Drug & supplement interaction

Chrysin + Medroxyprogesterone Acetate, Oestrogens, Conjugated

Medroxyprogesterone Acetate, Oestrogens, Conjugated brand name: Premique.

Moderate Interaction
Medically reviewed by · Updated September 2026
The bottom line Moderate

Medroxyprogesterone Acetate, Oestrogens, Conjugated falls into 2 drug categories that Chrysin can interact with; the most serious is rated moderate. Theoretically, chrysin might decrease the effects of estrogen therapy.

Read the full interaction report
SeverityModerate
LikelihoodPossible
Interactions2
EvidenceD
What do Severity, Likelihood & Evidence mean?
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Interaction report

Chrysin and Medroxyprogesterone Acetate, Oestrogens, Conjugated

These two interact in 2 distinct ways. Each one is explained separately below.

Why Are There 2 Interactions?

Chrysin interacts with whole categories of medication. Medroxyprogesterone Acetate, Oestrogens, Conjugated falls into 2 of those categories, so it can interact with Chrysin in 2 different ways. We’ve listed each one below — your overall risk is driven by the most serious of them (Moderate).

Moderate

ESTROGENS

1 of 2

Why this applies to Medroxyprogesterone Acetate, Oestrogens, Conjugated

Medroxyprogesterone Acetate, Oestrogens, Conjugated falls under ESTROGENS — the group Chrysin interacts with.

Theoretically, chrysin might decrease the effects of estrogen therapy.
In vitro research suggests that chrysin might have antiestrogenic activity.
Severity Moderate Likelihood Possible Evidence D

Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

Premique combines conjugated estrogens with a progestin, and it's usually prescribed to ease menopause symptoms like hot flashes, night sweats, and vaginal dryness. The concern here is that chrysin, at least in test-tube studies, can act against estrogen activity, so in theory it might blunt how well your estrogen therapy works. If that happened, you could notice symptoms creeping back, such as more flushing or sweats.

I want to be honest about the strength of this, though. The evidence is only lab-based, with nothing proven in real people, and the body absorbs very little chrysin to begin with. So the real risk is likely small. Still, if you're using a chrysin supplement, it's worth a quick chat with your pharmacist or doctor before mixing the two.

Contact Dr. Brian directly if you have additional questions on this interaction
References
  1. Han, D. H., Denison, M. S., Tachibana, H., and Yamada, K. Relationship between estrogen receptor-binding and estrogenic activities of environmental estrogens and suppression by flavonoids. Biosci.Biotechnol.Biochem 2002;66(7):1479-1487. PubMed
  2. Collins, B. M., McLachlan, J. A., and Arnold, S. F. The estrogenic and antiestrogenic activities of phytochemicals with the human estrogen receptor expressed in yeast. Steroids 1997;62(4):365-372. PubMed
  3. Kuiper, G. G., Lemmen, J. G., Carlsson, B., Corton, J. C., Safe, S. H., van der Saag, P. T., van der Burg, B., and Gustafsson, J. A. Interaction of estrogenic chemicals and phytoestrogens with estrogen receptor beta. Endocrinology 1998;139(10):4252-4263. PubMed
Minor

GLUCURONIDATED DRUGS

2 of 2

Medroxyprogesterone Acetate, Oestrogens, Conjugated also falls under GLUCURONIDATED DRUGS.

Theoretically, chrysin might increase the clearance of drugs that are UGT1A1 substrates, thereby reducing their effectiveness.
In vitro research suggests that chrysin might induce UDP-glucuronosyltransferase 1A1 (UGT1A1).
Severity Minor Likelihood Unlikely Evidence D

Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans..

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

Premique combines conjugated estrogens with the progestin medroxyprogesterone, and your body partly clears estrogens through a liver process called glucuronidation (the UGT1A1 enzyme is one player here). The theory is that chrysin might speed up that enzyme a little, which could nudge your body to clear the estrogen portion faster. In plain terms, that might mean slightly weaker estrogen effect, so things like hot flashes, night sweats, or vaginal dryness could creep back.

I want to keep this in perspective. This concern comes only from lab and test-tube work, not from people, and chrysin is barely absorbed when taken by mouth. So a real-world problem is unlikely. Still, before adding chrysin, it is worth a quick chat with your pharmacist or doctor.

Contact Dr. Brian directly if you have additional questions on this interaction
References
  1. Galijatovic A, Walle UK, Walle T. Induction of UDP-glucuronosyltransferase by the flavonoids chrysin and quercetin in Caco-2 cells. Pharm Res 2000;17:21-6.
  2. Walle T, Otake Y, Galijatovic A, et al. Induction of UDP-glucuronosyltransferase UGT1A1 by the flavonoid chrysin in the human hepatoma cell line hep G2. Drug Metab Dispos 2000;28:1077-82. DOI
  3. Galijatovic A, Otake Y, Walle UK, Walle T. Induction of UDP-glucuronosyltransferase UGT1A1 by the flavonoid chrysin in Caco-2 cells--potential role in carcinogen bioinactivation. Pharm Res 2001;18:374-9. PubMed

What These Ratings Mean

Every interaction above is graded three ways — here’s the key to each label.

Severity how clinically significant the interaction is
Major

Clinically significant. Avoid the combination, or use only under close professional supervision.

Moderate

Usually worth avoiding or managing — may need monitoring, a dose change, or timing apart.

Minor

Generally not serious. Be aware of it and mention it to your pharmacist.

Likelihood how strong the evidence is that the interaction actually happens in people
  • LikelyWell-controlled human studies have demonstrated the likely existence of this interaction.
  • ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
  • UnlikelyInteraction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
Evidence the quality of the studies behind the rating (graded A–D)
  • AHigh-quality meta-analysis (quantitative systematic review).
  • BCase-control study.
  • CConsensus.
  • DAnecdotal evidence.

These ratings are for information only. Never start, stop, or otherwise change your therapy before speaking with your provider.

Keep it in perspective

Chrysin Also Interacts With Other Medications

Chrysin has 178 moderate, 179 minor known drug interactions in our database — the Medroxyprogesterone Acetate, Oestrogens, Conjugated one above is among them. If you take anything else, check it against the full list below.

Moderate 178 Minor 179 No known interaction 2,473 (incl. Medroxyprogesterone Acetate, Oestrogens, Conjugated)
Taking anything else?

Check Another of Your Medications Against Chrysin

Covers the 2,830 medications we’ve checked against Chrysin. Pick one to open its full report.

Everything else you take

See Every Supplement That Interacts With Medroxyprogesterone Acetate, Oestrogens, Conjugated

This page covers Chrysin only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Medroxyprogesterone Acetate, Oestrogens, Conjugated page lists 187 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Grapefruit (major), St. John's Wort (major), Acacia Rigidula (moderate) and Adrafinil (moderate).

By severity: 3 major · 152 moderate · 32 minor.

From our pharmacist’s overview on the Medroxyprogesterone Acetate, Oestrogens, Conjugated page

“Menopause and herbal remedies tend to travel together, so anyone taking Premique (medroxyprogesterone acetate with conjugated estrogens) should read this page with real care. Three of its 187 ingredients rate major, and those three matter most.”

Reviewed by 2 · Jul 18, 2026

Open the Medroxyprogesterone Acetate, Oestrogens, Conjugated interaction page

One more smart check

Taking Chrysin as Part of a Dietary Supplement Product? Check It for Interactions

We hold 272 real supplement products containing Chrysin, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Chrysin. Your product may carry other ingredients that interact with Medroxyprogesterone Acetate, Oestrogens, Conjugated too, on top of Chrysin — and those would not show on this page. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Chrysin and Medroxyprogesterone Acetate, Oestrogens, Conjugated Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Chrysin
Top 25%

#303 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Medroxyprogesterone Acetate, Oestrogens, Conjugated
Steady interest

#2,272 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Supplement

About Chrysin

What is Chrysin?

  • Bodybuilding and testosterone support
  • Anxiety and stress
  • Anti-inflammatory
  • Antioxidant support
  • Prostate health

Chrysin is a plant flavonoid sold mainly as a bodybuilding supplement claimed to raise testosterone or block estrogen, but human studies have not shown these benefits, largely because the body absorbs very little of it. Evidence for its other proposed uses is mostly limited to laboratory and animal research, so its real-world value is unclear. Talk with your pharmacist or doctor before using it.

Read the full Chrysin monograph & all interactions
Keep checking

Other Drugs & Chrysin

Browse every other medication we’ve checked against Chrysin — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
178Moderate
179Minor
2,472No known interaction
178 Moderate 179 Minor 2,472 No interaction
Moderate

178 interactions

Showing 60 of 178 moderate interactions — see all 178 on the Chrysin page.

Minor

179 interactions

Showing 60 of 179 minor interactions — see all 179 on the Chrysin page.

No interaction 2,472 drugs checked — show the list

We also checked Chrysin against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,472 medications checked with no known interaction — see the full Chrysin list.

See the full Chrysin interactions page
See every supplement checked against Medroxyprogesterone Acetate, Oestrogens, Conjugated, ranked by severity
Sources

Sources & How We Checked

Interaction details are evidence-graded and sourced from the Natural Medicines database. The medication overview comes from MedlinePlus.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Chrysin monograph › Uses, safety, and every drug interaction in one place Medroxyprogesterone Acetate, Oestrogens, Conjugated supplement interactions › Every supplement checked against Medroxyprogesterone Acetate, Oestrogens, Conjugated, ranked by severity Supplement interaction checker › Check any supplement or product against your medications Browse medications A–Z › Every drug we've checked against herbs & supplements Ask a pharmacist › Free, personal answer from our licensed team
Pharmacist Counseling Corner

Taking Chrysin and Medroxyprogesterone Acetate, Oestrogens, Conjugated Together: Common Questions

Can you take Chrysin with Medroxyprogesterone Acetate, Oestrogens, Conjugated?
There is a moderate interaction, so it may be acceptable with monitoring or timing changes — but check with your pharmacist first. Read the full details on this page and confirm with your pharmacist before combining them.
Why are there 2 interactions listed for Chrysin and Medroxyprogesterone Acetate, Oestrogens, Conjugated?
Medroxyprogesterone Acetate, Oestrogens, Conjugated belongs to more than one drug category, and Chrysin interacts with each of those categories a little differently. We list every one so nothing is missed — your overall risk is driven by the most serious of them.
How serious is the Chrysin and Medroxyprogesterone Acetate, Oestrogens, Conjugated interaction?
We rate it Moderate. This combination may require monitoring, a dose adjustment, or separating the times you take each one. Consult your pharmacist before using them together.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Still Have a Question About Medroxyprogesterone Acetate, Oestrogens, Conjugated and Chrysin?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.