Ginkgo + Medroxyprogesterone Acetate, Oestrogens, Conjugated
Medroxyprogesterone Acetate, Oestrogens, Conjugated brand name: Premique.
Medroxyprogesterone Acetate, Oestrogens, Conjugated falls into 2 drug categories that Ginkgo can interact with; the most serious is rated moderate. Theoretically, ginkgo might decrease levels of drugs metabolized by CYP3A4.
Read the full interaction reportGinkgo and Medroxyprogesterone Acetate, Oestrogens, Conjugated
These two interact in 2 distinct ways. Each one is explained separately below.
Why Are There 2 Interactions?
Ginkgo interacts with whole categories of medication. Medroxyprogesterone Acetate, Oestrogens, Conjugated falls into 2 of those categories, so it can interact with Ginkgo in 2 different ways. We’ve listed each one below — your overall risk is driven by the most serious of them (Moderate).
CYTOCHROME P450 3A4 (CYP3A4) SUBSTRATES
1 of 2Why this applies to Medroxyprogesterone Acetate, Oestrogens, Conjugated
Medroxyprogesterone Acetate, Oestrogens, Conjugated falls under CYTOCHROME P450 3A4 (CYP3A4) SUBSTRATES — the group Ginkgo interacts with.
There is conflicting evidence about whether ginkgo induces or inhibits CYP3A4. Ginkgo does not appear to affect hepatic CYP3A4. However, it is not known if ginkgo affects intestinal CYP3A4. Preliminary clinical research suggests that taking ginkgo does not significantly affect levels of donepezil, lopinavir, or ritonavir, which are all CYP3A4 substrates. Other clinical research also suggests ginkgo does not significantly affect CYP3A4 activity. However, there are two case reports of decreased efavirenz concentrations and increased viral load in patients taking ginkgo. It is suspected that terpenoids from the ginkgo extract reduced drug levels by inducing cytochrome P450 3A4 (CYP3A4).
Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
Premique combines conjugated estrogens with medroxyprogesterone, and your liver and gut use an enzyme called CYP3A4 to help break these hormones down. The theory here is that ginkgo might speed that enzyme up a little. If that happened, your body could clear the hormones a bit faster, which in theory could weaken the benefit you are taking Premique for (for example, hot flashes or night sweats creeping back, or some return of vaginal dryness).
I want to be honest: this is mostly theoretical. The evidence is mixed, and ginkgo does not seem to affect the liver's CYP3A4 much. Neither hormone is a prodrug, so the worry would be slightly less effect, not more. Please don't stop or change anything on your own. Just check with your pharmacist or doctor so they can keep an eye on it.
- Gurley BJ, Gardner SF, Hubbard MA. Clinical assessment of potential cytochrome P450-mediated herb-drug interactions. AAPS Ann Mtg & Expo Indianapolis, IN: 2000; Oct 29 - Nov 2:presentation #3460.
- Galluzzi S, Zanetti O, Binetti G, et al. Coma in a patient with Alzheimer's disease taking low dose trazodone and Ginkgo biloba. J Neurol Neurosurg Psychiatry 2000;68:679-80. DOI
- Budzinski JW, Foster BC, Vandenhoek S, Arnason JT. An in vitro evaluation of human cytochrome P450 3A4 inhibition by selected commercial herbal extracts and tinctures. Phytomedicine 2000;7:273-82. PubMed
- Gurley BJ, Gardner SF, Hubbard MA, et al. Cytochrome P450 phenotypic ratios for predicting herb-drug interactions in humans. Clin Pharmacol Ther 2002;72:276-87.. PubMed
- Yale SH, Glurich I. Analysis of the inhibitory potential of Ginkgo biloba, Echinacea purpurea, and Serenoa repens on the metabolic activity of cytochrome P450 3A4, 2D6, and 2C9. J Altern Complement Med 2005;11:433-9.
- Yasui-Furukori N, Furukori H, Kaneda A, et al. The effects of Ginkgo biloba extracts on the pharmacokinetics and pharmacodynamics of donepezil. J Clin Pharmacol 2004;44:538-42.
- Markowitz JS, Donovan JL, Lindsay DeVane C, et al. Multiple-dose administration of Ginkgo biloba did not affect cytochrome P-450 2D6 or 3A4 activity in normal volunteers. J Clin Psychopharmacol 2003;23:576-81. PubMed
- Wiegman DJ, Brinkman K, Franssen EJ. Interaction of Ginkgo biloba with efavirenz. AIDS 2009;23:1184-5. PubMed
- Naccarato M, Yoong D, Gough K. A potential drug-herbal interaction between Ginkgo biloba and efavirenz. J Int Assoc Physicians AIDS Care (Chic). 2012;11(2):98-100. doi: 10.1177/1545109711435364. Epub 2012 Feb 9.
- Robertson, S. M., Davey, R. T., Voell, J., Formentini, E., Alfaro, R. M., and Penzak, S. R. Effect of Ginkgo biloba extract on lopinavir, midazolam and fexofenadine pharmacokinetics in healthy subjects. Curr Med Res Opin 2008;24(2):591-599. PubMed
- Penzak, S. R., Busse, K. H., Robertson, S. M., Formentini, E., Alfaro, R. M., and Davey, R. T., Jr. Limitations of using a single postdose midazolam concentration to predict CYP3A-mediated drug interactions. J Clin Pharmacol 2008;48(6):671-680. PubMed
- Jalloh MA, Gregory PJ, Hein D, et al. Dietary supplement interactions with antiretrovirals: a systematic review. Int J STD AIDS. 2017 Jan;28(1):4-15. PubMed
- Bai J, Zhang C. Metabolic interaction between biflavonoids in Ginkgo biloba leaves and tacrolimus. Biopharm Drug Dispos 2023;44(2):157-164.
P-GLYCOPROTEIN SUBSTRATES
2 of 2Medroxyprogesterone Acetate, Oestrogens, Conjugated also falls under P-GLYCOPROTEIN SUBSTRATES.
A small clinical study in healthy volunteers shows that using ginkgo leaf extract 120 mg orally three times daily for 14 days can increase levels of the P-glycoprotein substrate, talinolol, by 36% in healthy male individuals. However, single doses of ginkgo do not have the same effect.
Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
Premique combines conjugated estrogens with medroxyprogesterone, a combination used for menopause symptoms. There's a theory that ginkgo can slow down a transporter called P-glycoprotein, which helps move certain medications around your body. If ginkgo blocks it, your hormone levels could nudge a little higher than expected.
To be honest, this is mostly a theoretical concern. The real study behind it looked at a blood pressure drug (talinolol), not your hormones, and only saw a modest bump after two weeks of steady ginkgo use, not from a single dose. Still, if hormone levels crept up, you might notice more breast tenderness, bloating, nausea, or spotting. Nothing to panic over, but it's worth a quick chat with your pharmacist or doctor before adding regular ginkgo.
- Fan, L., Tao, G. Y., Wang, G., Chen, Y., Zhang, W., He, Y. J., Li, Q., Lei, H. P., Jiang, F., Hu, D. L., Huang, Y. F., and Zhou, H. H. Effects of Ginkgo biloba extract ingestion on the pharmacokinetics of talinolol in healthy Chinese volunteers. Ann Phar PubMed
What These Ratings Mean
Every interaction above is graded three ways — here’s the key to each label.
Clinically significant. Avoid the combination, or use only under close professional supervision.
Usually worth avoiding or managing — may need monitoring, a dose change, or timing apart.
Generally not serious. Be aware of it and mention it to your pharmacist.
- LikelyWell-controlled human studies have demonstrated the likely existence of this interaction.
- ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
- PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
- UnlikelyInteraction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
- AHigh-quality meta-analysis (quantitative systematic review).
- BCase-control study.
- CConsensus.
- DAnecdotal evidence.
These ratings are for information only. Never start, stop, or otherwise change your therapy before speaking with your provider.
Ginkgo Also Interacts With Other Medications
Ginkgo has 1 major, 1,264 moderate known drug interactions in our database — the Medroxyprogesterone Acetate, Oestrogens, Conjugated one above is among them. If you take anything else, check it against the full list below.
Check Another of Your Medications Against Ginkgo
We haven’t checked that one against Ginkgo yet — ask our pharmacists directly.
Covers the 2,830 medications we’ve checked against Ginkgo. Pick one to open its full report.
Questions About Ginkgo or Medroxyprogesterone Acetate, Oestrogens, Conjugated
These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Ginkgo or Medroxyprogesterone Acetate, Oestrogens, Conjugated, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:
- Can I Take Ginkgo With Apixaban (Eliquis) and Atorvastatin? ›
- Does Lisinopril Interact With Ginkgo Biloba? ›
- Supplements for Leg Circulation Safe With Citalopram and Lisinopril ›
Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.
See Every Supplement That Interacts With Medroxyprogesterone Acetate, Oestrogens, Conjugated
This page covers Ginkgo only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Medroxyprogesterone Acetate, Oestrogens, Conjugated page lists 187 supplements it has a documented interaction with, worst first, each one explained.
The most serious there right now: Activated Charcoal (major), Grapefruit (major), St. John's Wort (major), Acacia Rigidula (moderate) and Adrafinil (moderate).
By severity: 3 major · 152 moderate · 32 minor.
From our pharmacist’s overview on the Medroxyprogesterone Acetate, Oestrogens, Conjugated page
“Menopause and herbal remedies tend to travel together, so anyone taking Premique (medroxyprogesterone acetate with conjugated estrogens) should read this page with real care. Three of its 187 ingredients rate major, and those three matter most.”
Reviewed by 2 · Jul 18, 2026
Open the Medroxyprogesterone Acetate, Oestrogens, Conjugated interaction page
Taking Ginkgo as Part of a Dietary Supplement Product? Check It for Interactions
We hold 4,399 real supplement products containing Ginkgo, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Ginkgo. Your product may carry other ingredients that interact with Medroxyprogesterone Acetate, Oestrogens, Conjugated too, on top of Ginkgo — and those would not show on this page. Find your product and we’ll check every ingredient on its label:
Where Ginkgo and Medroxyprogesterone Acetate, Oestrogens, Conjugated Sit Against Everything Else
Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.
#49 of 1,452 supplements looked up here in the last 7 days
#918 of 2,830 medications looked up here in the last 7 days
Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.
About Ginkgo
What is Ginkgo?
- Memory and cognitive support
- Age-related mental decline
- Circulation problems
- Tinnitus (ringing in the ears)
- Dizziness or vertigo
Ginkgo is one of the world's most popular herbal supplements, mostly taken to support memory and circulation. The evidence for these uses is mixed and generally weak, and it is not proven to prevent memory loss or dementia. It is usually well tolerated in healthy adults, but it can thin the blood, so talk to your pharmacist or doctor before using it.
Other Drugs & Ginkgo
Browse every other medication we’ve checked against Ginkgo — both the ones with a known interaction and the ones without. Select any drug for the full detail.
No drugs match “”.
1 interaction
1,264 interactions
- Diclofenac Sodium ›
- Diltiazem ›
- Theophylline ›
- Nifedipine ›
- Ibuprofen ›
- Metronidazole ›
- Diphenhydramine ›
- Aspirin ›
- Hydrocortisone ›
- Insulin (rdna) ›
- Methylphenidate ›
- Naproxen ›
- Doxycycline ›
- Erythromycin ›
- Estradiol ›
- Minocycline ›
- Propranolol ›
- Tetracycline ›
- Lidocaine ›
- Ranitidine ›
- Amoxicillin ›
- Norethindrone ›
- Testosterone ›
- Verapamil ›
- Levonorgestrel ›
- Prednisone ›
- Quinidine ›
- Cyclosporine ›
- Dexamethasone ›
- Glyburide ›
- Insulin (pork) ›
- Triazolam ›
- Zopiclone ›
- Bupropion ›
- Chloroquine ›
- Ciprofloxacin ›
- Colchicine ›
- Fentanyl ›
- Flurbiprofen ›
- Oxybutynin ›
- Oxycodone ›
- Penicillin V Potassium ›
- Phenytoin ›
- Prednisolone ›
- Tacrolimus ›
- Temazepam ›
- Triamcinolone ›
- Amphotericin B ›
- Ampicillin ›
- Apomorphine ›
- Budesonide ›
- Carbamazepine ›
- Ceftazidime ›
- Clindamycin ›
- Dextromethorphan ›
- Diclofenac Potassium ›
- Dipyridamole ›
- Doxorubicin ›
- Fluticasone ›
- Formoterol ›
Showing 60 of 1,264 moderate interactions — see all 1,264 on the Ginkgo page.
No interaction 1,564 drugs checked — show the list
We also checked Ginkgo against these medications and found no known interaction in our sources. Open any page to confirm.
- Levothyroxine ›
- Escitalopram ›
- Rosuvastatin ›
- Docusate ›
- Methamphetamine ›
- Sumatriptan ›
- Hydroxyurea ›
- Isotretinoin ›
- Lisdexamfetamine ›
- Lisinopril ›
- Pregabalin ›
- Azithromycin ›
- Levothyroxine, Liothyronine ›
- Dextroamphetamine ›
- Methylene Blue ›
- Candesartan Cilexetil ›
- Cyclopentolate ›
- Ezetimibe ›
- Acetaminophen, Dextromethorphan, Doxylamine ›
- Thyroid Hormone ›
- Mannitol ›
- Roxithromycin ›
- Spironolactone ›
- Levothyroxine Sodium ›
- Mitomycin ›
- Minoxidil ›
- Daptomycin ›
- Hydroxychloroquine ›
- Magnesium Hydroxide (otc Drug) ›
- Alginic Acid, Aluminum Hydroxide ›
- Hydrochlorothiazide ›
- Pegunigalsidase Alfa-iwxj ›
- Hexobarbitone ›
- Bentoquatam ›
- Pizotifen ›
- Casanthranol, Docusate ›
- Birth Control Pills ›
- Telmisartan ›
- Succinylcholine ›
- Flutemetamol F-18 ›
- Factor 7a ›
- Triptorelin ›
- Vancomycin ›
- Alglucosidase Alpha ›
- Hethylphenidate Hcl ›
- Azelaic Acid ›
- Salbutamol Sulfate ›
- Tocainide ›
- Phenylephrine ›
- Olmesartan Medoxomil ›
- Articaine, Epinephrine ›
- Bendroflumethiazide, Rauwolfia Serpentina ›
- Rituximab ›
- Lenvatinib ›
- Chenodiol ›
- Hydrochlorothiazide, Lisinopril ›
- Choline Magnesium Trisalicylate ›
- Ribavirin Aerosol ›
- Bleomycin ›
- Dirithromycin ›
Showing the 60 most looked-up of 1,564 medications checked with no known interaction — see the full Ginkgo list.
Sources & How We Checked
Interaction details are evidence-graded and sourced from the Natural Medicines database. The medication overview comes from MedlinePlus.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference for vitamins, herbs and supplements — the basis for our interaction data.
- MedlinePlus, U.S. National Library of Medicine — NIH consumer drug information, used for the medication overviews.
- NIH Dietary Supplement Label Database (DSLD) — Official supplement product labels.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC
Medroxyprogesterone Acetate, Oestrogens, Conjugated Is Linked to Lower Levels of 5 Nutrients
Natural Medicines records Medroxyprogesterone Acetate, Oestrogens, Conjugated as a medicine that can lower these. This is not an interaction with Ginkgo — it is a separate effect of the medicine, and it is a reason some people are advised to supplement rather than to avoid one:
Read the full Medroxyprogesterone Acetate, Oestrogens, Conjugated nutrient depletion report ›
Depletion records come from the licensed Natural Medicines database. Do not start a supplement on the strength of this page — ask your pharmacist or doctor whether it applies to you.
Taking Ginkgo and Medroxyprogesterone Acetate, Oestrogens, Conjugated Together: Common Questions
Can you take Ginkgo with Medroxyprogesterone Acetate, Oestrogens, Conjugated?
Why are there 2 interactions listed for Ginkgo and Medroxyprogesterone Acetate, Oestrogens, Conjugated?
How serious is the Ginkgo and Medroxyprogesterone Acetate, Oestrogens, Conjugated interaction?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.