Medication interaction hub

What Supplements Interact with Medroxyprogesterone Acetate, Oestrogens, Conjugated?

Medroxyprogesterone Acetate, Oestrogens, Conjugated brand name: Premique. Every interaction below applies to the brands too.

187 Interactions 3 Major 152 Moderate 32 Minor
Curated & coded by · Clinical Pharmacist · Updated September 22, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Medroxyprogesterone Acetate, Oestrogens, Conjugated? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Medroxyprogesterone Acetate, Oestrogens, Conjugated against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

Menopause and herbal remedies tend to travel together, so anyone taking Premique (medroxyprogesterone acetate with conjugated estrogens) should read this page with real care. Three of its 187 ingredients rate major, and those three matter most. St. John's wort speeds the body's clearance of these hormones and can quietly weaken the therapy, grapefruit does the opposite and pushes levels higher, and activated charcoal can soak up a dose before it ever absorbs.

Most of the 152 moderate entries repeat a few patterns, with another 32 rated minor. Sixty ingredients have estrogen-like activity of their own and could compete with the hormones you are actually prescribed. Estrogen also slows caffeine clearance, so caffeinated teas, coffees, and herbs may hit harder while you are on this treatment. If you use a bulk fiber or charcoal product, take it well apart from your tablet so it cannot block absorption.

— , Clinical Pharmacist · July 18, 2026

Major 3 Moderate 152 Minor 32 No known interaction 1,265

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Most Viewed Ingredient Interactions

Medroxyprogesterone Acetate, Oestrogens, Conjugated: Top Interactions at a Glance

The Medroxyprogesterone Acetate, Oestrogens, Conjugated supplement & herbal interactions people checked most in the last 24 hours, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 187 interacting ingredients — plus 1,265 more checked with no known interaction. See the complete ranked list.

Start here

The Most-Checked Medroxyprogesterone Acetate, Oestrogens, Conjugated Combinations Today

The Medroxyprogesterone Acetate, Oestrogens, Conjugated + supplement pages people viewed most in the last 24 hours (resets at midnight). Open any card for the full report.

Moderate Likelihood Probable Black Tea + Medroxyprogesterone Acetate, Oestrogens, Conjugatedi

Theoretically, estrogens might increase the levels and adverse effects of caffeine.

Read the full interaction Moderate Likelihood Probable Coffee + Medroxyprogesterone Acetate, Oestrogens, Conjugatedi

Theoretically, estrogens might increase the levels and adverse effects of caffeine.

Read the full interaction Moderate Likelihood Possible Vitamin E + Medroxyprogesterone Acetate, Oestrogens, Conjugatedi

Theoretically, vitamin E might induce metabolism of CYP3A4, possibly reducing the levels CYP3A4 substrates.

Read the full interaction Moderate Likelihood Possible Black Pepper + Medroxyprogesterone Acetate, Oestrogens, Conjugatedi

Theoretically, black pepper might increase levels of drugs metabolized by CYP3A4.

Read the full interaction Minor Likelihood Possible Marshmallow + Medroxyprogesterone Acetate, Oestrogens, Conjugatedi

Theoretically, mucilage in marshmallow might impair absorption of oral drugs.

Read the full interaction Moderate Likelihood Possible Kudzu + Medroxyprogesterone Acetate, Oestrogens, Conjugatedi

Theoretically, kudzu might alter the effects of estrogen therapy.

Read the full interaction
The complete list

Every Supplement Checked Against Medroxyprogesterone Acetate, Oestrogens, Conjugated

All 1,452 ingredients in our database, ranked by severity — 187 with a Medroxyprogesterone Acetate, Oestrogens, Conjugated interaction on file and 1,265 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Medroxyprogesterone Acetate, Oestrogens, Conjugated?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Black Tea with Medroxyprogesterone Acetate, Oestrogens, Conjugated?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, estrogens might increase the levels and adverse effects of caffeine.

Full Black Tea + Medroxyprogesterone Acetate, Oestrogens, Conjugated answer

Can you take Coffee with Medroxyprogesterone Acetate, Oestrogens, Conjugated?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, estrogens might increase the levels and adverse effects of caffeine.

Full Coffee + Medroxyprogesterone Acetate, Oestrogens, Conjugated answer

Can you take Vitamin E with Medroxyprogesterone Acetate, Oestrogens, Conjugated?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, vitamin E might induce metabolism of CYP3A4, possibly reducing the levels CYP3A4 substrates.

Full Vitamin E + Medroxyprogesterone Acetate, Oestrogens, Conjugated answer

Can you take Black Pepper with Medroxyprogesterone Acetate, Oestrogens, Conjugated?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, black pepper might increase levels of drugs metabolized by CYP3A4.

Full Black Pepper + Medroxyprogesterone Acetate, Oestrogens, Conjugated answer

Can you take Marshmallow with Medroxyprogesterone Acetate, Oestrogens, Conjugated?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, mucilage in marshmallow might impair absorption of oral drugs.

Full Marshmallow + Medroxyprogesterone Acetate, Oestrogens, Conjugated answer

Can you take Sweet Orange with Medroxyprogesterone Acetate, Oestrogens, Conjugated?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Sweet orange juice seems to modulate P-glycoprotein (P-gp), which might affect the blood levels of P-gp substrates.

Full Sweet Orange + Medroxyprogesterone Acetate, Oestrogens, Conjugated answer

Can you take Syrian Rue with Medroxyprogesterone Acetate, Oestrogens, Conjugated?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, Syrian rue might increase the levels and clinical effects of drugs metabolized by CYP3A4.

Full Syrian Rue + Medroxyprogesterone Acetate, Oestrogens, Conjugated answer

Can you take Terminalia with Medroxyprogesterone Acetate, Oestrogens, Conjugated?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, use of Terminalia arjuna may increase the levels and clinical effects of CYP3A4 substrates.

Full Terminalia + Medroxyprogesterone Acetate, Oestrogens, Conjugated answer

Can you take Thunder God Vine with Medroxyprogesterone Acetate, Oestrogens, Conjugated?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, thunder god vine might increase the levels and clinical effects of CYP3A4 substrates.

Full Thunder God Vine + Medroxyprogesterone Acetate, Oestrogens, Conjugated answer

Can you take Thyme with Medroxyprogesterone Acetate, Oestrogens, Conjugated?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, thyme might competitively inhibit the effects of estrogen replacement therapy.

Full Thyme + Medroxyprogesterone Acetate, Oestrogens, Conjugated answer

Can you take Tragacanth with Medroxyprogesterone Acetate, Oestrogens, Conjugated?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, tragacanth might alter absorption of oral drugs.

Full Tragacanth + Medroxyprogesterone Acetate, Oestrogens, Conjugated answer

Can you take Turmeric with Medroxyprogesterone Acetate, Oestrogens, Conjugated?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Turmeric might increase or decrease levels of drugs metabolized by CYP3A4.

Full Turmeric + Medroxyprogesterone Acetate, Oestrogens, Conjugated answer

Can you take Uva Ursi with Medroxyprogesterone Acetate, Oestrogens, Conjugated?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, uva ursi may decrease the metabolism of CYP3A4 substrates.

Full Uva Ursi + Medroxyprogesterone Acetate, Oestrogens, Conjugated answer

Can you take Valerian with Medroxyprogesterone Acetate, Oestrogens, Conjugated?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Valerian might weakly inhibit glucuronidation and increase concentrations of drugs metabolized by UGT1A1 and UGT2B7.

Full Valerian + Medroxyprogesterone Acetate, Oestrogens, Conjugated answer

Can you take White Pepper with Medroxyprogesterone Acetate, Oestrogens, Conjugated?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. In vitro evidence suggests that piperine, a constituent of white pepper, inhibits cytochrome P450 3A4 (CYP3A4).

Full White Pepper + Medroxyprogesterone Acetate, Oestrogens, Conjugated answer

Can you take Wild Cherry with Medroxyprogesterone Acetate, Oestrogens, Conjugated?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. In vitro research suggests that wild cherry can inhibit cytochrome P450 3A4 (CYP3A4) enzymes.

Full Wild Cherry + Medroxyprogesterone Acetate, Oestrogens, Conjugated answer

Can you take Wild Yam with Medroxyprogesterone Acetate, Oestrogens, Conjugated?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, wild yam might increase or decrease the effects of estrogen.

Full Wild Yam + Medroxyprogesterone Acetate, Oestrogens, Conjugated answer

Can you take Zedoary with Medroxyprogesterone Acetate, Oestrogens, Conjugated?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, zedoary might increase levels of drugs metabolized by CYP3A4.

Full Zedoary + Medroxyprogesterone Acetate, Oestrogens, Conjugated answer

Can you take Thyroid Extract with Medroxyprogesterone Acetate, Oestrogens, Conjugated?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Food and medications can interfere with thyroid hormone absorption.

Full Thyroid Extract + Medroxyprogesterone Acetate, Oestrogens, Conjugated answer

Can you take Acerola with Medroxyprogesterone Acetate, Oestrogens, Conjugated?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, concomitant use of acerola with estrogens might increase estrogenic effects.

Full Acerola + Medroxyprogesterone Acetate, Oestrogens, Conjugated answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Medroxyprogesterone Acetate, Oestrogens, Conjugated is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Medroxyprogesterone Acetate, Oestrogens, Conjugated, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Medroxyprogesterone Acetate, Oestrogens, Conjugated sits in 7 interaction categories. Open any one to see what the group means:

Cytochrome P450 3A4 (Cyp3A4) Substrates 121 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

121 of the supplement ingredients on this page reach Medroxyprogesterone Acetate, Oestrogens, Conjugated through this category.

Estrogens 60 ingredients

Hormone-related medications. Supplements with hormone-like activity can add to or interfere with them.

60 of the supplement ingredients on this page reach Medroxyprogesterone Acetate, Oestrogens, Conjugated through this category.

P-Glycoprotein Substrates 37 ingredients

A drug-transport group: these medications are moved in and out of cells by the P-glycoprotein pump. Supplements that affect the pump can change how much of the drug is absorbed or kept in the body.

37 of the supplement ingredients on this page reach Medroxyprogesterone Acetate, Oestrogens, Conjugated through this category.

Oral Drugs 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Medroxyprogesterone Acetate, Oestrogens, Conjugated through this category.

Glucuronidated Drugs 12 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

12 of the supplement ingredients on this page reach Medroxyprogesterone Acetate, Oestrogens, Conjugated through this category.

Ethinyl Estradiol 3 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

3 of the supplement ingredients on this page reach Medroxyprogesterone Acetate, Oestrogens, Conjugated through this category.

Progestin 1 ingredient

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

1 of the supplement ingredient on this page reaches Medroxyprogesterone Acetate, Oestrogens, Conjugated through this category.

Related: does Medroxyprogesterone Acetate, Oestrogens, Conjugated deplete any nutrients?

Medroxyprogesterone Acetate, Oestrogens, Conjugated has 5 reported nutrient associations in the research literature — see the Medroxyprogesterone Acetate, Oestrogens, Conjugated nutrient depletion report.

Check a real product

Take a Supplement Product? Check the Whole Bottle Against Medroxyprogesterone Acetate, Oestrogens, Conjugated

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Medroxyprogesterone Acetate, Oestrogens, Conjugated.

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Pharmacist Counseling Corner

Medroxyprogesterone Acetate, Oestrogens, Conjugated & Supplements: Common Questions

What supplements interact with Medroxyprogesterone Acetate, Oestrogens, Conjugated?
More than you might expect — 187 in total, though they are far from equal: 3 are rated major, 152 moderate, and 32 minor. The ranked list on this page puts the ones that genuinely matter first, and every entry opens a full report on that exact pair. The highest-ranked right now: Grapefruit, Activated Charcoal, St. John's Wort.
Which Medroxyprogesterone Acetate, Oestrogens, Conjugated supplement interactions are the most serious?
The 3 major-rated combinations — led by Grapefruit, Activated Charcoal and St. John's Wort — deserve real caution: these are the ones generally best avoided, or used only with your prescriber watching. If you take any of them today, don't panic and don't stop anything abruptly — call your pharmacist first. Jump to the ranked list.
Can I take vitamins or supplements while on Medroxyprogesterone Acetate, Oestrogens, Conjugated?
Usually yes — most people on Medroxyprogesterone Acetate, Oestrogens, Conjugated can take most supplements. The catch is the exceptions, and they aren't always the exotic ones (St. John's Wort trips up more prescriptions than almost anything sold next to it). Look up each ingredient you actually take in the list above, and treat "no known interaction" as a green-ish light, not a guarantee. Try the label scanner or the interaction checker.
Do brands like Premique have the same supplement interactions as Medroxyprogesterone Acetate, Oestrogens, Conjugated?
Yes — Premique all contain Medroxyprogesterone Acetate, Oestrogens, Conjugated, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
Does Medroxyprogesterone Acetate, Oestrogens, Conjugated deplete any vitamins or nutrients?
It might — Medroxyprogesterone Acetate, Oestrogens, Conjugated has 5 reported nutrient-depletion associations in the research literature, which is a different question from interactions: instead of a supplement changing the drug, the drug may lower a nutrient over time. See the Medroxyprogesterone Acetate, Oestrogens, Conjugated nutrient depletion report for the specifics and what to discuss with your pharmacist.
What about Medroxyprogesterone Acetate, Oestrogens, Conjugated and my other medications?
This page covers Medroxyprogesterone Acetate, Oestrogens, Conjugated against supplements and herbal ingredients. Checking Medroxyprogesterone Acetate, Oestrogens, Conjugated against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 22, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.