Inositol + Sildenafil
Sildenafil brand name: Revatio.
We found no known interaction between Inositol and Sildenafil in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.
Inositol and Sildenafil
We checked these two against our interaction database. Here is what we found.
No Known Interaction Found
We did not find a documented interaction between Sildenafil and Inositol in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.
If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.
Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.
Inositol safety at a glance
Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.
Why No Interaction Is Listed for Sildenafil
Interactions in our licensed database are recorded against drug classes, not just single drug names. Sildenafil is filed under 6 classifications — including phosphodiesterase-5 inhibitors, vasodilators, cytochrome p450 2c9 (cyp2c9) substrates. Inositol has documented interactions with 1 drug class — the most serious being antidiabetes drugs (moderate) — and none of Sildenafil’s classifications are among them.
Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.
Inositol Does Interact With Other Medications
Inositol has 86 moderate known drug interactions in our database — Sildenafil isn’t one of them. If you take anything else, check it against the full list below.
Check Another of Your Medications Against Inositol
We haven’t checked that one against Inositol yet — ask our pharmacists directly.
Covers the 2,830 medications we’ve checked against Inositol. Pick one to open its full report.
Inositol in Pregnancy & Breastfeeding
When used orally and appropriately, short-term. Myo-inositol has been used with apparent safety in amounts up to 4000 mg daily during pregnancy.
DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center
What Sildenafil Is Prescribed For, and What Inositol Has Been Studied For
These two come up together because they touch the same health topic — not because they do the same job. Sildenafil is a prescription medicine with approved uses on its FDA label. Inositol is a supplement: what follows is what researchers have looked at it for, and how strong that evidence is.
Sildenafil is prescribed for: Sildenafil treats two distinct conditions depending on the product. Viagra (tablet) and Vybrique (dissolving oral film) are approved for erectile dysfunction (ED) — difficulty getting or keeping an erection. Generic sildenafil tablets and oral film are also approved for ED. Revatio and several generic sildenafil products (tablets, oral suspension, and injection) are used for pulmonary arterial hypertension (PAH) — high blood pressure in the arteries of the lungs — in adults to improve exercise ability and slow the disease from getting worse.
Read the rest of what Sildenafil is prescribed for
Revatio oral suspension and injection are also approved for PAH in children ages 1 to 17.
Inositol has been studied for:
-
Hypertension studied, not established Inositol has been studied for this. Natural Medicines rates the evidence: Insufficient Reliable Evidence To Rate Read what the research shows
Inositol for hypertension
Although there has been interest in using oral inositol for hypertension, there is insufficient reliable information about the clinical effects of inositol for this condition.
Effectiveness ratings and the research summaries above are the verbatim record from the Natural Medicines database, which grades evidence from “Effective” down to “Insufficient Reliable Evidence To Rate”. A rating below the top of that scale means researchers have looked at it — not that it works, and never that it can stand in for a prescribed medicine. Do not stop or replace Sildenafil on your own; if you are taking Inositol for the same health topic, tell your prescriber, especially if the medicine is being adjusted to a target.
Questions About Inositol or Sildenafil
These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Inositol or Sildenafil, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:
- Is Inositol Safe With Ozempic (Semaglutide)? ›
- Which Medications Interact With Nitric Oxide Supplements? ›
- Can You Take Benadryl With L-Theanine, Glycine And Inositol? ›
- Can You Cut, Split Or Crush Viagra (Sildenafil Citrate)? ›
Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.
See Every Supplement That Interacts With Sildenafil
This page covers Inositol only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Sildenafil page lists 160 supplements it has a documented interaction with, worst first, each one explained.
The most serious there right now: Activated Charcoal (major), American Mistletoe (major), Grapefruit (major), Hawthorn (major) and St. John's Wort (major).
By severity: 5 major · 114 moderate · 41 minor.
From our pharmacist’s overview on the Sildenafil page
“Sildenafil relaxes blood vessels, whether prescribed as Revatio for pulmonary hypertension or as Viagra, and that blood-pressure-lowering action makes this list one to treat with genuine care. Of the 160 supplement and herbal ingredients on file, five carry a major rating, and those deserve understanding first.”
Reviewed by 2 · Jul 18, 2026
Taking Inositol as Part of a Dietary Supplement Product? Check It for Interactions
We hold 10,116 real supplement products containing Inositol, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Inositol. Even though Inositol itself has no known interaction with Sildenafil, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:
Where Inositol and Sildenafil Sit Against Everything Else
Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.
#26 of 1,452 supplements looked up here in the last 7 days
#574 of 2,830 medications looked up here in the last 7 days
Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.
Where does our data come from?
- Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
- Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Inositol reference on this page ↓
- Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Inositol and Sildenafil records this page draws on were last updated July 11, 2026.
- What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
About Inositol
What is Inositol?
- Polycystic ovary syndrome (PCOS)
- Anxiety and panic
- Depression and mood
- Insulin and blood sugar support
- Fertility support
- Metabolic syndrome
Inositol is a sugar alcohol made naturally in the body and found in many foods, and it is sold as a supplement (often myo-inositol) mainly for PCOS, mood, and metabolic concerns. The strongest evidence is for PCOS-related symptoms, while support for other uses is more limited. It is generally well tolerated, but talk with your pharmacist or doctor before starting it, especially if you are pregnant or have a health condition.
Not applicable (a sugar alcohol found in foods and made by the body) · Capsules, tablets, powder (often as myo-inositol or D-chiro-inositol)
An interaction check asks whether these two react with each other — it does not ask whether Inositol is a good idea for someone in your situation. Here is what our Inositol record says about it on its own.
Inositol: dosing
There is no single official or standardized dose of inositol for general health. Do not assume that higher doses are better or safer.
From our Inositol monograph — the full record covers uses, side effects and every documented interaction.
About Sildenafil
What Is Sildenafil Used For?
Brand name: Revatio
Sildenafil treats two distinct conditions depending on the product. Viagra (tablet) and Vybrique (dissolving oral film) are approved for erectile dysfunction (ED) — difficulty getting or keeping an erection. Generic sildenafil tablets and oral film are also approved for ED.
Revatio and several generic sildenafil products (tablets, oral suspension, and injection) are used for pulmonary arterial hypertension (PAH) — high blood pressure in the arteries of the lungs — in adults to improve exercise ability and slow the disease from getting worse. Revatio oral suspension and injection are also approved for PAH in children ages 1 to 17.
Most-Reported Side Effects for Sildenafil
From FAERS, the FDA’s public side-effect reporting system (126,564 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.
Other Drugs & Inositol
Browse every other medication we’ve checked against Inositol — both the ones with a known interaction and the ones without. Select any drug for the full detail.
No drugs match “”.
86 interactions
- Insulin (rdna) ›
- Glyburide ›
- Insulin (pork) ›
- Insulin (human) ›
- Acarbose ›
- Insulin Glargine ›
- Semaglutide ›
- Chlorpropamide ›
- Exenatide ›
- Glipizide ›
- Glucagon ›
- Insulin Lispro ›
- Metformin ›
- Repaglinide ›
- Sitagliptin ›
- Tirzepatide ›
- Acetohexamide ›
- Albiglutide ›
- Alogliptin ›
- Canagliflozin ›
- Dapagliflozin ›
- Dasiglucagon Hydrochloride ›
- Dulaglutide ›
- Empagliflozin ›
- Ertugliflozin ›
- Exenatide Synthetic ›
- Gliclazide ›
- Glimepiride ›
- Glucose ›
- Inhaled Insulin ›
- Insulin ›
- Insulin (bovine) ›
- Insulin Aspart ›
- Insulin Degludec ›
- Insulin Determir ›
- Insulin Glargine (rdna) ›
- Insulin Glargine Recombinant ›
- Insulin Glulisine (rdna) ›
- Insulin Lispro Recombinant ›
- Insulin Lispro-aabc ›
- Linagliptin ›
- Liraglutide ›
- Liraglutide Recombinant ›
- Lixisenatide ›
- Metformin Hydrochloride ›
- Metformin Xr ›
- Miglitol ›
- Muraglitazar ›
- Nateglinide ›
- Pioglitazone ›
- Pramlintide ›
- Rosiglitazone Maleate ›
- Saxagliptin ›
- Sotagliflozin ›
- Tobutamide ›
- Tolazamide ›
- Tolbutamide ›
- Troglitazone ›
- Vildagliptin ›
- Metformin, Sitagliptin ›
Showing 60 of 86 moderate interactions — see all 86 on the Inositol page.
No interaction 2,743 drugs checked — show the list
We also checked Inositol against these medications and found no known interaction in our sources. Open any page to confirm.
- Apixaban ›
- Levothyroxine ›
- Amlodipine ›
- Methylphenidate ›
- Warfarin ›
- Sertraline ›
- Testosterone ›
- Losartan Potassium ›
- Metoprolol ›
- Ivermectin ›
- Aspirin ›
- Rivaroxaban ›
- Rosuvastatin ›
- Escitalopram ›
- Acetaminophen ›
- Tadalafil ›
- Clopidogrel ›
- Atorvastatin ›
- Docusate ›
- Valacyclovir ›
- Hydroxyurea ›
- Abemaciclib ›
- Ibuprofen ›
- Methamphetamine ›
- Sumatriptan ›
- Warfarin Sodium ›
- Prednisone ›
- Propranolol ›
- Bupropion ›
- Lisdexamfetamine ›
- Amoxicillin ›
- Acyclovir ›
- Lisinopril ›
- Bendamustine ›
- Amitriptyline ›
- Doxycycline ›
- Methotrexate ›
- Lamotrigine ›
- Fluoxetine ›
- Amphetamine ›
- Gabapentin ›
- Pregabalin ›
- Acetaminophen, Codeine ›
- Azithromycin ›
- Dextroamphetamine ›
- Isotretinoin ›
- Clonazepam ›
- Omeprazole ›
- Quetiapine ›
- Methylene Blue ›
- Amlodipine Besylate ›
- Duloxetine ›
- Letrozole ›
- Buspirone ›
- Citalopram ›
- Naproxen ›
- Ciprofloxacin ›
- Bisoprolol ›
- Levothyroxine, Liothyronine ›
- Acetaminophen, Oxycodone ›
Showing the 60 most looked-up of 2,743 medications checked with no known interaction — see the full Inositol list.
Inositol References
The 14 references that drive our Inositol monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.
- Palatnik A, Frolov K, Fux M, Benjamin J. Double-blind, controlled, crossover trial of inositol versus fluvoxamine for the treatment of panic disorder. J Clin Psychopharmacol 2001;21:335-9.. PubMed
- Allan SJ, Kavanagh GM, Herd RM, Savin JA. The effect of inositol supplements on the psoriasis of patients taking lithium: a randomized, placebo-controlled trial. Br J Dermatol 2004;150:966-9. PubMed
- Machado-Vieira R, Viale CI, Kapczinski F. Mania associated with an energy drink: the possible role of caffeine, taurine, and inositol. Can J Psychiatry 2001;46:454-5. PubMed
- Kamenov Z, Kolarov G, Gateva A, Carlomagno G, Genazzani AD. Ovulation induction with myo-inositol alone and in combination with clomiphene citrate in polycystic ovarian syndrome patients with insulin resistance. Gynecol Endocrinol 2015;31(2):131-5. PubMed
- Matarrelli B, Vitacolonna E, D'Angelo M, et al. Effect of dietary myo-inositol supplementation in pregnancy on the incidence of maternal gestational diabetes mellitus and fetal outcomes: a randomized controlled trial. J Matern Fetal Neonatal Med 2013;26(1 PubMed
- Mukai T, Kishi T, Matsuda Y, Iwata N. A meta-analysis of inositol for depression and anxiety disorders. Hum Psychopharmacol 2014;29(1):55-63. PubMed
- Farren M, Daly N, McKeating A, Kinsley B, Turner MJ, Daly S. The Prevention of Gestational Diabetes Mellitus With Antenatal Oral Inositol Supplementation: A Randomized Controlled Trial. Diabetes Care. 2017;40(6):759-63. PubMed
- Zheng X, Liu Z, Zhang Y, et al. Relationship Between Myo-Inositol Supplementary and Gestational Diabetes Mellitus: A Meta-Analysis. Medicine (Baltimore). 2015;94(42):e1604. PubMed
- Crawford TJ, Crowther CA, Alsweiler J, Brown J. Antenatal dietary supplementation with myo-inositol in women during pregnancy for preventing gestational diabetes. Cochrane Database Syst Rev. 2015;(12):CD011507. PubMed
- Maurizi AR, Menduni M, Del Toro R, et al. A pilot study of D-chiro-inositol plus folic acid in overweight patients with type 1 diabetes. Acta Diabetol. 2017;54(4):361-65. PubMed
- Leppink EW, Redden SA, Grant JE. A double-blind, placebo-controlled study of inositol in trichotillomania. Int Clin Psychopharmacol. 2017;32(2):107-14. PubMed
- Lam S, Mandrekar SJ, Gesthalter Y. A Randomized Phase IIb Trial of myo-Inositol in Smokers with Bronchial Dysplasia. Cancer Prev Res (Phila). 2016;9(12):906-14.
- Wozniak J, Faraone SV, Chan J, et al. A randomized clinical trial of high eicosapentaenoic acid omega-3 fatty acids and inositol as monotherapy and in combination in the treatment of pediatric bipolar spectrum disorders: a pilot study. J Clin Psychiatry. PubMed
- Vitale SG, Corrado F, Caruso S, et al. Myo-inositol supplementation to prevent gestational diabetes in overweight non-obese women: bioelectrical impedance analysis, metabolic aspects, obstetric and neonatal outcomes - a randomized and open-label, placebo-
Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
Taking Inositol and Sildenafil Together: Common Questions
Is it safe to take Inositol with Sildenafil?
Do Inositol and Sildenafil have any of the same side effects?
Are Inositol and Sildenafil used for the same thing?
How was the Inositol and Sildenafil combination checked?
Does Inositol interact with any other medications?
Does Sildenafil interact with any supplements?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.