreek come from the Natural Medicines adverse-effect record, quoted above. Where a percentage is shown, it is the share of 1,071 voluntary FDA FAERS reports for Latanoprostene Bunod that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

Special populations

Fenugreek in Pregnancy & Breastfeeding

Pregnancy Likely Unsafe

When used orally in amounts greater than those found in food. Fenugreek has potential oxytoxic and uterine stimulant activity. There are case reports of congenital malformations, including hydrocephalus, anencephaly, cleft palate, and spina bifida, after consumption of fenugreek seeds during pregnancy. Consumption of fenugreek immediately prior to delivery may cause the neonate to have unusual body odor. Although this does not appear to cause long-term sequelae, it may be misdiagnosed as maple syrup urine disease.

Lactation Possibly Safe

When used orally to stimulate lactation, short-term. Although most available clinical studies lack safety testing in the lactating parent or infant, some evidence suggests that taking fenugreek 1725 mg three times daily orally for 21 days does not cause negative side effects in the infant.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

Overlapping uses

What Latanoprostene Bunod Is Prescribed For, and What Fenugreek Has Been Studied For

These two come up together because they touch the same health topic — not because they do the same job. Latanoprostene Bunod is a prescription medicine with approved uses on its FDA label. Fenugreek is a supplement: what follows is what researchers have looked at it for, and how strong that evidence is.

Latanoprostene Bunod is prescribed for: Vyzulta (latanoprostene bunod ophthalmic solution) 0.024% is used to reduce intraocular pressure (pressure inside the eye) in people with open-angle glaucoma or ocular hypertension (higher-than-normal eye pressure without glaucoma damage yet). Lowering eye pressure is important because high eye pressure is a major risk factor for worsening glaucoma and vision loss.

Fenugreek has been studied for:

  • Hypertension studied, not established Fenugreek has been studied for this. Natural Medicines rates the evidence: Insufficient Reliable Evidence To Rate Read what the research shows

    Fenugreek for hypertension

    Analysis of small clinical studies suggests that oral fenugreek might slightly improve systolic blood pressure (SBP).

Effectiveness ratings and the research summaries above are the verbatim record from the Natural Medicines database, which grades evidence from “Effective” down to “Insufficient Reliable Evidence To Rate”. A rating below the top of that scale means researchers have looked at it — not that it works, and never that it can stand in for a prescribed medicine. Do not stop or replace Latanoprostene Bunod on your own; if you are taking Fenugreek for the same health topic, tell your prescriber, especially if the medicine is being adjusted to a target.

One more smart check

Taking Fenugreek as Part of a Dietary Supplement Product? Check It for Interactions

We hold 2,385 real supplement products containing Fenugreek, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Fenugreek. Even though Fenugreek itself has no known interaction with Latanoprostene Bunod, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Fenugreek and Latanoprostene Bunod Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Fenugreek
Top 10%

#77 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Latanoprostene Bunod
Top 25%

#566 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Fenugreek reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Fenugreek and Latanoprostene Bunod records this page draws on were last updated July 11, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Fenugreek

What is Fenugreek?

Fenugreek
  • Blood sugar control
  • Boosting breast milk supply
  • High cholesterol
  • Digestive upset
  • Low testosterone or libido

Fenugreek is a common kitchen spice that is also taken as a supplement, mainly for blood sugar, cholesterol, and to support breast milk production. Some early research is encouraging for blood sugar, but overall the evidence is mixed and far from settled. It is generally well tolerated as food, but talk with your pharmacist or doctor before using it as a supplement, especially if you are pregnant.

Trigonella foenum-graecum · Fabaceae · Seeds and leaves · Capsules, powder, seeds, tea, extracts, and as a culinary spice

An interaction check asks whether these two react with each other — it does not ask whether Fenugreek is a good idea for someone in your situation. Here is what our Fenugreek record says about it on its own.

Fenugreek: dosing

There is no official standardized dose for fenugreek, and the right amount depends on the product and reason for use. Studies have used a wide range of doses and different preparations, so there is no single agreed-upon amount.The best approach is to follow the directions on the product label and not exceed them.

From our Fenugreek monograph — the full record covers uses, side effects and every documented interaction.

Read the full Fenugreek monograph & all interactions
Medication

About Latanoprostene Bunod Ophthalmic

What Is Latanoprostene Bunod Ophthalmic Used For?

Brand name: Vyzulta

Vyzulta (latanoprostene bunod ophthalmic solution) 0.024% is used to reduce intraocular pressure (pressure inside the eye) in people with open-angle glaucoma or ocular hypertension (higher-than-normal eye pressure without glaucoma damage yet). Lowering eye pressure is important because high eye pressure is a major risk factor for worsening glaucoma and vision loss.

Most-Reported Side Effects for Latanoprostene Bunod

From FAERS, the FDA’s public side-effect reporting system (1,071 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Eye pain 109 reports
Eye irritation 100 reports
Ocular hyperaemia 75 reports
Intraocular pressure increased 63 reports
Vision blurred 46 reports
See full Latanoprostene Bunod Ophthalmic drug information
Keep checking

Other Drugs & Fenugreek

Browse every other medication we’ve checked against Fenugreek — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
224Moderate
165Minor
2,440No known interaction
224 Moderate 165 Minor 2,440 No interaction
Moderate

224 interactions

Showing 60 of 224 moderate interactions — see all 224 on the Fenugreek page.

Minor

165 interactions

Showing 60 of 165 minor interactions — see all 165 on the Fenugreek page.

No interaction 2,440 drugs checked — show the list

We also checked Fenugreek against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,440 medications checked with no known interaction — see the full Fenugreek list.

See the full Fenugreek interactions page
See every supplement checked against Latanoprostene Bunod, ranked by severity
Evidence & sources

Fenugreek References

The 30 references that drive our Fenugreek monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Madar Z, Thorne R. Dietary fiber. Prog Food Nutr Sci 1987;11:153-74.
  2. Sharma RD, Raghuram TC, Rao NS. Effect of fenugreek seeds on blood glucose and serum lipids in type I diabetes. Eur J Clin Nutr 1990;44:301-6.
  3. Patil SP, Niphadkar PV, Bapat MM. Allergy to fenugreek (Trigonella foenum graecum). Ann Allergy Asthma Immunol 1997;78:297-300. PubMed
  4. Lambert J, Cormier J. Potential interaction between warfarin and boldo-fenugreek. Pharmacotherapy 2001;21:509-12. PubMed
  5. Bordia A, Verma SK, Srivastava KC. Effect of ginger (Zingiber officinale Rosc.) and fenugreek (Trigonella foenumgraecum L.) on blood lipids, blood sugar and platelet aggregation in patients with coronary artery disease. Prostaglandins Leukot Essent Fatty PubMed
  6. Yalcin SS, Tekinalp G, Ozalp I. Peculiar odor of traditional food and maple syrup urine disease. Pediatr Int 1999;41:108-9. PubMed
  7. Sewell AC, Mosandl A, Bohles H. False diagnosis of maple syrup urine disease owing to ingestion of herbal tea. N Engl J Med 1999;341:769.. PubMed
  8. Abdo MS, al-Kafawi AA. Experimental studies on the effect of Trigonella foenum-graecum (abstract). Planta Med 1969;17:14-8.
  9. Gupta A, Gupta R, Lal B. Effect of Trigonella foenum-graecum (fenugreek) seeds on glycaemic control and insulin resistance in type 2 diabetes mellitus: a double blind placebo controlled study. J Assoc Physicians India 2001;49:1057-61.
  10. Gabay MP. Galactogogues: medications that induce lactation. J Hum Lact 2002;18:274-9. PubMed
  11. Chevassus H, Gaillard JB, Farret A, et al. A fenugreek seed extract selectively reduces spontaneous fat intake in overweight subjects. Eur J Clin Pharmacol 2010;66(5):449-55. PubMed
  12. Turkyilmaz C, Onal E, Hirfanoglu IM, et al. The effect of galactagogue herbal tea on breast milk production and short-term catch-up of birth weight in the first week of life. J Altern Complement Med 2011;17(2):139-42. PubMed
  13. Swafford S, Berens P. Effect of fenugreek on breast milk volume. Abstract presented at: 5th International Meeting of the Academy of Breastfeeding Medicine; September 11-13,2000, Tucson, Arizona.
  14. Abdel-Barry, J. A., Abdel-Hassan, I. A., Jawad, A. M., and al Hakiem, M. H. Hypoglycaemic effect of aqueous extract of the leaves of Trigonella foenum-graecum in healthy volunteers. East Mediterr.Health J 2000;6(1):83-88. DOI
  15. Parvizpur, A., Ahmadiani, A., and Kamalinejad, M. Probable role of spinal purinoceptors in the analgesic effect of Trigonella foenum (TFG) leaves extract. J Ethnopharmacol 3-8-2006;104(1-2):108-112. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Fenugreek and Latanoprostene Bunod Together: Common Questions

Is it safe to take Fenugreek with Latanoprostene Bunod?
We do not list a known interaction between Fenugreek and Latanoprostene Bunod. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Fenugreek and Latanoprostene Bunod have any of the same side effects?
Yes — our sources link each of them separately to one of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
Are Fenugreek and Latanoprostene Bunod used for the same thing?
They overlap in purpose, which usually means the real question is whether you need both rather than whether they are safe together. This page lists the shared uses and how strong the evidence is for Fenugreek in each. That is a conversation for your prescriber, especially if Latanoprostene Bunod is being adjusted to a target.
Does Fenugreek interact with any other medications?
Yes. Fenugreek has 389 documented drug interactions in our database — Latanoprostene Bunod is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Fenugreek monograph Uses, safety profile, and every drug interaction in one place Latanoprostene Bunod Ophthalmic drug information The full plain-English guide to this medication Latanoprostene Bunod supplement interactions Every supplement checked against Latanoprostene Bunod, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 30 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Latanoprostene Bunod and Fenugreek?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.