Drug & supplement interaction

Figwort + Letrozole

Letrozole brand name: Femara.

No Known Interaction
Medically reviewed by · Updated June 2026 · Pair last verified Oct 4, 2026
The bottom line No known interaction

We found no known interaction between Figwort and Letrozole in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

Know someone taking this? Share
Facebook Post Reddit Email
On this page
Interaction report

Figwort and Letrozole

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Letrozole and Figwort in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Figwort safety at a glance

Figwort overall Use caution Limited safety data exist, so use with care and short-term only.
Pregnancy Avoid Not enough safety information; best avoided during pregnancy.
Breastfeeding Avoid No reliable safety data, so it is best to avoid while breastfeeding.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Letrozole and Figwort? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Letrozole

Interactions in our licensed database are recorded against drug classes, not just single drug names. Letrozole is filed under 4 classifications — including aromatase inhibitors, cytochrome p450 2c19 (cyp2c19) inhibitors, cytochrome p450 3a4 (cyp3a4) substrates. Figwort has documented interactions with 2 drug classes — the most serious being diuretic drugs (moderate) and lithium (moderate) — and none of Letrozole’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Figwort Does Interact With Other Medications

Figwort has 76 moderate known drug interactions in our database — Letrozole isn’t one of them. If you take anything else, check it against the full list below.

Moderate 76 No known interaction 2,754 (incl. Letrozole)
Taking anything else?

Check Another of Your Medications Against Figwort

Covers the 2,830 medications we’ve checked against Figwort. Pick one to open its full report.

What to actually watch for

What Letrozole’s Own FDA Label Lists

This is not an interaction — none of it involves Figwort. These are the most notable effects listed in the ADVERSE REACTIONS section of Letrozole’s own FDA label, for the medication by itself. Knowing the drug’s own list makes it easier to work out the likely cause if something new turns up while you take both. One of them is worth acting on rather than waiting out — marked below.

  • Bleeding or bruising Worth acting on
  • Flushing
  • Sweating
  • Joint pain
  • Muscle pain
  • Swelling
  • Tiredness
  • Dizziness
  • Headache
  • Nausea

From the ADVERSE REACTIONS section of the FDA label for Letrozole. Read the label on DailyMed › Figwort’s licensed record lists no adverse effects our clinical vocabulary could match, so there is no Figwort side to compare — that is a limit of the record, not a statement that Figwort has no side effects.

From our Q&A

Questions About Figwort or Letrozole

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Figwort or Letrozole, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Letrozole

This page covers Figwort only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Letrozole page lists 142 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Grapefruit (major), St. John's Wort (major), 7-methoxyflavone (moderate) and Acacia Rigidula (moderate).

By severity: 3 major · 99 moderate · 40 minor.

From our pharmacist’s overview on the Letrozole page

“Letrozole (Femara) is prescribed to keep hormone-driven breast cancer from returning, so a supplement that shifts its blood level can quietly undercut treatment. Give this list of 142 ingredients genuine respect, and learn the three major entries first.”

Reviewed by 2 · Jul 18, 2026

Open the Letrozole interaction page

One more smart check

Taking Figwort as Part of a Dietary Supplement Product? Check It for Interactions

We hold 147 real supplement products containing Figwort, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Figwort. Even though Figwort itself has no known interaction with Letrozole, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Figwort and Letrozole Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Figwort
Top half

#555 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Letrozole
Top 5%

#51 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Figwort reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified October 4, 2026. The Figwort and Letrozole records this page draws on were last updated June 22, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Figwort

What is Figwort?

  • Skin conditions like eczema and psoriasis
  • Minor wounds and rashes
  • Swelling and inflammation
  • Mild constipation
  • Traditional 'detox' or lymphatic support

Figwort is a traditional herb used mainly for skin problems and minor swelling, but solid human studies are lacking, so its benefits remain unproven. It is generally used short-term and topically, and people with heart conditions, pregnant women, and nursing mothers should avoid it until more is known.

Scrophularia nodosa · Scrophulariaceae · Aerial parts (leaves, stems, flowers) and sometimes the root · Tea, tincture, capsules, dried herb, topical creams or ointments

An interaction check asks whether these two react with each other — it does not ask whether Figwort is a good idea for someone in your situation. Here is what our Figwort record says about it on its own.

Figwort: dosing

There is no established standardized dose for figwort. Traditional use varies by the form (tea, tincture, capsule, or ointment) and by the product maker. Avoid using more than the label suggests, and do not use it for long periods without professional advice.

From our Figwort monograph — the full record covers uses, side effects and every documented interaction.

Read the full Figwort monograph & all interactions
Medication

About Letrozole

What Is Letrozole Used For?

Brand name: Femara

Letrozole (brand name Femara, or available as generic letrozole tablets) is used to treat breast cancer in postmenopausal women whose tumors are hormone receptor positive — meaning the cancer feeds on estrogen. It is used in several situations: as an adjuvant treatment (therapy given after primary treatment to reduce the risk of the cancer returning) for early breast cancer, and as extended adjuvant treatment for women who have already completed five years of tamoxifen therapy.

Femara and letrozole tablets are also used as first-line or second-line treatment for locally advanced or metastatic (spread to other areas) breast cancer in postmenopausal women, including cases where the cancer has progressed after other anti-estrogen therapy.

See full Letrozole drug information
Keep checking

Other Drugs & Figwort

Browse every other medication we’ve checked against Figwort — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
76Moderate
0Minor
2,753No known interaction
76 Moderate 2,753 No interaction
Moderate

76 interactions

Showing 60 of 76 moderate interactions — see all 76 on the Figwort page.

No interaction 2,753 drugs checked — show the list

We also checked Figwort against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,753 medications checked with no known interaction — see the full Figwort list.

See the full Figwort interactions page
See every supplement checked against Letrozole, ranked by severity
Evidence & sources

Figwort References

The 1 references that drive our Figwort monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Figwort and Letrozole Together: Common Questions

Is it safe to take Figwort with Letrozole?
We do not list a known interaction between Figwort and Letrozole. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
How was the Figwort and Letrozole combination checked?
Interactions in our licensed database are recorded against drug classes. Letrozole is filed under 4 classifications, and Figwort has documented interactions with 2 drug classes — none of Letrozole's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Figwort interact with any other medications?
Yes. Figwort has 76 documented drug interactions in our database — Letrozole is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Letrozole interact with any supplements?
Yes. Letrozole has documented interactions with 142 supplements in our database — Figwort is not one of them. The Letrozole interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Figwort monograph Uses, safety profile, and every drug interaction in one place Letrozole drug information The full plain-English guide to this medication Letrozole supplement interactions Every supplement checked against Letrozole, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 1 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Letrozole and Figwort?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.