Drug & supplement interaction

Gotu Kola + Ketoprofen

Ketoprofen brand names: Orudis, Oruvail Gel, Powergel, Oruvail Injection.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Gotu Kola and Ketoprofen in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the label for Ketoprofen states a food rule worth keeping to, and the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Gotu Kola and Ketoprofen

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Ketoprofen and Gotu Kola in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Gotu Kola safety at a glance

Gotu Kola overall Use caution Generally considered well tolerated short-term, but quality evidence is limited and liver concerns have been reported.
Pregnancy Possibly Safe When used topically and appropriately. There is insufficient reliable information available about the safety gotu kola when used orally during pregnancy; avoid... Read the full pregnancy detail
Breastfeeding Avoid Safety during breastfeeding is unknown, so it is best avoided.

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Ketoprofen and Gotu Kola? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Ketoprofen

Interactions in our licensed database are recorded against drug classes, not just single drug names. Ketoprofen is filed under 8 classifications — including nonsteroidal anti-inflammatory drugs (nsaids), anticoagulant/antiplatelet drugs, organic anion transporter 3 (oat3) substrates. Gotu Kola has documented interactions with 2 drug classes — the most serious being cns depressants (moderate) and hepatotoxic drugs (moderate) — and none of Ketoprofen’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Gotu Kola Does Interact With Other Medications

Gotu Kola has 579 moderate known drug interactions in our database — Ketoprofen isn’t one of them. If you take anything else, check it against the full list below.

Moderate 579 No known interaction 2,251 (incl. Ketoprofen)
Taking anything else?

Check Another of Your Medications Against Gotu Kola

Covers the 2,830 medications we’ve checked against Gotu Kola. Pick one to open its full report.

What to actually watch for

No Interaction Found — But Data Suggests Gotu Kola and Ketoprofen May Share Several of the Same Side Effects

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do. One of them is worth acting on rather than waiting out — marked below.

  • Liver problems Worth acting on Additional detail

    Gotu Kola

    “There is concern that gotu kola may cause liver toxicity in some patients. There are at least four case reports of hepatotoxicity associated with gotu kola; however, hepatotoxic contaminants cannot be ruled out, as laboratory analysis was not conducted on the products used. Additionally, the doses of gotu kola used in these cases were not reported.”

    Gotu Kola · Natural Medicines adverse-effect record, reported in acne.

    3 sources cited
    1. 13182. Jorge OA, Jorge AD. Hepatotoxicity associated with the ingestion of Centella asiatica. Rev Esp Enferm Dig 2005;97:115-24. PubMed
    2. 92506. Dantuluri S, North-lewis P, Karthik SV. Gotu Kola induced hepatotoxicity in a child - need for caution with alternative remedies. Dig Liver Dis. 2011;43(6):500. PubMed
    3. 11065. Cesarone MR, Incandela L, De Sanctis MT, et al. Evaluation of treatment of diabetic microangiopathy with total triterpenic fraction of Centella asiatica: a clinical prospective randomized trial with a microcirculatory model. Angiology 2001;52 Suppl 2 DOI

    Ketoprofen

    Listed in the ADVERSE REACTIONS section of the FDA label for Ketoprofen. Read the label on DailyMed ›

  • Stomach upset / Nausea reported in 6.1% of FDA reports for Ketoprofen Additional detail

    Gotu Kola

    “In some patients, gotu kola can extract cause gastrointestinal upset and nausea.”

    Gotu Kola · Natural Medicines adverse-effect record, reported in nausea and vomiting.

    3 sources cited
    1. 780. Pointel JP, Boccalon H, Cloarec M, et al. Titrated extract of Centella asiatica (TECA) in the treatment of venous insufficiency of the lower limbs. Angiol 1987;38:46-50. PubMed
    2. 6887. Brinkhaus B, Lindner M, Schuppan D, Hahn EG. Chemical, pharmacological and clinical profile of the east Asian medical plant Centella asiatica. Phytomedicine 2000;7:427-48.
    3. 52894. Marastoni, F., Baldo, A., Redaelli, G., and Ghiringhelli, L. [Centella asiatica extract in venous pathology of the lower limbs and its evaluation as compared with tribenoside]. Minerva Cardioangiol. 1982;30(4):201-207.

    Ketoprofen

    Listed in the ADVERSE REACTIONS section of the FDA label for Ketoprofen, and in voluntary FDA adverse-event reports. Read the label on DailyMed ›

  • Itching / A skin rash Additional detail

    Gotu Kola

    “Topically, gotu kola can cause allergic contact dermatitis, characterized by erythema, itching, papules, and a burning sensation (4,6887,9789,52875,52887,52896,52902). One specific gotu kola product (Blasteostimulina, Almirall, S. A.) has been reported to cause allergic contact dermatitis in some patients. However, not all patients who react to this product are sensitive to gotu kola;”

    Gotu Kola · Natural Medicines adverse-effect record, reported in dermatitis.

    6 sources cited
    1. 4. Newall CA, Anderson LA, Philpson JD. Herbal Medicine: A Guide for Healthcare Professionals. London, UK: The Pharmaceutical Press, 1996.
    2. 6887. Brinkhaus B, Lindner M, Schuppan D, Hahn EG. Chemical, pharmacological and clinical profile of the east Asian medical plant Centella asiatica. Phytomedicine 2000;7:427-48.
    3. 9789. Eun HC, Lee AY. Contact dermatitis due to madecassol. Contact Dermatitis 1985;13:310-3.. PubMed
    4. 52875. Izu, R., Aguirre, A., Gil, N., and Diaz-Perez, J. L. Allergic contact dermatitis from a cream containing Centella asiatica extract. Contact Dermatitis 1992;26(3):192-193.
    5. 52887. Santucci, B., Picardo, M., and Cristaudo, A. Contact dermatitis due to Centelase. Contact Dermatitis 1985;13(1):39. PubMed
    6. 52896. Danese, P., Carnevali, C., and Bertazzoni, M. G. Allergic contact dermatitis due to Centella asiatica extract. Contact Dermatitis 1994;31(3):201.

    “Topically, gotu kola may cause eczema. Also, gotu kola can cause allergic contact dermatitis, characterized by erythema, itching, papules, and a burning sensation (4,6887,9789,52875,52887,52896,52902). One specific gotu kola product (Blasteostimulina,Almirall, S. A.) has been reported to cause allergic contact dermatitis. However, not all patients with reactions to this product are sensitive to gotu kola;”

    Gotu Kola · Natural Medicines adverse-effect record, reported in dermatitis.

    6 sources cited
    1. 10277. Hausen BM. Centella asiatica (Indian pennywort), an effective therapeutic but a weak sensitizer. Contact Dermatitis 1993;29:175-9..
    2. 10278. Bilbao I, Aguirre A, Zabala R, et al. Allergic contact dermatitis from butoxyethyl nicotinic acid and Centella asiatica extract. Contact Dermatitis 1995;33:435-6.
    3. 4. Newall CA, Anderson LA, Philpson JD. Herbal Medicine: A Guide for Healthcare Professionals. London, UK: The Pharmaceutical Press, 1996.
    4. 6887. Brinkhaus B, Lindner M, Schuppan D, Hahn EG. Chemical, pharmacological and clinical profile of the east Asian medical plant Centella asiatica. Phytomedicine 2000;7:427-48.
    5. 9789. Eun HC, Lee AY. Contact dermatitis due to madecassol. Contact Dermatitis 1985;13:310-3.. PubMed
    6. 52875. Izu, R., Aguirre, A., Gil, N., and Diaz-Perez, J. L. Allergic contact dermatitis from a cream containing Centella asiatica extract. Contact Dermatitis 1992;26(3):192-193.

    Ketoprofen

    Listed in the ADVERSE REACTIONS section of the FDA label for Ketoprofen. Read the label on DailyMed ›

  • Stomach pain / Vomiting Additional detail

    Gotu Kola

    Recorded for Gotu Kola in the same Natural Medicines adverse-effect record shown under Liver problems above.

    Ketoprofen

    Listed in the ADVERSE REACTIONS section of the FDA label for Ketoprofen. Read the label on DailyMed ›

Reported for Gotu Kola but not commonly for Ketoprofen: acne.

Effects for Ketoprofen come from the ADVERSE REACTIONS section of its FDA label; effects for Gotu Kola come from the Natural Medicines adverse-effect record, quoted above. Where a percentage is shown, it is the share of 13,040 voluntary FDA FAERS reports for Ketoprofen that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

Special populations

Gotu Kola in Pregnancy & Breastfeeding

Pregnancy Possibly Safe

When used topically and appropriately. There is insufficient reliable information available about the safety gotu kola when used orally during pregnancy; avoid using.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

How to take them

Some Ketoprofen Products Have a Food Rule — Gotu Kola Should Not Break It

At least one FDA label for a product containing Ketoprofen says to take it with food. If you take Gotu Kola on an empty stomach out of habit, keep them separate — and take Ketoprofen with a meal where the label says to.

This may not be true of your version. Food instructions belong to the product, not the ingredient: two Ketoprofen products can carry different directions, and extended-release forms often differ from immediate-release ones. The label we read is quoted below — check the directions on your own box or bottle, or ask your pharmacist, for how to take the exact product you were given.

Although food delays the absorption of both formulations (see CLINICAL PHARMACOLOGY ) in most of the clinical trials ketoprofen was taken with food or milk.

From the Dosage and Administration section of the FDA label we read for Ketoprofen — where that label names a specific product, the instruction is that product's. Read the label on DailyMed ›

A food rule is not an interaction — it is about how much of the medicine you absorb. The directions that came with your own product, and your pharmacist, outrank anything on this page.

Everything else you take

See Every Supplement That Interacts With Ketoprofen

This page covers Gotu Kola only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Ketoprofen page lists 252 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Asarabacca (major), Beer (major), Danshen (major) and Piracetam (major).

By severity: 7 major · 217 moderate · 28 minor.

From our pharmacist’s overview on the Ketoprofen page

“Bleeding is what worries me most with ketoprofen (Orudis, Oruvail Gel). As an NSAID, it already irritates the stomach lining and slows clotting, and 202 of the 252 supplements and herbs on this page can push that bleeding risk further.”

Reviewed by 2 · Jul 18, 2026

Open the Ketoprofen interaction page

One more smart check

Taking Gotu Kola as Part of a Dietary Supplement Product? Check It for Interactions

We hold 1,832 real supplement products containing Gotu Kola, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Gotu Kola. Even though Gotu Kola itself has no known interaction with Ketoprofen, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Gotu Kola and Ketoprofen Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Gotu Kola
Top 10%

#137 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Ketoprofen
Top half

#719 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Gotu Kola reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Gotu Kola and Ketoprofen records this page draws on were last updated July 11, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Gotu Kola

What is Gotu Kola?

Gotu Kola
  • Wound healing
  • Varicose veins and poor circulation
  • Anxiety and stress
  • Memory and mental clarity
  • Skin health and scarring

Gotu kola is a traditional Ayurvedic and Asian herb that people use for wound healing, circulation, skin problems, and as a calming or memory-supporting herb. Some early studies suggest possible benefits for vein health and skin, but the overall evidence is limited and not strong. Talk to your pharmacist or doctor before using it, especially if you are pregnant, breastfeeding, or have liver problems.

Centella asiatica · Apiaceae · Leaves and stems (aerial parts) · Tea, capsules, tablets, tinctures, dried herb, topical creams and ointments

An interaction check asks whether these two react with each other — it does not ask whether Gotu Kola is a good idea for someone in your situation. Here is what our Gotu Kola record says about it on its own.

Gotu Kola: dosing

There is no single official or proven dose for gotu kola. The amount used in studies has varied widely depending on the product, the extract used, and the condition being studied.Because products differ a lot in strength and form (tea, capsule, tincture, cream), the best approach is to follow the directions on the product label. Do not use more than the label recommends.

From our Gotu Kola monograph — the full record covers uses, side effects and every documented interaction.

Read the full Gotu Kola monograph & all interactions
Medication

About Ketoprofen

What Is Ketoprofen Used For?

Brand names: Orudis, Oruvail Gel, Powergel, Oruvail Injection

Ketoprofen capsules (including the brand Orudis) are used to manage the signs and symptoms of rheumatoid arthritis and osteoarthritis, to treat pain, and to treat primary dysmenorrhea (painful menstrual periods).

Ketoprofen extended-release capsules are approved for rheumatoid arthritis and osteoarthritis only. Because of the way they slowly release the drug, ketoprofen extended-release capsules are not recommended for treating acute (sudden) pain.

Most-Reported Side Effects for Ketoprofen

From FAERS, the FDA’s public side-effect reporting system (13,040 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Headache 1,232 reports
Fatigue 932 reports
Nausea 799 reports
Infusion site pain 764 reports
Fever 756 reports
See full Ketoprofen drug information
Keep checking

Other Drugs & Gotu Kola

Browse every other medication we’ve checked against Gotu Kola — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
579Moderate
0Minor
2,250No known interaction
579 Moderate 2,250 No interaction
Moderate

579 interactions

Showing 60 of 579 moderate interactions — see all 579 on the Gotu Kola page.

No interaction 2,250 drugs checked — show the list

We also checked Gotu Kola against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,250 medications checked with no known interaction — see the full Gotu Kola list.

See the full Gotu Kola interactions page
See every supplement checked against Ketoprofen, ranked by severity
Evidence & sources

Gotu Kola References

The 18 references that drive our Gotu Kola monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Newall CA, Anderson LA, Philpson JD. Herbal Medicine: A Guide for Healthcare Professionals. London, UK: The Pharmaceutical Press, 1996.
  2. Pointel JP, Boccalon H, Cloarec M, et al. Titrated extract of Centella asiatica (TECA) in the treatment of venous insufficiency of the lower limbs. Angiol 1987;38:46-50. PubMed
  3. Brinkhaus B, Lindner M, Schuppan D, Hahn EG. Chemical, pharmacological and clinical profile of the east Asian medical plant Centella asiatica. Phytomedicine 2000;7:427-48.
  4. Eun HC, Lee AY. Contact dermatitis due to madecassol. Contact Dermatitis 1985;13:310-3.. PubMed
  5. Hausen BM. Centella asiatica (Indian pennywort), an effective therapeutic but a weak sensitizer. Contact Dermatitis 1993;29:175-9..
  6. Bilbao I, Aguirre A, Zabala R, et al. Allergic contact dermatitis from butoxyethyl nicotinic acid and Centella asiatica extract. Contact Dermatitis 1995;33:435-6.
  7. Cesarone MR, Incandela L, De Sanctis MT, et al. Evaluation of treatment of diabetic microangiopathy with total triterpenic fraction of Centella asiatica: a clinical prospective randomized trial with a microcirculatory model. Angiology 2001;52 Suppl 2 DOI
  8. Bradwejn J, Zhou Y, Koszycki D, Shlik J. A double-blind, placebo-controlled study on the effects of Gotu Kola (Centella asiatica) on acoustic startle response in healthy subjects. J Clin Psychopharmacol 2000;20:680-4. PubMed
  9. Young GL, Jewell D. Creams for preventing stretch marks in pregnancy. Cochrane Database Syst Rev 2000;(2):CD000066. PubMed
  10. Jorge OA, Jorge AD. Hepatotoxicity associated with the ingestion of Centella asiatica. Rev Esp Enferm Dig 2005;97:115-24. PubMed
  11. Mallol J, Belda MA, Costa D, et al. Prophylaxis of striae gravidarum with a topical formulation. A double blind trial. Int J Cosmet Sci 1991;3:51-7.
  12. Izu, R., Aguirre, A., Gil, N., and Diaz-Perez, J. L. Allergic contact dermatitis from a cream containing Centella asiatica extract. Contact Dermatitis 1992;26(3):192-193.
  13. Santucci, B., Picardo, M., and Cristaudo, A. Contact dermatitis due to Centelase. Contact Dermatitis 1985;13(1):39. PubMed
  14. Vena, G. A. and Angelini, G. Contact allergy to Centelase. Contact Dermatitis 1986;15(2):108-109. PubMed
  15. Marastoni, F., Baldo, A., Redaelli, G., and Ghiringhelli, L. [Centella asiatica extract in venous pathology of the lower limbs and its evaluation as compared with tribenoside]. Minerva Cardioangiol. 1982;30(4):201-207.

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Gotu Kola and Ketoprofen Together: Common Questions

Is it safe to take Gotu Kola with Ketoprofen?
We do not list a known interaction between Gotu Kola and Ketoprofen. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Gotu Kola and Ketoprofen have any of the same side effects?
Yes — our sources link each of them separately to 7 of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
Should I take Gotu Kola and Ketoprofen at the same time of day?
At least one FDA label for a product containing Ketoprofen says to take it with food. If you take Gotu Kola on an empty stomach out of habit, keep them separate and take Ketoprofen with a meal where the label says to. Food instructions belong to the product rather than the ingredient — two Ketoprofen products can differ — so check the directions on your own box. This is about absorption, not an interaction.
How was the Gotu Kola and Ketoprofen combination checked?
Interactions in our licensed database are recorded against drug classes. Ketoprofen is filed under 8 classifications, and Gotu Kola has documented interactions with 2 drug classes — none of Ketoprofen's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Gotu Kola interact with any other medications?
Yes. Gotu Kola has 579 documented drug interactions in our database — Ketoprofen is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Ketoprofen interact with any supplements?
Yes. Ketoprofen has documented interactions with 252 supplements in our database — Gotu Kola is not one of them. The Ketoprofen interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Gotu Kola monograph Uses, safety profile, and every drug interaction in one place Ketoprofen drug information The full plain-English guide to this medication Ketoprofen supplement interactions Every supplement checked against Ketoprofen, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 18 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Ketoprofen and Gotu Kola?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.